The first building with more than 2500 m2 of active area is already

constructed. But there is no investments for

technological equipment.

The investigations are carried out in the fields of bioorganic and organic

chemistry, molecular biology and immunology, biochemistry and

biotechnology.

• Founded inFounded in 1964 1964 • Previous namePrevious name

• President-OrganizerPresident-Organizer

Institute of Biologically Active SubstancesInstitute of Biologically Active Substances

Academician GAcademician G..BB. . ElyakovElyakov

.. Acting Director (from 2001)Acting Director (from 2001)Academician V.A. StonikAcademician V.A. Stonik

TotalTotal - 3 - 35656 personspersons

Scientific staffScientific staff – 1 – 18383, , includingincluding::

Academician of RASAcademician of RAS - 2 - 2 Corresponding member of RASCorresponding member of RAS - - 11 Doctor of ScienceDoctor of Science - - 2222 Ph. D.Ph. D. - - 158158Young scientistsYoung scientists - - 3434

Department of Low MolecularDepartment of Low Molecular RegulatorsRegulators Department of the Molecular ImmunologyDepartment of the Molecular Immunology Laboratory of the Plant Chemotaxonomy Laboratory of the Plant Chemotaxonomy Laboratory of the Enzyme ChemistryLaboratory of the Enzyme Chemistry Laboratory of theLaboratory of the Marine BiochemistryMarine Biochemistry Laboratory of theLaboratory of the Structural and Analytical MethodsStructural and Analytical Methods Laboratory of theLaboratory of the Instrumental and Radionuclide MethodsInstrumental and Radionuclide Methods Laboratory of theLaboratory of the BiotechnologyBiotechnology Group of the N.M.R.-SpectroscopyGroup of the N.M.R.-Spectroscopy Group of theGroup of the PhytoimmunityPhytoimmunity Group of theGroup of the New Medicines and PreventivesNew Medicines and Preventives Other Scientific ServicesOther Scientific Services

Laboratory of the Chemistry of Marine Natural Laboratory of the Chemistry of Marine Natural CompoundsCompounds

Laboratory of the ChemistryLaboratory of the Chemistry of Microbial Metabolites of Microbial Metabolites Laboratory of the Peptide ChemistryLaboratory of the Peptide ChemistryLaboratory of theLaboratory of the Organic SynthesisOrganic SynthesisLaboratory of the ChemistryLaboratory of the Chemistry of Natural Quinoid of Natural Quinoid

CompoundsCompoundsLaboratory of theLaboratory of the MicrobiologyMicrobiologyLaboratory of theLaboratory of the Bioassay Bioassay Group of the Lipid ChemistryGroup of the Lipid Chemistry

Laboratory of the Carbohydrate ChemistryLaboratory of the Carbohydrate Chemistry

Laboratory of the Chemistry of Non-Laboratory of the Chemistry of Non-Infective ImmunityInfective Immunity

Laboratory of theLaboratory of the Molecular Basics of Molecular Basics of Antibacterial ImmunityAntibacterial Immunity

The Marine Experimental StationThe Marine Experimental Station Research Vessel Research Vessel ««Akademik OparinAkademik Oparin» » Department of Scientific InformationDepartment of Scientific Information Department of PatentsDepartment of Patents VivaryVivary Pilot GroupPilot Group Department of DevicesDepartment of Devices Group of GlasswareGroup of Glassware Laboratory of the Trade EcologyLaboratory of the Trade Ecology Group of MarketingGroup of Marketing

(Pacific Institute of Bioorganic Chemistry)(Pacific Institute of Bioorganic Chemistry)

(Official acronym in World Federation (Official acronym in World Federation for Culture Collection – WFCC)for Culture Collection – WFCC)

BacteriaBacteria Marine fungiMarine fungi

This unique vessel is specially designed for hydrobiological, This unique vessel is specially designed for hydrobiological, chemical and biochemical studies of marine macro- and chemical and biochemical studies of marine macro- and

microorganisms to search for organisms producing microorganisms to search for organisms producing physiologically active substances with antibiotic, antitumor, physiologically active substances with antibiotic, antitumor,

immunomodulatory, and other types of effectsimmunomodulatory, and other types of effects..

This unique vessel is specially designed for hydrobiological, This unique vessel is specially designed for hydrobiological, chemical and biochemical studies of marine macro- and chemical and biochemical studies of marine macro- and

microorganisms to search for organisms producing microorganisms to search for organisms producing physiologically active substances with antibiotic, antitumor, physiologically active substances with antibiotic, antitumor,

immunomodulatory, and other types of effectsimmunomodulatory, and other types of effects..

