The Mind’s Eye:Imaging Structureand Function in theLiving Brain

Daniel K. Sodickson, MD, PhDDaniel K. Sodickson, MD, PhDVice-Chair for Research, Department of RadiologyVice-Chair for Research, Department of Radiology

Director, Center for Biomedical ImagingDirector, Center for Biomedical ImagingOctober 21, 2009October 21, 2009

DK Sodickson 10/09

The Mind’s Eye: Imaging Structure and Function in the Living Brain

Yulin Ge, MD

Pathology slide(invasive)

MRI(noninvasive)

420 tons steel

Big Magnet: 7 Tesla140,000 x earth’s field

State-of-the-artelectronics

Leading-edge arraysof transmittersand detectors

BIGBIG APPLEAPPLE70 staff

20 principalinvestigators

4 onsite industryrepresentatives

1 apple1 apple

High-field MRI @ NYU

Residual vascular tumor

Multiple Sclerosis

Residual vascular tumor

CancerAlzheimer’s Disease

ADHD

Brain Injury

TrainingLearningWisdomThe field of radiology is undergoing a remarkable trans-

formation. Once limited to the study of anatomy, radiolo-gists can now visualize the function of tissue, taking the art and science of diagnosis to unprecedented levels.

- Robert I. Grossman, MD

Residual vascular tumor

DK Sodickson 10/09

Imaging Structure and Function in the Living Brain: Outcomes• Characterize the brain at work

• Catch disease early– Alzheimer’s, ADHD, brain cancer, MS, brain injury, stroke …

• Guide treatment and evaluate new drugs

• Generate new scientific understandings

• See the unseen

AM and MCI Individual Subject MeansMedial temproal Lobe FA versus MK

0.10

0.14

0.18

0.22

0.26

0.30

0.80 0.85 0.90 0.95 1.00

MK

FA

MCI AM

Clinical needs, technological solutions