VOLUME 224 ACTING EXECUTIVE OFFICER OF THE SOCIETY KAY CROKER THE JOURNAL OF JANUARY-MARCH 1983 Parmaco1ogy AND EXPERIMENTAL THERAPEUTICS FOUNDED BY JOHN J. ABEL 1909 Official Publication of The American Society for Pharmacology and Experimental Therapeutics, Inc. EDITOR Eva King Killam ASSISTANT EDITOR Mannfred A. Hollinger EDITORS FOR SPECIFIC FIELDS Analgesia and Drug Abuse Joseph Cochin Autonomic Pharmacology Joseph J. McPhiIIips Robert E. Stitzel Behavioral Pharmacology John A. Harvey Cardiovascular Pharmacology Henry R. Besch, Jr. Theodore M. Brody Donald V. Priola Cell Pharmacology Toshlo Narahashi George B. Weiss Chemotherapy H. George Mandel Developmental Pharmacology Bernard L. Mirkin Drug Metabolism and Disposition Edward Bresnick Jordan L. Holtzman Endocrine Pharmacology Paula H. Stern Gastrointestinal Pharmacology Thomas F. Burks Immunopharmacology Sydney Spector Neurophannacology S. J. Enna A. James Hance Charles 0. Rutledge Prostaglandins and Leukotrienes John C. McGlff Pulmonwy Pharmacology Mannfred A. Hollinger Renal Pharmacology William 0. Berndt Toxicology Curtis D. Klaassen EDITORIAL ADVISORY BOARD Martin W. Adler Edson X. Albuquerque Edmund G. Anderson Lewis Aronow Leslie E. Bailey Michael D. Baffle Robert L Baister Paul Bass John A. Bevan C. Paul Bianchi Leslie C. Blaber David A. Blake Floyd E. Bloom Gary Brooker Carl K. Buckner David B. Bylund Theodore J. Cicero Doris H. Clouet Leonard Cook E. E. Daniel William C. de Groat Walter R. Dixon J. W. Downie Linda Dykstra Hugh L Evans James A. Ferrendelli Lawrence J. Fischer William W. Fleming Ray W. Fuller Timothy S. Gaginella Gerard L Gebber James W. Gibb Shri N. Gin Dora B. Goldstein Frank R. Goodman Charles W. Gorodetzky Garrett J. Gross T. Kendall Harden Harold F. Hardman Louis S. Harris Philip C. Hoffmann Stephen G. Holtzman Jerry B. Hook David M. Jacobowitz Donald R. Jasinski Alain F. Junod S. M. Kirpekar Conan Kornetaky Edwin A. Kroeger Wayne Levin Louis Levy George E. Lindenmayer Walter Lovenberg Benedict R. Lucchesi K. U. Malik Donald E. McMillan Jerry Mitchell Perry B. Molinoff W. H. Morse Josse M. Musacchio Mary J. Mycek Robert A. Neal Achilles J. Pappano William A. Pettinger Larissa A. Pohorecky James W. Putney, Jr. Arthur Raines Barbara Rennick G. Alan Robison C. R. Ross Ronald P. Rubin Robert R Ruffolo, Jr. Betty I. Sasyniuk Arnold Schwartz Lewis S. Seiden Eric J. Simon Roger P. Smith John L. Sutko Robert I. Taber A. E. Takemori Robert E. Ten Eick Thomas R. Tephly Richard E. Tessel C. D. Thron U. Trendelenburg Betty N. Twarog Norman J. Uretsky Martin A. Wasserman I. M. Weiner Benjamen Weiss Richard M. Welch David P. Westfall Martin M. Winbury Barry B. Wolfe Ben G. Zimmerman BOARD OF PUBLICATIONS TRUSTEES NORMAN WEINER, Chairman; JAMES A. BAIN, JOEL G. HARDMAN, EVA KING KIuM, BErFIE SUE MASTERS, JERRY R. Mn’cnau, WALTER MODELL, PAUL L. MUNSON, CLEMENT A. STONE, PALMER W. TAYLOR, VINCENT G. ZANNONI
Transcript
VOLUME 224
ACTING EXECUTIVE OFFICER OF THE SOCIETYKAY CROKER
THE JOURNAL OF
JANUARY-MARCH 1983
Par�maco1ogyAND EXPERIMENTAL THERAPEUTICS
FOUNDED BY JOHN J. ABEL 1909
Official Publication of The American Society forPharmacology and Experimental Therapeutics, Inc.
