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Results from 3 pivotal studies of investig-ational agent ALO-02 at APS meeting........41
26 THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
27THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
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EDITORIAL
28
he Federation of Indian Chamber of Commerce implementation of universal health coverage (UHC) over
and Industry (FICCI) recently has approached the the next decade. If the government is serious about
new Union health minister's to seek its containing the rising cost of healthcare, it should provide Tintervention for sorting out several issues arising out of conducive environment by facilitating regulatory
the implementation of Drug Price Control Order (DPCO) environment to promote innovative products and
2013. FICCI also asked the minister to devise different practices to make India a hub for medical technology.
guidelines for biopharmaceuticals that involve The Government should focus on investments in
formulations based on biological products from chemical preventive and promotive health in light of the rapid
drugs. DPCO 2013 is inundated with a host of issues demographic and epidemiological transition in the
which could only make its implementation difficult. First country. This measure can help in reducing the disease
and foremost is that there is no clarity on inclusion of burden. Also, significant incentives need to be extended
different dosage and different delivery system in the to the health insurance and healthcare industry to
National List of Essential Medicines (NLEM) List. The introduce products and services focused on prevention.
Fixed Dose Second is the long time taken during the These are not all. There are several other issues
process of price approval of new drugs and retail and in DPCO 2013 that warrants immediate attention from
wholesale margins to trade etc. Third, NLEM list is the Health Ministry. Some of the major lacuna seen in
expected to be further expanded. Now such an exercise DPCO 2013 include Fixed Dose Combinations (FDCs)
will only lead to creating conflicting situations for drug being left out of price control. The increase of medicines
manufacturers, importers, marketers and retailers. to DPCO has been roughly 10% on 1st April year after
Further the patients or consumers may have to bear the year. The patented drugs are not covered which will lead
brunt of all this on account of lack of access of to domestic manufacturers suffering and MNCs
medicines to the community at large. The trade body benefitting. There are about 900 total medicines. The
also asked the health ministry to exclude brands with price regulation will cover only 348 drugs. This will only
less than 1 per cent market share from ceiling price give rise to lots of opportunity to shift from regulated to
calculation and apply price fixation formula only to unregulated drugs. Combinations of two drugs (within
products, dosages and strengths specified in Scheduled 348) will be out of price control. An estimated half of all
I of DPCO, 2013. It also demanded to revise trade dosage forms will be out of price control on this account.
margin for retailers to compensate loss under DPCO The policy and its instrument, the DPCO 2013, are
2013. The FICCI also demanded price implementation in surprisingly silent on these escape routes. Also it is not
45 days of notification/order from prospective batches. uncommon that manufacturers producing medicines
A high level FICCI delegation led by the president under price control, in this case the drugs in National List
Sidharth Birla met Union health minister Dr Harsh of Essential Medicines (NLEM) 2011, are likely to stop
Vardhan recently and recommended a blended approach making them and migrate to other medicines of the same
towards universal health coverage (UHC), one that chemical class as these other equivalent drugs are not in
strengthens the links of social health insurance to the NLEM 2011 and therefore, sneak out of the purview
healthcare providers (both public and private) but ties of DPCO 2013. The other route to escape price control is
funding to performance. Dr A Didar Singh, secretary by making a FDC of the drug under price control, or, by
general FICCI, Dr Narottam Puri, chairman NABH and manufacturing non-standard strengths of the same drug
advisor to FICCI healthcare services and Rakesh (like 650 mg instead of 500 mg paracetamol). Since
Sharma, co-chair, FICCI forum on medical devices and these strengths are not mentioned in the scheduled list
head, regulatory affairs, BD India were the other of DPCO 2013, they will not fall under the price control
members of the delegation. radar. The only remedy to prevent such 'migration' is to
Moreover, there is need for introducing a new put all chemical analogues of the medicines included in
National Health Policy which can support NLEM under price ceiling.
HURDLES IN IMPLEMENTATION OF DPCO 2013
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
29THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
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40 THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
PHARMACEUTICALS NEWSMumbai : European regulatory and the UK, who were joined by STRIDES ARCOLAB authorities have finalised their inspectors from Switzerland and RECEIVES US FDA assessment of reported non- Australia to undertake an
APPROVAL FOR compliance with Good unannounced international
METHOXSALEN Manufacturing Practice (GMP) at inspection of the site. The GMP
CAPSULES Ranbaxy Laboratories' inspection concluded that
appropriate corrective and Bengaluru : Strides Arcolab has manufacturing site in Toansa, India
preventive measures have been put received the approval from the that had led to the suspension of
in place by the manufacturer. The United States Food & Drug the GMP certificate for the site in
inspection team concluded that Administration (US FDA) for the European Union (EU). Although
there was no evidence that any Methoxsalen capsules USP, 10 mg the assessment showed that there
medicines on the EU market that (soft gelatin capsules). According to were a number of GMP deficiencies
have an active pharmaceutical IMS data, the US market for generic at the concerned site, assessment
ingredient manufactured in Toansa Methoxsalen capsule is of all available information has
were of unacceptable quality or approximately USD 13.6 million, reassured European regulators that
presented a risk to the health of with no generic player. The product there has been no risk to public
patients taking them. This will be manufactured at the health from these deficiencies.
conclusion was supported by tests company's US FDA approved oral Patients should continue to take
of samples of these medicines, all dosage facility at Bengaluru and their medicines as prescribed by
of which met the correct quality marketed directly by Strides in the their healthcare professional.
specifications. European regulatory US market. Methoxsalen is a drug European regulators also considered
authorities have identified the need used to treat psoriasis, eczema, the corrective measures put in place
to keep the Toansa site under close vitiligo and some cutaneous by the company and were satisfied
supervision and this will be done in lymphomas in conjunction with that the measures are sufficient to
collaboration with India and other exposing the skin to UVA light from ensure GMP-compliant manufacture
regulatory authorities around the lamps or sunlight. Methoxsalen of products at the site. As a
globe. modifies the way skin cells receive consequence, the EU authorities will
the UVA radiation, clearing up the reinstate the GMP certificate which NIGERIAN BUSINESS disease. Strides Arcolab develops was suspended in January 2014. LEADER SIR EMEKA and manufactures a wide range of The certificate will be re-entered into
OFFOR DONATES US IP-led niche pharmaceutical EudraGMDP, the EU database that
$1MN TO ROTARY'S products. The company has five contains GMP certificates. The
manufacturing facilities presence in POLIOPLUS assessment followed an inspection
more than 75 countries in by the US Food and Drug PROGRAMMEdeveloped and emerging markets. Administration (US FDA) which Abuja, Nigeria : For the second
revealed areas of non-compliance EMA FINDS consecutive year, Nigerian with GMP at the site. The European philanthropist and business leader RANBAXY'S medicines regulatory network Sir Emeka Offor (affectionately MANUFACTURING SITE responded quickly to the FDA's known as Sir Emeka) has donated
IN TOANSA NO RISK findings, and sent a team of US$1 million to Rotary's PolioPlus TO PUBLIC HEALTH inspectors from Germany, Ireland
41THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
programme. Sir Emeka announced They also work with religious and fund critically-needed immunization
his gift at the organisation's annual traditional leaders whose support is activities to ensure the disease is
convention, which is taking place needed for successful immunisation stopped for good. The $1 million
this week in Sydney, Australia, and campaigns. Furthermore, two gifts from both 2013 and 2014 are
has drawn more than 18,000 months ago, Sir Emeka opened a eligible for matching funds under the
Rotarians from 150 countries. Last PolioPlus Ambassador's Office at no End Polio Now. Make History Today
year's gift was also announced at cost to Rotary in Abuja, Nigeria. This fundraising campaign, carried out in
Rotary's convention, held in Lisbon. office, which was commissioned by conjunction with the Bill & Melinda
The eradication effort is a personal Rotary Trustee Chair Dong Kurn Lee, Gates Foundation. Under the
commitment for Sir Emeka, who serves as a hub for Sir Emeka's agreement, the Gates Foundation
hails from one of the three countries PolioPlus ambassadorial activities in will match 2 for 1 every dollar Rotary
where wild polio has never been Nigeria and supports the work of commits to polio eradication, up to
stopped (the others are Afghanistan Rotary's National PolioPlus $35 million per year. Thus, Sir
and Pakistan). Committee. “Rotary is proud to be Emeka's $2 million in support of
working with a business and PolioPlus leverages $6 million “Polio was common during my
humanitarian leader like Sir Emeka toward polio eradication.childhood in Kafanchan, Kaduna
Offor,” said Past Rotary vice State, Nigeria,” explained Sir Beyond last year's $1 million
president John Germ, who leads the Emeka, the executive vice chairman gift, Sir Emeka has previously
organization's fundraising efforts for of the Chrome Group, a Nigerian oil supported Rotary's polio eradication
polio eradication. “With Sir Emeka's and gas conglomerate. “My friends, work through a $250,000 gift to
support, Nigeria has made classmates, and their siblings all celebrate World Polio Day, and has
significant progress and is closer fell victim to this terrible disease. also generously contributed to
than ever to eliminating polio within As a young man, I vowed I would Rotary's maternal and child health,
its borders. We are confident we will someday do something significant peace and conflict resolution and
eliminate this disease from the world to end polio in Nigeria.” Sir Emeka educational programs. His gifts
and ensure no child ever again has has made good on his promise. This make him the largest contributor
to suffer from its crippling effects. ” new gift brings his total from Africa in Rotary's 109 year
contributions to Rotary to $3.1 Sir Emeka's support comes at history. In addition to his support for
million; however, he has done far a critical time for global polio Rotary, he is the founder of the Sir
more than simply donate money to eradication efforts. Nigeria in Emeka Offor Foundation, which
fight polio. Since last year's particular has seen tremendous focuses on poverty alleviation
contribution, he has been progress in recent years and is through literacy and education
increasingly active as Rotary's closer than ever to ending the programs in West Africa's poorest
PolioPlus Ambassador in Nigeria. Sir disease. In 2013, the country had communities.
