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2015 Catalog Instruments for Magnetic nanoHeating The next step on Magnetic nanoHeating research
2015 Catalog
Instruments for Magnetic nanoHeating
The next step onMagnetic nanoHeating research
DM100 Series System Controller
Main features
Fully automated software operation
Compatible with all DM100 applicator
USB and Serial port connetivity
Touch screen monitor
Maximum productivity, ergonomyand control power for all kinds of
magnetic heating experiments
DMC1 is the brain and the power of all DM100 Series setups.
nB's unique embedded software,MANIAC, helps you program and controls
your experiments, records the measured data, and processes your experimental results into truly useful
and ready to publish reports and graphic presentations.
A reliable, powerful, fully automated and easy way of moving forward on
your magnetic hyperthermia research plans
Local User Interfase15’ tactile color monitor
Optional mouse and keyboardTwo lines LCD status display
SoftwareControl and automation software
for embedded systemData Analysis software for
embedded system.SAR and ILP calculation
Experiment sequence programmingConnectivity
USB Storage portSerial port
Instruments forMagnetic nanoHeating
DMC1 System controller
Instruments for Magnetic nanoHeating
nB nanoScale Biomagnetics introduces the DM100 Series, the only integral, immediate and reliable solution for laboratory tests on Magnetic HyperThermia and Induction nanoHeating.
One sole equipment to apply, measure and analyze the results. One model for every application. The DM100 Series gives the answer to all your needs in MHT/InH instrumentation either with its series models or custom made applications. DM100 Series is also the only integral, immediate and reliable solution to the instrumentation needs of MHT through all its stages: from magnetic characterization to clinical application.
The design conceptualization of the DM100 series emerges from the real need of the Magnetic Hyperthermia lab of the Institute of Nanosciences of Aragón (Spain). The speci�c needs involved in the process of applying a magnetic �eld, measuring and analyzing the results were thoroughly examined and approached one by one, leading to an integrated and �nal solution that guarantees the highest standards in Magnetic Hyperthermia research. The results achieved with DM100 Series are now endorsed by published results on characterization of nanostructured materials, experiments with cell culture, parasithology, among other �elds.
Come and take a close look to DM100 devices and accessories and �nd the best setup for you.
Calle Panamá 2, Local 1Zaragoza 50012
Spain
t. +34 976 741 [email protected]
IndexDMC1 System controller 3
DM1 applicator for calorimetry 4
DM2 applicator for multiple uses 6
DM3 applicator for In vivo test 8
10DM100 Accessories Guide
MaNIaC DM100 Embedded Software 11
MAGNO Magnetic Colloid for InH 11
DM100 Series Configuration Guide 12
Electrical specifications
- Input voltage: 100-240 V AC, 50-60
Hz
- Maximum input power: 2600 W
- Maximum input current: 16 A
Mechanical specifications
- Dimmensions: 505 x 489 x 230
mm3
- Weight: 24 kg
Environmental and safety
specifications
- See DM1
System requirements
- Electrical supply:
o 100-240 VAC – 50-60 Hz, 2600W
Software featuresMANIAC v1.0 is the software
environment which allows the user to run and schedule induction heating tests for research in magnetic hyperthermia in DM100 devices, as well as monitoring and analyzing the results of such tests.
Main functions:
- Test: induction heating test implementation on DM100 series equipments
- Experiments: tests automation on DM100 series equipments
- Selection of magnetic field or temperature as control variable in tests and experiments
- Definition of set point as constant or in function of time in experiments
- Real-time monitoring of equipment sensors.
- Equipment sensors readings log.
The Zar v1.0 application of the software MANIAC analyzes the heating curves of a magnetic colloid type sample which are obtained when carrying out an induction heating test with a DM100 series device.
Main functions:- Visualization of the heating curves - Numerical adjustment of the
heating curves - Calculation of the sample's SPA
and ILP indexes
DM100 Series Applicator for calorimetry
Magnetic hyperthermia tests
SAR measurement
Magnetic colloid characterization
Magnetic nanoparticle heating
Precision and reproducibility in magnetic colloid characterization.
DM1 is the only device on the market specially designed for an
accurate determination of the physical parameters that describe the heating effects of alternating
magnetic fields on magnetic nanosystems.
