Tricia Ann Thornton-Wells Curriculum Vitae · 2010-2011 Vishal Gandi, Ph.D. Dissertation Committee...

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Tricia Ann Thornton-Wells Curriculum Vitae

Center for Human Genetics Research Vanderbilt University 519 Light Hall Nashville, TN 37232 615.343.5851

2009 Linden Avenue Nashville, TN 37212

615.310.7372 [email protected]

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EDUCATION and TRAINING 1991-1995 Vanderbilt University, B.A. (Philosophy) 2000-2005 Vanderbilt University, M.S. (Biomedical Informatics)

Thesis Title: Comparison of Three Clustering Methods for Dissecting Trait Heterogeneity in Simulated Genotypic Data

2000-2006 Vanderbilt University, Ph.D. (Neuroscience) Dissertation Title: Confronting Complexity: A Comprehensive Statistical and Computational Strategy for Identifying the Missing Link between Genotype and Phenotype

2007 Functional MRI Visiting Fellowship, Athinoula A. Martinos Center for Biomedical Imaging, Mass Gen Hospital, Harvard-MIT, Boston, MA

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APPOINTMENTS and POSITIONS

ACADEMIC: 2000-2006 Graduate Research Assistant (Statistical Genetics & Bioinformatics)

Mentors: Jonathan L. Haines, Ph.D. and Jason H. Moore, Ph.D. Department of Molecular Physiology and Biophysics Center for Human Genetics Research Vanderbilt University, Nashville, TN

2006-2009 Postdoctoral Fellow (Neuroimaging / Neurodevelopment) Mentors: Elisabeth Dykens, Ph.D. and John Gore, Ph.D. Biobehavioral Intervention Training Program Vanderbilt Kennedy Center for Research on Human Development Vanderbilt University Institute of Imaging Science Vanderbilt University, Nashville, TN

2009-2010 Research Instructor Center for Human Genetics Research Division of Human Genomics, Dept. of Molecular Physiology & Biophysics Vanderbilt University, Nashville, TN

2010-Pres Assistant Professor (tenure-track) Center for Human Genetics Research Division of Human Genomics, Dept. of Molecular Physiology & Biophysics Department of Biomedical Informatics Vanderbilt University, Nashville, TN

Tricia A. Thornton-Wells, Ph.D. December 2014

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2013-Pres Core Director Core C, Statistical and Methodological Services The Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center; Vanderbilt Kennedy Center Vanderbilt University, Nashville, TN

NON-ACADEMIC: 1996-2000 Quality Improvement Coordinator

Patient Outcomes Research; Database Development & Administration Direct Supervisor: Raymond M. Hakim, M.D. (Chief Medical Officer) Renal Care Group, Inc. (now Fresenius Medical Care), Nashville, TN

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PROFESSIONAL ORGANIZATIONS 2000 - Pres Society for Neuroscience (SFN) 2001 - Pres American Society for Human Genetics (ASHG) 2001 - Pres International Genetic Epidemiology Society (IGES) ____________________________________________________________________________

PROFESSIONAL ACTIVITIES INTRAMURAL ACTIVITIES: 2001-2002 President, Graduate Student Council

2002-2003 Outreach Coordinator, Neuroscience Student Organization

2003-2005 Student Editorial Board, J Am Med Informatics Assoc

2005-2007 Assistant Editor, Vanderbilt University Editors' Club

2007-2008 Editor-In-Chief, Vanderbilt University Editors' Club

2010-2011 Pre-Review Committee Member for Genotyping and Statistical Analysis Plans, Vanderbilt’s DNA Repository (BioVU), Vanderbilt Institute for Clinical and Translational Research

2010 Chair, 11th Annual Genetics Symposium, Vanderbilt Center for Human Genetics Research, October 13, 2010

2011-Pres Scientific Review Committee Member for Vanderbilt’s DNA Repository (BioVU), Vanderbilt Institute for Clinical and Translational Research

