Dependable Raman Analysis
Thermo ScientificDXR SmartRaman
Spectrometer
m o l e c u l a r s p e c t r o s c o p y
Walk-up ease of use for routine sampling and quality control
Uncompromising performance
Comprehensive range of sampling accessories
Powerful analytical tool for sample identification
Part of Thermo Fisher Scientific
TH E RA M A N SP E C T R O S C O P Y SO L U T I O N
Dyes and Chemicals
Academic Research
Forensics
Polymers
Food and Packaging
Pharmaceuticals
From the Experts in Raman Spectroscopy
The DXR SmartRaman SpectrometerThe DXR SmartRaman spectrometer is a Raman spectrometer designed for bulk sample analysisin busy multi-purpose analytical labs where the users are looking for reproducible and accurateresults from a dependable, low maintenance instrument. With patented autoalignment andautomated calibration, the DXR SmartRaman is easy for the user to maintain at peak performancewithout instrument downtime. Featuring autoexposure, autofocus, automated fluorescence correction, laser power regulation and Variable Dynamic Point Sampling, the DXR SmartRamandelivers optimal results, reproducibly time after time, without demanding that the user become a Raman expert.
• Walk-up results• Excellent sensitivity• Full spectral range• Interchangeable Smart sampling
accessories• Full range of sample formats• Low maintenance• Expandable
Sample formats include:• Powders in plastic packages • Liquids in clear and brown glass bottles• Powders, liquids, slurries in multi-well plates• Samples in tubes, vials, cuvettes• Tablets• Samples in blister-packs
Typical departments for the DXR SmartRaman: • QC/QA • Analytical methods development• R&D • Process development • Routine analysis
Typical industries:• Forensics • Academic Research• Dyes and Chemicals • Polymers• Food and Packaging • Pharmaceuticals
We have long been known for our innovativeFT-IR and Raman spectrometers. We havenow built on this experience to tailor a newRaman spectrometer specifically to meetthe needs of the multi-purpose analyticallab. Raman used to be regarded as toofinicky and too unreliable to be used as aroutine analytical tool. With the DXRSmartRaman spectrometer we have incorporated revolutionary new patentedfeatures making it easy to maintain peakperformance, and deliver answers routinelyand reliably.
The DXR SmartRaman Spectrometer and Your Applications
One of the most attractive characteristics ofRaman spectroscopy is its ease of sampling.Sample preparation is minimal and samples arereadily analyzed through glass and plastic packaging. Raman spectroscopy complementsthe FT-IR in your lab; samples that absorb IRweakly tend to be strong Raman scatterers and vice versa.
The DXR SmartRaman is a true walk-up,Raman spectrometer, designed as an analyticaltool to take full advantage of the benefits ofRaman spectroscopy.
PE R F O R M A N C E A N D DE P E N D A B I L I T Y
Introducing – Your new workhorse!Whatever the sample, the DXR SmartRaman has the answer.
RE V O L U T I O N A RY RA M A N
Users can configure the DXR SmartRaman withup to three different excitation frequencies – at 532, 633 and 780 nm. The lasers, togetherwith the appropriate filters and gratings, lockinto place on the SmartRaman using SmartLocktechnology for precisely reproducible results.OMNIC software recognizes each component,records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Technology for Reproducible Results
The Power of Raman in an Easy to Use Format
Automatic Intensity Correction –compensates for detector wave-
length dependence.
Automatic FluorescenceCorrection – automaticallycorrects for fluorescenceinterference. Available for allexcitation lasers. Spectrum ofan anti-histamine: (a) withoutfluorescence correction; (b) with fluorescence correction.
Variable Dynamic PointSampling – overcomesthe challenge of collectingrepresentative spectra fromheterogeneous samples.VDPS technology rasters theexcitation laser beam overthe surface of the samplewithout loss of signal.Spectra of painkiller tablettaken at multiple samplingpoints: (a) with VDPS on; (b) without the use of VDPS.
Autofocus – optimizes the focus to maximize theRaman signal automatically.
Smart Background – the DXR SmartRaman collects backgrounddata during instrument downtime, so theuser never has to wait.
Autoexposure – let theDXR SmartRaman calculatethe exposure time and numberof exposures for optimal sensitivity.
Collecting Quality Data
Raman is a powerful analytical tool, but it used to be difficult to use it to get reliable answers. It was hard to collect top quality data, hard to interpret the data and hard to keep a Raman instrument performing sufficiently well that the results could be trusted. We have fixed all that with the revolutionary and patented innovations in the DXR SmartRaman.
SmartLock Lasers
Top Quality Results Made Easy – unique software features such as Autoexposure,Smart Background and Autofocus supply theexpertise required to collect optimal Raman data.
a
b
DXR SmartRam Interior 2-18-09 2/20/09 1:07 PM Page 2
From the Experts in Raman Spectroscopy
The DXR SmartRaman SpectrometerThe DXR SmartRaman spectrometer is a Raman spectrometer designed for bulk sample analysisin busy multi-purpose analytical labs where the users are looking for reproducible and accurateresults from a dependable, low maintenance instrument. With patented autoalignment andautomated calibration, the DXR SmartRaman is easy for the user to maintain at peak performancewithout instrument downtime. Featuring autoexposure, autofocus, automated fluorescence correction, laser power regulation and Variable Dynamic Point Sampling, the DXR SmartRamandelivers optimal results, reproducibly time after time, without demanding that the user become a Raman expert.