EDITOR
Eva King Killam
ASSISTANT EDITOR
Mannfred A. Hollinger
EDITORS FOR SPECIFIC FIELDS
Analgesia and Drug AbuseJoseph Cochin
Autonomic Pharmacology
Joseph J. McPhiIIipsRobert E. Stitzel
Behavioral Pharmacology
John A. Harvey
Cardiovascular Pharmacology
Henry R. Besch, Jr.Theodore M. BrodyDonald V. Priola
Cell Pharmacology
Toshlo NarahashiGeorge B. Weiss
ChemotherapyH. George Mandel
Developmental Pharmacology
Bernard L. Mirkin
Drug Metabolism and Disposition
Edward BresnickJordan L. Holtzman
Endocrine PharmacologyPaula H. Stern
Gastrointestinal PharmacologyThomas F. Burks
Immunopharmacology
Sydney Spector
Neurophannacology
S. J. Enna A. James HanceCharles 0. Rutledge
Prostaglandins and Leukotrienes
John C. McGlff
Pulmonwy Pharmacology
Mannfred A. Hollinger
Renal PharmacologyWilliam 0. Berndt
Toxicology
Curtis D. Klaassen
EDITORIAL ADVISORY BOARD
Martin W. AdlerEdson X. AlbuquerqueEdmund G. AndersonLewis AronowLeslie E. BaileyMichael D. BaffleRobert L BaisterPaul BassJohn A. BevanC. Paul BianchiLeslie C. BlaberDavid A. BlakeFloyd E. BloomGary BrookerCarl K. BucknerDavid B. BylundTheodore J. CiceroDoris H. ClouetLeonard CookE. E. DanielWilliam C. de GroatWalter R. DixonJ. W. DownieLinda Dykstra
Hugh L EvansJames A. FerrendelliLawrence J. FischerWilliam W. FlemingRay W. FullerTimothy S. GaginellaGerard L GebberJames W. GibbShri N. GinDora B. GoldsteinFrank R. GoodmanCharles W. GorodetzkyGarrett J. GrossT. Kendall HardenHarold F. HardmanLouis S. HarrisPhilip C. HoffmannStephen G. HoltzmanJerry B. HookDavid M. JacobowitzDonald R. JasinskiAlain F. JunodS. M. KirpekarConan Kornetaky
Edwin A. KroegerWayne LevinLouis LevyGeorge E. LindenmayerWalter LovenbergBenedict R. LucchesiK. U. MalikDonald E. McMillanJerry MitchellPerry B. MolinoffW. H. MorseJosse M. MusacchioMary J. MycekRobert A. NealAchilles J. PappanoWilliam A. PettingerLarissa A. PohoreckyJames W. Putney, Jr.Arthur RainesBarbara RennickG. Alan RobisonC. R. RossRonald P. RubinRobert R Ruffolo, Jr.
Betty I. SasyniukArnold SchwartzLewis S. SeidenEric J. SimonRoger P. SmithJohn L. SutkoRobert I. TaberA. E. TakemoriRobert E. Ten EickThomas R. TephlyRichard E. TesselC. D. ThronU. TrendelenburgBetty N. TwarogNorman J. UretskyMartin A. WassermanI. M. WeinerBenjamen WeissRichard M. WelchDavid P. WestfallMartin M. WinburyBarry B. WolfeBen G. Zimmerman
BOARD OF PUBLICATIONS TRUSTEESNORMAN WEINER, Chairman; JAMES A. BAIN, JOEL G. HARDMAN, EVA KING KIu�M, BErFIE SUE MASTERS,
JERRY R. Mn’cnau�, WALTER MODELL, PAUL L. MUNSON, CLEMENT A. STONE, PALMER W. TAYLOR, VINCENT G. ZANNONI
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (ISSN 002-3565) is published monthly by The American Society
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5 ..A1�.. ,. One controller for I to 8 animal cages #{149}Continuous measurement of OxygenConsumption over a 24 hour period in ml oxygen/kg of body weight/hour in STP units.. Pnnter prints results every four (4) minutes for each of 1 to 8 animals as well as oxygenpercent level in each animal cage #{149}System adaptable to small or large animals #{149}Contin-uous airflow through system with oxygen level measurements at the output and input#{149}High accuracy, >98% of full measuring range e.g. typical error ±30 ml oxygen/kg/hour in3000 ml oxygen/kg/hour range #{149}User adjustable alarm warns user of possible hypoxia#{149}Reuseable absorbants #{149}Auto reference assures high accuracy, system periodicallymeasures ambient air and corrects itself #{149}Optional RS.232 interface for communicationwith other computers #{149}Insensitive to temperature variations in the animal cage.