2012 Chair of Systems Neuroscience Poster Session for the Vanderbilt Kennedy Center Science Day, February 28, 2012

EXTRAMURAL ACTIVITIES: 2003-Pres Ad-hoc Reviewer for the following peer-reviewed journals:

Alzheimer’s & Dementia, American Journal of Intellectual and Developmental Disabilities, Annals of Human Genetics, BioData Mining, Bioinformatics, BMC Genetics, European Conference on Evolutionary Computation, Genetic Epidemiology, Genomics, Human Brain Mapping, Human Genetics, Human Heredity, Journal of Alzheimer Disease, Journal of Artificial Evolution and


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Applications, Journal of Neurodevelopmental Disorders, Journal of Neuroscience, Machine Learning and Data Mining in Bioinformatics, Magnetic Resonance Imaging, Molecular Genetics and Metabolism, Molecular Psychiatry, Neurobiology of Aging, NeuroImage, Neuropsychiatric Genetics, Pacific Symposium on Biocomputing, Pharmacogenetics and Genomics, PLoS Genetics, PLoS ONE, Psychiatric Research - Neuroimaging

2010 Grant Reviewer, Israel Science Foundation

2010 Ad-Hoc Study Section Member / Grant Reviewer, Neurological, Aging and Musculoskeletal Epidemiology (NAME) Study Section, National Institutes of Health

2010 Reviewer, ASHG/GEON Genetics Concepts in State Science Standards

2011-Pres Review Editor, Frontiers in Statistical Genetics and Epidemiology

2011-Pres Editorial Board Member, Academic Editor, PLoS ONE

2012-2013 Grant Reviewer, Qatar National Research Fund

2012-2014 Grant Reviewer, Alzheimer’s Association Intl Research Grant Program

2013-Pres Committee Member, Down Syndrome Biomarker Initiative (DSBI)

2014-Pres Associate Editor, Journal of Alzheimer’s Disease

OTHER PROFESSIONAL ACTIVITIES: 2012 Scientific Program Committee Member, American Society for Human

Genetics Annual Meeting, San Francisco, CA, November 6-10, 2012.

2013 Scientific Program Committee Member, Alzheimer’s Association International Conference (AAIC), Boston, MA, July 13-18, 2013.

SPECIAL HONORS, AWARDS AND RECOGNITIONS: 2001-2002 NIMH Neuroscience Training Grant Fellowship (T32 MH64913)

2001 Vanderbilt University Graduate School Travel Grant

2002-2006 NLM Informatics Training Grant Fellowship (LMO7450-01)

2002 Vanderbilt University Graduate School Travel Grant

2003 Roger Williams Predoctoral Award Finalist, International Genetic Epidemiology Society

2006-2008 NIH Roadmap for Medical Research Postdoctoral Fellowship, Biobehavioral Intervention Training Program (T32 MH75883)

2008 Vanderbilt Kennedy Center Travel Award

2009 Featured Postdoc Presentation, Vanderbilt Kennedy Center Science Day

2010 Genome Technology Magazine 5th Annual Young Investigators Award

2011 Featured Scientist, Vanderbilt Brain Institute (November 2011)

2012 Invited “Rising Star” Guest, Institute of Medicine Meeting, April 23, 2012, Nashville, TN


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TEACHING ACTIVITIES MEDICAL SCHOOL COURSES: 2002 Teaching Assistant, Biostatistics (IGP 300B), Interdisciplinary Graduate

Program, Vanderbilt University, Nashville, TN.

