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Contents.......

*%&..-

. - . . . ... . . . - - . . . . - . . . . . . .

reface t o the First Edition xix

- . -

I I . Drug inventionand the Pharmaceutical

Suzanne M. Rivera and Alfred Goodman Gilman

&.~pharmaookipe~cs:heDynamics ofDrug! Absorption, Distribution,Metabolism,

.......................................................,andElimination 17

'Pain L. 0.Buxton and Leslie Z. Benet

Phannadynamics: MoIeeularMechanismsI--.

ofDmg Action .................................. ...................41.Donald IC Bhmenthal and ; l am6 C Garrison

prug Toxicity andPoisoning............... ..................73Kevin C. Osterhoudt and Trwor M. Penning

, 5. MembrmeTransportersandw u g Response........................................................ 89ka~lleen . Giammini and YuichiSugiyam

i 6. Drug Metalmlism ................................................. 123I -

' Frank J. Gonzalez, MichaelCoughtrie,? a n d Robert H . Tukey I . , ! , .. :

7. Phnrrnacogenetics., ......,. .;..<>....;............. ...........145Mary V. Relling and Kathleen M. Giacomini

beurottansmission:TheAutonomic

grid SomaticMotorNervous Systems................... 171Thomas C.westfalland David P Westfall

I , . I , , . . I.

9.Muscarinic ~ecep tor ~ o r f i ' g k , ' . , ' ' I,

. I . . - - ,' ,. ; , -. , , 4 , , 1 ;.:

and Antagonists....r? ....1

. , , . 1

Joan HetlerBrown and Nora Laiken

.... ...0.AnticholinesterslseAgents..............,.... ...Palmer Taylor

1 1. Agents Acting at the Neuromusculor

Junction andAutonomicGangh .........................Ryan E. tlibbs and A k n d e r C Zambon

12. Admergic Agonists andAntagonists.................Thomas C. Weiffatl and Oarid P WestFall

13.5-Hydroxy tryptamine (Seraonin)and Dapamine...................................................EIaineSanders-Bush and Lisa H a x e l w d

14. Neurotransrnission and the Central .Nervous System .;k~c~::4j:;:~;;?.; .... , .;:. i&;*:tPeny B. Molinoff , -

, , I,., , ,: : . i i m K r i15. DrugTherapy ofDepression , > ... I

and Anxiety Dkde r s........... . ..................... 2

James M. O'DonneU and Richard C. Shdton16.PharmacotherapyofPsychosis hm

andMania...............................................................Jonathan H. Meyer

17. Hypnotics and Sedatives.......................................S. John Mihic and R Admn ktarris

18.Opioids,Analgesia, and Pain

Management.....................................~...........~, ...Tony 1.Yaksh and Hark S. W a k e

18.GeneralAnesthetics and TherapeuticGnst .....Piyurh M. PateL HemalH. Patel,

'and David M. Roth

20.Local Anesthetics ..................................................William A. CattewU and Kbnneth bdde

......................J,,PRannacotherapy of he Epilepsies;James0. McNamara

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22.TreatmentofCentralNervous SystemDegenerativeDisorders........................................,09David G. Standaert and Erik D. Roberson

23. Ethanol andMethanol......................................... 629Marc A. Schuckit

24. Drug Addiction...................................................... 649

Chades P (r8rien

I Modutation of Caaiwascular

-Function 66925. Regulation ofRenal Function. and VascularVoIume ................................... 1........671

Robert F. Reilly and Edwin K. Jackson

26. Renin and Angiotensin .......................................... 721Randa Hilal-Dandan

27. Tkatment ofMymadial Ischemia

andHypertension ...............................,,..,.. JThomas Michel and Brian B, Hoffman

28. Phamacotherapyof Coagestive

Heart Failure., ...,..,.....,...,.......,...,,......,...,.a.-,............789Bradley A. Maron and Thomas P, Rocco

29.Anti-Arrhytfmic Drugs ......................................... 815Kevin 3. Sampson,and RobertS. Kass

30:BloodCoagulation qndAnticqqgNant,

Fibrinolytic, and AntiplateletDmgs.. ......,,........-849Jeffrey I. Weitz

31.Drugmerapy f ~ rypercholesterolemiaandDyslipidemia ..........................................%.......7'7Thomas P. +ot

and Hematopoiesis 909

32.Histamine, Bradykinin, and Their

.........................................................ntagoaists.. .91RandalA. Skid& AUen P &plan, and Elvin G. Erdiis

33. Lipid-DerivedAutacoids:Eicmmoidsand Platelet-Activ&tingFactor............................... 937Emer M. Smyth, Tilo Grosser, and Ga>r@ A. FibGerald

34. Anti-inflammatbry,Antipyreti4and Analgesic

........................gents; ~harrnacothqai~f Gout 959

Tilo Gmsser, Emr M. Smyth, a d GarretA. FibGerald

35.Tmmunosuppressants,Tolerogens,andImrnunostimulants..................... ,.................... 1 005

Alan M. Krensky, William H. enn nett, and wo Yfncenti

36.Plllrnonary Pharmacology.................................. .1M1

Peter 3. Barnes

37. HematopoieticAgents:GrowthF-,Minerals, andVitamins....................................... 1067

Kenneth thushandy and ThomasJ. Kipps

Hormones and HormoneAntagonists 3138. IntroductionToEndmrinology:

The~ypohhmi~l'ituitaryxis ...................... . IKeithL Parker and Bernard P Sd-hrnmer

...................9.Thyroid and Anti-Thyroid Drugs ....Gregory A. Brentand Ronald J. Kwnig

40. Esbgen s and Progestins. . . . . . . . . ~~~~~ms R. Lwin and Stephen R. Hamines

41. Androgens........................................................... 1Peter3. Snyder

42.ACTH,Adrenal Steroids,andPharmacology

.............................ftheAdrenalCortex.. . .1

Bernard P Schimmr and John W. Funder

43 .Endocrine Pancreas and Phmacotherapy.............f DiabetesMellitus and Hypoglycemia 12

Alvin C. Powers and DavidW A k m

44. AgentsAffectingMineral Io n

Homeostasisand Bone Turnover......................... 1

Peter A. Friedman

BECT~ON I-. ..- -- - .

Drugs Affecting Gastrointestinal

~ u n d o n 1345. fiarmacotherapy of GastricAcidity, Peptic

Ulcers, andGastroesophagealReflux Disease ... I3John L. Wallace an d Keith A. Sharkey

46.Treatment-of Disorders of BowelMotility andWaterHux;:Anti-Emetics;Agents Used in

Biliary and Pandrkatic ,Disease ...........................Keith A. Sharkey an d John L. Wallace

47. Phmacotherapy df InflammatoryBowelWsease............................................... 1

John L. Wallace and Keith A, Sharkey

Diseases 1348. General Principles ofAntimicrobial

............. ...................................herapy , 1Tawanda Gumbo

49. Chemothempy ofMalaria .................................13Joseph M. Vinetr, Jbrbme Ctain, Vlengngeun Bounkeua,

Wchard T Eastman, and David Fidock b A v y l rH

50. Chemotherapy of Protozoal Infections:Amebiasis, Gid ias i s ,Trichomoniasis, a!.Try anosomiasis.Leishmaniasis,and Other

Protoml Infections............................................ 14Margaret A. PhiUipr andSamuet L Stanley, Jr.

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