Built for the Pacific Built for the Pacific Institute of Bioorganic Institute of Bioorganic Chemistry in Finland Chemistry in Finland

((19851985). ).

Displacement -Displacement - 2600 2600 tt,,

Speed, designed – 15.2 knotsSpeed, designed – 15.2 knots

Officers and crew -Officers and crew - 3 39 9 personspersons, , scientific staffscientific staff –– 30 30

personspersons..

Built for the Pacific Built for the Pacific Institute of Bioorganic Institute of Bioorganic Chemistry in Finland Chemistry in Finland

((19851985). ).

Displacement -Displacement - 2600 2600 tt,,

Speed, designed – 15.2 knotsSpeed, designed – 15.2 knots

Officers and crew -Officers and crew - 3 39 9 personspersons, , scientific staffscientific staff –– 30 30

personspersons..

There are laboratory building, There are laboratory building, diving complexdiving complex, , shipsships andand boatsboats, ,

dwelling houses dwelling houses

Located on the coast of Located on the coast of picturesque Bay ofpicturesque Bay of Troitsa (Trinity Troitsa (Trinity

Bay) inBay) in 100 100 km to the south of km to the south of VladivostokVladivostok

Was founded in Was founded in 19671967

+

NH

NH

NH2

NH

NH

O

Cl-+

NH

NH

NH2

NH

NH

O

Cl-

+

NH

NH

N

N

OH

BrBr

ONH2

Cl-+

NH

NH

N

N

OH

BrBr

ONH2

Cl-

Over 5Over 50000 new biologically active new biologically active compounds, including 2-3% of total compounds, including 2-3% of total number of presently known marine number of presently known marine natural products were isolated and natural products were isolated and

studied in Institute. studied in Institute.

The peculiarities of their biogenesis, The peculiarities of their biogenesis, biological effects, and taxonomical biological effects, and taxonomical

distribution were investigateddistribution were investigated

Over 5Over 50000 new biologically active new biologically active compounds, including 2-3% of total compounds, including 2-3% of total number of presently known marine number of presently known marine natural products were isolated and natural products were isolated and

studied in Institute. studied in Institute.

The peculiarities of their biogenesis, The peculiarities of their biogenesis, biological effects, and taxonomical biological effects, and taxonomical

distribution were investigateddistribution were investigatedO

NH

NH

O

O

NH

NH

O

NH

N

NH2

NH

NH

O

Br

NH

N

NH2

NH

NH

O

BrN

NH

O

BrBr

NH

NH

NH2+

Cl-

N

NH

O

BrBr

NH

NH

NH2+

Cl-

N

N

O

BrBr

NH

NH

NH2+

Cl-

N

N

O

BrBr

NH

NH

NH2+

Cl-

About 200 new biologically active About 200 new biologically active compounds were isolated from compounds were isolated from

different plants.different plants.

Their biological effects, chemical Their biological effects, chemical properties, and possibilities of using as properties, and possibilities of using as

chemotaxonomic markers in higher chemotaxonomic markers in higher plants systematics were studied.plants systematics were studied.

O

OH

OH

OH

OH OH

OMe

OMe

HH

H H

H

maackolin

OMeOH

OH

OH

OH

O

O

O

O

maackiasin

OH

OHOH

OH

OH

OH

O

O

maackin

OH

OH

O

OH

OH

OH

OH OH

maackin А

Polyphenols of some Far-Eastern plants Polyphenols of some Far-Eastern plants possessing an antioxidant activitypossessing an antioxidant activity

Polyphenols of some Far-Eastern plants Polyphenols of some Far-Eastern plants possessing an antioxidant activitypossessing an antioxidant activity

1,31,3;1,6-;1,6--D-Glucans-D-Glucans

a

edcb

- - 33,,6-О-6-О-di-substituted Glc residuedi-substituted Glc residue

- nonsubstituted Glc residue- nonsubstituted Glc residue

- - 3-О-3-О-substituted Glc residuesubstituted Glc residue

- - 6-О-6-О-substituted Glc residuesubstituted Glc residue

a b cfrom Laminaria cichorioides

a b c

from Fucus evanescens

Solov’eva T.F., Elyakova L.A., Zvyagintseva T.N., Yermak I.M. Marine Technol. Soc. 1996. 30: 35

Fucoidans of brown seaweeds of the russian Far East.2 structural types.