• Walk-up results• Excellent sensitivity• Full spectral range• Interchangeable Smart sampling
accessories• Full range of sample formats• Low maintenance• Expandable
Sample formats include:• Powders in plastic packages • Liquids in clear and brown glass bottles• Powders, liquids, slurries in multi-well plates• Samples in tubes, vials, cuvettes• Tablets• Samples in blister-packs
Typical departments for the DXR SmartRaman: • QC/QA • Analytical methods development• R&D • Process development • Routine analysis
Typical industries:• Forensics • Academic Research• Dyes and Chemicals • Polymers• Food and Packaging • Pharmaceuticals
We have long been known for our innovativeFT-IR and Raman spectrometers. We havenow built on this experience to tailor a newRaman spectrometer specifically to meetthe needs of the multi-purpose analyticallab. Raman used to be regarded as toofinicky and too unreliable to be used as aroutine analytical tool. With the DXRSmartRaman spectrometer we have incorporated revolutionary new patentedfeatures making it easy to maintain peakperformance, and deliver answers routinelyand reliably.
The DXR SmartRaman Spectrometer and Your Applications
One of the most attractive characteristics ofRaman spectroscopy is its ease of sampling.Sample preparation is minimal and samples arereadily analyzed through glass and plastic packaging. Raman spectroscopy complementsthe FT-IR in your lab; samples that absorb IRweakly tend to be strong Raman scatterers and vice versa.
The DXR SmartRaman is a true walk-up,Raman spectrometer, designed as an analyticaltool to take full advantage of the benefits ofRaman spectroscopy.
PE R F O R M A N C E A N D DE P E N D A B I L I T Y
Introducing – Your new workhorse!Whatever the sample, the DXR SmartRaman has the answer.
RE V O L U T I O N A RY RA M A N
Users can configure the DXR SmartRaman withup to three different excitation frequencies – at 532, 633 and 780 nm. The lasers, togetherwith the appropriate filters and gratings, lockinto place on the SmartRaman using SmartLocktechnology for precisely reproducible results.OMNIC software recognizes each component,records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Technology for Reproducible Results
The Power of Raman in an Easy to Use Format
Automatic Intensity Correction –compensates for detector wave-
length dependence.
Automatic FluorescenceCorrection – automaticallycorrects for fluorescenceinterference. Available for allexcitation lasers. Spectrum ofan anti-histamine: (a) withoutfluorescence correction; (b) with fluorescence correction.
Variable Dynamic PointSampling – overcomesthe challenge of collectingrepresentative spectra fromheterogeneous samples.VDPS technology rasters theexcitation laser beam overthe surface of the samplewithout loss of signal.Spectra of painkiller tablettaken at multiple samplingpoints: (a) with VDPS on; (b) without the use of VDPS.
Autofocus – optimizes the focus to maximize theRaman signal automatically.
Smart Background – the DXR SmartRaman collects backgrounddata during instrument downtime, so theuser never has to wait.
Autoexposure – let theDXR SmartRaman calculatethe exposure time and numberof exposures for optimal sensitivity.
Collecting Quality Data
Raman is a powerful analytical tool, but it used to be difficult to use it to get reliable answers. It was hard to collect top quality data, hard to interpret the data and hard to keep a Raman instrument performing sufficiently well that the results could be trusted. We have fixed all that with the revolutionary and patented innovations in the DXR SmartRaman.
SmartLock Lasers
Top Quality Results Made Easy – unique software features such as Autoexposure,Smart Background and Autofocus supply theexpertise required to collect optimal Raman data.
a
b
DXR SmartRam Interior 2-18-09 2/20/09 1:07 PM Page 2
From the Experts in Raman Spectroscopy
The DXR SmartRaman SpectrometerThe DXR SmartRaman spectrometer is a Raman spectrometer designed for bulk sample analysisin busy multi-purpose analytical labs where the users are looking for reproducible and accurateresults from a dependable, low maintenance instrument. With patented autoalignment andautomated calibration, the DXR SmartRaman is easy for the user to maintain at peak performancewithout instrument downtime. Featuring autoexposure, autofocus, automated fluorescence correction, laser power regulation and Variable Dynamic Point Sampling, the DXR SmartRamandelivers optimal results, reproducibly time after time, without demanding that the user become a Raman expert.
• Walk-up results• Excellent sensitivity• Full spectral range• Interchangeable Smart sampling
accessories• Full range of sample formats• Low maintenance• Expandable
Sample formats include:• Powders in plastic packages • Liquids in clear and brown glass bottles• Powders, liquids, slurries in multi-well plates• Samples in tubes, vials, cuvettes• Tablets• Samples in blister-packs
Typical departments for the DXR SmartRaman: • QC/QA • Analytical methods development• R&D • Process development • Routine analysis
Typical industries:• Forensics • Academic Research• Dyes and Chemicals • Polymers• Food and Packaging • Pharmaceuticals
We have long been known for our innovativeFT-IR and Raman spectrometers. We havenow built on this experience to tailor a newRaman spectrometer specifically to meetthe needs of the multi-purpose analyticallab. Raman used to be regarded as toofinicky and too unreliable to be used as aroutine analytical tool. With the DXRSmartRaman spectrometer we have incorporated revolutionary new patentedfeatures making it easy to maintain peakperformance, and deliver answers routinelyand reliably.
The DXR SmartRaman Spectrometer and Your Applications
One of the most attractive characteristics ofRaman spectroscopy is its ease of sampling.Sample preparation is minimal and samples arereadily analyzed through glass and plastic packaging. Raman spectroscopy complementsthe FT-IR in your lab; samples that absorb IRweakly tend to be strong Raman scatterers and vice versa.
The DXR SmartRaman is a true walk-up,Raman spectrometer, designed as an analyticaltool to take full advantage of the benefits ofRaman spectroscopy.
PE R F O R M A N C E A N D DE P E N D A B I L I T Y
Introducing – Your new workhorse!Whatever the sample, the DXR SmartRaman has the answer.