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428 East Preston Street/Baltimore, Maryland 21202
The Journal of Pharmacology and ExperImental Therapeutics
Contents Continued from iii
The Effects of Photoperiod on the Responses of the Hamster Vas Deferens to Nerve Stimulation. A. Johns, R. W.Steger and A. Bartke . . . . . . . . . . . . . 155
RDS-127 (2-di-n-Propylam.ino-4,7-Dimethoxyindane): Central Effects of a New Dopamine Receptor Agonist. StephenP. Arneri#{233}, John P. Long, Michael Williams, David B. Goodale, James Mott, Joan M. Lakoski and Gerald F. Gebhart 161
A Comparison of Some of the Pharmacological Properties of Etintidine, a New Histamine H2-Receptor Antagonist,
with Those of Cimetidine, Ranitidine and Tiotidine. Robert L. Cavanagh, Jeffrey J. Usakewicz and Joseph P. Buyniski 171
Disposition of Caffeine and Its Metabolites in Man. D. Dan-Shya Tang-Liu, Roger L. Williams and Sidney Riegelman 180
Characterization ofAdrenergic Receptor Binding in Rat Lung: Physiological Regulation. Jamshid Latifpour and David
B.Bylund 186
Interactions of Salsolinol and Its Mono-O-Methylated Analogs with Adrenergic and Dopaminergic Receptors in the
Rabbit Ear Artery. Sharon Herbert Nelson and Odd S. Steinsland . . . . 193
Relative Potency of Dopamine Agonists on Autoreceptor Function in Various Brain Regions of the Rat. Thomas C.
Westfall, Linda Naes and Carol Paul . . . . . . . . . . 199
Antihypertensive Activity of LY141865, a Selective Presynaptic Dopamine Receptor Agonist. Richard A. Hahn, Brian
R. MacDonald and Marilyn A. Martin . . . . . . . . . . . . 206
Use of Selective Antagonists for Determining the Types ofReceptors Mediating the Actions of 5-Hydroxytryptamine
and Tryptamine in the Isolated Rabbit Aorta. Jay S. Stollak and Robert F. Furchgott . . 215
Alpha and Beta Adrenoceptor Blockade in Normotensive and Deoxycorticosterone (DOC)-Hypertensive Rats;
Plasma Vasopressin and Vasopressin Pressor Effect. M. Burnier, J. Biollaz, D. B. Brunner, H. Gavras and H. R.
Brunner . . . . . . . . . 222
The Effects of a Beta-2 Selective Adrenergic Receptor Antagonist (ICI 118,551) on Twitch Tension in Cat SoleusMuscle. Howard J. Smith, Sharon B. Halliday and William Rouse . . . . . . 228
Postjunctional Supersensitivity of the Smooth Muscle of the Rat Vas Deferens Induced by Calmodulin-AntagonizingDrugs Applied Locally to the Hypogastric Plexus. Katsutoshi Goto . . . . . . 231
Inhibition ofOuabain-Induced Increase in Na Content of Cultured Myocardial Cells by Quiidine and Procainamide.Kiyota Goshima and Shigeo Wakabayashi . . . . 239
Baroreflex Sensitivity as a Determinant of Responses to Hydralazine in Dogs. Horacio Vidrio . 247
Covalent Binding of Metabolites of 4-Ipomeanol to Rabbit Pulmonary and Hepatic Microsomal Proteins and to theEnzymes of the Pulmonary Cytochrome P-450-Dependent Monooxygenase System. Shelley R. Slaughter, Charles N.
Statham, Richard M. Philpot and Michael R. Boyd - . . .. . . 252
AUTHOR INDEX
Aarons, R. D., 1
Abramson, F. P., 55, 62Arneri#{233},S. P., 161
Bai, S. A., 55, 62
Bartke, A., 155
Biollaz, J., 222Boyd, M. R., 252Brocco, M. J., 34Brunner, D. B., 222
Brunner, H. H., 222
Burch, R. M., 108Burnier, M., 222
Busse,L.W., 13
Buyniski, J. P., 171
Bylund, D. B., 186
Catravas, J. D., 28Cavanagh, R. L., 171
Cheng, S. S., 51Churchill, M. C., 68Churchill, P. C., 68
Connor, J. D., 148Corvasce, M. C., 141Da.sGupta, B. R., 135DeWeese, J., 127Drust, E. G., 148Eberle, D. E., 141
Evans, M. A., 73
Faison, E. P., 40Fujimoto, J. M., 13, 51
Furchgott, R. F., 215
Gavras, H., 222
Gebhart, G. F., 161Gerber, J. G., 1GiIIiS, C. N., 28
Goldberg, D. M., 127Goldberg, S. R., 127Goodale, D. B., 161Goshima, K., 239
Goto, K., 231
Gudelsky, G. A., 21
Hahn, R. A., 206Halliday, S. E., 228
Halushka, P. V., 108Harden, T. K., 118