2002 Lecturer, Biostatistics (IGP 300B), Interdisciplinary Graduate Program, Vanderbilt University, Nashville, TN.

2002 Lecturer, Biostatistics (IGP 300B), Interdisciplinary Graduate Program, Vanderbilt University, Nashville, TN.

2005-2006 Lecturer, Research Methodology, Department of Cancer Biology, Vanderbilt University, Nashville, TN

2007 Adjunct Teacher, School for Science and Math at Vanderbilt, Nashville, TN

2007-2009 Lecturer, Scientific Outreach Program, Vanderbilt University Institute of Imaging Science, Nashville, TN

2010-Pres Lecturer, Human Genetics II (HGEN 341), Graduate Program in Human Genetics, Vanderbilt University, Nashville, TN. (2 lectures; offered each Spring semester)

2011-Pres Lecturer, Systems Biology (BMIF 310), Department of Biomedical Informatics, Vanderbilt University, Nashville, TN (2 lectures; offered every other Spring semester)

2011-Pres Course Director and Lecturer, Genetics of Neurodevelopmental Disorders, Interdisciplinary Graduate Program, Vanderbilt University, Nashville, TN. (5 lectures, 5 class discussions; offered each Spring semester)

2013-Pres Course Co-Director, Special Topics in Human Genetics (HGEN 330), Graduate Program in Human Genetics, Vanderbilt University, Nashville, TN. (3 lectures, 8 class discussions, offered every other Spring semester)

2013-Pres Lecturer, Brain and Behavior, Vanderbilt Medical School, Vanderbilt University, Nashville, TN (1 lecture; offered each Fall semester)

GRADUATE SCHOOL COURSES: 2008 Guest Lecturer, Issues in Developmental Disabilities (PSY2100-1),

Vanderbilt University, Nashville, TN

2013 Guest Lecturer, “Imaging Genetics of Sociability in Williams Syndrome,” Psychology Graduate Seminar, Vanderbilt University, Nashville, TN

2014 Guest Lecturer, “Williams Syndrome: Genetics & Cognitive Science,” Educational & Cognitive Neuroscience (PSY3690), Vanderbilt University, Nashville, TN

UNDERGRADUATE SCHOOL COURSES: 2014 Guest Lecturer, “Experienced Reality and Concept of Self in Individuals with

Neurodevelopmental Disorders,” Psychology Undergraduate Honors Seminar, Vanderbilt University, Nashville, TN


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2014-Pres Course Director & Lecturer, Neurogenetics: Special Topics in Neuroscience (NSC 285), Interdisciplinary Program in Neuroscience, College of Arts & Science, Vanderbilt University, Nashville, TN. (41 lecture hours; offered each Fall semester)

2014-Pres Guest Lecturer, “Genomics and Personalized Medicine,” Biological Sciences 105, Vanderbilt University, Nashville, TN (1 lecture; offered each Fall semester)

RESEARCH SUPERVISION: Mentor/Advisor Roles

2007-2009 Laura Keppley – currently Undergraduate at Eastern Mennonite University Mentor, High School Science Fair Projects

Regional Science Fair Award Winner & Penn State Scholarship Recipient Christopher Dock High School, Lansdale, PA

2007-2009 Liam Solus – currently PhD Student in Mathematics at University of Kentucky Co-Mentor, Summer Research Assistant, Vanderbilt Kennedy Center

Undergraduate, Oberlin College, Oberlin, OH

2009-2013 Jennifer Pryweller, Ph.D. – currently Postdoctoral Fellow at St. Jude Children’s Research Hopsital Mentor, Interdisciplinary Ph.D. Program on Neuroimaging of Neurodevelopmental Disorders Vanderbilt University, Nashville, TN

2010-2012 Tracy Porchak, M.S. – currently Program Manager at Vanderbilt University Institute of Imaging Science Co-Mentor, M.S. Student, Master of Laboratory Investigation Program Vanderbilt University School of Medicine, Nashville, TN

2010-2014 Mary Ellen I. Koran, Ph.D. – currently MSTP student at Vanderbilt University Mentor, Human Genetics Ph.D. Program M.D./Ph.D. Medical Scientist Training Program (MSTP) Vanderbilt University School of Medicine, Nashville, TN

2011-2013 Jennifer N. Vega – currently Ph.D. candidate at Vanderbilt University Mentor, Ph.D. Candidate, Systems Neuroscience Graduate Program Vanderbilt University, Nashville, TN

