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National Aeronautics and Space AdministrationSpace Life & Physical Sciences Research & Applications Division
Human Exploration & Operations Mission DirectorateDivision Director: D. Marshall Porterfield
Research for Human Exploration
National Aeronautics and Space AdministrationSpace Life and Physical Sciences
• NASA's Space Life and Physical Sciences Research and Applications Division (SLPS) has been formulated to execute high quality, high value research and application activities in the areas of:– Fundamental Space Biology– Physical Sciences – Human Research
• These programs conduct fundamental and applied research to advance basic knowledge and to support human exploration in the environment of space.
• Division serves as the agency liaison with the ISS National Laboratory management organization (CASIS)
National Aeronautics and Space Administration
3Draft. Internal NASA Use Only
SLPSRA Organizational Chart
SLPS Director(Porterfield)
Physical Sciences Space BiologyHuman Research
Spaceflight Mission
OperationsSLPS Chief Scientist
CASIS Liason
Budget Integration
NASA Chief Scientist Office
HRP Program Office (JSC)
RMO Lead
National Aeronautics and Space AdministrationSLPS Research and Application Focus Areas
Human Research Physical SciencesSpace Life Sciences
• Uses the space environment to enhance understanding of the response of living organisms and biological processes to spaceflight conditions.
• Works toward an understanding of the requirements of terrestrial life in non-Earth environments
• Conducts fundamental and applied research in space to explore the processes that form materials and determine the performance of fluid, thermal, and combustion systems.
• Builds engineering knowledge to enable the design of fluid, thermal, and chemical process devices for space environments
• Develops scientific and technological foundations for a safe, productive human presence in space for extended periods.
• Focuses on investigating and mitigating the highest risks to human health and performance in order to enable safe, reliable, and productive human space exploration.
• Applies this knowledge and technology to improve our nation's competitiveness, education and the quality of life on Earth.
National Aeronautics and Space Administration
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Human Health Emphasis
Biological Systems Emphasis
Human ExplorationEmphasis
Humans
Exploration Subsystems
SmallOrganisms(Mice, Rats)
Tissue, Organs
BioMolecules
MammalianCells
ModelOrganisms,Microbes
Life Sciences Research in Space
4
National Aeronautics and Space AdministrationGravity-Dependent Physical Sciences
6
Fluid Physics
• Two-phase flow• Phase separation• Boiling, condensation• Capillary and interfacial phenomena
Materials Science• Solidification• Crystal growth• Metals, alloys • Electronic materials• Glasses, ceramics• Polymers
Complex Fluids
• Colloids• Liquid crystals• Foams• Dusty plasmas• Granular flows
Fundamental Physics• Atomic Clock• Low temperature physics• Quantum measurement
techniques• Ultra-cold atom physics • Test mass techniques
Combustion Science• Spacecraft fire safety• Solids, liquids, droplets, gasses• Supercritical reacting fluids• Soot
National Aeronautics and Space Administration
ISS Research – Human Research ProgramCritical to mitigating 18 of 28 health risks relevant to human exploration
Exercise Facilities
On-Orbit Research Facilities Biomedical Research
Human Research Rack-1 Human Research Rack-2
Biomedical Capabilities Development
Physiological Changes and Exercise
Countermeasures
Immunological Changes
Crew Sleep and Performance Research
Lightweight Trauma Module
IV Fluid Generation
Integrated heath caresystem
Nutritional Requirements
Portable Medical Imaging
International Research Collaborations
ESA Muscle Physiology Facility CSA Cardiovascular
Function Experiment
JAXA Bone Loss Countermeasure
Experiment
Russian Fluid ShiftCountermeasure
Experiment
National Aeronautics and Space AdministrationOverview: Components of HRP
• Science Management Office– Peer Review, Task/Risk Management, Life Sciences Data Archive
• Program Integration Office– Program planning, integration & control
• Elements– Behavioral Health and Performance
• Individual and interpersonal– Human Health and Countermeasures
• Physiology, Visual Impairment/Intracranial Pressure– ISS Medical Project
• Infrastructure for flight experiments– Exploration Medical Capability
• Medical care for missions beyond low Earth orbit– Space Human Factors and Habitability
• Interfaces between humans and vehicles/habitats – Space Radiation
• Radiation exposure and biological effect
• NSBRI funded by HRP through a cooperative agreement to pursue research that complements the HRP portfolio 8
National Aeronautics and Space Administration
Response to the decadal survey: Perspectives and approaches for going forward.
