Trends in Technology and Applications

Dr. Manfred Kircher Chairman CLIB2021

January 13th, 2010

OECD Workshop on the Outlook on Industrial Biotechnology Vienna

State of the Art

Emerging Trends

Priorities

Coordinating the Development

Supporting Measures by Governments and Industry

Biotechnology is Key

in Biobased Production

Oils & Fats

Starch

Cellulose

Saccharose

Other

Fossil Oil

80%

Coal

8%

Natural Gas

2%

BioRenewable

Feedstocks

10%

0 5 10 15 20 25

bio $

15 % Products from

Chemical Processes

10 % BioCatalytic

Microbes & Enzymes

75 % Products

from Biotech-Processes

30 bio $; USA (2007) USITC publication 4020: „Industrial Biotechnology:

Development and adoption by the US Chemicals and Biofuel industries“ July 2007 Germany 2008; Source: VCI

85% Bio-based Chemical Sales

Based on Biotechnology

2 mio t/a BioRenewable Feedstocks

are Exploited by the Chemical Industry

0 5 10 15 20 25 30 35 40 45 50

Annual Sales of the German Chemical Industry (€ bio; 2007)

Blue: Biotechnological products established

Source: VCI 2009

Polymers

Pharmaceuticals

Fine & Special Chemistry

Petrochemicals and Derivates

Detergents & Bodycare

Anorg. Basic Chemistry

Biotechnology is Established

in the Chemical Industry…

94%

ChemoProducts

6%

BioProducts

..but still a Niche

Midwest Lysine LLC, Blair Neb.USA

Available only by Biotechnology:

L-Lysin for Feed, Food & Pharma

aqueous

waste

raw mat.

reaction

desodor.

bleaching

drying

filtration

packing

volatile

comp.

aqueous

waste

solid

waste

Conventional

> 180°C

140°C

100°C

60°C

20°C

temperature

catalyst

recycled

Enzymatic

reaction

raw mat.

packing

Biotechnology is More Competitive:

Emmolients (Cosmetic Esters)

catalyst

bleach

steam

Most established Processes

are pure BioCatalysis

BioRenewable Feedstock

BioCatalysis

Product

Current Industrial Biotechnology

is Based on Pathways given by Nature

Amino acids

Organic acids

Fuels

&

Solvents

Biotechnological Products

are established in higher value business segments

Feedstock BioCatalysis Products

Strengths & Weaknesses

• theoretical productivity & yield

not fully exploited

• insufficient genetic stability

• enzymatic catalysis

limited to hydrolases

• product removal & purification

costly

• insufficient

feedstock

flexibility

• limited to

biological

products

• limited to

natural pathways

State of the Art

Emerging Trends

Priorities

Coordinating the Development

Supporting Measures by Governments and Industry

Biorenewable Feedstocks Compete

with Petrochemical Carbon Sources

OHOH

O

O

CH2

OHCH

3

O

O OO

OH

OH OH

OH

OHOH

OH

OH

OH

OH

OH OH

OH

OH

OH

OHOH

O

OO

OH

O

OH OH OH

O

OHOH

O

ONH2

OHOH

O

OH

OH

OH

OH

O

OH OH

O

NH2

O

succinic acid 3-hydroxypropionic

acid

2,5-furandicarboxylic

acid

aspartic acid glutamic acidglucaric acid

itaconic acid

glycerol

levulinic acid

sorbitol

3-

hydroxybutyrolactone

xylitol

Fig. 2 DOE „TOP12“ Platform Chemicals from

Carbohydrates [8]

Organic Chemicals

Pharmaceuticals

Fine & Specialty Chemistry

Detergent & Hygiene Chemicals

Polymers

Petrochemicals & Derivatives

Agrochemicals

Corn

The Chemical Industry

gets ready for launching the KBBE

Company Carbon Source BioProduct Product

Braskem

BRA Sugar

Ethanol

200 kt Ethylene

HDPE 2010

Perstorp

SWE Starch/Sugar 3-Hydroxy-

propionic acid

(meth)acrylic acid/

1,3-PDO 2012

Isoprene Rubber 2013

Dow/Crystalsev

BRA Sugar

Ethanol

350 kt

Ethylene

HDPE

2011

Solvay Indba

BRA Sugar

Ethenol

60 kt

Ethylene

PVC 2010

Genencor/Goodyear

USA

Corn cobs

Switchgras

Genomatica

USA Sucrose 1,4-butanediol Platform chemical 2010

03/2009

12/2008

09/2008

09/2008

12/2007

07/2007

Press

Release Launch

0 5 10 15 20 25 30 35 40 45 50

Annual Sales of the German Chemical Industry (€ bio; 2007)