2012-2013 Mike Sivley – currently Ph.D. student in Biomedical Informatics at Vanderbilt Co-Mentor, M.S. Thesis Student, Computer Science Graduate Program Vanderbilt University, Nashville, TN

2012-2014 Timothy J. Hohman, Ph.D. – currently Research Instructor, Department of Neurology, Vanderbilt University Medical Center Mentor, Postdoctoral Research Fellow, NIMH Neurogenomics Training Program; PhRMA Found. Postdoc in Translational Medicine & Therapeutics Vanderbilt University, Nashville, TN

2012-2014 Laura D’Aoust, Ph.D. – currently MSTP student at Vanderbilt University Co-Mentor, Human Genetics Ph.D. Program M.D./Ph.D. Candidate, Medical Scientist Training Program (MSTP) Vanderbilt University, Nashville, TN


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2013 Courtney M. Edwards – currently undergraduate student, Hampton University Mentor, Vascular Biology Short-Term Training Program Vanderbilt University, Nashville, TN

2013-2014 Jordan Plaxico, B.A. – currently Graduate Student at Vanderbilt University School of Nursing Co-Mentor, Undergraduate Honors Thesis Student in Psychology Vanderbilt University Summer Research Program Vanderbilt University, Nashville, TN

2013-2014 Uzoamaka Ugochukwu, B.S. – currently Medical student at Vanderbilt Univ. Mentor, Medical Student Biomedical Research Project Vanderbilt University, Nashville, TN

2014 Jarryd Rigby – currently undergraduate student, University of Melbourne Mentor, Vanderbilt International Scholars Program Vanderbilt University, Nashville, TN

2014-Pres Jacob Hall, B.S. (Co-Mentor) Ph.D. Student in Human Genetics Ph.D. Program Vanderbilt University, Nashville, TN

2014-Pres Nicole Restrepo, B.S. (Co-Mentor) Ph.D. Student in Human Genetics Ph.D. Program M.S. Student in Interdisciplinary Biostatistics Graduate Program Vanderbilt University, Nashville, TN

2014 Matt Oetjens, Ph.D. – currently postdoctoral fellow at University of Michigan Co-Mentor, M.S. Student in Interdisciplinary Biostatistics Graduate Program Vanderbilt University, Nashville, TN

Thesis/Dissertation Committees

2010-2011 Vishal Gandi, Ph.D. Dissertation Committee Chair, Human Genetics Ph.D. Program Vanderbilt University School of Medicine, Nashville, TN

2010-2013 Olivia Veatch – currently Postdoctoral Fellow at Vanderbilt University Dissertation Committee Chair, Human Genetics Ph.D. Program Vanderbilt University School of Medicine, Nashville, TN

2012 Ryan Urbanowicz – currently Postdoctoral Fellow at Dartmouth College External Examiner, Graduate Program in Genetics; Neukom Institute Fellow

Dartmouth Medical School, Hanover, NH

2012-2014 Joshua Hoffman Dissertation Committee Member, Human Genetics Ph.D. Program Vanderbilt University School of Medicine, Nashville, TN

2012-2014 Matt Oetjens, Ph.D. Dissertation Committee Member, Human Genetics Ph.D. Program Vanderbilt University School of Medicine, Nashville, TN

2012-2013 Carrie Buchanan Moore, Ph.D. – currently MSTP Student at Vanderbilt Univ. Dissertation Committee Member, Human Genetics Ph.D. Program, Medical Scientist Training Program Vanderbilt University School of Medicine, Nashville, TN


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2012-2014 Laura D’Aoust, Ph.D. – currently MSTP Student at Vanderbilt Univ. Dissertation Committee Chair, Human Genetics Ph.D. Program, Medical Scientist Training Program (MSTP) Vanderbilt University, Nashville, TN

2013-Pres Laura Wiley Dissertation Committee Member, Human Genetics Ph.D. Program, Biomedical Informatics M.S. Program Vanderbilt University, Nashville, TN