A reliable, powerful, fully automated and easy way of moving forward on
your magnetic hyperthermia research plans
Main features
SensorsOptic fiber temperature probeWater pressure sensorControl methodB field user selectable curveSample temperature user selectable curveCombined B-T user selectable curve
RF SectionUp to 8 user selectable frequencies from 10KHz to 850KHzUp to 350 Oe (27825 A/m) field.Water cooling connection (chiller not included)Sample SectionOpen Dewar flask with vacuum socket 2ml disposable vial sample holder
Low frequency DM1 applicators
f [kHz] Bmin [G] Bmax [G]
610 48 300
300 48 300
270 48 300
230 48 300
215 48 300
185 48 300
175 48 300
130 48 300
125 48 300
120 48 300
115 48 300
110 48 300
105 48 300
Frequency and field corrections < 2%
Full frequency range DM1 applicators
f [kHz] Bmin [G] Bmax [G]
810 48 250
725 48 250
590 48 300
540 48 300
480 48 300
460 48 300
400 48 300
325 48 300
300 48 300
295 48 300
285 48 300
275 48 300
270 48 300
265 48 300
250 48 300 Frequency correction < 2%, field
correction < 3%
Standard operation modesA maximum of 8 modes can be activated on a single device. The tables cannot be merged into one single device.Intensity magnitudes provided in peak Gauss value. For peak to peak value, multipy by 2.
Custom made frequency and higher intensity modes on demand
Volume conf. Axial field attenuation Radial field boost
0.5ml <1.5% <1.5%
1ml <5% <1.5%
1.5ml <11% <1.5%
Field distribution on the sample volumeTypical values. Each device is individually callibrated and documented.
Electrical specifications
- Operating connection I:
o Voltage range: 0-360 V DC
o Maximum power: 1500 W
o Maximum current: 15A
- Operating connection II:
o Voltage: 115 V, 50 Hz
o Maximum power: 130 W
o Maximum current: 2.5 A
Mechanical specifications
- Dimmensions: 415 x 712 x 285 mm3
- Weight: 29 kg
Environmental and safety specifications
- Temperature ranges:
o Normal operation: 5-40 ºC
o At maximum power: 5-30 ºC
o Storage: -20 – 70ºC
- Humidity: 20-80%
- Electromagnetic Compatibility: EMC
2004/108/EC according UNE-EN
61326-1:2006 Class A
- Safety: Low Voltage Directive (LVD)
2006/95/EC according
UNE-EN-61010-1:2011
System requirements
- Electrical supply: connect the applicator-
controller connecting hose before starting
- Liquid refrigeration system
o Minimum cooling power: 1600W
o Typical flow: 5-7 l/min
o Typical input pressure: 2.9 bar
o Two flexible tubes of 10mm
internal diameter to connect to
the provided series 24 hydraulic
connectors .
- If vacuum in the dewar flask is desired, an
appropriate connection to the applicator
connector DN16 ISO-KF is required
Standard accessories
- Two 24 series hydraulic connectors for the
cooling system
- Temperature measuring system:
o FPI-HR-2-F2-SCAI-V dual channel
high resolution fiber optic signal
conditioner
o FOT-L-NS-705 fiber optic
temperature contact sensor with
protected tip
Technical specifications:
o Measuring range: -10ºC to 120 ºC
o Precision: ±0.2 ºC
- Probe-column sample holder set:
o Temperature sensor
o Sample holder column
o Kit of sample/probe position
calibration parts
Instruments forMagnetic nanoHeating
The next step on Magnetic nanoHeating research
DM1 applicator
www.nbnanoscale.com
Instruments forMagnetic nanoHeating
The next step on Magnetic nanoHeating research
DM2 applicator
DM100 Series Applicator for in vitro tests and multiple uses
Main features
Magnetic hyperthermia in vitro tests
Magnetic colloid characterization
Combined experiments
Custom designed accesories
Precision and reproducibility in magnetic heating experiments.
DM2 is the most versatile tool you can imagine for studying
the heating effects of alternating magnetic fields on magnetic
nanosystems on in vitro, in vivo or new material tests
A reliable, powerful, fully automated and easy way of moving forward on
your magnetic hyperthermia research plans
RF SectionUp 4 user selectable frequencies from 100KHz to 500KHz Up to 200 Gauss (15.9 kA/m) field.Water cooling connection (chiller not included)Sample SectionMultiple optional sample holders60 mm/80 mm diameter versatile sample chamber in vitro, in vivo and calorimetry accessories.Sensors1 or 3 fiber optic temperature sensorWater pressure sensorControl methodB field user selectable curveSample temperature user selectable curveCombined B-T user selectable curve
Compatible assessories (see accesories datasheet on page 10)
CAT: Controlled atmosphere accessory for in vitro testsCAL: Vacuum dewar flask calorimeter with sensor probeHBM: Heartbeat monitor system for small animalsIR1: Infrared thermal image systemDRM: Drug release monitor system for in vitro tests
Custom designed sample holders, probes and accessories.