RE V O L U T I O N A RY RA M A N
Users can configure the DXR SmartRaman withup to three different excitation frequencies – at 532, 633 and 780 nm. The lasers, togetherwith the appropriate filters and gratings, lockinto place on the SmartRaman using SmartLocktechnology for precisely reproducible results.OMNIC software recognizes each component,records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Technology for Reproducible Results
The Power of Raman in an Easy to Use Format
Automatic Intensity Correction –compensates for detector wave-
length dependence.
Automatic FluorescenceCorrection – automaticallycorrects for fluorescenceinterference. Available for allexcitation lasers. Spectrum ofan anti-histamine: (a) withoutfluorescence correction; (b) with fluorescence correction.
Variable Dynamic PointSampling – overcomesthe challenge of collectingrepresentative spectra fromheterogeneous samples.VDPS technology rasters theexcitation laser beam overthe surface of the samplewithout loss of signal.Spectra of painkiller tablettaken at multiple samplingpoints: (a) with VDPS on; (b) without the use of VDPS.
Autofocus – optimizes the focus to maximize theRaman signal automatically.
Smart Background – the DXR SmartRaman collects backgrounddata during instrument downtime, so theuser never has to wait.
Autoexposure – let theDXR SmartRaman calculatethe exposure time and numberof exposures for optimal sensitivity.
Collecting Quality Data
Raman is a powerful analytical tool, but it used to be difficult to use it to get reliable answers. It was hard to collect top quality data, hard to interpret the data and hard to keep a Raman instrument performing sufficiently well that the results could be trusted. We have fixed all that with the revolutionary and patented innovations in the DXR SmartRaman.
SmartLock Lasers
Top Quality Results Made Easy – unique software features such as Autoexposure,Smart Background and Autofocus supply theexpertise required to collect optimal Raman data.
a
b
DXR SmartRam Interior 2-18-09 2/20/09 1:07 PM Page 2
SA M P L I N G VE R S AT I L I T Y
Smart Accessories for All Your NeedsSamples come in all kinds of formats, so it is important to have samplingaccessories that are designed for the full range of sample types. Additional versatility comes from being able to select from up to three excitation frequencies,guaranteeing optimal results whatever the samples.
The DXR SmartRaman sampling accessories use pinned-in-place technologyto attach to the DXR SmartRaman base, where they are immediately recognizedby the OMNIC™ software using Smart technology. The identity and serial numberof the accessory are recorded with the results for complete traceability.
The Bottle Holder for analyzing the contents of standard bottles.
The Tablet Holder fortablets – with its iris formatthe Tablet Holder acceptstablets in a range of sizes.
The Array Autosampler automatesanalysis of multi-well plates and other samples in array formats.
The Universal Plate forsamples such as plasticbags and glass vials.
The Universal Platform Sampling Accessory
The Universal Platform Sampling accessory accepts up to four pinned-in-place, Smart tool heads, each designed to accommodate a particular sample format.
The Universal Platform Sampling accessoryemploys Variable Dynamic Point Sampling (VDPS)technology to average the Raman signal from a heterogeneous sample without loss of Raman intensity. This unique technology overcomes the challenge of collecting representative spectra fromheterogeneous samples, such as mixed powders orpharmaceutical tablets, without sacrificing Ramansignal. The effective spot size is user-selectable andunder software control.
The 180 Degree Sampling Accessory
For labs that handle samples in a variety of formats, the 180 Degree sampling accessory isthe best option. Designed as a simple device toaccommodate vials, tubes, powders and othersamples, the 180 Degree accessory also permitsthe use of specialty cells, including cryogenic,high-temperature, electrochemical and controlled-humidity chambers. The 180 Degree samplingaccessory is particularly useful in environmentsthat value diverse sample formats over highlyautomated data collection.
Remote Sampling
For remote sampling the DXRSmartRaman accepts fiber optic probes.
The Carousel Autosampler Accessory
The Carousel Autosampler accessory automates data collection from standard sample tubes. The removable carousels come in two sizes and accept standard 5-, and 13-mm tubes. The accessory rotates the tubes during data collection to avoid sampling artifacts from heterogeneous samples.
Maintaining Peak Performance Effortlessly
Automated Calibration – spectrograph, laser and Raman intensitycalibrations are completely automated by OMNIC software usingstandards located in the alignment/calibration pod.
Laser Power Regulator –compensates for changes in laser power output and guarantees consistent powerat the sample.
Smart Lasers – automatically track laser lifetime.
Easy-to-maintain-Spectrograph – no moving parts, uniquepatented design optimizesperformance at all wavelengths.
Pre-aligned Smart Components – factory-aligned components permitlasers, gratings and filters to be easily exchanged.
Lasers, gratings, filters, fiber launcher and Smart accessories identify themselves by serial number and wavelength. OMNIC softwarechecks for component compatibility.
Patented Autoalignment – keeps the excitation laser and the Ramanscatter beam paths precisely aligned to the same sampling point formaximum sampling precision. No manual alignment necessary.
Single USB Connection – full instrument control fromeither a desktop or laptopcomputer through a singleUSB port.
Fine-adjust Assembly – software-controlled to maintain peak performance.
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis.For hard-to-resolve bands, high-resolution gratings areavailable for all three lasers.
User-replaceable Components – no service calls required to replace a laser.
MA X I M U M PR O D U C T I V I T Y
A fully calibrated and aligned instrument delivers reproducible resultsdependably. With patented autoalignment, calibration and other features,routine instrument maintenance is easily incorporated into standard laboperating procedures.