Emeka works with a team of Rotary only 53 cases of polio, a record low
leaders to liaise with the for a nation that, as recently as
Government of Nigeria through the 2012, was home to more than half
federal and state health systems the world's cases. However, conflict
and primary health centers in local and insecurity continue to pose
government areas where polio challenges to polio eradication. Sir
eradication efforts are most needed. Emeka's new gift will help Rotary
PHARMACEUTICALS NEWS
42 THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
ovartis announced the results cent of patients with laBCC and 15.4 events (AEs) reported in >=2 per cent
of a pivotal phase II trial per cent of patients with mBCC, in the of patients receiving treatment with Ndemonstrating that patients 200 mg arm, and 35.2 per cent of the 200 mg dose were elevated levels
with locally advanced (laBCC) or patients with laBCC and 17.4 per cent of creatine phosphokinase (6.3 per
metastatic basal cell carcinoma of patients with mBCC in the 800 mg cent), increased lipase (5.1 per cent),
(mBCC) taking the investigational oral arm, achieved an objective response. h ypertension (2.5 per cent), asthenia,
compound LDE225 (sonidegib) had Secondary endpoints included or weakness (2.5 per cent) and
marked and sustained tumour duration of response (DoR), muscle spasms (2.5 per cent). The
shrinkage after a median follow-up of progression-free survival (PFS) and most common Grade 3/4 AEs,
13.9 months. The data were revealed time to tumor response (TTR), a reported in >=2 per cent of patients
for the first time today in an oral measure of how quickly the tumor receiving treatment with the 800 mg
presentation at the 50th Annual responded to treatment. Median DoR dose were elevated levels of creatine
Meeting of the American Society of for patients with laBCC in both phosphokinase (12.7per cent),
Clinical Oncology (ASCO) in Chicago. treatment arms could not be increased lipase (5.3 per cent),
"These results represent an important estimated since the majority of muscle spasms (5.3 per cent),
milestone in the clinical development patients who had a response had no decreased weight (5.3 per cent),
of LDE225, as well as in our research event at the time of the analysis (an decreased appetite (4.0 per cent),
strategy to develop new therapies for event is defined as progression or rhabdomyolysis, or the breakdown of
patients with unmet needs," said death due to any cause) Median DoR muscle fibers (3.3per cent), nausea
Alessandro Riva, managing director, was 8.3 months for patients with (2.7 per cent), hypertension (2.7per
Global Head, Novartis Oncology mBCC treated with LDE225 800 mg; cent), increased alanine
Development and Medical Affairs. however, it could not be estimated for aminotransferase (2.7per cent),
"These data will form the basis for patients with mBCC in the 200 mg increased aspartate aminotransferase
the filing of another important new arm because they had no event at the (2.7 per cent), fatigue (2.0 per cent),
medicine for a skin-related disease in time of the analysis. The median PFS syncope, or fainting (2 per cent),
which Novartis is building a leading for patients with laBCC in both anaemia (2 per cent), dehydration (2
position." The trial assessed the treatment arms could not be per cent), hyperkalemia (2 per cent)
efficacy and safety of two oral doses estimated since the majority of and myalgia, or muscle pain (2.0per
of LDE225, 200 mg and 800 mg, in patients had no event at the time of cent) Overall, Grade 3/4 events were
patients with laBCC or mBCC. The the analysis. The median PFS per observed less frequently in the 200
primary endpoint was the objective central review for patients with mBCC mg group (30.4 per cent) than in the
response rate (ORR), defined as the was 13.1 months in the 200 mg arm 800 mg group (56.0 per cent).
proportion of patients with complete and 7.6 months in the 800 mg arm. Basal cell carcinoma (BCC)
or partial tumor response, or Median TTR per central review for accounts for more than 80 per cent of
shrinkage, as measured by a central patients with laBCC was 3.9 months non-melanoma skin cancers.
review committee. The study met the (95 per cent) in the 200 mg arm and Worldwide incidence of BCC is rising
primary endpoint in both treatment 3.7 months (95 per cent) in the 800 by 10 per cent each year due to
arms with ORRs of 41.8 per cent (95 mg arm, and 4.6 months (95 per factors such as an aging population
per cent) confidence interval in the cent) and 1.0 month (95 per cent) for and increased ultraviolet exposure.
200 mg arm and 32.5 per cent (95 patients with mBCC in the 200 mg Although BCC rarely becomes
per cent CI: 25.1, 40.5) in the 800 and 800 mg arms, respectively. The advanced or metastatic, there are few
mg arm. More specifically, 47.0 per most common Grade 3/4 adverse treatment options at these stages of
PHARMACEUTICALS ARTICLE
PHASE II TRIAL OF INVESTIGATIONAL COMPOUND LDE225 SHOW MARKED TUMOR RESPONSES IN ADVANCED BASAL CELL CARCINOMA
the disease. "LDE225 showed breast cancer in the adjuvant setting. (<1per cent ), with no clear pattern to
marked tumor responses in patients Further analysis of these data will the reported events. AEs leading to
with locally advanced or metastatic continue over the coming months,” discontinuation were higher in the
basal cell carcinoma," said lead said Dr. Rafael Amado, senior vice lapatinib containing arms (23 per
investigator, Michael Robert Migden, president Oncology R&D at GSK. cent in the combination arm)
managing director, University of “We are most grateful to the more compared with the trastuzumab arm
Texas managing director, Anderson than 8,000 patients across the world (8%).
Cancer Center. "If approved, LDE225 who participated in ALTTO—their ALTTO (Adjuvant Lapatinib
could provide an important treatment generous contribution to the and/or Trastuzumab Treatment
option for patients suffering from this scientific community will facilitate a Optimisation trial; NCT00490139) is
disease that can be disfiguring and greater understanding of this a randomised, multi-centre, open-
life-threatening in advanced stages." aggressive disease.” The primary label, Phase III study of adjuvant
The data from this pivotal trial will analysis of the study tested for lapatinib, trastuzumab, their
serve as the basis for worldwide superiority (p=0.025) between the sequence and their combination in
regulatory filings for the 200 mg dose combination arm and trastuzumab patients with HER2 positive primary
of LDE225 in advanced basal cell alone with respect to DFS; the breast cancer. Randomised patients
carcinoma. trastuzumab followed by lapatinib received anti-HER2 therapy (lapatinib,
PHASE III STUDY OF ANTI-HER2 arm was tested for non-inferiority trastuzumab) after completing all
(p=0.025). The results showed that chemotherapy, concurrent with a AGENTS LAPATINIB &
at four years, 88 per cent of women taxane following anthracycline, or TRASTUZUMAB FAILS TO MEET
lived without their disease returning concurrent with a non-anthracycline, PRIMARY ENDPOINT :
(4-year DFS) in the lapatinib plus platinum-containing regimen.GlaxoSmithKline plc (GSK) announced
trastuzumab arm and 86 per cent in ALTTO randomised 8,381 that the phase III study of two anti-
the trastuzumab arm . The 4-year patients at nearly 1,000 research HER2 agents, lapatinib
DFS rate for the trastuzumab sites in 44 countries. Patient (Tykerb/Tyverb) and trastuzumab, did
followed by lapatinib arm was 87 per enrolment began in June 2007 and not meet the primary endpoint of
cent compared to 86 per cent in the was completed in July 2011. The improved disease free survival (DFS)
trastuzumab arm lapatinib arm was discontinued in compared to single agent therapy
Adverse events (AEs) more frequently 2011, after an independent review with trastuzumab as adjuvant
reported in the lapatinib plus committee determined that the treatment for HER2 positive early
trastuzumab arm compared to the lapatinib alone arm was unlikely to breast cancer. The safety profile was
trastuzumab arm were diarrhoea meet the pre-specified criteria to consistent with the established
(75per cent vs. 20 per cent ), rash demonstrate non-inferiority to safety profile of the study drugs, with
(55 per cent vs. 20 per cent ) and trastuzumab alone with respect to no new safety signals observed.
hepatobiliary (23 per cent vs. 16 per disease-free survival. Lapatinib an These results were presented at the
cent). Diarrhoea, grade 3 or higher, orally active, reversible, small 50th Annual Meeting of the American
was increased in all lapatinib molecule TKI that potently inhibits Society of Clinical Oncology (ASCO) in
containing treatment arms (5-15 per both ErbB1 and ErbB2 tyrosine Chicago, Illinois.
cent ), compared to trastuzumab kinase activity is marketed as Tykerb “While it is disappointing that
alone (1per cent ). The incidence of in the US. and as Tyverb in Europe ALTTO did not meet its primary
febrile neutropenia was <1 per cent and other countries across the world. endpoint, we now have a tremendous
across treatment arms and primary Lapatinib is not approved or licensed amount of information that will help
cardiac endpoints were <1per cent anywhere in the world for the to further our knowledge of the
in all arms. Overall, fatal AEs were treatment of HER2 positive early biology of this disease and inform
consistent between treatment groups breast cancer.future studies in HER2 positive
PHARMACEUTICALS ARTICLE
43THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l 44
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THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l 58
PRESS RELEASE
Directors - Mr. M. K Bhatia / Mr.P K Bhatia (4th & 3rd from left) alongwith AVA team members at IPhex India 2014
Mumbai headquartered speciality chemicals company AVA Chemicals exhibited its updated range of fine chemicals at India's leading pharmaceutical and Lab reagents event IPhex India 2014.
