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Lecture 9 Slides

LIPIDCATABOLISM

lipid menagerie

phospholipid

triglyceride

from McDonalds to Metabolism…

fig17-1

from McDonalds to Metabolism…

The chylomicron: a lipoprotein

fig17-2

mobilization ofglycerol

fig17-4

fig17-5

connecting the FAto CoA-SH

fig17-5

connecting the FAto CoA-SH

goodleavinggroup

fig 19-1

Carnitine: Charon* of the matrix!

* you know, the boatman on the River Styx

Carnitine: Charon* of the matrix!

* you know, the boatman on the River Styx

fig17-6

Transport of acyl-carnitine into the matrix

rate-limiting step for oxidation of FAs

oxidation offatty acids:three steps,one new…

fig17-7

b-oxidation:taking ittwo carbonsat a time

fig17-8

fig17-8

iterated metabolic pathway

b-oxidation challenges…

monounsaturated FA

odd-carbon FA

b-oxidation challenges…

monounsaturated FA

polyunsaturated FA

odd-carbon FA

b-oxidationof a mono-unsaturatedfatty acid

fig17-9

b-oxidation challenges…

monounsaturated FA

polyunsaturated FA

odd-carbon FA

what about3-carbonleftovers?

fig17-11

what about3-carbonleftovers?

fig17-11

fig 17-11

what about3-carbonleftovers?

the coenzyme B12 reaction

box17-2

deoxyadenosylcobalomin orcoenzyme B12

box17-2

box17-2

comparisonof FA oxidationmitochondriavs.peroxisomes

box17-13

catalase

fatty acidmetabolismin seeds…

fig17-14

enzyme evolution in fatty acid oxidation

fig17-15

oneprotein

ketone bodies

fig17-16

fig17-18

formationof ketone bodies fromAc-CoA

formation of ketone bodies from Ac-CoA

fig17-18

formation of ketone bodies from Ac-CoA

fig17-18

formation of ketone bodies from Ac-CoA

fig17-18

fig17-18

formation of ketone bodies from Ac-CoA

metabolism of a ketone body

fig17-19

fig17-19

fig17-19

fig17-19

liver synthesis of ketone bodies when TCA activity is low

fig17-20