CAT
CAL
IR1
Field distribution on the sample volumeTypical values. Each device is individually callibrated and documented.
Volume configuration
Axial field attenuation
Minimum radial field attenuation
Maximum radial field attenuation
H = 40mm <9% <8% <18%
Low frequency DM2
applicators
f [kHz] Bmin [G] Bmax [G]
230 36 200
120 36 200
100 36 200
85 36 200
Frequency correction < 2%,
Field correction < 4%
High frequency DM2
applicators
Frequency correction < 2%,
Field correction < 4%
f [kHz] Bmin [G] Bmax [G]
405 36 172
315 36 172
285 36 180
250 36 180
HBM
DM100 Series Applicator for in vitro tests and multiple uses
www.nbnanoscale.com
Electrical specifications
- Operating connection I:
o Voltage range: 0-360 V DC
o Maximum power: 1500 W
o Maximum current: 15A
- Operating connection II:
o Voltage: 115 V, 50 Hz
o Maximum power: 130 W
o Maximum current: 2.5 A
Mechanical specifications
- Dimmensions: 439 mm x 712 mm x
259 mm
- Weight: 29 kg
Environmental and safety specifications
- Temperature ranges:
o Normal operation: 5-40 ºC
o At maximum power: 5-30
ºC
o Storage: -20 – 70ºC
- Humidity: 20-80%
- EMC 2004/108/EC according
UNE-EN 61326-1:2006 Class A
- Low Voltage Directive (LVD)
2006/95/EC according
UNE-EN-61010-1:2011
System requirements
- Electrical supply: connect the
applicator-controller connecting
hose before starting
- Liquid refrigeration system
o Minimum cooling power:
1600W
o Typical flow: 5-7 l/min
o Typical input pressure: 2.9
bar
o Two flexible tubes of
10mm internal diameter
to connect to the
provided series 24
hydraulic connectors .
Standard accessories
- Two 24 series hydraulic connectors
for the cooling system
- Temperature measuring system:
o Dual or quad channel high
resolution fiber optic signal
conditioner
o 1 or 3 fiber optic temperature
sensor with protected of
unprotected tip
Technical specifications:
o Measuring range: -10ºC to 120
ºC
o Precision: ±0.2 ºC
- Probe-holder sample set:
o Temperature sensor
o Sample holder
Compatible accessories
- DMR: Drug release monitor for in
vitro tests
- CAT: Controlled atmosphere and
temperature accessory for in vitro
tests
- CAL: Vacuum dewar flask
calorimeter with sensor probe
- HBM: Heartbeat monitor for small
animals
- IR1: Infrared thermal image system
- Custom designed sample holders,
probes and accessories
Standard operation modesFrequencies and intensities on available devices may differ. Please, ask nB before ordering.
Exceptionally, values on final devices may present up to 5% factory tolerance in some high energy modes. Typical tolerance is 2%.
Intensity magnitudes provided in peak Gauss value. For peak to peak value, multipy by 2.Custom models can host up to 8 modes with 40mm diameter sample chamber
Custom frequency modes on demand
Instruments forMagnetic nanoHeating
The next step on Magnetic nanoHeating research
DM100 Series Applicator for in vivo hyperthermia tests
Magnetic hyperthermia in vivo tests
Local and systemic temperature sensing
Local or whole body versions
Heartbeat monitoring
Thermal imaging
Maximum precision and ergonomyfor in vivo developing and testing
of magnetic hyperthermia and drug realease therapies
DM3 is the only device on the market specially designed for an
accurate application of alterating magnetic field, local sensing
and experiment monitoring in mice and rats on laboratory hyperthermia procedures
A reliable, powerful, fully automated and easy way of moving forward on
your magnetic hyperthermia research plans
Main featuresRF Section4 user selectable frequencies from 80KHz to 450KHz (According to user requirements)Up to 450/300 Gauss/Oersted (35.7/27.8 kA/m) field.Water cooling connection (chiller not included)Sample SectionAnimal bed for mice or rats Surface and whole body application versionsSensors1 or 3 local temperature sensorWater pressure sensorControl methodB field user selectable curveLocal temperature user selectable control optionCombined B-T user selectable curveInfrared imaging control loopCompatible assessoriesHBM: Heartbeat monitor system for small animalsIR1: Infrared thermal image systemDRM: Drug release monitor system for in vitro testsMicro CAT: Controlled atmophere for tests in small petri platesCustom designed sample holders, probes and accessories.