Fine chemicals and Sequestering/Chelating Agents manufactured by AVA Chemicals are of high quality passing with various standards like USP/IP/BP/FCC. Our laboratory reagents are of LR, EP, ACS, GR Grade and appreciated by companies like Merck, Thermofischer and many more. Products are regularly supplied globally to various industries like Pharmaceuticals, Food, Beverages, dairy products and other industries.
With increased focus on the pharmaceutical industry, AVA Chemicals participated in IPHEX India 2014 held at Bombay Exhibition Centre in May 2014.
" At IPhex India, We have showcased our expertise as an experienced one-stop manufacturer of Fine chemicals / Chelating agents catering to the fast growing Indian Pharmaceutical Market. " said Mr. M.K Bhatia - Director of AVA Chemicals Pvt Ltd.
"With our upgraded infrastructure and advance manufacturing capabilities, AVA is in a position to effectively cater to customer's requirements of high quality speciality chemicals. In line with our philosophy of providing value added services, AVA has created infrastructure to provide services like Contract / Custom manufacturing and private labelling of fine chemicals and chelates. AVA with its technical expertise in manufacturing Fine Chemicals provides large and diverse portfolio of products" explained by Mr. Vijay Bhatia, Head Business
AVA CHEMICALS SHOWCASES FINE CHEMICALS AT IPHEX INDIA 2014
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l 59
FOLLOWING PRODUCTS ARE AV AILABLE FROM READ Y STOCK
New Product Launch?Stabilized Bromine (Bromine Additive 10%)
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THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l 63
PET IN VIVO IMAGING SYSTEMS FOR PRECLINICAL RESEARCH
ofie Biosciences, a leader in the the global preclinical research choose from the new, flexible video field of PET imaging, and community,” said Brian Kim, delivery options available, including PerkinElmer Inc., a global leader president, life sciences & technology, hybrid and on-premises video, S
focused on the health and safety of PerkinElmer. “In vivo preclinical depending on the option that works people and the environment, have imaging plays an integral role in best for their business models and entered into an agreement in which translational research and drug budgets. All of the options include the PerkinElmer will exclusively discovery, facilitating a unique same benefits now what the size of the commercialize and sell preclinical understanding of disease initiation, investment making RealPresence One Positron Emission Tomography (PET) – progression and therapeutic truly scalable.X-Ray and 3-dimensional Computed responses.” “Our relationship Polycom's new RealPresence Tomography (CT) imaging systems combines PerkinElmer's preclinical Platform options include virtualised developed by, or in conjunction with, leadership with Sofie's PET expertise collaboration through a subscription. Sofie Biosciences. PET imaging is an to bring new translational imaging Here the RealPresence Platform essential preclinical research tool in solutions to the global research software and services for video, voice understanding the biology of disease, community,” said Patrick Phelps, and content collaboration are available biological impact of drugs, and clinical president and CEO of Sofie on an annual subscription basis. The translation. PerkinElmer will work Biosciences. company stated that this was an ideal
PRODUCTIVITY BOOST WITH together with Sofie on the solution for customers who want to manufacturing and development of implement voice, video and content PERSONAL VIRTUAL MEETING these new imaging instrument systems collaboration solutions in their ROOMS FOR HEALTHCARE INDUSTRY and assist Sofie in marketing Sofie's organisations for the first time. The : Polycom RealPresence One is all set chemical synthesis and advanced Virtual editions of individual to change the dynamics of the video probe development capabilities. These RealPresence Platform components conferencing market in India benchtop PET imaging systems provide are now available as virtualised particularly in the healthcare space. highly sensitive and quantitative software that runs on industry-standard Launched early this year and has been biological assays for application data servers in existing data centers. useful for industries like in such fields as oncology, Polycom RealPresence, virtual editions manufacturing, healthcare, education, immunology, neurobiology, cardiology, are ideal for organisations who want to government, financial services and and pharmacology. These systems are optimise, streamline or expand their various other verticals, it is now complementary to PerkinElmer's existing video networks, and will work available across all the cities in India. current portfolio of preclinical offerings, alongside hardware appliances, for a It is a comprehensive package for which includes IVIS optical imaging seamless, hybrid network. Polycom video and content collaboration which systems (available with integrated x-ray RealPresence One has been enhanced is now sold by subscription making it or CT,), high-performance dedicated to model the way present users are even easier for companies to adopt Quantum microCT systems and a full accessing critical business systems. human collaboration. According to a line of imaging reagents and probes, These include a comprehensive recent forecast by Gartner, the top 10 including PET radioisotopes. offering of the software and services. technology trends and drivers that will In addition to the current G4 There is no need for capex investment, be strategic for Indian organizations in PET/X Ray system, PerkinElmer and but the users could increase video 2014 include 'collaboration Sofie are announcing a new resources anytime, and renew technologies' which encompasses translational imaging solution, the G8 subscription annually. Further, the voice over IP, file sharing, PET/CT Small Animal Imaging System. healthcare providers investing in the videoconferencing, content archiving, This offering integrates PET and CT RealPresence One could add video media streaming, feedback and into an innovative, high-performance infrastructure to their existing polling. Real-time collaboration bench top system built to enable virtualized data center. There is scope technologies not included in the web preclinical workflows for biologists, to easily spin-up and spin-down video conferencing category include instant biochemists, and pharmacologists. “As capacity based on one's organization's messaging and stand-alone audio a leading provider of imaging platforms changing needs. There could also be conferencing. In India where for cellular, tissue and in vivo research, reduction in deployment time especially enterprises look for a customized PerkinElmer is pleased to partner with for trials and proof-of-concepts. “This product or service for all their business Sofie, a leader in the field of PET opens up new opportunities for needs, now with Polycom imaging, to deliver these systems to businesses in India to adopt RealPresence One organisations can
MACHINERY ARTICLE
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l 64
collaboration solutions that would truly offered only autologous stem cell D.V.M., M.P.V.M., founder and chief enable their teams to benefit from face therapy as a service (adipose tissue, executive officer of Vet-Stem, stated, to face collaboration no matter where also known as fat tissue, is harvested "Aratana is the ideal commercial they are across India.” said Minhaj Zia, from the patient from which stem cells partner for our regenerative cell managing director, India & SAARC. are isolated then reintroduced into the therapy for osteoarthritis, based upon Indian based businesses as they can same patient). The positive their deep expertise in pain and the strengthen their competitive offerings experience using adipose-derived overall quality of their pet heath not just across India but in the global stem cells in this way is strong, with organisation. We look forward to market place as well. This is an ideal thousands of veterinarians utilising accelerating development of what we solution for customers who want to the service since its introduction in believe to be an effective and implement voice, video and content 2004. Although excess doses can be potentially disease-modifying therapy, collaboration solutions in their frozen and banked, they can be used and to offering a more streamlined organisations for the first time,” he only as a future therapy for the original therapeutic option for veterinarians added. donor patient. and their patients." Aratana and Vet-
VET-STEM FOR ALLOGENEIC STEM Vet-Stem has now developed a Stem expect to initiate a blinded, multi-technology platform for producing centre, placebo-controlled, dose CELL THERAPY TECHNOLOGY : allogeneic stem cell therapies, where confirmation study later this month. Aratana Therapeutics, Inc. a pet a single donor sample can be used to Aratana does not expect US FDA therapeutics company focussed on generate a large bank of doses that approval before 2016. Dr. St. Peter licencing, developing and can be stored and used to treat concluded, "The advantages of a commercialising innovative multiple patients. Aratana has product-based stem cell therapy versus biopharmaceutical products for cats, licenced this allogeneic therapy, which the current service-based model dogs and other companion animals, will be tested for safety and efficacy in include the potential for lower overall has entered into an exclusive licence randomised, placebo-controlled dogs treatment costs for osteoarthritis, agreement with Vet-Stem, Inc., for its with osteoarthritis and submitted to higher market penetration, the benefit novel, allogeneic stem cell therapy the FDA for approval. Steven St. Peter, of scheduled campaign manufacturing, technology. Under the agreement, managing director, president & chief and for patients and their owners, no Aratana obtains exclusive rights to executive officer of Aratana need for surgery to harvest tissue." commercialise Vet-Stem's allogeneic Therapeutics, stated, "As we continue Under the terms of the agreement, stem cells in the United States, which to build our pipeline, we have made a Aratana will have an exclusive licence if approved, will be the first FDA-clear strategic investment in the high- to develop and commercialise products regulated, "off the shelf" regenerative need area of pain management for our in the US., based upon Vet-Stem cell therapy for the treatment of pets. We therefore are pleased to Technology for the treatment of pain osteoarthritis in dogs.Vet-Stem expand our pain franchise further by and inflammation of canine pioneered the use of adipose tissue as adding an allogeneic, regenerative cell osteoarthritis. Vet-Stem will continue a source for stem cells in veterinary therapy product, which in addition to to be responsible for the ongoing regenerative medicine, but to date has
its aim of reducing development of its allogeneic stem cell the pain of technology. Aratana will pay $500,000 osteoarthritis, has upon signing of the licence as a the potential to reimbursement to Vet-Stem for a impact the portion of its past development progression of the expenses and will be responsible for disease, and to funding future budgeted development. promote tissue Aratana will also pay up to $4.5 million regeneration. We in success-based development and will examine this regulatory milestones, as well as tiered phenomenon in royalties upon potential planned studies, commercialisation of the stem cell which could result therapy, based on potential sales. in product Aratana will also have the exclusive labelling that right to negotiate expansion of the specifies disease- agreement to include the European modifying Union countries during the calendar properties." year of 2014.Robert J. Harman,
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l 66
CDC REPORTS 41 SALMONELLA TYPHIMURIUM ILLNESSES LINKED TO LABS
he US Centers for Disease agency laboratories, obtains DNA report being hospitalized — not an
Control and Prevention (CDC) “fingerprints” of Salmonella bacteria unusual rate for standard infections.
