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Case Study II
Modular Bio Containment facility
BSL 3 Seed LabThomas [email protected]+49 172 610 11 81
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The Case
BSL 3 Seed Lab Client is Confidential Location: Europe Reasons to choose modular approach:
Fast track realisation, start up before the next vaccination campaignstarts in autumn
Removable building: in case of an outbreak, the building could be
moved to e.g. Spain
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Overview
BSL 3 Seed Laboratory within 6 months
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Planning (artist view made by our visualisation department)
Realisation
. .
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Layout, Cleanroom classes
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Layout, pressure levels
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Shell in shell system
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Construction
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Requirements
Several regulations have to be considered in the design:e.g. DIN/EN Norms, GenTSV, EN 1717, DIN 1946 part 7, ..
First objective: protection of the staff and environment
Method: Disinfections, HAVC, procedures, Controlled access Method: Locked doors and windows, interlocking, card reader, code
switches
Person protection by visible workplaces Method: doors with windows, walls with windows
Smooth surfaces, easy to clean Method:pool design, pvc welded on floors and wall, trespa ceiling
Personnel safety equipment
Safety procedures Method: SOPs, touch less taps, emergency shower, eye shower, towel
and disinfection dispenser
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Requirements
Waste treatment Method: double door decontamination autoclave, kill tank, H13 filters
Disinfection of working table tops
Method: curb on table tops, water retention on the floor, no floor drains Fire protection
Method: F90 Building, F30 Windows, fire extinguisher, no sprinkler,floor curb at the entrance, problem to keep underpressure
Drinking water protection Method: water line separation valve
Hermetic closure of the building in case of an emergency fumigation
Emergency power supply for ventilation, illumination, emergency call andcommunication systems Two escape routes
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Decontamination Autoclave
Media connectionsMinimised, centralised,In separate insulated panels
roomsPVC on walls and floor,Trespa on the ceiling
roomsFumigation with H2O2, triple
glas windows,Shell-System fumigation withformaldehyde
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HVAC
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Police filter H13Fumigation withformalin
Waste air incinerationFor kill tank
Pressureregulator
For small roomswith a water valve
Volume control valvesAll installed in the technicalarea
Shell-Filter H13
Fumigation with formalin
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Fumigation with H2O2
Disinfection procedure 10 pages word document! VHP compatibility: Steris-Bioquell(see also: http://www.bioquell.com/)
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Time schedule
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Time Schedule
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Cost benchmarks
Transport;
50.000,00;
4%
Engineering
/ Hours;
185.000,00;
13%
Equipment;
1.184.725,0
0; 83%
Modules;
620.000,00;
52%
HVAC;
350.000,00;
30%
Waste
Water
Treatment;
96.500,00;8%
Decontamin
ationAutoclave;
82.500,00;
7%
Monitoring;
30.925,00;
3%Lab
Furniture;4.800,00;
0%
1,4 Million Euro
5,400 /m
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Questions ?