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The history of psychiatry Sandor Fekete M.D. PhD klinika -Pécs Dept.of Psychiatry and Psychotherapy Univ.of Pecs, http://psychiatry.pote.hu The history of psychiatry I. Pre-scientific era - before the XIX.th.century prehistoric data - 2000 B.C. – Scandinavian burial place findings - trepanation shamanism - demonism Old Testament (Saul and David..) classical greek culture Hippokrates (459 - 377 B.C.) temperaments The oldest medical document in existence, the Eber Papyrus (probably composed in 1900 B.C.), contains references to specific syndromes such as depression. Biblical writings also contain descriptions of individuals with major mental illnesses; for example, in I Samuel, Saul is portrayed as falling into a serious depression, for which he is treated with soothing music. Hippocrates argued that mental illnesses, as well as all other cognitive and emotional functions, derived principally from the brain. Galen and his followers believed that mental illnesses were due to imbalances in quantities of body fluids. Melancholia, for example, was due to an excess of black bile. The history of psychiatry classical roman culture Galen, Celsus middle age connection with religion – philosophy
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Page 1: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

The history of psychiatry

Sandor Fekete M.D. PhD

klinika -Pécs

Dept.of Psychiatry and PsychotherapyUniv.of Pecs, http://psychiatry.pote.hu

The history of psychiatryI. Pre-scientific era - before the

XIX.th.centuryprehistoric data - 2000 B.C. –Scandinavian burial place findings -

trepanation shamanism - demonism Old Testament (Saul and David..)classical greek culture

Hippokrates (459 - 377 B.C.)temperaments

The oldest medical document inexistence, the Eber Papyrus (probablycomposed in 1900 B.C.), containsreferences to specific syndromes such asdepression.

Biblical writings also containdescriptions of individuals with major mental illnesses; for example, in I Samuel, Saul is portrayed as falling intoa serious depression, for which he is treated with soothing music.

Hippocrates argued that mentalillnesses, as well as all other cognitive andemotional functions, derived principallyfrom the brain. Galen and his followersbelieved that mental illnesses were due toimbalances in quantities of body fluids. Melancholia, for example, was due to anexcess of black bile.

The history of psychiatry

classical roman cultureGalen, Celsus

middle ageconnection with religion – philosophy

Page 2: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

Salem Witchcraft Trials1692 The history of psychiatry

Pinel 1793

Esquirol

Griesinger Kraepelin E. Bleuler(1855-1926)

The history of psychiatry

Ph. Pinel 1793 - scientific era EsquirolGriesingerKraepelin (1855-1926) E. Bleuler

P. Pinel, a one of the leader of the FrenchRevolution, is usually considered to be thefounding father of modern psychiatry. In 1793, he was named director of the Bicêtre, thehospital in Paris for insane men.

Soon afterward he instituted a grand, symbolic change by removing the chains thatbound the patients to the walls at the Becêtreand instituted a new type of treatment that he referred to as „moral treatment.”

The French Revolution and Pinel's Moral Treatment of the Mentally Ill

In addition to introducing psychotherapy, inthe form of moral treatment, and stressing theimportance of empirical observation, Pinelalso applied the scientific method to the studyof psychiatry.

Page 3: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

Mesmer 1720-1815 „animalmagnetism”

Dynamic psychiatry-psychotherapyXIX. - XX.th century

Charcot P. - Janet – hypnosis

Freud - Adler, Jung psychoanalysis

Ferenczi, Balint, Mahler, Klein, Erikson, Rogers

social psychiatry - and - biological psychiatry

social psychiatry bio - psycho - social unit

The history of psychiatryPsychotherapy XIX. - XX.th century

Charcot P. Janet

Freud Adler JungFerenczi

Balint, Mahler, Klein, Erikson, RogersEdward Munch: A sikoly, 1893.

Page 4: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

Charcot 1825-1893 hypnotic treatment ofhysteria

Sigmund Freud

Freud

Roots of Psychoterapies I

Freud 1856-1939Stekel 1868-1940Adler 1870-1937

psychoanalysisFerenczi 1873-1933Jung 1875-1961Abraham 1877-1925

Roots of Psychoterapies II

Rogers 1902-1987 person-centered, client-centered therapy

Wolf 1926

Slater 1949 behavioural therapies

Wolpe 1958

Bandura 1963

A.Beck, Ellis cognitive therapy

PsychotherapiesPsychotherapies�� DynamicDynamic - - interpretation of unconscious interpretation of unconscious

conflicts to produce insight conflicts to produce insight (trauma, (trauma, losseslosses))

�� CognitiveCognitive - - learninglearning, , perceptionperception, , cognitivecognitive schemesschemes, , correctioncorrection

�� InterpersonalInterpersonal – – familyfamily therapytherapy., ., socsoc. . skillsskills, , communicationcommunication, , copingcoping

�� SupportiveSupportive thth: : problem solvingproblem solving, , adaptationadaptation, , strengthening patient’s defensesstrengthening patient’s defenses

�� Crisis interventionCrisis intervention�� IndividiualIndividiual vsvs groupgroup therapiestherapies

Page 5: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

biological therapies

1887 Wagner von Jauregg – fevertherapy

1926 Klaesi sleep - therapy1933 Sakel insulin coma1935 Meduna cardiazol-convulsions1936 Moniz psycho-surgery1938 Cerletti,Bini

electroconvulsivetherapy

Delgado, unpublished.