in its recent report has through diagnostic testing with No deaths have been reported to Tclaimed that 41 cases of pulsed-field gel electrophoresis, or date.
Salmonella Typhimurium since PFGE. The strains in this outbreak The outbreak strains include
November 2013 have been linked to are the same ones known to be Newport, Hartford and Oranienburg.
exposure to various clinical and commercially available for teaching The 44 cases reported across four
college and university teaching laboratories and have been used at Canadian provinces include these,
microbiology laboratories. Of those the laboratories associated with this as well as the Saintpaul strain. Six
who became ill, 62 were 21 years outbreak. At least 109 people in of the Canadian victims have been
old or younger, and 36 percent were 2011 were sickened with one of hospitalized. Antimicrobial
hospitalized. No deaths were these same strains of Salmonella resistance levels are unclear as test
reported. These same strains of Typhimurium via exposure at clinical results are still pending. “This is
Salmonella Typhimurium have been and teaching microbiology the first time that chia seeds have
associated with outbreaks linked to laboratories. been identified as a food that
microbiology laboratory exposure in transmits Salmonella,” said Dr. 65 SALMONELLA INFECTIONS
the past, the CDC said. Those Laura Gieraltowski, an COULD LEAD TO EXPANDING
exposed to bacteria used in epidemiologist with the U.S. Centers RECALL OF CHIA SEEDS : Chia
laboratory settings can spread the for Disease Control and Prevention seeds are an increasingly popular
bacteria to others with whom they (CDC) and one of the lead ingredient in the health food world.
come into contact outside the lab, investigators on the outbreak. The The Dr. Oz Show and various health
including young children who may be list of recalled products has been magazines have been highlighting
especially vulnerable. CDC has expanding since the first one issued them, and recipes with this
produced an educational flyer by Navitas Naturals on May 28. Two “superfood” have been popping up
entitled, “What You Work With Can other U.S. companies have since all over Pinterest and BuzzFeed. But
Make You Sick,” to remind those recalled their chia powder products, before you go adding chia powder to
who work in laboratory settings of and Navitas has expanded its recall your morning smoothie, check to be
the potential risk of carrying to include a broader date range. sure it isn't on the list of recalled
pathogens outside the lab. The “The traceback investigation is still products that might be
agency also recommends that ongoing, but [the U.S. Food and contaminated with Salmonella.
laboratories use non-pathogenic or Drug Administration] did trace back At least 65 Salmonella
attenuated bacterial strains when chia products reported by the ill infections in the U.S. and Canada
possible. Public health investigators people that did show that it came have been linked to such products
used the CDC's PulseNet system to from a particular farm,” Gieraltowski since May. The 21 cases in the U.S.
recognize the outbreak. PulseNet, said. Eight brands in Canada have are in people aged 1 to 81 across
the national subtyping network of announced their own recalls of 12 states. Among 15 ill persons
public health and food regulatory seeds, powders, trail mix, and fruit with available information, two
FOOD INGREDIENT
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014l 67
FOOD INGREDIENTPOLLEN, HIDES HONEY ORIGINS : and nut bars. “I don't think it was them to the place of purchase for a
More than three-fourths of the honey surprising that it's in a lot of other refund.
sold in U.S. grocery stores isn't products, but it's definitely While first investigating the
exactly what the bees produce, worrisome,” Gieraltowski said. Most cluster of Salmonella Newport
according to tests done recently. of the people CDC officials talked to illnesses identified in PulseNet,
The results show that the pollen have reported putting chia powder in Gieraltowsk said the initial signals
frequently has been filtered out of their smoothies, but it can be a bit pointed to “health food.” Vegan,
products labeled “honey.” The of a “stealthy” ingredient if people vegetarian and dairy-free diets were
removal of these microscopic don't realize it was an ingredient in being reported by victims.
particles from deep within a flower their smoothie mix or other food. So Investigators decided to do open-
would make the nectar flunk the folks at CDC are concerned that ended interviews rather than a
quality standards set by most of the information about the recall isn't longer standardized questionnaire
world's food safety agencies.getting out. Because chia seeds in which a health food product or
The food safety divisions of have a long shelf-life, it's possible supplement was unlikely to be
the World Health Organization, the that people are still eating covered. When the same brand of
European Commission and dozens potentially contaminated product. chia powder came up in the first
of others also have ruled that “My own family members — two of three interviews, “We knew that we
without pollen there is no way to which use chia seeds — had no had it from there,” Gieraltowski
determine whether the honey came idea about the recall,” Gieraltowski said. After starting their
from legitimate and safe sources. In noted. Chia products are usually investigation, CDC noticed similar
the US, the Food and Drug eaten raw, so there's not much cases in Canada via PulseNet and
Administration says that any product consumers can do to minimize their reached out to their counterparts up
that's been ultra-filtered and no risk. CDC, FDA, the Public Health north. When the Canadians looked
longer contains pollen isn't honey. Agency of Canada, and the into their cases, they also found
However, the FDA isn't checking Canadian Food Inspection Agency the chia product commonality. “It
honey sold here to see if it contains are telling consumers not to eat the was a really great joint investigation
pollen. Ultra filtering is a high-tech recalled foods. Instead, they're with our international partners as
procedure where honey is heated, advised to throw them out or return well,” Gieraltowsk said. The
sometimes watered down and then agencies are still trying to
forced at high pressure through determine the relationship between
extremely small filters to remove the actual chia seeds and the
pollen, which is the only foolproof powder. Chia powder is made by
sign identifying the source of the sprouting the seeds and then
honey. It is a spin-off of a technique grinding up the sprouts. Since
refined by the Chinese, who have sprouts are a common vehicle for
illegally dumped tons of their honey pathogens, Gieraltowski said this
– some containing illegal antibiotics process may be amplifying the
– on the US market for years.contamination of the seeds.