Raman Spectrometer• Class I laser safe; safe to use in the open lab
• 532, 633 and 780 nm lasers; factory aligned, user-interchangeable
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1*
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region)
• SmartLock technology for reproducibly mounting lasers, gratings and filters
• Smart components to report identity and serial numbers for compatibilitychecking, traceability and laser lifetime tracking
• Patented Autoalignment procedure to ensure optimal alignment
• Rapid automated calibration to ensure validity of results
• Convenient storage for additional lasers, gratings and filters
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling• Versatile pin-in-place sampling accessories accept all sample formats
• Smart technology records sampling accessory and tool head identity,plus serial number for comprehensive traceability
• Automation for high sample throughput – multi well plates, tablets, tubes
• Variable Dynamic Point Sampling for representative spectra from heterogeneous samples
• Fiber launch port accepts fiber optic probes for remote sampling
Software• Comprehensive OMNIC software suite for full instrument control
and data processing
• OMNIC Specta software for highly efficient management and processingof spectral data for materials identification
• Extensive Raman libraries and easy to use search capabilities
• OMNIC Array Automation for automated data collection using the Array Autosampler toolhead and for post collection data processing
• TQ Analyst™ with chemometrics for comprehensive data analysis
Maintenance • Single beam path spectrometer for robustness
• Spectrograph with no moving parts for dependable performance and reliability
• Minimal service requirements
• All consumables, including lasers, are user-replaceable
• Alignment and calibration software-controlled and performed routinely by the user
Validation• ValPro™ System Qualification package
for full validation to meet all regulatory requirements.
SI M P LY TH E BE S T
Multiple Lasers – Be ready for any sample. Expand thecapabilities of the DXR SmartRaman by adding a second orthird excitation laser. Minimize fluorescence interference, orenhance sensitivity by up to 10-fold. Facilities with more thanone DXR SmartRaman or microscope can share lasers, gratingsand filters between instruments for even greater versatility.
DXR SmartRam Interior 2-18-09 2/20/09 1:07 PM Page 1
SA M P L I N G VE R S AT I L I T Y
Smart Accessories for All Your NeedsSamples come in all kinds of formats, so it is important to have samplingaccessories that are designed for the full range of sample types. Additional versatility comes from being able to select from up to three excitation frequencies,guaranteeing optimal results whatever the samples.
The DXR SmartRaman sampling accessories use pinned-in-place technologyto attach to the DXR SmartRaman base, where they are immediately recognizedby the OMNIC™ software using Smart technology. The identity and serial numberof the accessory are recorded with the results for complete traceability.
The Bottle Holder for analyzing the contents of standard bottles.
The Tablet Holder fortablets – with its iris formatthe Tablet Holder acceptstablets in a range of sizes.
The Array Autosampler automatesanalysis of multi-well plates and other samples in array formats.
The Universal Plate forsamples such as plasticbags and glass vials.
The Universal Platform Sampling Accessory
The Universal Platform Sampling accessory accepts up to four pinned-in-place, Smart tool heads, each designed to accommodate a particular sample format.
The Universal Platform Sampling accessoryemploys Variable Dynamic Point Sampling (VDPS)technology to average the Raman signal from a heterogeneous sample without loss of Raman intensity. This unique technology overcomes the challenge of collecting representative spectra fromheterogeneous samples, such as mixed powders orpharmaceutical tablets, without sacrificing Ramansignal. The effective spot size is user-selectable andunder software control.
The 180 Degree Sampling Accessory
For labs that handle samples in a variety of formats, the 180 Degree sampling accessory isthe best option. Designed as a simple device toaccommodate vials, tubes, powders and othersamples, the 180 Degree accessory also permitsthe use of specialty cells, including cryogenic,high-temperature, electrochemical and controlled-humidity chambers. The 180 Degree samplingaccessory is particularly useful in environmentsthat value diverse sample formats over highlyautomated data collection.
Remote Sampling
For remote sampling the DXRSmartRaman accepts fiber optic probes.
The Carousel Autosampler Accessory
The Carousel Autosampler accessory automates data collection from standard sample tubes. The removable carousels come in two sizes and accept standard 5-, and 13-mm tubes. The accessory rotates the tubes during data collection to avoid sampling artifacts from heterogeneous samples.
Maintaining Peak Performance Effortlessly
Automated Calibration – spectrograph, laser and Raman intensitycalibrations are completely automated by OMNIC software usingstandards located in the alignment/calibration pod.
Laser Power Regulator –compensates for changes in laser power output and guarantees consistent powerat the sample.
Smart Lasers – automatically track laser lifetime.
Easy-to-maintain-Spectrograph – no moving parts, uniquepatented design optimizesperformance at all wavelengths.
Pre-aligned Smart Components – factory-aligned components permitlasers, gratings and filters to be easily exchanged.
Lasers, gratings, filters, fiber launcher and Smart accessories identify themselves by serial number and wavelength. OMNIC softwarechecks for component compatibility.
Patented Autoalignment – keeps the excitation laser and the Ramanscatter beam paths precisely aligned to the same sampling point formaximum sampling precision. No manual alignment necessary.
Single USB Connection – full instrument control fromeither a desktop or laptopcomputer through a singleUSB port.
Fine-adjust Assembly – software-controlled to maintain peak performance.
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis.For hard-to-resolve bands, high-resolution gratings areavailable for all three lasers.
User-replaceable Components – no service calls required to replace a laser.
MA X I M U M PR O D U C T I V I T Y
A fully calibrated and aligned instrument delivers reproducible resultsdependably. With patented autoalignment, calibration and other features,routine instrument maintenance is easily incorporated into standard laboperating procedures.
