The HVTN is supported through a cooperative agreementwith the National Institute of Allergy and Infectious Diseases
HVTN 505Lessons learned in year 1
Niles Eaton, MPHManager, Community Education Unit
HVTN Core Operations Center
Draft – 12 Nov 2010
HIV Vaccine trials in US MSM at high risk
0
200
400
600
800
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1400
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CumulativeExpected
CumulativeEnrolled
Where are we now?
5/30
/200
9
6/25
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7/21
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8/16
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9/11
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10/7
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11/2
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11/2
8/20
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12/2
4/20
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1/19
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2/14
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3/12
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4/7/
2010
5/3/
2010
5/29
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6/24
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7/20
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8/15
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9/10
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10/6
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11/1
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11/2
7/20
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12/2
3/20
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1/18
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2/13
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3/11
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1
4/6/
2011
5/2/
2011
5/28
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6/23
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7/19
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8/14
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1
9/9/
2011
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CumulativeExpected
CumulativeEnrolled
5/30
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9
6/15
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7/1/
2009
7/17
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8/2/
2009
8/18
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9/3/
2009
9/19
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11/6
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11/2
2/20
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12/8
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12/2
4/20
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1/9/
2010
1/25
/201
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2/10
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2/26
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5/1/
2010
5/17
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6/2/
2010
6/18
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7/4/
2010
7/20
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8/5/
2010
8/21
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9/6/
2010
9/22
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10/8
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10/2
4/20
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11/9
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11/2
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12/1
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CumulativeExpected
CumulativeEnrolled
HVTN 505 enrollment, an iterative process
Version 2.0 approved: risk criteria simplification & specific language on
transgender
Initial Core-generated materials available
Amendment: upper age limit elevated to 50
Rapid needs assessment of all sites
Site expansion process
Strategies Initiated by HVTN Core: May 2010
Working Only So-So Not Working N/A In Process (TBD)
Hope Takes Action web contacts 3 6 1
Facebook Ads 1 2 3 3 1
Banner ads on hook-up websites 1 2 7Twitter 5 4 1
Media stories initiated by HVTN Core 3 6 1
Transit advertising (bus, train, etc.) 2 3 1 4
Bus bench/shelter ads 1 2 3 4
Phone kiosk ads 1 9
Print ads in local paper(s) 4 2 3 1
Hope Takes Action Posters 2 2 5 1
Hope Takes Action Palm cards 2 5 2 1
Hope Takes Action Post Cards 1 5 2 2
Hope Takes Action small poster w/ tear-off pads 2 2 5 1
Hope Takes Action drink coasters 2 1 7Hope Takes Action give-away items: Condoms 3 4 3
Hope Takes Action give-away items: Bags 4 3 3
Hope Takes Action give-away items: Lip Balm 5 3 2
Hope Takes Action give-away items: Yo-Yos 7 1 2
Hope Takes Action give-away items: Gum 8 1 1Hope Takes Action give-away items: Hand Sanitizer 6 2 2
Other give-aways (rubber duckies, etc.) 1 1 8
Cling ads for bathroom posting 1 7 2
Hope Takes Action table tents 1 3 4 2
T-shirts for recruiters 3 3 2 2
Not Working: - Banner ads on hook-up sites- Twitter- Media stories generated by HVTN Core-Hope Takes Action:
- Action Posters - Small posters with tear offs
- Coasters- Cling ads
Working:-Hope Takes Action give-aways
Lip BalmYo-yosGumHand Sanitizer
Survey of HVTN 505 sites, May 2010Referral Source:
Screened EnrolledBar/Street/Other Outreach 312 66 (38%)Internet 398 40 (23%)Core placed ads 153 10 (6%)Site placed ads/flyers 354 23 (13%)Other (referrals, rollovers, unk) 240 30 (18%)To be classified 28 2 (<1%)
1485 171
*missing: Birmingham, Los Angeles, VRC
Survey of HVTN 505 sites, Sep 2010Referral Source:
Screened EnrolledBar/Street/Other Outreach 576 145 (39%)Pride activities 49 6 (<1%)
Internet 334 80 (22%)Core placed ads 144 23 (6%)Site placed ads/flyers 245 46 (12%)Other (referrals, rollovers, unk) 257 67 (18%)To be classified 1 3 (<1%)
Total 1606 370
CEU & Legacy Project staffSite Visits
Main objective: assess recruitment & screening process for any obvious gaps
Collect & disseminate best practices Provide recommendations Report to Community Affairs & Site
Assistance Working Group (CASA) for additional review & feedback
HVTN 505 branding: evolution & customizing
Jul-09 Aug-09
Sep-09
Oct-09
Nov-09
Dec-09
Jan-10 Feb-10
Mar-10
Apr-10
May-10
Jun-10 Jul-10 Aug-10
Sep-10
Oct-10
Nov-10
(half)
0
10000
20000
30000
40000
50000
60000
Visitors to HopeTakesAction.org
Web & social media: generating contacts
Jul-09 Aug-09
Sep-09
Oct-09
Nov-09
Dec-09
Jan-10 Feb-10
Mar-10
Apr-10
May-10
Jun-10 Jul-10 Aug-10
Sep-10
Oct-10
Nov-10
(half)
0
100
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Contact Cards completed
New campaigns launched
Changed Facebook ad targeting
Site developed brands & materials
Summary of lessons learned
It can take time for the community to respond to a study starting up
Make materials available prior to study start, or plan on “lead-in” period
Evaluate, tweak & refresh strategies, campaigns and processes
R E L E N T L E S S L Y
Summary of lessons learned
Recognize the balance between local site initiatives and national campaigns, and accommodate
Sites can have other priorities Recognize and acknowledge good work
when you see it
Acknowledgements
The site staff making first contact with potential participants
The trial participants, without whom this work would not be possible