2,4-Dichloro Benzoic AcidChemaroma Drug House................................44 D K Pharmchem Pvt. Ltd................................Back Inside Bliss Unlimited................................................33
4-Chloro Benzene Sulphonic Acid Sod. Khandelwal Laboratories Pvt Ltd....................35S. R. Group Of Companies.............................312-Chloro1,3-
(S)-4-Benzyl-2-Oxazolidinone SaltAcesulfameBis(Dimethylamino)Trimethinium Hexa Khandelwal Laboratories Pvt Ltd....................35 D K Pharmchem Pvt. Ltd................................Back InsideDevson Impex Pvt. Ltd....................................18
Rumit International..........................................39Khandelwal Laboratories Pvt Ltd....................35 D K Pharmchem Pvt. Ltd................................Back InsideAcetonitrile For Hplc
1-Bromo-3-Chloro PropaneDhruv Chem Industries...................................45 International Drug & Chemical Co..................594-Toluene Sulphonic Aicd SolutionDhruv Chem Industries...................................453-Bromo Nitro Benzene Acrysol K-140 / K-150 / El-135D K Pharmchem Pvt. Ltd................................Back Inside
1-ButaneDhruv Chem Industries...................................45 International Drug & Chemical Co..................595,5-Diphenyl-3[(Phosphoonoxy)Methyl]-Molychem........................................................343-Nitro Benzaldehyde Actinomycin D2,4-Imidazolinedione Dibenzyl Ester1-HeptaneKhushbu Chemicals........................................60 Ruskin Chemipharm.......................................14-15Jpn Pharma Pvt. Ltd.......................................46Molychem........................................................343-Pyridyl Acetic Acid Hydrochloride Activated Carbon / Charcool5-[4-[2-(5-Ethyl-2-1-HexaneJpn Pharma Pvt. Ltd.......................................46 Jay Chem Marketing.......................................60Pyridyl)Ethoxy]Phenyl]Methylene-2-Molychem........................................................34
Nova Chemie..................................................484-Aminobutyric Acid1-Octane 4thiazolidinedione
S. V. Enterprises.............................................65Jpn Pharma Pvt. Ltd.......................................46Molychem........................................................34 Jpn Pharma Pvt. Ltd.......................................46
PelletsCarboximidamideMolychem........................................................34 D K Pharmchem Pvt. Ltd................................Back InsideEuro Fine Chemicals.......................................62Bliss Unlimited................................................33
Aerosil Ruskin Chemipharm.......................................14-15 Global Pharma................................................8 Molychem........................................................34
Western Pharma.............................................62 J. B. Khokhani & Co........................................Front Inside Titan Biotech Ltd.............................................30AmisulprideRavi Chem......................................................49 Ruskin Chemipharm.......................................14-15 Bees WaxOm Laboratories.............................................22
Af-Coat / Seal Artesunate SterileAril Pharmaceuticals.......................................16 Global Merchants............................................65
Excellent Pharma Care (India)........................45 Global Pharma................................................8 Global Pharma................................................8 Unicorn Petroleum Industries Pvt Ltd.............51
Orbit Lifescience Pvt. Ltd................................12 Western Pharma.............................................62Af-Coat Pearl Ascorbic Acid
Amitriptyline Hcl Benazepril HclExcellent Pharma Care (India)........................45 Ruskin Chemipharm.......................................14-15
Aligns International.........................................26 Turakhia Brothers............................................24Agar Agar AspartameAril Pharmaceuticals.......................................16 BendamustineTitan Biotech Ltd.............................................30 Cosmos International......................................44Shubham Pharmachem Pvt. Ltd.....................11 Devson Impex Pvt. Ltd....................................18 Chemipack Corporation..................................32AjinomotoAmlodipine Base / Besylate Aspirine BenzaldoximeDevson Impex Pvt. Ltd....................................18S. R. Group Of Companies.............................31 Global Pharma................................................8 Khushbu Chemicals........................................60Ajowan OilAligns International.........................................26
Astaxanthin Benzalkonium ChlorideChemical Process Consultants.......................59Aril Pharmaceuticals.......................................16
PowderChemical Process Consultants.......................59 Jay Chem Marketing.......................................60Global Pharma................................................8
Cosmos International......................................44Ruskin Chemipharm.......................................14-15 Chemaroma Drug House................................44Ampicillin Sodium Sterile / Trihydrate J. B. Khokhani & Co........................................Front InsideAlphacalcidol Benzoyl Chloride / HydrazineCompacted Orbit Lifescience Pvt. Ltd................................12Siddhivinayak Pharma....................................51 Bliss Unlimited................................................33Rumit International..........................................39Ruskin Chemipharm.......................................14-15D K Pharmchem Pvt. Ltd................................Back Inside Khushbu Chemicals........................................60Ruskin Chemipharm.......................................14-15Ampicillin TrihydrateAlprazolam Benzyl Acetate / AlcoholAzithromycin Amine / DihydrateFarmachem Life Pvt Ltd..................................7Aril Pharmaceuticals.......................................16 Global Pharma................................................8Rumit International..........................................39Analgin Dab10
Ravi Chem......................................................49Alvimopan Farmachem Life Pvt Ltd..................................7Ruskin Chemipharm.......................................14-15S. V. Enterprises.............................................65Mehta Pharmaceutical Industries....................9Ruskin Chemipharm.......................................14-15
Anemometer Bliss Unlimited................................................33S. V. Enterprises.............................................65Ambroxol Kahan Pharmaceuticals..................................38 Dhruv Chem Industries...................................45Siddhivinayak Pharma....................................51Global Pharma................................................8Anethi Oil Global Pharma................................................8Sna Healthcare Pvt. Ltd..................................61
Ambroxol Hcl Grindlays Pharmaceuticals Pvt. Ltd................Back CoverChemical Process Consultants.......................59BaclofenAligns International.........................................26 Ravi Chem......................................................49Anhydrous GlucoseGlobal Pharma................................................8Aril Pharmaceuticals.......................................16 S. V. Enterprises.............................................65Ruskin Chemipharm.......................................14-15BacopaKahan Pharmaceuticals..................................38
Carbamazepine Ceric Ammonium SulphateMolychem........................................................34 BusalphanRuskin Chemipharm.......................................14-15 Molychem........................................................34Biotin Chemipack Corporation..................................32Shubham Pharmachem Pvt. Ltd.....................11 Cetirizine Di HclNova Chemie..................................................48 BuspironeCarbimazole S. R. Group Of Companies.............................31Bisacodyl Ruskin Chemipharm.......................................14-15Ruskin Chemipharm.......................................14-15 Sun Moon Industries.......................................50Dishman Pharmaceuticals & Chemicals Ltd...37 Turakhia Brothers............................................24
Carbidopa Cetodet 500Jpn Pharma Pvt. Ltd.......................................46 C. A. P. B / C. M / C. M. CRuskin Chemipharm.......................................14-15 Niram Chemicals.............................................60Bisoxatin Acetate Cosmos Plastics & Chemicals........................59
Western Pharma.............................................62 Chemical Process Consultants.......................59 Aril Pharmaceuticals.......................................16Titan Biotech Ltd.............................................30
Ravi Chem......................................................49 Calamine CarboplatinCetrimide Strong 40% Solution In
Blended Lakes : Apple / Pea Green Mehta Pharmaceutical Industries....................9 Khandelwal Laboratories Pvt Ltd....................35Isopropylalcohol
Bortezomib Ihs Dhruv Chem Industries...................................45 Chemical Process Consultants.......................59Chemicals For Cosmetic Ind.
Khandelwal Laboratories Pvt Ltd....................35 Gangotri Inorganic (P) Ltd...............................17 Caustic Soda FlakesPowder Pack Chem........................................48Ravi Chem......................................................49Bosentan Monohydrate Royal Drugs & Pharmaceuticals.....................5Chemicals For Feed Ind.S. V. Enterprises.............................................65Dishman Pharmaceuticals & Chemicals Ltd...37 Cedarwood OilPowder Pack Chem........................................48Western Pharma.............................................62
Bosutinib Chemical Process Consultants.......................59CephalexinCalcium Chloride / CitrateDishman Pharmaceuticals & Chemicals Ltd...37 CefaclorFarmachem Life Pvt Ltd..................................7G. Amphray Pharmaceuticals Pvt. Ltd............13
Brilliant Blue Fcf Lake Aligns International.........................................26Sima Chemicals..............................................65 Chloramine T
Standardcon Pvt. Ltd......................................51 Cefadroxil MonohydrateCalcium Cmc D K Pharmchem Pvt. Ltd................................Back Inside
Bromelain Farmachem Life Pvt Ltd..................................7Patel Chem Specialities P. Ltd........................29 Chloramphenicol
International Drug & Chemical Co..................59 Cefazolin Sodium SterileCalcium D Pantothenate Cosmos International......................................44Likir Chemical.................................................61 Ruskin Chemipharm.......................................14-15
Global Pharma................................................8 Khandelwal Laboratories Pvt Ltd....................35Ammonium ClozapineS. R. Group Of Companies.............................31 CycloserineRavi Chem......................................................49 Unitrade Agencies...........................................21
Citalopram J. B. Khokhani & Co........................................Gate FoldChloroacetyl Chloride Coco DiethanolamideGlobal Pharma................................................8 CyclosporineS. R. Group Of Companies.............................31 Niram Chemicals.............................................60
