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Musketeers Course 2012
In Course Presentation
Yogyakarta, May 2th, 2012
Tenri A.W.
MAJOR CONCEPT
“The BIG IDEA”
MAJOR CONCEPT
WHAT IS DENDRITIC CELL?
DENDRITIC CELL (DC)IS AN ANTIGEN PRESENTING CELL (APC)
DC IS EXPRESSING SEVERAL PATTERN-RECOGNITION RECEPTOR(PRR), INCLUDING TOLL-LIKE RECEPTOR (TLR)
MAJOR CONCEPT
ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
TOLL-LIKE RECEPTOR
TLR, LIGAND, AND ADJUVANT
(DUIN ET AL., 2006)
ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
TLR SIGNALING PATHWAY
TLR SIGNALING PATHWAY
SIGNALING MOLECULE
PHOSPORILATION CASCADE
TRANSCRIPTION FACTOR
ACTIVATION
CYTOKINE SECRETION
TLR SIGNALING PATHWAY (CONT)
TLR SIGNALING INDUCE CCR7 EXPRESSION
TLR SIGNALING UPREGULATE MHC II AND CO-STIMULATORY MOLECULE
ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
DC PRESENT ANTIGEN TO NAÏVE T CELL
DC INDUCE BOTH CD 4 & CD 8T CELL ACTIVATION
DC INDUCE CD 4 T-CELL DIFFERENTIATION
IN MOST CASE, VIA TLRACTIVATION, INDUCE
DEVELOPING T HELPER 1 RESPONSE
(TRINCHIERY, 2003)
TH 1 CELL in INTRACELLULAR DEFENSE
TH 1 INDUCE Ig G, NK CELL, MACROPHAGE AND OTHER CELL ACTIVATION IN INTRACELLULARDEFENSE MECHANISM
MAJOR CONCEPT
VACCINE IN INFECTIOUS DISEASE
MYCOBACTERIUM BCG VACCINE
• BCG VACCINE IS USING TLR 2 AND TLR 4 – MYD88 PATHWAY
TLR 2 - TLR 4 – MYD88 PATHWAY
VACCINE IN MELANOMA CANCER
• MELANOMA CANCER VACCINE IS DNA VACCINE, USING TLR 9 – MYD88 PATHWAY
PRINCIPLE OF TLR SIGNALING
THANK YOU TO THESE GUYS
MAJOR CONCEPT
SUMMARY