• Results from evaluation of decadal recommendations will be adapted into NRA announcements.
• NRAs in Fundamental Space Biology will adopt a “wide net” approach in order to attract the highest quality investigations.
• Close coordination with HRP is assuring competent overlap in animal models will be supported.
• Reorganizing participation in ISLSWG and JWG in order to assure international partner collaborations are aligned with the Decadal
• NAC subcommittee on Life and Physical Sciences Research is being developed
National Aeronautics and Space AdministrationStatus of the ISS Nation Lab management organization
CASIS ad hoc science team reviewed life sciences flight experiments for near-term commercial potential. Identified rodent model of bone demineralization and growth of bio-molecular crystals for x-ray structural analysis as two top candidates
Agreement with Merck to pursue flight experiments in protein crystal growth
Working with Merck, Sanofi, and GSK to determine feasibility of using a mouse model of bone demineralization to test the effectiveness of osteoporosis drugs
Concluded first research solicitation with the selection of three projects in protein crystal growth for ISS experiments
Solicitations for projects in materials science and Earth observations from the ISS are in progress
National Aeronautics and Space AdministrationStatus of the ISS Nation Lab management organization
CASIS Board of Directors process nearing conclusion – new board installation expected next month. Six board candidates have been conferring with CASIS leadership and are planning a rollout event on December 15.
France Cordova – former NASA Chief Scientist, former President of Purdue University
Bess Dawson-Hughes – Director, Bone Metabolism Laboratory, Tufts University
Lewis Duncan – President of Rollins College
Arnold Levine – Emeritus Professor, Institute for Advanced Study, former President, Rockefeller University
Andrei Ruckenstein, Vice President and Associate Provost for Research, Boston University
Gordana Vunjak-Novakovic, Director, Laboratory for Stem Cells and Tissue Engineering, Columbia University
New Executive Director to be selected by the new board from 5-6 final candidates identified by a search firm. NASA is working with the current board and retains approval authority on the selection per the cooperative agreement
First annual report from CASIS was received last week is under evaluation.
National Aeronautics and Space AdministrationStatus of the HEOAC Research Subcommittee
NASA Advisory Council formally recommended the formation of a subcommittee of the HEO Advisory Committee to address research and educational aspects of the long-range human exploration of space at their March 8, 2012 meeting.
After the appointment of the permanent Director for SLPS in Summer 2012, a group of candidates were identified and contacted. We are currently working with the Office of the Administrator to form a subcommittee with appropriate expertise and balance.
National Aeronautics and Space AdministrationSLPSRA Research Selection Process
(Space Biology/ Physical Sciences)
• NASA Research Announcement (NRA) is developed based on research topics selected based on Decadal Survey input and specific Discipline Science Plans.
• NRA is released to the research Community for proposal submittal.
• Proposals are reviewed by a non-NASA external panel of Subject Matter Experts (SME).
• Proposal are ranked and SLPSRA selects a number of Principal Investigators (PI) proposals for grant selection based on available budget for grant execution.
• Selected PI’s are assigned to specific NASA centers for grant management and for spaceflight hardware development.
National Aeronautics and Space Administration
Customer Review Peer Review
Reviewed by Standing Review Panels
Reviewed by IOM
SLPSRA Research Selection Process(Human Research Program)
Architecture: Evidence Risks Gaps Tasks Deliverables
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Evidence Base – Flight and Ground• Science• Clinical• Operational
experience
Exploration Missions &
Architectures
NASA Spaceflight Human System
Standards
Risks
Results and Deliverables• Mitigate Risks• Update Standards• Countermeasures• Medical Technologies• Results New Gaps
Solicitations & Directed Research
Integrated Research Plan/Human Research Roadmap
Prioritization & Implementation Approach
Constrained by• Customer need
dates• Budgets• Research platform
availability
Gaps
HSRB Reviews/RefinesRisk Posture
Utilize HSRB to review
and refine risk posture
National Aeronautics and Space Administration
Questions?