Citric Acid Kahan Pharmaceuticals..................................38Shubham Pharmachem Pvt. Ltd.....................11ChlorzoxazoneSiddhivinayak Pharma....................................51 Shubham Pharmachem Pvt. Ltd.....................11Coleus ForskohliiWestern Pharma.............................................62Ravi Chem......................................................49 CytarabineJ. B. Khokhani & Co........................................Front Inside Aligns International.........................................26Ultimed Pharma Pvt. Ltd.................................20 Turakhia Brothers............................................24Chlorpheniramine Maleate Colistin SulphateCitric Acid Anhydrous / Mono D - CycloserineSiddhivinayak Pharma....................................51 Turakhia Brothers............................................24Desmo Exports Limited...................................Front Cover Ruskin Chemipharm.......................................14-15Ravi Chem......................................................49 Colloidal Silicon DioxideCosmos International......................................44Shubham Pharmachem Pvt. Ltd.....................11 D - LimoneneSiddhivinayak Pharma....................................51Citronella OilTamarind Drugs & Cosmetics.........................19 Chemical Process Consultants.......................59Colorimetric ReagentsChemical Process Consultants.......................59Chlorpromazine D. C. P / D. E. A / D. H. A / D. C. D. AMolychem........................................................34Citrus BioflavonoidsGlobal Pharma................................................8 Likir Chemical.................................................61ColostrumShubham Pharmachem Pvt. Ltd.....................11Chlorpromazine Hcl Ravi Chem......................................................49Aligns International.........................................26Clarcel-Diatomite-Filter Aid-Equi To Siddhivinayak Pharma....................................51Cosmos International......................................44
Chandra Biotech.............................................20 D. M. F / D. M. S. O / D. S. DJay Chem Marketing.......................................60Columbia AgarRuskin Chemipharm.......................................14-15 Chemaroma Drug House................................44Clarithromycin Titan Biotech Ltd.............................................30
Chlorpropamide Desmo Exports Limited...................................Front CoverJ. B. Khokhani & Co........................................Front InsideComplete Film Forming System
Ultimed Pharma Pvt. Ltd.................................20 Chemical Process Consultants.......................59 Om Laboratories.............................................22Clavulanate Potassium Sterile + Choline Dihydrogen Citrate Croscarmellose Sodium Ruskin Chemipharm.......................................14-15
Amoxicillin Sodium SterileArochem Industries.........................................5 Ravi Chem......................................................49 DaptomycinLaffans Petrochemicals Limited......................47
Ajmera Pharmasure Pvt. Ltd...........................27Choline Salicylate / Theophyllinate Ruskin Chemipharm.......................................14-15Cleaning Agents Global Pharma................................................8Arochem Industries.........................................5 DarifenacinMolychem........................................................34 International Drug & Chemical Co..................59
Global Pharma................................................8 Ravi Chem......................................................49Deodourised KeroseneCilnidipine
Clobetasol Dipropionate / Propionate Culture MediaUnicorn Petroleum Industries Pvt Ltd.............51International Drug & Chemical Co..................59
Chemical Process Consultants.......................59DesloratadineCinnamic Acid Clomipramine Hcl
Cupric ChlorideAligns International.........................................26Chemaroma Drug House................................44 Aril Pharmaceuticals.......................................16
Euro Fine Chemicals.......................................62 Aril Pharmaceuticals.......................................16Cinnamon Extract / Oil ClonazepamCuprous Bromide / Cyanide Chemipack Corporation..................................32Aligns International.........................................26 Aril Pharmaceuticals.......................................16Dhruv Chem Industries...................................45 Shubham Pharmachem Pvt. Ltd.....................11Chemical Process Consultants.......................59
Clopidogrel Bisulphate / Intermediate Euro Fine Chemicals.......................................62 DesvenlafaxineCinnamon Leaf Oil Aligns International.........................................26Curcumin Chemipack Corporation..................................32Chemical Process Consultants.......................59 Aril Pharmaceuticals.......................................16Aligns International.........................................26 Dexchlorpheniramine MaleateCinnarizine S. R. Group Of Companies.............................31Customized Preparation Siddhivinayak Pharma....................................51Aligns International.........................................26 ClosantelExcellent Pharma Care (India)........................45 Dex CpmAril Pharmaceuticals.......................................16 Global Pharma................................................8Cyanoacetic Acid Ravi Chem......................................................49Global Pharma................................................8
Closantel SodiumGlobal Merchants............................................65 DexamethasoneCiprofloxacin Hcl Aarambh Life Science.....................................Ear PanelCyano Diol Hbr Kahan Pharmaceuticals..................................38Farmachem Life Pvt Ltd..................................7
ClotrimazoleAjmera Pharmasure Pvt. Ltd...........................27 S. R. Group Of Companies.............................31 Dexamethasone BaseUnitrade Agencies...........................................21Rumit International..........................................39 Cyanoacetamide Rumit International..........................................39
CloxacillinRuskin Chemipharm.......................................14-15 Khushbu Chemicals........................................60 Dexamethasone Base & Sodium Kahan Pharmaceuticals..................................38Cisplatin Cyclopentolate Hcl PhosphateCloxacillin SodiumKhandelwal Laboratories Pvt Ltd....................35 Turakhia Brothers............................................24 Ajmera Pharmasure Pvt. Ltd...........................27Shubham Pharmachem Pvt. Ltd.....................11Citalopram Khandelwal Laboratories Pvt Ltd....................35 Gaurav Enterprises.........................................46Farmachem Life Pvt Ltd..................................7Hrishabh Life Sciences...................................65 Sun Moon Industries.......................................50 Global Pharma................................................8
Erythromycin Salts / Stearate / Diflunisal Doxycycline Hcl Fast Green Fcf Lake
Turakhia Brothers............................................24 Farmachem Life Pvt Ltd..................................7 Standardcon Pvt. Ltd......................................51ThiocyanateRuskin Chemipharm.......................................14-15Diiodohydroxyquinoline Fast Red E LakeGlobal Pharma................................................8Doxylamine SuccinateJ. B. Khokhani & Co........................................Front Inside J. B. Khokhani & Co........................................Front Inside Standardcon Pvt. Ltd......................................51
Aril Pharmaceuticals.......................................16 Global Pharma................................................8EscitalopramGlobal Pharma................................................8
Dimethyl Acetamide / Carbonate Fennel Seed OilRavi Chem......................................................49 Global Pharma................................................8
Chemaroma Drug House................................44 Chemical Process Consultants.......................59Dried Ferrous Sulphate Escitalopram OxalateCosmos International......................................44 FenofibrateSushant Industries..........................................50 Chemipack Corporation..................................32
Hydrocortisone BaseS. R. Group Of Companies.............................31 Turakhia Brothers............................................24Flavoxate Ajmera Pharmasure Pvt. Ltd...........................27Sri Pharmacare...............................................61
I. P. A / I. P. MJpn Pharma Pvt. Ltd.......................................46 Titan Biotech Ltd.............................................30Guaifenesin Western Pharma.............................................62Fluorometholone Micronised GemcitabineHrishabh Life Sciences...................................65 Molychem........................................................34Aaditya Pharmachem......................................18 Dishman Pharmaceuticals & Chemicals Ltd...37Shubham Pharmachem Pvt. Ltd.....................11 Ravi Chem......................................................49Aligns International.........................................26FluoxetineGuanidine Hcl Royal Drugs & Pharmaceuticals.....................5Ruskin Chemipharm.......................................14-15Shubham Pharmachem Pvt. Ltd.....................11Chemaroma Drug House................................44 Siddhivinayak Pharma....................................51
IbuprofenS. V. Enterprises.............................................65Turakhia Brothers............................................24Fluvastatin Sodium Ajmera Pharmasure Pvt. Ltd...........................27Gum CarrageenanGentamycin SulphateTurakhia Brothers............................................24 J. B. Khokhani & Co........................................Front InsideDevson Impex Pvt. Ltd....................................18Ruskin Chemipharm.......................................14-15Fluvoxamine Maleate Ruskin Chemipharm.......................................14-15
H. E. C / H. P. L. C / H. P. M. CUnitrade Agencies...........................................21Aril Pharmaceuticals.......................................16 IdebenoneCosmos International......................................44Ginkgo Biloba ExtractFolic Acid Turakhia Brothers............................................24Cosmos Plastics & Chemicals........................59Turakhia Brothers............................................24Nova Chemie..................................................48 IfosfamideGlobal Pharma................................................8
Ruskin Chemipharm.......................................14-15 K. P. Manish Global Ingredients P...................6 Farmachem Life Pvt Ltd..................................7KaolinLaffans Petrochemicals Limited......................47Iodine L. I. Q. AmmoniaRavi Chem......................................................49
Iron Protein Succinylate Liquid Glucose / ParaffinL - Cysteine Aligns International.........................................26International Drug & Chemical Co..................59 Siddhivinayak Pharma....................................51K. P. Manish Global Ingredients P...................6
Loperamide HclDevson Impex Pvt. Ltd....................................18Dhruv Chem Industries...................................45Lemon Oil Global Pharma................................................8K. P. Manish Global Ingredients P...................6
Isocarboxazid Chemical Process Consultants.......................59LoratadineL - LysineKhandelwal Laboratories Pvt Ltd....................35
Lemongrass Oil Aligns International.........................................26Aril Pharmaceuticals.......................................16Isomalt Chemical Process Consultants.......................59 Aril Pharmaceuticals.......................................16Nova Chemie..................................................48Devson Impex Pvt. Ltd....................................18
Lenalidomide Kahan Pharmaceuticals..................................38L - Lysine AcetateIsooctane Shubham Pharmachem Pvt. Ltd.....................11Turakhia Brothers............................................24K. P. Manish Global Ingredients P...................6Chemaroma Drug House................................44
Shubham Pharmachem Pvt. Ltd.....................11Turakhia Brothers............................................24LevetiracetamK. P. Manish Global Ingredients P...................6
Ultimed Pharma Pvt. Ltd.................................20Isovaleraldehyde J. B. Khokhani & Co........................................Gate FoldL - ProlineLovastatinOrbit Lifescience Pvt. Ltd................................12 Jpn Pharma Pvt. Ltd.......................................46K. P. Manish Global Ingredients P...................6Turakhia Brothers............................................24Isoxsuprine Turakhia Brothers............................................24