SO3 SO3 SO3 SO3 SO3 SO3

↓ ↓ ↓ ↓ ↓ ↓ 4 4 4 4 4 4→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→3) -α-L-Fucp-(1→ 2 2 2 2 2 2 ↑ ↑ ↑ ↑ ↑ ↑ SO3 SO3 SO3 SO3 SO3 SO3

→3)-α-L-Fucp-(1→4)-α-L-Fucp-(1→3)-α-L-Fucp-(1→4)-α-L-Fucp-(1→ 2 2 2 2 ↑ ↑ ↑ ↑ SO3 SO3 SO3 SO3

1,3;1,6--D-glucans and alginic acids are found out in some terrestrial organisms, but in the sea are distributed much more widely. Fucoidans are family of sulfated homo- and heteropolysaccharides, containing

L-fucose as the basic component, and galactose, mannose, xylose, glucuronic acid in minor amounts. Fucoidans are found out only in sea organisms.

→4)-[α-L-Fucp-(1→3)]n-α-L-Fucp-(1→4)-α-L-Fucp-(1→3)-[α-L-Fucp-(1→4)]m -α-L-Fucp-(1→

2 2 2 2 2

↑ ↑ ↑ ↑ ↑

SO3 SO3 SO3 SO3 SO3

1. из Fucus evanescens

2. из Laminaria cichorioides

1→3 : 1→4 1 : 1

1→3 : 1→4 3.5 : 1

EndoEndo- - andand exoexo-1,3--1,3---D-glucanases D-glucanases

Alginat lyases Alginat lyases

Fucoidanases Fucoidanases

EndoEndo-1,6--1,6---D-glucanasesD-glucanases

CellulasesCellulases

- - andand --D-GlucosidasesD-Glucosidases

- - and and --D-GalactosidasesD-Galactosidases

- - and and --D-MannosidasesD-Mannosidases

--LL--FucosidasesFucosidases

SulfatasesSulfatases

S'

S''-A ((reaction of reaction of

transglycosylationtransglycosylation))

S

A

H2OESE+S ES''

S''-ОН((reaction of reaction of hydrolysishydrolysis))

S''-S((glucanosyl glucanosyl transferase transferase

activityactivity))

Marine invertebrates and seaweeds are the valuable sources Marine invertebrates and seaweeds are the valuable sources of the biologically active polysaccharides, the enzymes with of the biologically active polysaccharides, the enzymes with

unique specificity involved in their transformation and unique specificity involved in their transformation and inhibitors of these enzymes.inhibitors of these enzymes.

Marine invertebrates and seaweeds are the valuable sources Marine invertebrates and seaweeds are the valuable sources of the biologically active polysaccharides, the enzymes with of the biologically active polysaccharides, the enzymes with

unique specificity involved in their transformation and unique specificity involved in their transformation and inhibitors of these enzymes.inhibitors of these enzymes.

SoSo, , endoendo-1,3--1,3---DD--glucanases of marine organismsglucanases of marine organisms, , found at found at first as hydrolasesfirst as hydrolases, , catalyze three reactions running catalyze three reactions running

simultaneously and practically with almost equal efficiency.simultaneously and practically with almost equal efficiency.

SoSo, , endoendo-1,3--1,3---DD--glucanases of marine organismsglucanases of marine organisms, , found at found at first as hydrolasesfirst as hydrolases, , catalyze three reactions running catalyze three reactions running

simultaneously and practically with almost equal efficiency.simultaneously and practically with almost equal efficiency.

LAMINARANLAMINARAN

TRANSLAMimmunomodulator, radioprotector,

antitumor agent, cryoprotector

TRANSLAMimmunomodulator, radioprotector,

antitumor agent, cryoprotector

ANTIVIRphytoimmunostimulator: potato, tobacco,

tomato, soybean

ANTIVIRphytoimmunostimulator: potato, tobacco,

tomato, soybean

Glucose and glucooligosaccharides(Glcn, n=1,2,3 as main

components)

Glucose and glucooligosaccharides(Glcn, n=1,2,3 as main

components)

E

Fractions of Fractions of 113;13;16-6--D--D-glucans with higher molecular glucans with higher molecular masses and more branched than initial laminaran were found masses and more branched than initial laminaran were found among the products of its enzymatic transformation byamong the products of its enzymatic transformation by endoendo--

1,3-1,3---DD--glucanase. These fractions designated as “Antivirglucanase. These fractions designated as “Antivir" " andand ““Translam” are the products of the prominent glucanosyl Translam” are the products of the prominent glucanosyl transferase ability of the enzyme and its ability to catalyze transferase ability of the enzyme and its ability to catalyze synthesis not only synthesis not only --113-,3-, but also but also -1-16-6-glucosyl links.glucosyl links.