DM3 applicator
Standard operation modesFrequencies and intensities on available devices may differ. Please, ask nB before ordering.
Exceptionally, values on final devices may present up to 10% factory tolerance in some high energy modes. Typical tolerance is 2%.
Intensity magnitudes provided in peak Gauss value. For peak to peak value, multipy by 2.A maximum of 8 modes can be activated on a single device
Custom frequency modes on demand
DM3 - GWhole Body applicator
DM3 - JSurface applicator
www.nbnanoscale.com
Electrical specifications
- See DM1
Mechanical specifications
- Dimmensions: 439 mm x 712 mm x 259 mm
- Weight: 29 kg
Environmental and safety specifications
- See DM1
System requirements
- See DM1
Standard accessories
- Two 24 series hydraulic connectors for the cooling
system
- Temperature measuring system:
o Dual channel high resolution fiber optic signal
conditioner
o 1 or 3 fiber optic temperature sensor with protected or
unprotected tip
Technical specifications:
o Measuring range: -10ºC to 120 ºC
o Precision: ±0.2 ºC
Animal bed:
o Adjustable positioning
Compatible accessories
- HBM: Heartbeat monitor for small animals
- IR1: Infrared thermal image system
- DRM: Drug release monitor for in vitro tests
- Micro CAT: Controlled atmosphere for tests in small
petri plates
Custom designed sample holders, probes and accessories
available
DM3 - HWhole Body
open view applicator NEW!
� DM3-H DM3-G f [kHz] Bmáx[G] f [kHz] Bmáx[G] f [kHz] Bmáx[G]
461 300 455 190 449 300
261 400 273 250 278 400
227 400 234 260 237 400
151 400 148 280 154 400
143 400 141 285 141 400
126 400 125 290 135 400
99 400 106 295 100 400
87 400 92 300 92 400
81 400 86 300 80 400
DM3-J
The next step on Magnetic nanoHeating research
DM2 Controlled Atmosphere andTemperature cell culture holder
CAT
DM100 Thermal Image SystemIR1
DM2 Accessory for Calorimetryand SAR measurement
CAL
Hot point detectionHistogramVisible video monitoringImage backfed field control loopImage data analysisRaw data available for external analysisOptional local probe callibrationUseful for in vitro, ex vivo, materials and in vivo tests.
Allows you to make real time surface thermal images and movies in DM2 and DM3 experiments.
Fully integrated with MANIAC embedded software, featuring advanced analysis functions.
Enables IR data-controlled experiments
Main features
Turns your DM2 in a high quality calorimeter for SAR determination and thermal characerization of liquid samples.
Includes ZAR software option, for instant data fitting, SAR/SPA and ILP calculations.
2ml vial sample holderFiber optic high accuracy thermometerOpen dewar flask with vacuum pumpconnection socket (pump not included)ZAR data analysis software package
Main features
Enables atmosphere and temperature controlin cell culture experiments in DM2
Micro CAT available for DM3 for small petri plates
The only blood pressure monitoring systemfor small animals fully compatible
with high intensity AC fields
Advanced integration with MANIAC embedded software
Enables heart rate-controlled experiments
Hydraulic sensing via internal catheter(minor surgery needed)Distant electric transductionReal time blood pressure graphReal time heart rate measureIntegrated dataloggingCompatible with IR1
Main features
Designed for
DM2 DM3
Designed for
DM2 DM3
Designed for DM3
Designed for DM2
Compatible withDM2 HBM
DM100 HeartBeat Monitor system for small animals
Main internal chamber with input andoutput socket for gas mix flowSecondary external chamber with input and output sockets for thermalization waterCompatible with up to 30 mm petri dishesEnables multiple dish experimentsAdjustable high accuracy optic thermometerCustom design for IR imaging with IR1 accessory
Main features
DM100 Series Accessories guide
MaNIaCDM100 Series Embedded Software
Fully automatic test execution
Ease of use and high productivity
Complex experiment sequencing
Integration and automation of accessories
Quick calculations and data processing
Data import/export
Expandability
Performing individual testsMANIAC allows you to carry out inductive heating tests in a matter of seconds. Using “test” mode, an automatic fi el application can be started and dcontrolled just by indicating the field values you wish to attain.