Raman Spectrometer• Class I laser safe; safe to use in the open lab
• 532, 633 and 780 nm lasers; factory aligned, user-interchangeable
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1*
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region)
• SmartLock technology for reproducibly mounting lasers, gratings and filters
• Smart components to report identity and serial numbers for compatibilitychecking, traceability and laser lifetime tracking
• Patented Autoalignment procedure to ensure optimal alignment
• Rapid automated calibration to ensure validity of results
• Convenient storage for additional lasers, gratings and filters
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling• Versatile pin-in-place sampling accessories accept all sample formats
• Smart technology records sampling accessory and tool head identity,plus serial number for comprehensive traceability
• Automation for high sample throughput – multi well plates, tablets, tubes
• Variable Dynamic Point Sampling for representative spectra from heterogeneous samples
• Fiber launch port accepts fiber optic probes for remote sampling
Software• Comprehensive OMNIC software suite for full instrument control
and data processing
• OMNIC Specta software for highly efficient management and processingof spectral data for materials identification
• Extensive Raman libraries and easy to use search capabilities
• OMNIC Array Automation for automated data collection using the Array Autosampler toolhead and for post collection data processing
• TQ Analyst™ with chemometrics for comprehensive data analysis
Maintenance • Single beam path spectrometer for robustness
• Spectrograph with no moving parts for dependable performance and reliability
• Minimal service requirements
• All consumables, including lasers, are user-replaceable
• Alignment and calibration software-controlled and performed routinely by the user
Validation• ValPro™ System Qualification package
for full validation to meet all regulatory requirements.
SI M P LY TH E BE S T
Multiple Lasers – Be ready for any sample. Expand thecapabilities of the DXR SmartRaman by adding a second orthird excitation laser. Minimize fluorescence interference, orenhance sensitivity by up to 10-fold. Facilities with more thanone DXR SmartRaman or microscope can share lasers, gratingsand filters between instruments for even greater versatility.
DXR SmartRam Interior 2-18-09 2/20/09 1:07 PM Page 1
SA M P L I N G VE R S AT I L I T Y
Smart Accessories for All Your NeedsSamples come in all kinds of formats, so it is important to have samplingaccessories that are designed for the full range of sample types. Additional versatility comes from being able to select from up to three excitation frequencies,guaranteeing optimal results whatever the samples.
The DXR SmartRaman sampling accessories use pinned-in-place technologyto attach to the DXR SmartRaman base, where they are immediately recognizedby the OMNIC™ software using Smart technology. The identity and serial numberof the accessory are recorded with the results for complete traceability.
The Bottle Holder for analyzing the contents of standard bottles.
The Tablet Holder fortablets – with its iris formatthe Tablet Holder acceptstablets in a range of sizes.
The Array Autosampler automatesanalysis of multi-well plates and other samples in array formats.
The Universal Plate forsamples such as plasticbags and glass vials.
The Universal Platform Sampling Accessory
The Universal Platform Sampling accessory accepts up to four pinned-in-place, Smart tool heads, each designed to accommodate a particular sample format.
The Universal Platform Sampling accessoryemploys Variable Dynamic Point Sampling (VDPS)technology to average the Raman signal from a heterogeneous sample without loss of Raman intensity. This unique technology overcomes the challenge of collecting representative spectra fromheterogeneous samples, such as mixed powders orpharmaceutical tablets, without sacrificing Ramansignal. The effective spot size is user-selectable andunder software control.
The 180 Degree Sampling Accessory
For labs that handle samples in a variety of formats, the 180 Degree sampling accessory isthe best option. Designed as a simple device toaccommodate vials, tubes, powders and othersamples, the 180 Degree accessory also permitsthe use of specialty cells, including cryogenic,high-temperature, electrochemical and controlled-humidity chambers. The 180 Degree samplingaccessory is particularly useful in environmentsthat value diverse sample formats over highlyautomated data collection.
Remote Sampling
For remote sampling the DXRSmartRaman accepts fiber optic probes.
The Carousel Autosampler Accessory
The Carousel Autosampler accessory automates data collection from standard sample tubes. The removable carousels come in two sizes and accept standard 5-, and 13-mm tubes. The accessory rotates the tubes during data collection to avoid sampling artifacts from heterogeneous samples.
Maintaining Peak Performance Effortlessly
Automated Calibration – spectrograph, laser and Raman intensitycalibrations are completely automated by OMNIC software usingstandards located in the alignment/calibration pod.
Laser Power Regulator –compensates for changes in laser power output and guarantees consistent powerat the sample.
Smart Lasers – automatically track laser lifetime.
Easy-to-maintain-Spectrograph – no moving parts, uniquepatented design optimizesperformance at all wavelengths.
Pre-aligned Smart Components – factory-aligned components permitlasers, gratings and filters to be easily exchanged.
Lasers, gratings, filters, fiber launcher and Smart accessories identify themselves by serial number and wavelength. OMNIC softwarechecks for component compatibility.
Patented Autoalignment – keeps the excitation laser and the Ramanscatter beam paths precisely aligned to the same sampling point formaximum sampling precision. No manual alignment necessary.
Single USB Connection – full instrument control fromeither a desktop or laptopcomputer through a singleUSB port.
Fine-adjust Assembly – software-controlled to maintain peak performance.
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis.For hard-to-resolve bands, high-resolution gratings areavailable for all three lasers.
User-replaceable Components – no service calls required to replace a laser.
MA X I M U M PR O D U C T I V I T Y
A fully calibrated and aligned instrument delivers reproducible resultsdependably. With patented autoalignment, calibration and other features,routine instrument maintenance is easily incorporated into standard laboperating procedures.