Fractions of Fractions of 113;13;16-6--D--D-glucans with higher molecular glucans with higher molecular masses and more branched than initial laminaran were found masses and more branched than initial laminaran were found among the products of its enzymatic transformation byamong the products of its enzymatic transformation by endoendo--

1,3-1,3---DD--glucanase. These fractions designated as “Antivirglucanase. These fractions designated as “Antivir" " andand ““Translam” are the products of the prominent glucanosyl Translam” are the products of the prominent glucanosyl transferase ability of the enzyme and its ability to catalyze transferase ability of the enzyme and its ability to catalyze synthesis not only synthesis not only --113-,3-, but also but also -1-16-6-glucosyl links.glucosyl links.

Translam and Antivir are the first Translam and Antivir are the first biologically active polysaccharides biologically active polysaccharides

obtained by enzymic synthesisobtained by enzymic synthesis. .

Preclinic trials of translam as medicine Preclinic trials of translam as medicine for acute radiation sickness are being for acute radiation sickness are being

finishedfinished. .

Translam belongs to rare medicines possessing Translam belongs to rare medicines possessing postradiation effect.postradiation effect. SoSo, , its injection to monkeys, its injection to monkeys,

irradiated with dose close to lethal one, protect about irradiated with dose close to lethal one, protect about 60% of them against radiation.60% of them against radiation.

Above of 170 Patents and Certificates of Authorship (including several of International ones) cover processes of obtaining, syntheses and practical

applications of new drugs, food suppliments, veterinary preparations, enzymes, diagnostics etc. based on the biologically active compounds from

marine organisms and terrestrial higher plants.

More than 20 Patents of PIBOC are used in industry. One of the first-rate factories of Far-Eastern food industry is named in the honor of our invention

as «Ussuriisky Balsam».

Above of 170 Patents and Certificates of Authorship (including several of International ones) cover processes of obtaining, syntheses and practical

applications of new drugs, food suppliments, veterinary preparations, enzymes, diagnostics etc. based on the biologically active compounds from

marine organisms and terrestrial higher plants.

More than 20 Patents of PIBOC are used in industry. One of the first-rate factories of Far-Eastern food industry is named in the honor of our invention

as «Ussuriisky Balsam».

MedicineMedicine

PerfumeryPerfumery

Leather IndustryLeather Industry

Food IndustryFood Industry

Patent mPatent medicinedicinee was developed was developed on the base of enzymatic on the base of enzymatic

preparation isolated from the preparation isolated from the crabs’ processing wastes.crabs’ processing wastes.

Patent mPatent medicinedicinee was developed was developed on the base of enzymatic on the base of enzymatic

preparation isolated from the preparation isolated from the crabs’ processing wastes.crabs’ processing wastes.

Reduces the necrotic zone in 1.5-2 fold Reduces the necrotic zone in 1.5-2 fold Restores the functions of left ventricleRestores the functions of left ventricle Reduces the frequency of reperfusion arrhythmiaReduces the frequency of reperfusion arrhythmia Promotes the restoration of heart’s contractionPromotes the restoration of heart’s contraction Inhibits the erythrocytes aggregation Inhibits the erythrocytes aggregation

THE RESULTS OF THE CLINICAL TESTSTHE RESULTS OF THE CLINICAL TESTS

A highly effective preparation forA highly effective preparation for • prophylaxis of reperfusion damages after myocardial infarction prophylaxis of reperfusion damages after myocardial infarction • treating ischemia and infarction in acute forms. treating ischemia and infarction in acute forms.

Diseases of cornea (to increase epithelization); Dystrophic damages of retina and diabetic retinopathy as a

retinoprotector; Proliferous processes, degeneration and hemophthalmia of

various geneses;

Contusions, burns and penetrating wounds of eyes;

Cataract; Keratitis; Uveitis.

It is prescribed for treatment of:

High hepato-protecting High hepato-protecting activity;activity;

Hypolipidemic effect; Hypolipidemic effect; Antithrombotic effect; Antithrombotic effect; Hypocholesterinemic Hypocholesterinemic

effect;effect; Antioxidative effect;Antioxidative effect; AntiatheroscleroticAntiatherosclerotic

effect;effect; Non-toxic. Non-toxic.