Serotonin and Serotonin and NorepinephrineNorepinephrine: : Effect on Depressive SymptomsEffect on Depressive Symptoms

NorepinephrineVigilance

AnxietyIrritability

Impulsivity

MotivationSex

AppetiteAggression

Cognitive functionMood

Emotion

Serotonin

Pain

Dual action agents may provide the broadest spectrum of therapeutic effect across the full range of emotional and physical symptoms of depression

Ventromedialis

DLPFC

Orbitofrontalis

DLPFC right•Negatíve affectsAnxiety – increased activation (afterprovocation)•Working memory

Amygdala

DLPFC left•injury – positíve affects disturbed•Depression positíve affects deficit nucleus accumbens also involved

Ventromedial PFC:

•Anticipation of positíve andnegatíve consequences•Affectíve working memory

OFC

cognitive and affectiveintegration

Amygdala•negative affectsperception•Positíve emotions

Conscious

perception

unconscious perception

Page 6: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

Within psychiatry as a specializeddiscipline, the major sources of impact fromneuroscience have been neuro-pharmacology and neurochemistry.

Coupled with the overall developmentin neuroscience, the discovery of relativelypotent pharmacological treatments for major mental illnesses has also served toreawaken interest in clinical neurobiology

biological therapies

1949 Cade líthium (mood stabilizer)1952 Delay chlorpromazine

(antipsychotics)

1957 Kuhn imipramine(antidepressants)

1962 Carlsson, Schildkrautneurotransmitter changes inschizophrenia and depression

Other somatic/biological butnon-pharmacological therapies

• Sleep withdrawal (depression, „chronobiological model)

• Light therapy (seasonal, atypicaldepression)

• Psychosurgery (resistent OCD cases)• ECT (th resistent depressive cases,

catatonic schizophrenia)

Social psychiatry

1905 Pratt group-therapy with tbc patients1912 Durkheim suicidal behaviour1917 Simon working therapy1920 Moreno psychodrama

Social psychiatry

1953 Jones community psychiatry1958 Hollmgshead, epidemiology

1961 Moore cross-cultural psychiatry1960Szász, Laing, antipsychiatry

Sociotherapies

• Ergotherapy• Vocational rehabilitation• Social skills training• Assertive training• Non-verbal therapies• Bibliotherapy• Poetry therapy

Page 7: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

The „antipsychiatry”

social psychiatry - antipsychiatry

Szasz Laing

•• WhatWhat is is „„normalnormal”” oror „„pathologicalpathological”” humanhuman behaviourbehaviour

•• CanCan thethe „„pathologicalpathological””, , thethe diagnosisdiagnosis be be justjust a a labellabel oror stigma? (stigma? (socialsocial deviancydeviancy modelmodel, , „„constructionconstruction””) ) -- //.... antipsychiatryantipsychiatry/ /

•• BUT:BUT:

•• symptomssymptoms, , outcomeoutcome, , familyfamily clusteringclustering areare differentdifferentinin thesethese disordersdisorders, ,

•• TheyThey alsoalso havehave thethe biologicalbiological backgroundbackground, , specificspecificresponsesresponses inin treatmenttreatment

•• The The purposepurpose ofof diagnosisdiagnosis andand classificationclassification is is totoisolateisolate a a groupgroup ofof discretediscrete diseasedisease entitiesentities,, eacheach ofofwhichwhich is is characterizedcharacterized byby a a distinctdistinct pathophysiologypathophysiologyandand//oror etiologyetiology..

bio - psycho - social approach

stress – vulnerability modell

These developments have placedpsychiatry in the 1990s squarely withinthe traditions of medicine andneuroscience.

To an interest in neuropharmacologyhave been added interests inneuroimaging and molecularbiology/genetics

Modern students of psyhiatry must simultaneously view their patients onmultiple planes:

as human beings who have particularsymptoms (psychological),

as individuals living within a socialand cultural context (social),

as products of the geneticendowments given them by their parentsand coded in their chromosomes (genetic-molecular),

Page 8: The history of psychiatrypsychiatry.pote.hu/pdf/eng_1_001_history_slides.pdf · The history of psychiatry Ph. Pinel 1793 - scientific era Esquirol Griesinger Kraepelin (1855-1926)

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