The Cochrane The Cochrane Collaboration and the Collaboration and the

Cochrane LibraryCochrane Library

South Asian Cochrane Network South Asian Cochrane Network Workshop, IUB, DhakaWorkshop, IUB, Dhaka

4 May4 May 2007 2007

Andy OxmanNorwegian Knowledge Centre for the Health Services

What is a systematic review?What is a systematic review?

Establish objectives + selection criteriaEstablish objectives + selection criteria

Search for eligible studiesSearch for eligible studies

Apply selection criteriaApply selection criteria

Assess study quality + assemble dataAssess study quality + assemble data

Analyse results using meta-analysis, if Analyse results using meta-analysis, if appropriate and possibleappropriate and possible

Prepare report Prepare report

Keep it up to dateKeep it up to date

Questions about what a Questions about what a systematic review is?systematic review is?

The Cochrane CollaborationThe Cochrane Collaboration

An international organisation that aims to help people make well-informed decisions about healthcare by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of healthcare interventions.

PrinciplesPrinciplesCollaborationCollaborationBuilding on enthusiasm of individualsBuilding on enthusiasm of individualsAvoiding duplicationAvoiding duplicationMinimising biasMinimising biasKeeping up to dateKeeping up to dateStriving for relevanceStriving for relevancePromoting accessPromoting accessEnsuring qualityEnsuring qualityEnsuring continuityEnsuring continuityEnabling wide participation Enabling wide participation

A brief historyA brief history

1948 Streptomycin treatment of pulmonary 1948 Streptomycin treatment of pulmonary tuberculosis: a Medical Research Council tuberculosis: a Medical Research Council investigation. investigation. BMJ 1948; ii:769-82.BMJ 1948; ii:769-82.

1972 Cochrane AL.1972 Cochrane AL. Effectiveness and Effectiveness and Efficiency. Random Reflections on Health Efficiency. Random Reflections on Health ServicesServices

1974 Oxford Database of Perinatal Trials 1974 Oxford Database of Perinatal Trials (ODPT) conceived(ODPT) conceived

1989 ODPT first published1989 ODPT first published

The Cochrane CollaborationThe Cochrane Collaboration

1992 1992 UK Cochrane CentreUK Cochrane Centre

1993 1993 Cochrane CollaborationCochrane Collaboration

19941994Cochrane Database ofCochrane Database of

Systematic ReviewsSystematic Reviews

1996 1996 Cochrane Library Cochrane Library

Database Records

The Cochrane Database of Systematic Reviews (Cochrane Reviews)

Complete reviewsNewUpdated

Protocols

44102785

11158

1625

Database of Abstracts of Reviews of Effects (Other Reviews) 5574

The Cochrane Central Register of Controlled Trials (Clinical Trials) 477942

The Cochrane Database of Methodology Reviews (Methods Reviews) 23

The Cochrane Methodology Register (Methods Studies) 8408

Health Technology Assessment Database (Technology Assessments) 6011

NHS Economic Evaluation Database (Economic Evaluations) 18852

About The Cochrane Collaboration and the Cochrane Review Groups (Cochrane Groups)

91

Cochrane ReviewsCochrane Reviews

AccessAccessNational licensesNational licenses– Australia Australia – Denmark Denmark – England England – Finland Finland – IndiaIndia– IrelandIreland– New Zealand New Zealand – Norway Norway – Scotland Scotland – Sweden Sweden – Wales Wales

Low–Income CountriesLow–Income Countries – Health InterNetwork Access to Research Initiative (HINARI)Health InterNetwork Access to Research Initiative (HINARI)– International Network for the Availability of Scientific Publication's International Network for the Availability of Scientific Publication's

(INASP) (INASP) – South African Cochrane Centre sponsorshipSouth African Cochrane Centre sponsorship– Latin America, the Caribbean (BIREME)Latin America, the Caribbean (BIREME)

About the Cochrane CollaborationAbout the Cochrane Collaboration

Review GroupsReview Groups

Review GroupsReview Groups

Review GroupsReview Groups

Review GroupsReview Groups

Review GroupsReview Groups

CentresCentres

CentresCentres

CentresCentres

CentresCentres

Fields (Networks) & Methods GroupsFields (Networks) & Methods Groups

www.cochrane.orgwww.cochrane.org

Questions about the Questions about the Cochrane Collaboration or the Cochrane Collaboration or the

Cochrane Library?Cochrane Library?

Two perspectives of the Two perspectives of the Cochrane CollaborationCochrane Collaboration

“Massive data analysis can reduce the chaos of medical practice.” Richard Peto, Oxford