Holtzman, S. G., 95
Johns, A., 155Kaplowitz, N., 141Kelleher, R. T., 127
Korn, S. J., 118
Kuhlenkamp, J., 141
Lahti, R. A., 7Lakoski, J. M., 161
Lange,D.G., 13
Latifpour, J., 186Leander, J. D., 89Lincoln, T. M., 100
Long, J. P., 161
Ludens, J. H., 7MacDonald, B. R., 206Martin, M. A., 206Martin, M. W., 118
McMfflan, D. E., 34Meltzer, H. Y., 21
Molinoff, P. B., 1Mott,J., 161
Naes, L., 199
Nelson, S. H., 193
Nies,A.S., 1
O’Donnell, J. M., 80Paul, C., 199Petrini, J., 141Philpot, R. M., 252Riegelman, S., 180
Roerig,S.C., 13Rouse, W., 228Ruffolo, R. R., Jr., 46
Seiden, L. S., 80
Simonovic, M., 21
Simpson, L. L., 135
Slaughter, S. R., 252
Smith, H. J., 228
Spealman, R. D., 127
Statham, C. N., 252
Steger, R. W., 155Steinsland, 0. 5., 193
Stollak, J. S., 215Tang-Liu, D. D.-S., 180Taylor, D. A., 40Touloukian, J., 141Tseng, L.-F., 51
Usakewicz, J. J., 171Vidrio, H., 247
Vu, V. T., 55
VonVoigtlander, P. F., 7
Wakabayashi, S., 239
Westfall, T. C., 199White, J. M., 95Wiese, S., 40Williams, M., 161
Williams, R. L., 180
Yaden, E. L., 46Yarbrough, G. G., 40
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The Journal of Pharmacology and Experimental Therapeutics
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hiV�s ofA21659E
Naunyn-
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Pharmaco
October
F. A. Opmeer, A. Witter, J. M. van Ree:Interaction of Calcium with 3H-Morphine Bindingto Synaptosomes of the Guinea-Pig Ileum 1
H. Glossmann, F. L#{252}bbecke: (1251)-HEAT: FiftyPercent of the Ligand can Bind to the Alpha1-Adrenoceptors with Extremely High Affinity 7
G. Wiemer, A. Wellstein, D. Palm,H. M. v. Hattingberg, D. Brockmeier:Properties of Agonist Binding at the
1�-Adrenoceptor of the Rat Reticulocyte 11
H. Majewski, L. Hedler, K. Starke: TheNoradrenaline Release Rate in the AnaesthetizedRabbit: Facilitation by Adrenaline 20
P.Johansson, M. Henning: a-Monofluoro-methyldopa (MFMD) in Combination withL-DOPA: Effects on Tissue Catecholamines andBlood Pressure in Rats 28
J. Marwaha, G. K. Aghajanian: Typical andAtypical Neuroleptics are Potent Antagonists ata1-Adrenoceptors of the Dorsal Lateral GeniculateNucleus: An Electrophysiological Study 32
S. Gurtu, J. N. Sinha, K. P. Bhargava:Involvement of a2-Adrenoceptors of NucleusTractus Solitarius in Baroreflex MediatedBradycardia 38
H. Kitagawa, A. Walland: Augmentation ofVagal Reflex Bradycardia by Centrala2-Adrenoceptors in the Cat 44
L. Turski, M. Schwarz, K.-H. Sontag:Interaction Between Phenytoin and Diazepam inMutant Han-Wistar Rats with Progressive SpasticParesis 48
VoIume32l Numberl 1982
A. Tsujimoto, K. Morita : Facilitation ofStimulation- Evoked Catecholamine Release bySomatostatin in Dog Perfused Adrenal Glands 52
F. C. Boyle, K. G. Digges: Responses toCatecholamines of the Rat Isolated UterusThroughout the Natural Oestrous Cycle 56
R. A. Hahn, B. R. MacDonald : HemodynamicAlterations Produced by N,N - Di-n- Propyldopaminein Anesthetized Dogs 63
J.J.Sheets, 1. E.Vickery: Effects of Amino-glutethimide and Its Metabolite, N-Acetyl-aminoglutethimide, on Bovine Adrenocorticaland Human Placental Cytochromes P-45Oscc 70
Short Communications
K. Yoshida, J. Engel, S. Liljequist: The Effectof Chronic Ethanol Administration on HighAffinity 3H-Nicotinic Binding in Rat Brain 74
A. R. Wakade, T. D. Wakade: Does PresynapticRegulation of Sympathetic Transmission OccurWithin a Limited Range of Neuronal Activity? 77
D. R. Ferry, H. Glossmann: Evidence forMultiple Receptor Sites Within the PutativeCalcium Channel 80
U. Schwabe, V. Lenschow, D. Ukena,D. R. Ferry, H.Glossmann: [125I]N6-p-Hydroxyphenylisopropyladenosine, a New Ligandfor R. Adenosine Receptors 84
Indexed in Current Contents
I Springer International21 0 Naunyn- Schmiedeberg’s Arch Pharmacol