L - SerineAligns International.........................................26Kahan Pharmaceuticals..................................38 LevosulpirideDevson Impex Pvt. Ltd....................................18Loxapine SuccinateItraconazole Powder Ravi Chem......................................................49
L - ThreonineTurakhia Brothers............................................24Turakhia Brothers............................................24 LevocetirizineNova Chemie..................................................48LufenuronIvermectin Kahan Pharmaceuticals..................................38Devson Impex Pvt. Ltd....................................18Turakhia Brothers............................................24Global Pharma................................................8 Levocetirizine Hcl / Di HclK. P. Manish Global Ingredients P...................6LumefantrineKahan Pharmaceuticals..................................38 Aril Pharmaceuticals.......................................16L - Thyroxine SodiumSushant Industries..........................................50Om Laboratories.............................................22 Sun Moon Industries.......................................50Shubham Pharmachem Pvt. Ltd.....................11Global Pharma................................................8Ruskin Chemipharm.......................................14-15
LevodopaL - TryptophanJ. B. Khokhani & Co........................................Gate FoldJojoba Oil Ruskin Chemipharm.......................................14-15K. P. Manish Global Ingredients P...................6 Jpn Pharma Pvt. Ltd.......................................46Global Merchants............................................65 Turakhia Brothers............................................24
L - Tyrosine LurasidoneJosamycin LevofloxacinDevson Impex Pvt. Ltd....................................18 Ruskin Chemipharm.......................................14-15Ruskin Chemipharm.......................................14-15 Orbit Lifescience Pvt. Ltd................................12K. P. Manish Global Ingredients P...................6LuteinKanamycin Acid Sulphate Ruskin Chemipharm.......................................14-15
L - ValineLikir Chemical.................................................61Ruskin Chemipharm.......................................14-15 Levofloxacin HemihydrateDevson Impex Pvt. Ltd....................................18
PRODUCT INDEX
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014?74
Shubham Pharmachem Pvt. Ltd.....................11 Ruskin Chemipharm.......................................14-15 Global Merchants............................................65Melatonin
Rumit International..........................................39Ravi Chem......................................................49 Global Pharma................................................8 Mycophenolic Mesylate
Meta Nitrobenzyl AlcoholInternational Drug & Chemical Co..................59Magnesium Metal Turnnings / Powder Turakhia Brothers............................................24
Maize Starch Ad Pharmachem (P) Ltd.................................62Global Pharma................................................8Metformin
Siddhivinayak Pharma....................................51 N - Butyl ChlorideSna Healthcare Pvt. Ltd..................................61Farmachem Life Pvt Ltd..................................7Devson Impex Pvt. Ltd....................................18 Dhruv Chem Industries...................................45MicrobiologyMetformin HclRavi Chem......................................................49
N - DeceneMolychem........................................................34Sushant Industries..........................................50Western Pharma.............................................62Chemaroma Drug House................................44
Grindlays Pharmaceuticals Pvt. Ltd................Back Cover Microcrystalline Cellulose / WaxMaleic Acid / AnhydrideN - DodeceneInternational Drug & Chemical Co..................59 Western Pharma.............................................62Mehta Pharmaceutical Industries....................9Chemaroma Drug House................................44J. B. Khokhani & Co........................................Front Inside Patel Chem Specialities P. Ltd........................29Desmo Exports Limited...................................Front CoverN - Ethyl Para Toluene SulfonamideLikir Chemical.................................................61 Unicorn Petroleum Industries Pvt Ltd.............51
Melitracen HclRoyal Drugs & Pharmaceuticals.....................5 D K Pharmchem Pvt. Ltd................................Back InsideMicrocrystalline Cellulose PowderChemipack Corporation..................................32Shubham Pharmachem Pvt. Ltd.....................11 N - HeptaneRavi Chem......................................................49
Malt ExtractMethanol For Hplc Chemaroma Drug House................................44MifepristoneTitan Biotech Ltd.............................................30Molychem........................................................34 N - HexaneInternational Drug & Chemical Co..................59
N - Methyl PiperazineAril Pharmaceuticals.......................................16Mannitol Turakhia Brothers............................................24
Rumit International..........................................39MisoprostolSiddhivinayak Pharma....................................51 MethoxsalenN - OctaneInternational Drug & Chemical Co..................59Ruskin Chemipharm.......................................14-15 Aril Pharmaceuticals.......................................16
Shubham Pharmachem Pvt. Ltd.....................11 Chemaroma Drug House................................44Mannitol Salt Agar Gaurav Enterprises.........................................46
P - Bromo Phenol Pemetrexed Disodium HeptahydrateRuskin Chemipharm.......................................14-15Natural Vitamin E Oil Dhruv Chem Industries...................................45 Dishman Pharmaceuticals & Chemicals Ltd...37OlanzapineTurakhia Brothers............................................24
P - Bromo Toluene PenicillinAril Pharmaceuticals.......................................16Nebivolol Hcl Dhruv Chem Industries...................................45 Turakhia Brothers............................................24Global Pharma................................................8Western Pharma.............................................62P - Chloro Benzonitril Penicillin G Potassium 1st CrystalOleum LiniAril Pharmaceuticals.......................................16Chemaroma Drug House................................44 Ruskin Chemipharm.......................................14-15Siddhivinayak Pharma....................................51Nelfinavir MesylateP - Nitro Benzamide Penicillin G Potassium 1st CrystalOlive OilTurakhia Brothers............................................24Bliss Unlimited................................................33 Ruskin Chemipharm.......................................14-15Chemical Process Consultants.......................59Neomycin SulphateP - Nitro Benzene Sulfonyl Chloride / Penta+DomOlmesartan MedoxomilRuskin Chemipharm.......................................14-15Nosyl Chloride Chemipack Corporation..................................32Chemipack Corporation..................................32Neopentyl GlycolBliss Unlimited................................................33 PentoxifyllineShubham Pharmachem Pvt. Ltd.....................11Cosmos Plastics & Chemicals........................59P. C. M. C / P. E. G / P. G / P. V. P. K Tamarind Drugs & Cosmetics.........................19OlmisartanNevirapineRavi Chem......................................................49 Peppermint OilInternational Drug & Chemical Co..................59Aligns International.........................................26J. B. Khokhani & Co........................................Front Inside Chemical Process Consultants.......................59Omega 3 Fatty AcidTurakhia Brothers............................................24Niram Chemicals.............................................60
Niflumic Acid Ondansetron Palmarosa Oil Phase Transfer Reagent
Ruskin Chemipharm.......................................14-15 Gaurav Enterprises.........................................46 Chemical Process Consultants.......................59 Molychem........................................................34
Orbit Lifescience Pvt. Ltd................................12 J. B. Khokhani & Co........................................Front Inside Khushbu Chemicals........................................60Ruskin Chemipharm.......................................14-15Ruskin Chemipharm.......................................14-15 Kahan Pharmaceuticals..................................38 Phthaloyl AmlodipineOxetacaine
Royal Drugs & Pharmaceuticals.....................5Nortriptyline Hcl S. R. Group Of Companies.............................31Shubham Pharmachem Pvt. Ltd.....................11Ruskin Chemipharm.......................................14-15Aril Pharmaceuticals.......................................16 PhthalylsulfathiazoleOxybenzone Sri Pharmacare...............................................61
Nutmeg Oil G. Amphray Pharmaceuticals Pvt. Ltd............13Siddhivinayak Pharma....................................51 Ultimed Pharma Pvt. Ltd.................................20Chemical Process Consultants.......................59 Phytase 5000 Ftu/G GranulesOxybutynin Hcl Paraffin Liquid / WaxNutraceutical Products Nova Chemie..................................................48
Ritodrine HclPioglitazone Hcl Ruskin Chemipharm.......................................14-15J. B. Khokhani & Co........................................Front Inside
Likir Chemical.................................................61Jpn Pharma Pvt. Ltd.......................................46 PyrazinamidePovidone Iodine Powder / Sol
ResveratrolPiperacillin With Tazobactam Aligns International.........................................26Sushant Industries..........................................50
Aligns International.........................................26Farmachem Life Pvt Ltd..................................7 J. B. Khokhani & Co........................................Front InsidePralidoxime Chloride / Iodide
RosiglitazoneOm Laboratories.............................................22International Drug & Chemical Co..................59 Ranitidine HclTurakhia Brothers............................................24J. B. Khokhani & Co........................................Front Inside Proflavine Hemisulfate J. B. Khokhani & Co........................................Front InsideRosuvastatinMolychem........................................................34 Ravi Chem......................................................49 Ranitidine
Ravi Chem......................................................49 International Drug & Chemical Co..................59Progesterone Shubham Pharmachem Pvt. Ltd.....................11
G. Amphray Pharmaceuticals Pvt. Ltd............13 Aril Pharmaceuticals.......................................16Molychem........................................................34Propranolol HclJ. B. Khokhani & Co........................................Front Inside Ruthenium Red / TrichlorideRasagiline MesylateAril Pharmaceuticals.......................................16Khushbu Chemicals........................................60 Molychem........................................................34Turakhia Brothers............................................24Mirambika Pigment.........................................47Mehta Pharmaceutical Industries....................9
RutinReagents For Detection Of Metals IonsSun Moon Industries.......................................50Molychem........................................................34Turakhia Brothers............................................24Molychem........................................................34
Propyl Chloride / Gallate / PlainPotassium Permanganate / Phthalimide International Drug & Chemical Co..................59Reagents For Organics SynthesisBliss Unlimited................................................33Bliss Unlimited................................................33Rutin NfMolychem........................................................34Jpn Pharma Pvt. Ltd.......................................46Grindlays Pharmaceuticals Pvt. Ltd................Back CoverShubham Pharmachem Pvt. Ltd.....................11RebamipideSiddhivinayak Pharma....................................51Molychem........................................................34
PRODUCT INDEX
77THE MAZADA PHARMA GUIDE 23 June - 29 June 2014?
