Date post: | 22-Jan-2018 |
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Health & Medicine |
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Dr. Nippun Prinja
Plasmapheresis Plasma exchange
TPE Healthy Donors Plasma Exchange
Crystalloids Colloids Plasma Protein Fraction FFP
Removal Of Antibodies Removal Of Immune Complexes Hyperviscosity Syndromes Removal Of toxins Replacement Of Deficient Plasma
Components
1=standard& acceptable 2=generally accepted 3=case studies 4=lacking efficacy P=phase 3 pharma trials
Manual-by use of plastic bag Automated-by cell separator machines
Reaction to replacement fluids Vasovagal reactions Pyrogenic reactions Hypocalcemia Haemolytic transfusion reactions.
THERAPEUTIC LEUCAPHERESIS THERAPEUTIC THROMBOPHERESIS THERAPEUTIC ERYTHROPHERESIS
MANUAL APHERESIS MACHINE
INTERMITTENT FLOW CENTRIFUGATION. CONTINUOUS FLOW CENTRIFUGATION.
Haemonetics Density=redcells>white
cells>platelets>plasma Seprated components from bowl through
outlet port into seprated bag Centrifuge stops and pump get reversed Components not required returned to
individual 6-8 cycles are done till desired quality &
quantity
COMTEC,AMICUS. Blood is withdrawn,processed and returned
to the individual simultaneously. Earlier two venous access,now one. Advantage of speed,small extra corporeal
volume. Isovolumeic status of donor is maintained
minimizing fluid loss.
ICU Well trained staff First aid kit Written consent Adverse effects/reaction Availability of physician if complication