Raman Spectrometer• Class I laser safe; safe to use in the open lab
• 532, 633 and 780 nm lasers; factory aligned, user-interchangeable
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1*
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region)
• SmartLock technology for reproducibly mounting lasers, gratings and filters
• Smart components to report identity and serial numbers for compatibilitychecking, traceability and laser lifetime tracking
• Patented Autoalignment procedure to ensure optimal alignment
• Rapid automated calibration to ensure validity of results
• Convenient storage for additional lasers, gratings and filters
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling• Versatile pin-in-place sampling accessories accept all sample formats
• Smart technology records sampling accessory and tool head identity,plus serial number for comprehensive traceability
• Automation for high sample throughput – multi well plates, tablets, tubes
• Variable Dynamic Point Sampling for representative spectra from heterogeneous samples
• Fiber launch port accepts fiber optic probes for remote sampling
Software• Comprehensive OMNIC software suite for full instrument control
and data processing
• OMNIC Specta software for highly efficient management and processingof spectral data for materials identification
• Extensive Raman libraries and easy to use search capabilities
• OMNIC Array Automation for automated data collection using the Array Autosampler toolhead and for post collection data processing
• TQ Analyst™ with chemometrics for comprehensive data analysis
Maintenance • Single beam path spectrometer for robustness
• Spectrograph with no moving parts for dependable performance and reliability
• Minimal service requirements
• All consumables, including lasers, are user-replaceable
• Alignment and calibration software-controlled and performed routinely by the user
Validation• ValPro™ System Qualification package
for full validation to meet all regulatory requirements.
SI M P LY TH E BE S T
Multiple Lasers – Be ready for any sample. Expand thecapabilities of the DXR SmartRaman by adding a second orthird excitation laser. Minimize fluorescence interference, orenhance sensitivity by up to 10-fold. Facilities with more thanone DXR SmartRaman or microscope can share lasers, gratingsand filters between instruments for even greater versatility.
DXR SmartRam Interior 2-18-09 2/20/09 1:07 PM Page 1
SA M P L I N G VE R S AT I L I T Y
Smart Accessories for All Your NeedsSamples come in all kinds of formats, so it is important to have samplingaccessories that are designed for the full range of sample types. Additional versatility comes from being able to select from up to three excitation frequencies,guaranteeing optimal results whatever the samples.
The DXR SmartRaman sampling accessories use pinned-in-place technologyto attach to the DXR SmartRaman base, where they are immediately recognizedby the OMNIC™ software using Smart technology. The identity and serial numberof the accessory are recorded with the results for complete traceability.
The Bottle Holder for analyzing the contents of standard bottles.
The Tablet Holder fortablets – with its iris formatthe Tablet Holder acceptstablets in a range of sizes.
The Array Autosampler automatesanalysis of multi-well plates and other samples in array formats.
The Universal Plate forsamples such as plasticbags and glass vials.
The Universal Platform Sampling Accessory
The Universal Platform Sampling accessory accepts up to four pinned-in-place, Smart tool heads, each designed to accommodate a particular sample format.
The Universal Platform Sampling accessoryemploys Variable Dynamic Point Sampling (VDPS)technology to average the Raman signal from a heterogeneous sample without loss of Raman intensity. This unique technology overcomes the challenge of collecting representative spectra fromheterogeneous samples, such as mixed powders orpharmaceutical tablets, without sacrificing Ramansignal. The effective spot size is user-selectable andunder software control.
The 180 Degree Sampling Accessory
For labs that handle samples in a variety of formats, the 180 Degree sampling accessory isthe best option. Designed as a simple device toaccommodate vials, tubes, powders and othersamples, the 180 Degree accessory also permitsthe use of specialty cells, including cryogenic,high-temperature, electrochemical and controlled-humidity chambers. The 180 Degree samplingaccessory is particularly useful in environmentsthat value diverse sample formats over highlyautomated data collection.
Remote Sampling
For remote sampling the DXRSmartRaman accepts fiber optic probes.
The Carousel Autosampler Accessory
The Carousel Autosampler accessory automates data collection from standard sample tubes. The removable carousels come in two sizes and accept standard 5-, and 13-mm tubes. The accessory rotates the tubes during data collection to avoid sampling artifacts from heterogeneous samples.
Maintaining Peak Performance Effortlessly
Automated Calibration – spectrograph, laser and Raman intensitycalibrations are completely automated by OMNIC software usingstandards located in the alignment/calibration pod.
Laser Power Regulator –compensates for changes in laser power output and guarantees consistent powerat the sample.
Smart Lasers – automatically track laser lifetime.
Easy-to-maintain-Spectrograph – no moving parts, uniquepatented design optimizesperformance at all wavelengths.
Pre-aligned Smart Components – factory-aligned components permitlasers, gratings and filters to be easily exchanged.
Lasers, gratings, filters, fiber launcher and Smart accessories identify themselves by serial number and wavelength. OMNIC softwarechecks for component compatibility.
Patented Autoalignment – keeps the excitation laser and the Ramanscatter beam paths precisely aligned to the same sampling point formaximum sampling precision. No manual alignment necessary.
Single USB Connection – full instrument control fromeither a desktop or laptopcomputer through a singleUSB port.
Fine-adjust Assembly – software-controlled to maintain peak performance.
Choice of Spectral Resolution – choose standard spectral resolution for routine analysis.For hard-to-resolve bands, high-resolution gratings areavailable for all three lasers.
User-replaceable Components – no service calls required to replace a laser.
MA X I M U M PR O D U C T I V I T Y
A fully calibrated and aligned instrument delivers reproducible resultsdependably. With patented autoalignment, calibration and other features,routine instrument maintenance is easily incorporated into standard laboperating procedures.
