The Power of Networks for Innovation. Biological information is organized in small -world and scale-free networks where few nodes become hubs dominating the entire network. - PowerPoint PPT Presentation
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007 1 Rafael Rangel- Aldao • Biological information is organized in small - world and scale-free networks where few nodes become hubs dominating the entire network. • The topology or architecture of such biological networks could be useful to predict and prevent major causes of morbidity worldwide. • This knowledge from systems biology could also be transferred and translated to better health care of less developed countries, by self-organizing networks The Power of Networks for Innovation
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Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
1Rafael Rangel-Aldao
• Biological information is organized in small -world and scale-free networks where few nodes become hubs dominating the entire network.
• The topology or architecture of such biological networks could be useful to predict and prevent major causes of morbidity worldwide.
• This knowledge from systems biology could also be transferred and translated to better health care of less developed countries, by self-organizing networks
The Power of Networks for Innovation
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Information is organized into Networks
• Small-world:– Highly packed– Short paths– Lethality– Centrality
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Power Law (The rich gets richer)
Protein evolution
Team assembly networks
Scale-free networks:
Barabási, A.L. (2002) Linked, The New Science of Networks. Perseus.
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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AN EXAMPLE OF A GENE-HUB: PPAR
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Genome-wide association studies of common diseasesPrediction of morbidity
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Genotypes and Prognosis of Diabetes
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Biological information pathways to major causes of morbidity worldwide
0 2….. 4h …..6h….// 24h // YearsTime
Network of 1,556 genes (Nature,447, 1032, 2005)
ER stress Systemic inflammatory response
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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The Healthium Web
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Crecimiento Rentable
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I nnovación
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Estados Inicial
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Metabolic Genomic
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Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Key References
• Rangel-Aldao R (2003) Developing countries and systems biology. Nature Biotechnology, 21, 3-4
• Rangel-Aldao R (2004) Realities for Latin American and Caribbean Biotech. Nature Biotechnology, 22, 20
• Rangel-Aldao R (2005) Innovation, Complexity, Networks and Health. Innovation Strategy Today, 1, No. 2, 46-67
• Rangel-Aldao (2007) Patenting the gene-hubs of Endoplasmic Reticulum Stress: the Systems Biology Approach. Recent Patents on Biotechnology, Vol. 1, No. 3, In the press
Bridging the Gap in Global Health Innovation – From Needs to Access. Oxford University September 9-13, 2007
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Summary Slide
• Translational research for capacity building: from systems biology to preventative and networked health systems
• Self-organizing technology transfer: integrating clinicians and scientists by autonomous and synchronized local networks
• Small-world networks as a mean to bridge effective international technology transfer to less advanced countries