Blue: Biotechnological products established

Blue checkered: Early biotechnological products on the market

Source: VCI 2009

Polymers

Pharmaceuticals

Fine & Special Chemistry

Petrochemicals and Derivates

Detergents & Bodycare

Anorg. Basic Chemistry

BioCatalysis Enters Production

of Polymers

94%

ChemoProducts

6%

BioProducts

Biotechnology and Chemistry

Complement one another

BioRenewable Feedstock

BioCatalysis

Chemistry BioProduct

Product Intermediate

OH HO

H

OH

H OH H

H OH O

H

HO HO

OH

O~ P HO

OH

OH HO OH O

OH HO

OH HO

Escherichia coli

Klebsiella

pneumoniae

Saccharomyces

cerevisiae

1,3 PDO

Technology Push

by Synthetic Biology

Today Biotechnology is based on

Agricultural Carbon Sources

+ aerob fractionation

30%

70% of Biomass Carbon

BioEnergy Markets

will be Dominant

EU

USA

BRA

0

50

2004 2005 2006 2007 2008

Bioethanol-Plant Pischelsdorf

2004 2005 2006 2007 2008

40

30

20

10

0

50

Bioethanol Production

[mio m³]

Germany:

Bioethanol Consumption 2008-2009 +61%

Lignocellulose

is not yet Competitive

+

+

30%

aerob

fractionation

fractionation

aerob

70% of Biomass Carbon

+

80% of Biomass Carbon

20%

Syngas Fermentation

may Provide C4-Platform Chemicals

„Our collection of various acetogens from a variety of diverse ecological niches is a great pool of

genes essential for engineering of microbial catalysts

fermenting syngas to linear (4 - 5 carbons and up) or cyclic carbon backbone

Syngas Biofuels Energy, Inc. Houston 25.8.2009

CO2

CO

H2

Gasification

99 % Carbon Yield

+

+

Total Carbon Share

20-30%

aerob

fractionation

gasification

fractionation

aerob

anaerob

Total Carbon Share

70-80%

+

Total Carbon Yield

>99%%

Biotechnological Products

enter high volume & bulk business segments

Feedstock BioCatalysis Products

Options & Challenges

• availability of „chassis“ cells

• standardization of metabolic modules

• high-through-put (HTP)

cell engineering and screening

• continuous processes

• in situ product recovery (ISPR)

• integration of bio- and chemical

processes

• anaerobic processes and reactors

• economics of

lignocellulosic

carbon sources

• transformation

of syngas

• bioproducts

• precursors for

chemical

production

State of the Art

Emerging Trends

Priorities

Coordinating the Development

Supporting Measures by Governments and Industry

Priorities

• Biological Catalyst – synthetic biology

whole cell and enzymatic catalysis

• Process – continuos processes

– anaerobic processes

– in-situ product recovery (ISPR)

– bio-/chemo process-integration

– process flexibility in biorefineries

• Product Evaluation – standardized life cycle analysis (LCA)

State of the Art

Emerging Trends

Priorities

Coordinating the Development

Supporting Measures by Governments and Industry

Sugar cane

Soy

Corn

Seed

Consumer

Value

Value Chain

Microbial

intermediates

Fatty

acids Plant biomass

Industrial Biotechnology:

Cooperation all over the Value-Chain

Enantiomerically

pure drug

Polyurethane

Polylamides Succinic acid

Amino

Acid

Adhesives Adhesive

Peptides

Lignocellulose

Butanol

Ethanol

Super

absorber

Plastics

Butadiene

Acetaldehyde

Acrolein

Chemical products

Pyridines

Acrylic Acid

Food Additives

Agro-Industry

Feedstock-Supplier

Chemical Industry

Consumer Industries

Diaper

Yoghurt

Cosmetic

Bottle

Wood

Energy

Syngas

C5 Sugars

C6 Sugars

Lignin

Industry 8

SME 34

Academia 13

Investors 5

Infrastructure 10

BioProcess; 14

BioProducts; 11

Equipment; 4

Patents; 2

Consulting; 1Data&Studies; 1

Lawyer; 1

Hachured segments: international members

Industry 8

SME 34

Academia 13

Investors 5

Infrastructure 10

Members of CLIB2021

Include all Stakeholders

State of the Art

Emerging Trends

Priorities

Coordinating the Development

Supporting Measures by Governments and Industry

Supporting Measures

• Financing

– setting off R&D expenses

– public promotion of demo-plants

• Cooperation

– promote partnering in clusters

– promote R&D partnering in prioritized fields

• both by governments and industry

• Training

– promote international exchange of graduates

• in academia and industry

thank you for your attention !