BIOC 401

Topics In Biochemistry

Blood Sample To Detect Breast Cancer

Cancer is actually a group of many related diseases that all have to do with cells. Cells are the very small units that make up all living things, including the human body. There are billions of cells in each person's body.

What is the cancer?

Cancer cells usually group or clump together to form tumors. A growing tumor becomes a lump of cancer cells that can destroy the normal cells around the tumor and damage the body's healthy tissues. This can make someone very sick.

Sometimes cancer cells break away from the original tumor and travel to other areas of the body, where they keep growing and can go on to form new tumors. This is how cancer spreads.

More common types of cancer

Lung cancer

Liver cancerStomach cancer

Breast cancer

Breast cancer is a malignant tumor that starts from cells of the breast. A malignant tumor is a group of cancer cells that may invade surrounding tissues or spread to distant areas of

the body .

Breast cancer?

Most breast cancers begin in the cells that line the ducts (ductal cancers). Some begin in the cells that line the lobules (lobular cancers), while a small number start in other tissues.

Kind of Breast cancer? There are to kind of breast cancer

Benign Breast cancerMalignant Breast cancer

Symptoms of Breast Cancer

How To Detect Breast Cancer??

Currently, doctors rely on triple testing : breast examination, imaging with mammography and ultrasonography, and biopsy - to pick up these tumors.

Mammogram or Ultrasound BiopsyTo check the lump

In The Biochemistry Laboratory..

Many analysis done in the patient sample like hormone

and protein

Comes specimens for laboratory

Blood plasma is an easily accessible source of proteins which have diagnostic value, as it is in contact with practically all tissues in the human body.There are many protein in plasma was marker for breast cancer in

patient .

In the plasma..

Ca 15-3 Ca 19-1Ca 125 ll

Protein ?? This there protein marker

for breast cancer

Elecsys is machine

detect the protein in

plasma Ca 15-3 , ca

19-1 , ca 125ll

Breast cancer .. Blood test hope..

A new study by researchers from University College London says a simple blood test may detect breast cancer early before it shows up on a mammogram.

Unlike mammograms, which give false positives 10% of the time and false negatives about 20% of the time.

The blood test measures proteins in the blood and may detect changes in the levels caused by cancer.

The method analyzes specific proteins and these proteins tell us what is going on with the patient in terms of the disease and how the disease is playing out on the patient.

This gene, which was named mammaglobin, encodes a protein of 93 amino acid units

with a predicted molecular mass of 10.5 kd. Mammaglobin is a member of the

uteroglobin gene family

…Mammaglobin

Protein

Secreted by breast tumor cells

School of Medicine researchers have shown that mammaglobin, a protein secreted by breast tumor cells, can readily be detected in the blood serum of patients with metastatic breast cancer using an inexpensive, reliable clinical test.

They have tested this technique on 56 women without breast cancer and 26 women with metastatic breast cancer .

The results showed that women without breast cancer were found to have a steady, low level of mammaglobin in their blood.

This baseline level was not affected by age, body mass index, menopausal status, race, smoking history or a family history of breast cancer.

the women with metastatic breast cancer had on average much higher readings of mammaglobin than the baseline level.

Compared to the few other known biomarkers linked to breast cancer, mammaglobin is the best. The protein is found in breast tissue and is secreted by most breast tumors."

This technique, less intrusive, safer and much less expensive approaches for the early diagnosis of cancer, for distinguishing malignant and benign cancers, and for monitoring cancer therapy.

Ratio City22% Alshrgeah

17.5% Riyadh13% Makkah

7% Tabuk4% Qassim.

20%of Saudi women suffer from breast cancer

More than 40% of Saudi women living with breast cancer do not detect the disease only in very advanced stages of the third stage.

Thank you to lessen

We will not forget thanked Miss: Nasreen Tarabay

http://record.wustl.edu/news/page/normal/6133.html http://news.bbc.co.uk/1/hi/health/5244764.stm http://cancer.about.com/b/2006/08/06/new-blood-test-may-

help-detect-breast-cancer-early.htm h http://www.breastcancer.org/ http://www.breastcancer.org/ http://www.cancer.org/docroot/CRI/content/CRI_2_6x_How

_to_perform_a_breast_self_exam_5.asp http://www.patentstorm.us/patents/5922836/description.ht

ml http://www.patentstorm.us/patents/5922836/description.ht

ml http://images.google.com/images?ndsp=18&um=1&hl=ar

&rls=CYBA,CYBA:2008-49,CYBA:en&q=lab+biochemistry&start=126&sa=N

http://www.breastcancer.org/symptoms/testing/self_exam/bse_steps.jsp

http://www.newson6.com/Global/story.asp?S=8802077&Call=Email&Format=HTML

Reference:

Student name… Wafaa Bokhary 0523687Amera Al malki 0523527Amjad Alsalmi 0523668Mezna Albogami 0523592