THE MAZADA PHARMA GUIDE 23 June - 29 June 2014?78
S - Amlodipine Simvastatin Sodium Sulphide Liquid Sulbactam Sodium Sterile
Prudence Pharmachem..................................65 Tamarind Drugs & Cosmetics.........................19 Euro Fine Chemicals.......................................62 Ruskin Chemipharm.......................................14-15
Spectrophotometric ReagentsSemi Refined Paraffin Wax Laffans Petrochemicals Limited......................47T. H. F / T.C.PMolychem........................................................34Desmo Exports Limited...................................Front Cover Molychem........................................................34Orbit Lifescience Pvt. Ltd................................12
SpiramycinSerratiopeptidase Plain / Granules Sodium Hydrogen Sulphide Siddhivinayak Pharma....................................51Ruskin Chemipharm.......................................14-15International Drug & Chemical Co..................59 Euro Fine Chemicals.......................................62
Ad Pharmachem (P) Ltd.................................62Sevoflurane G. Amphray Pharmaceuticals Pvt. Ltd............13 TadalafilTurakhia Brothers............................................24Ruskin Chemipharm.......................................14-15 Ravi Chem......................................................49 Global Pharma................................................8Stains For HistologyShampoo Base Sodium Lauryl Sulfate Powder Om Laboratories.............................................22Molychem........................................................34Niram Chemicals.............................................60 Ravi Chem......................................................49 TalcStannous FluorideSieves Sodium Methyl Paraben Western Pharma.............................................62Sna Healthcare Pvt. Ltd..................................61Kiran Traders..................................................22 Global Pharma................................................8 Gangotri Inorganic (P) Ltd...............................17Stearic AcidSildenafil Citrate Sodium Mono Chloro Acetate Talcum PowderNiram Chemicals.............................................60Aligns International.........................................26 Patel Chem Specialities P. Ltd........................29 Siddhivinayak Pharma....................................51Stearyl AlcoholGlobal Pharma................................................8 S. R. Group Of Companies.............................31 Ravi Chem......................................................49Niram Chemicals.............................................60Silicone Tubing / Rubber Sushant Industries..........................................50Sodium Monophosphate / NitrateSiddhivinayak Pharma....................................51Kiran Traders..................................................22 Tamoxifen CitrateSiddhivinayak Pharma....................................51Streptomycin SulphateSilver Acetate /Compounds Global Merchants............................................65 Aligns International.........................................26Ruskin Chemipharm.......................................14-15Molychem........................................................34 Khandelwal Laboratories Pvt Ltd....................35Sodium Saccharin / SalicylateStrontium RanelateSilver Nitrate / Oxide TamsulosinCosmos International......................................44Dishman Pharmaceuticals & Chemicals Ltd...37International Drug & Chemical Co..................59Jpn Pharma Pvt. Ltd.......................................46 Aligns International.........................................26Ruskin Chemipharm.......................................14-15Salicylates & Chemicals Pvt. Ltd....................49Molychem........................................................34 Tartrazine LakeStructured PackingSiddhivinayak Pharma....................................51Silver Sulphadiazine / Sulphate Standardcon Pvt. Ltd......................................51Finepac Structures Pvt. Ltd.............................20Sodium Salt / SeleniteGaurav Enterprises.........................................46 TazaroteneSuccinic Acid / AnhydrideMolychem........................................................34Jpn Pharma Pvt. Ltd.......................................46 Turakhia Brothers............................................24
Nova Chemie..................................................48 Molychem........................................................34Molychem........................................................34Tazobactam Sodium
Sna Healthcare Pvt. Ltd..................................61 SucralfateSilymarin Ruskin Chemipharm.......................................14-15Sodium Starch Glycolate Farmachem Life Pvt Ltd..................................7Aril Pharmaceuticals.......................................16
Tazobactam Sodium SterileAjmera Pharmasure Pvt. Ltd...........................27 Aril Pharmaceuticals.......................................16K. P. Manish Global Ingredients P...................6
Turakhia Brothers............................................24International Drug & Chemical Co..................59 Unitrade Agencies...........................................21Shubham Pharmachem Pvt. Ltd.....................11
TeaPatel Chem Specialities P. Ltd........................29 SucraloseSimethicone
Ravi Chem......................................................49Ravi Chem......................................................49 Jay Chem Marketing.......................................60Ravi Chem......................................................49TegafurSodium Stearyl FumarateNiram Chemicals.............................................60 Sulbactam SodiumTurakhia Brothers............................................24Ravi Chem......................................................49Siddhivinayak Pharma....................................51 Cosmos International......................................44Tegaserod MaleateSodium Sulphate AnhydrousSimple Film Coating Unitrade Agencies...........................................21Turakhia Brothers............................................24Desmo Exports Limited...................................Front CoverExcellent Pharma Care (India)........................45
W. P. CRuskin Chemipharm.......................................14-15 Sna Healthcare Pvt. Ltd..................................61 Turakhia Brothers............................................24
Wheat StarchTongkat Ali Trypsin ChymotrypsinRuskin Chemipharm.......................................14-15
Devson Impex Pvt. Ltd....................................18Aligns International.........................................26 International Drug & Chemical Co..................59Temozolomide
White / Colored FormedTopiramate TryptoneKhandelwal Laboratories Pvt Ltd....................35
Thioacetic Acid Turakhia Brothers............................................24Z. P. T. OVitamin A / Ad3Chemaroma Drug House................................44
Zinc Carnosine / CyanideThiosemicarbazide Global Pharma................................................8 Farmachem Life Pvt Ltd..................................7
Euro Fine Chemicals.......................................62Molychem........................................................34 Nova Chemie..................................................48Trifluoperazine Hcl
Bliss Unlimited .......................................................33...................Mumbai Nova Chemie..........................................................48...................Mumbai
Chandra Biotech.....................................................20...................Mumbai Om Laboratories.....................................................22...................Ahmedabad
Chemaroma Drug House .......................................44...................Mumbai Orbit Lifescience Pvt. Ltd. ......................................12...................Mumbai
Chemical Process Consultants...............................59...................Mumbai Orex Pharma Pvt. Ltd. ...........................................Ear Panel.......Thane
Chemipack Corporation..........................................32...................Mumbai Patel Chem Specialities P. Ltd. ..............................29...................Ahmedabad
D K Pharmchem Pvt. Ltd........................................Back Inside....Mumbai Rasino Herbs Pvt. Ltd.............................................67...................Mumbai
Desmo Exports Limited...........................................Front Cover....Navi Mumbai Ravi Chem .............................................................49...................Mumbai
Devson Impex Pvt. Ltd............................................18...................Mumbai Royal Drugs & Pharmaceuticals.............................5.....................Guna
Dhruv Chem Industries...........................................45...................Ahmedabad Rumit International .................................................39...................Mumbai
Ekta Export.............................................................64...................Mumbai S. R. Group Of Companies.....................................31...................Hyderabad
Euro Fine Chemicals..............................................62...................Mumbai S. V. Enterprises.....................................................65...................Mumbai
Excellent Pharma Care (India)................................45...................Haryana Salicylates & Chemicals Pvt. Ltd............................49...................Mumbai
Farmachem Life Pvt Ltd..........................................7.....................Mumbai Shah Tc Overseas Pvt Ltd......................................36...................Delhi
Gaurav Enterprises.................................................46...................Indore Sna Healthcare Pvt. Ltd..........................................61...................Mumbai
Global Merchants....................................................65...................Mumbai Sri Pharmacare.......................................................61...................Mumbai
Global Pharma........................................................8.....................Mumbai Standardcon Pvt. Ltd..............................................51...................Mumbai
Grindlays Pharmaceuticals Pvt. Ltd. ......................Back Cover....Mumbai Sun Moon Industries...............................................50...................Thane
Hrishabh Life Sciences...........................................65...................Mumbai Sushant Industries..................................................50...................Mumbai
International Drug & Chemical Co..........................59...................Mumbai Tamarind Drugs & Cosmetics.................................19...................Mumbai
J. B. Khokhani & Co. ..............................................Front Inside....Mumbai Titan Biotech Ltd. ...................................................30...................Delhi
J. B. Khokhani & Co. ..............................................Gate Fold.......Mumbai Turakhia Brothers...................................................24...................Mumbai
Jay Chem Marketing...............................................60...................Mumbai Ultimed Pharma Pvt. Ltd.........................................20...................Mumbai
K. P. Manish Global Ingredients P. .........................6.....................Mumbai Unitrade Agencies...................................................21...................Mumbai
Kahan Pharmaceuticals..........................................38...................Mumbai West-Coast Pharmaceutical Works Ltd..................23...................Ahmedabad
Khandelwal Laboratories Pvt Ltd............................35...................Mumbai Western Pharma.....................................................62...................Mumbai