Raman Spectrometer• Class I laser safe; safe to use in the open lab
• 532, 633 and 780 nm lasers; factory aligned, user-interchangeable
• Full range gratings for complete spectra in one shot. 50 cm-1 to 3500 cm-1*
• High-resolution gratings for difficult to resolve bands. 50 cm-1 to 1800 cm-1 (fingerprint region)
• SmartLock technology for reproducibly mounting lasers, gratings and filters
• Smart components to report identity and serial numbers for compatibilitychecking, traceability and laser lifetime tracking
• Patented Autoalignment procedure to ensure optimal alignment
• Rapid automated calibration to ensure validity of results
• Convenient storage for additional lasers, gratings and filters
* Spectral range for the 780 nm excitation laser is 50 cm-1 to 3300 cm-1
Sampling• Versatile pin-in-place sampling accessories accept all sample formats
• Smart technology records sampling accessory and tool head identity,plus serial number for comprehensive traceability
• Automation for high sample throughput – multi well plates, tablets, tubes
• Variable Dynamic Point Sampling for representative spectra from heterogeneous samples
• Fiber launch port accepts fiber optic probes for remote sampling
Software• Comprehensive OMNIC software suite for full instrument control
and data processing
• OMNIC Specta software for highly efficient management and processingof spectral data for materials identification
• Extensive Raman libraries and easy to use search capabilities
• OMNIC Array Automation for automated data collection using the Array Autosampler toolhead and for post collection data processing
• TQ Analyst™ with chemometrics for comprehensive data analysis
Maintenance • Single beam path spectrometer for robustness
• Spectrograph with no moving parts for dependable performance and reliability
• Minimal service requirements
• All consumables, including lasers, are user-replaceable
• Alignment and calibration software-controlled and performed routinely by the user
Validation• ValPro™ System Qualification package
for full validation to meet all regulatory requirements.
SI M P LY TH E BE S T
Multiple Lasers – Be ready for any sample. Expand thecapabilities of the DXR SmartRaman by adding a second orthird excitation laser. Minimize fluorescence interference, orenhance sensitivity by up to 10-fold. Facilities with more thanone DXR SmartRaman or microscope can share lasers, gratingsand filters between instruments for even greater versatility.
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From the Experts in Raman Spectroscopy
The DXR SmartRaman SpectrometerThe DXR SmartRaman spectrometer is a Raman spectrometer designed for bulk sample analysisin busy multi-purpose analytical labs where the users are looking for reproducible and accurateresults from a dependable, low maintenance instrument. With patented autoalignment andautomated calibration, the DXR SmartRaman is easy for the user to maintain at peak performancewithout instrument downtime. Featuring autoexposure, autofocus, automated fluorescence correction, laser power regulation and Variable Dynamic Point Sampling, the DXR SmartRamandelivers optimal results, reproducibly time after time, without demanding that the user become a Raman expert.
• Walk-up results• Excellent sensitivity• Full spectral range• Interchangeable Smart sampling
accessories• Full range of sample formats• Low maintenance• Expandable
Sample formats include:• Powders in plastic packages • Liquids in clear and brown glass bottles• Powders, liquids, slurries in multi-well plates• Samples in tubes, vials, cuvettes• Tablets• Samples in blister-packs
Typical departments for the DXR SmartRaman: • QC/QA • Analytical methods development• R&D • Process development • Routine analysis
Typical industries:• Forensics • Academic Research• Dyes and Chemicals • Polymers• Food and Packaging • Pharmaceuticals
We have long been known for our innovativeFT-IR and Raman spectrometers. We havenow built on this experience to tailor a newRaman spectrometer specifically to meetthe needs of the multi-purpose analyticallab. Raman used to be regarded as toofinicky and too unreliable to be used as aroutine analytical tool. With the DXRSmartRaman spectrometer we have incorporated revolutionary new patentedfeatures making it easy to maintain peakperformance, and deliver answers routinelyand reliably.
The DXR SmartRaman Spectrometer and Your Applications
One of the most attractive characteristics ofRaman spectroscopy is its ease of sampling.Sample preparation is minimal and samples arereadily analyzed through glass and plastic packaging. Raman spectroscopy complementsthe FT-IR in your lab; samples that absorb IRweakly tend to be strong Raman scatterers and vice versa.
The DXR SmartRaman is a true walk-up,Raman spectrometer, designed as an analyticaltool to take full advantage of the benefits ofRaman spectroscopy.
PE R F O R M A N C E A N D DE P E N D A B I L I T Y
Introducing – Your new workhorse!Whatever the sample, the DXR SmartRaman has the answer.
RE V O L U T I O N A RY RA M A N
Users can configure the DXR SmartRaman withup to three different excitation frequencies – at 532, 633 and 780 nm. The lasers, togetherwith the appropriate filters and gratings, lockinto place on the SmartRaman using SmartLocktechnology for precisely reproducible results.OMNIC software recognizes each component,records the serial numbers and checks for compatibility. A convenient storage container is provided for when the components are not in use.
SmartLock Technology for Reproducible Results
The Power of Raman in an Easy to Use Format
Automatic Intensity Correction –compensates for detector wave-
length dependence.
Automatic FluorescenceCorrection – automaticallycorrects for fluorescenceinterference. Available for allexcitation lasers. Spectrum ofan anti-histamine: (a) withoutfluorescence correction; (b) with fluorescence correction.
Variable Dynamic PointSampling – overcomesthe challenge of collectingrepresentative spectra fromheterogeneous samples.VDPS technology rasters theexcitation laser beam overthe surface of the samplewithout loss of signal.Spectra of painkiller tablettaken at multiple samplingpoints: (a) with VDPS on; (b) without the use of VDPS.
Autofocus – optimizes the focus to maximize theRaman signal automatically.
Smart Background – the DXR SmartRaman collects backgrounddata during instrument downtime, so theuser never has to wait.