High hepato-protecting High hepato-protecting activity;activity;

Hypolipidemic effect; Hypolipidemic effect; Antithrombotic effect; Antithrombotic effect; Hypocholesterinemic Hypocholesterinemic

effect;effect; Antioxidative effect;Antioxidative effect; AntiatheroscleroticAntiatherosclerotic

effect;effect; Non-toxic. Non-toxic.

The therapeutic activity is caused by its favorable The therapeutic activity is caused by its favorable effect on the metabolism, function and structure of the effect on the metabolism, function and structure of the liver damaged.liver damaged.

Inhibits free radicals and depresses the toxic products Inhibits free radicals and depresses the toxic products of lipid peroxidation reactions. of lipid peroxidation reactions.

Its activity is higher than that of the well-known drugs Its activity is higher than that of the well-known drugs from from Silybum marianumSilybum marianum Gaerth: Silybor, Legalon, Gaerth: Silybor, Legalon, Carsyl.Carsyl.

The therapeutic activity is caused by its favorable The therapeutic activity is caused by its favorable effect on the metabolism, function and structure of the effect on the metabolism, function and structure of the liver damaged.liver damaged.

Inhibits free radicals and depresses the toxic products Inhibits free radicals and depresses the toxic products of lipid peroxidation reactions. of lipid peroxidation reactions.

Its activity is higher than that of the well-known drugs Its activity is higher than that of the well-known drugs from from Silybum marianumSilybum marianum Gaerth: Silybor, Legalon, Gaerth: Silybor, Legalon, Carsyl.Carsyl.

As enterosorbent is well suitable for endogenous toxicoses As enterosorbent is well suitable for endogenous toxicoses after trauma and some diseases, such as: diseases of internal after trauma and some diseases, such as: diseases of internal organs, acute infections of alimentary canal, suppurative organs, acute infections of alimentary canal, suppurative processes, burns, and radiation sickness.processes, burns, and radiation sickness.

Is successful as an antidote and antimutagenous remedy.Is successful as an antidote and antimutagenous remedy. Removes heavy metals from human organism.Removes heavy metals from human organism. Shows antisclerotic activity lowering cholesterol level in the Shows antisclerotic activity lowering cholesterol level in the

blood.blood. Can be successful as ancillary antidiabetic remedy.Can be successful as ancillary antidiabetic remedy.

Permitted in Russia as a patented medicinal Permitted in Russia as a patented medicinal and prophylactic supplement to the food stuffs.and prophylactic supplement to the food stuffs.

As a food supplement shows antiulcerous effect, As a food supplement shows antiulcerous effect, normalizes gastrointestinal functions.normalizes gastrointestinal functions.

A series of non-alcoholic balsams, which A series of non-alcoholic balsams, which are produced from terrestrial and are produced from terrestrial and marine natural products, are unique marine natural products, are unique remedies for rehabilitation after various remedies for rehabilitation after various diseases of gastrointestinal tract diseases of gastrointestinal tract (gastritis, ulcer, disbacteriosis, colitis), (gastritis, ulcer, disbacteriosis, colitis), cardiovascular system, hypertonia, and cardiovascular system, hypertonia, and oncological diseases, as well as for oncological diseases, as well as for elimination of heavy metals and elimination of heavy metals and radionuclides from human organism.radionuclides from human organism.

HERBAMARIN is approved by Food HERBAMARIN is approved by Food Institute of the Russian Academy of Medical Institute of the Russian Academy of Medical

Sciences and recommended as a food Sciences and recommended as a food supplement.supplement.

HERBAMARIN HERBAMARIN can be can be

manufactured with manufactured with modifications in modifications in composition as composition as

tablets and tablets and capsules.capsules.

HERBAMARIN HERBAMARIN can be can be

manufactured with manufactured with modifications in modifications in composition as composition as

tablets and tablets and capsules.capsules.

from Far-Eastern mussels,

immunomodulator,

anti-inflammatory properties,

hydratant, an ingredient of make-up preparations produced by Linda, Svoboda and other factories.

from Far-Eastern mussels,

immunomodulator,

anti-inflammatory properties,

hydratant, an ingredient of make-up preparations produced by Linda, Svoboda and other factories.

Polymannuronic acidPolymannuronic acid

Fucoidan Fucoidan

plusplus

Immunomodulator

FUCOLAM-CFUCOLAM-C

Substance for:

Supplements

Cosmetics

Medicine

Ethanol extract of the brown algaEthanol extract of the brown alga

PROPERTIES:PROPERTIES:•Antioxidant•Antiinflammatory action•Antitumor action•Immunomodilator

Use for•Cosmetics•In ophthalmology