Programming complex testsOne important characteristic of MANIAC is that it is able to carry out complex tests made up of fi elds of different characteristics, with pre-set intervals of time and even to control them through different parameters. A versatile tool for trying out new ideas.
Data registrationMANIAC keeps you informed in real time about the data registered during the experiment. Both the fi eld characteristics as well as variations measured in the sample are shown on screen, while they are fi led away together with all the other test data. MANIAC is compatible with USB storage devices, which allows you to manage all the files in standard format.
Analysis of ResultsEach applicator has an option for additional software with tools for analyzing experiments, which can speed up work fl ow in the lab. MANIAC is a fl exible and powerful environment that adapts to each experiment and makes the researcher’s daily life easier.
Depending on the available options, MANIAC can calculate a sample’s SAR, make graphic presentations and statistical charts, and is open to tailor-made designs and future modifications in accordance with the researcher’s needs.
Accessories managementMaNIaC is prepared to integrate and control every active DM100 accessory, like IR1 or HBM. All data and automatic functions of DM100 accessories can be viewed and processed within MaNIaC environment.
Magnetic colloid for Magnetic nanoHeating
Ma nogMAGNO is the �rst commercially available magnetic colloid specially designed for Inductive nanoHeating applications.
Optimizing the heating properties of MNPs is cumbersome and takes long time and dedicated manpower. Magno offers the solution for those researchers that need accurate data, repetibility and reliability to test new ideas such as physical models, or any heating applications.
MAGNO is a water-based magnetic colloid consisting of magnetite (Fe3O4) nanoparticles with average sizes of 25nm functionalized with a biocompatible polymer. The magnetic nanoparticles display an impressive SPA value (typically >210W/g, for f = 580KHz, H0 =23.877 KA/m).
MAGNO has been manufactured and synthesized under controlled
conditions using the DM100 technology. The precise control of the manufacturing conditions gives MAGNO a highly reproducible heating behavior and SPA values under different conditions, and an outstanding stability over the time.
MAGNO is the ideal raw material for a �rst approximation to inductive nano heating research as well as for a great variety of advanced applications, only limited by your imagination. Covered by Polyethylenimine (PEI), MAGNO nanoparticles constitutes a powerful tool not only for basic research on power absorption but also for different applications in most �elds of biomedicine.
MAGNO has been developed by nB nanoScale Biomagnetics under three basic principles for inductive heating research: repetibility, traceability and reliability.
www.nbnanoscale.com
A fully integrated system for the quantificationof a drug release experiment on liquid
and solid samples
Advanced integration with MANIAC software
Enables delivery rate-controlled experiments
Integrated spectrophometerPeristaltic pumpDynamic magnetic separationHolders for liquid and solid samples
Main featuresDesigned for
DM2 Compatible with
DM1 DM3 DRMDM100 Drug Release
Monitor system
NEW!Coming fall
2015
DM2 Accessory for Calorimetryand SAR measurement
CAL
HBMDM100 HeartBeat Monitor system for small animals
DM2 Controlled Atmosphere andTemperature cell culture holder
CAT
DM100 Thermal Image SystemIR1
100v-240v AC
Water chiller
DM100 Series Applicator for in vitro tests and multiple uses
DM100 Series Applicator for in vivo hyperthermia tests
DM100 Series Applicator for calorimetry
Rotary or turbomolecular vacuum pump(recommended for calorimetry)
Basic Setup
Mandatory third party gear Recommendedthird party gear
DM100 Series is a set of instruments, accesories and software tools that can be combined to form different configurations covering every kind of Magnetic Hyperthermia and Induction nanoHeating
experimental setup. Each DM100 configuration is a complete workstation that allows you to automatically run complex tests, register data and analyze your results.
DM100 Series is designed under a concept of modularity. One controller can be used to drive multiple applicators -not simultaneously. Here is a quick guide to how your DM100 system must to
be configured.
Accessories
Instruments for Magnetic nanoHeating Reseach
Calle Panamá 2, Local 1Zaragoza 50012
Spain
t. +34 976 741 [email protected]
MaNIaCDM100 Series Embedded Software
DRMDM100 Drug Release Monitor system
