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Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

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Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1
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Page 1: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Transcranial Magnetic Stimulation (TMS)

Peter P. Ricci

Biomedical Engineering

BME 281 Section 1

Page 2: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Background

Depression•Affects 350 million people on a daily basis

•The leading cause of disability worldwide and a major contributor to the global number of mental disorders

•Can develop at any age, but has a median onset of 35 years old

Page 3: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Introduction• TMS is the process of using a magnetic generator to

stimulation the brain cells that control mood

• Early clinical implementation has shown the ability to treat the effects of major brain damage and mental disorders

• Neurological Disorders

– Stroke symptoms

– Depression

– Motor neuron disease

Page 4: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Process1. A magnetic field generator, or coil, is placed near the desire

part to the brain

2. The coil then produces electric currents just above the head

3. The coil is attached to a pulse generator, which alternates the flow of the electric currents

1. The currents stimulate the neurons of the limbic system to control mood

Page 5: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Chervyakov, Alexander. “Possible mechanisms underlying the Therapeutic effects of transcranial magnetic stimulation.” Frontiers in human neuroscience 2015; 9: 303. Jun 16 2015

Page 6: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Clinical Study

• Research comprised of 24 drug resistant patients that were diagnosed with recurrent major depressive disorder

• Patients received daily TMS treatments for 4 weeks

• Patients were then split into two groups in which one received continual maintenance over a 12 month period while the other only received the initial treatment

Page 7: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Results

• Results displayed a significant reduction in HDRS scores for all patients involved

• Patients receiving follow-up maintenance showed even greater improvements

Page 8: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Results

Patients with TMS

Maintenance

Patients without TMS Maintenance

Baseline HDRS 23.83 23.50

Post TMS HDRS 9.83 9.92

6 month follow-up 9.33 13.75

12 month follow-up 12.92 16.17

Rapinesi, Chiara. “Maintenance Deep Transcranial Magnetic stimulation sessions are associated with reduced depressive relapses” Frontiers in Neurology 2015: 9: 16. Feb 6 2015

Page 9: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Advantages & Disadvantages

BlackHawk TMS <http://www.blackhawktms.com/transcranialmagneticstimulation/tms-side-effects.php

Page 10: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Future Implementation

• Research into the effects of debilitating brain injuries– i.e. stroke & motor neuron disease

• Treatment for numerous mental disorders– Hopefully a sustainable cure for depression

Page 11: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

Questions?

Page 12: Transcranial Magnetic Stimulation (TMS) Peter P. Ricci Biomedical Engineering BME 281 Section 1.

References

1. Chervyakov, Alexander. “Possible mechanisms underlying the Therapeutic effects of transcranial magnetic stimulation.” Frontiers in human neuroscience 2015; 9: 303. Jun 16 2015

1. Wikipedia: transcranial magnetic stimulation <https://en.wikipedia.org/wiki/Transcranial_magnetic_stimulation>.

1. Rapinesi, Chiara. “Maintenance Deep Transcranial Magnetic stimulation sessions are associated with reduced depressive relapses” Frontiers in Neurology 2015: 9: 16. Feb 6 2015

1. BlackHawk TMS <http://www.blackhawktms.com/transcranialmagneticstimulation/tms-side-effects.php >


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