Autoexposure – let theDXR SmartRaman calculatethe exposure time and numberof exposures for optimal sensitivity.
Collecting Quality Data
Raman is a powerful analytical tool, but it used to be difficult to use it to get reliable answers. It was hard to collect top quality data, hard to interpret the data and hard to keep a Raman instrument performing sufficiently well that the results could be trusted. We have fixed all that with the revolutionary and patented innovations in the DXR SmartRaman.
SmartLock Lasers
Top Quality Results Made Easy – unique software features such as Autoexposure,Smart Background and Autofocus supply theexpertise required to collect optimal Raman data.
a
b
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From Spectra to Answers
In a single step, OMNIC Specta reveals the identity ofthe three active ingredients in a tablet: acetaminophen,acetylsalicylic acid and caffeine.
Spectral Analysis and Interpretation – ground-breaking Thermo ScientificOMNIC Specta software provides efficient data management, simplified dataprocessing and powerful spectral identification.
Array Automation Software –gets answers from multi-wellplate and other experiments with data arrays. In this example,Array Automation uses hierarchicalcluster analysis to classify gemstones.
SmartLock GratingSmartLock Filters Ensures reproducible spectra even with multiplegrating exchanges (plot shows an overlay of 150 spectra; grating exchanged between each collect).
Multi-Component Search – streamlines theanalysis of mixtures. This unique searching featurequickly and effortlessly characterizes your spectrausing spectral libraries and data on your system,revealing the identity of components in mixtures.
BR51344_E 02/09M
Thermo Electron Scientific Instruments LLC, Madison, WI USA is ISO Certified.
The DXR SmartRaman spectrometer is a Class I laserproduct, unless it is used with the fiber launch option, in which case it is classified as Class IIIb laser-safe.
©2008, 2009 Thermo Fisher Scientific Inc. All rightsreserved. All trademarks are the property of ThermoFisher Scientific Inc. and its subsidiaries.
Specifications, terms and pricing are subject to change.Not all products are available in all countries. Pleaseconsult your local sales representative for details.
With its user-friendly patented autoalignment and calibration, plus its user-replaceable
lasers, gratings and filters, the DXR SmartRaman spectrometer has been designed to
need little service attention. However, we know that in today’s busy, multifunctional
laboratories you cannot afford to be without your workhorse instruments for even
the shortest time. With the most extensive world-wide organization of field service
engineers, you can count on us to keep you up and running.
First class service and support allow you to get the most out of your DXR SmartRaman
spectrometer and your samples. With our expertise in applications support, we can
also offer comprehensive training and technical know-how to take you to the next level.
In addition to these offices, ThermoFisher Scientific maintains a network of representative organizationsthroughout the world.
Africa-Other+27 11 570 1840 • [email protected]
Australia+61 2 8844 9500 • [email protected]
Austria+43 1 333 50 34 0 • [email protected]
Belgium+32 2 482 30 30 • [email protected]
Canada+1 800 530 8447 • [email protected]
China+86 10 8419 3588 • [email protected]
Denmark+45 70 23 62 60 • [email protected]
Europe -Other+43 1 333 50 34 0 • [email protected]
Finland / Norway / Sweden+46 8 556 468 00 • [email protected]
France+33 1 60 92 48 00 • [email protected]
Germany+49 6103 408 1014 • [email protected]
India+91 22 6742 9434 • [email protected]
Italy+39 02 950 591 • [email protected]
Japan+81 45 453 9100 • [email protected]
Latin America+1 608 276 5659 • [email protected]
Middle East+43 1 333 50 34 0 • [email protected]
Netherlands+31 76 579 55 55 • [email protected]
South Africa+27 11 570 1840 • [email protected]
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Switzerland+41 61 716 77 00 • [email protected]
UK+44 1442 233555 • [email protected]
USA+1 800 532 4752 • [email protected]
www.thermo.com
Laboratory Solutions Backed by Worldwide Service and Support
DXR Raman MicroscopeThe DXR Raman microscope is built on the same platformas the DXR SmartRaman and is designed for the user whoneeds the excellent spatial resolution and power ofRaman microscopy without necessarily needing the highthroughput capacity of the Almega XR. Like the DXRSmartRaman, the DXR Raman microscope is easy to maintain in top performance condition and can be configured with up to three excitation frequencies.
NXR FT-Raman SeriesThe Nicolet NXR FT-Raman spectrometer uses 1064- or 976-nm excitation lasers for radical reduction in fluorescence interference. With the most extensive sampling accessories available, including the FT-RamanMicroStage for microscopic analysis, the NXR FT-Ramanspectrometer can be configured either as a dedicated,stand-alone system or as an accessory for FT-IR spectrometers.
Nicolet Almega XRThe Thermo Scientific Nicolet™ Almega™ XR is a high-performance dispersive Raman spectrometer. Fully automated and with micro and macro sampling combinedin one instrument, the Almega XR offers the ultimate inperformance, automation and flexibility. The Almega XR is ready for any sample and meets the needs of even themost demanding applications.
The Thermo Scientific Family of Raman Spectrometers
We offer the world’s largest collection of commerciallyavailable Raman libraries. Over 18,000 compoundsare available in libraries covering polymers, organics,inorganics, pharmaceutical compounds, illicit drugsand controlled substances. Raman spectral librariesare integrated into Thermo Scientific OMNIC andOMNIC Specta software, giving you the ability toaccurately identify and characterize your most challenging samples.
Thermo Scientific Raman Spectral Libraries
DXR Smart Raman spectrometer is patented by US Patents 6,661,509 B2, 7,460,229 B2, 7,345,760 B2, 7,471,390 B2, and 7,233,870 B1. Other patents pending.