2014-Pres Brittany Hollister Dissertation Committee Member, Human Genetics Ph.D. Program Vanderbilt University, Nashville, TN

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RESEARCH PROGRAM Active Funding

2011-2014 Vanderbilt Kennedy Center Hobbs Discovery Award $27,840 “Novel MRI biomarkers for early detection of Alzheimer pathology in Down syndrome” Role: Principal Investigator

2013-2014 National Institute for Child Health & Human Development P30 HD015052 Eunice Kennedy Shriver Intellectual and Developmental Disability Research

Center, Core C: Statistics & Methodology Services PI: Elisabeth M. Dykens, Ph.D. (VU Psychology/Pediatrics/Psychiatry) Role: Director, Statistical & Methodology Services Core 2014-Pres National Institute of Mental Health R01 MH095621 “Iron and Mitochondrial Genomics in Neuro-Inflammation and HIV-Associated

Neurocognitive Disorders (HAND): A CHARTER Study” PI: Todd Hulgan, M.D., M.P.H. (VU Medicine) Role: Co-Investigator (Statistical Genetics) 2014-Pres Amercian Heart Association “Characterization of variants in PTGER3 genes as novel markers of

cardiovascular risk” PI: Olivier Boutaud, Ph.D. (VU Pharmacology) Role: Co-Investigator (Statistical Genetics) 2013-Pres National Institute of Mental Health R01 MH064735-08 “1/4-Prevention of Depression: Impact on the Transition to Early Adulthood” PI: Judy Garber, Ph.D. (VU Psychology/Psychiatry) Role: Co-Investigator (Statistical Genetics) 2014 –Pres Department of Defense Investigator Initiated Grant “VIPER II: Chronic Pain after Amputation: Inflammatory mechanisms, novel

analgesic pathways and improved patient safety” PI: Andrew D. Shaw, M.D. (VU Anesthesiology) Role: Co-Investigator (Statistical Genetics)


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Funding Applications In Progress

Pending Phase I Small Business Innovation Research Grant ”Whole-genome analysis methods for accurate Alzheimer’s risk prediction” PI: Ellen McRae, Ph.D. (Parabon Nanolabs, Inc.) Role: Alzheimer’s Disease Statistical Genetics Consultant Dec 2014 Subm Resubmission of BC140860 (scored 2.3 out of 5 in first submission) CDMRP-Breast Cancer Research Program Breakthrough Award (Level 1)

“Personalized Cognitive Intervention for Breast Cancer Survivors” Role: Principal Investigator Jan 2015 Subm RFA-AG-15-011 – NIA/NICHD “Biomarkers of Alzheimer’s Disease in Down Syndrome” Role: Co-Principal Investigator (Co-PI: Paul Newhouse)

Jan 2015 Subm NIA/NICHD U54 for Eunice Kennedy Shriver Intellectual and Developmental Disability Research Center, Core C: Biostatistics & Bioinformatics Core

PI: Elisabeth M. Dykens, Ph.D. (VU Psychology/Pediatrics/Psychiatry) Role: Associate Director, Biostatistics & Bioinformatics Core Completed Funding

2007-2008 Vanderbilt Kennedy Center Hobbs Discovery Grant, $24,262 “Williams Syndrome Paradox: Genetic and Neural Bases of Hypersociability and Nonsocial Fears” PI: Jennifer Blackford Role: Co-Investigator

2008 Vanderbilt Institute of Imaging Science Pilot Funding, $3,375 Vanderbilt Inst. for Clinical and Translational Research, $8,623

Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH “Williams Syndrome Paradox: Genetic and Neural Bases of Hypersociability and Nonsocial Fears” PI: Elisabeth Dykens Role: Co-Investigator

2009 Vanderbilt Inst. for Clinical and Translational Research $3,970 Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH “fMRI Study of Auditory Mirror Neuron System in Williams Syndrome” Role: Principal Investigator

2009-2010 Vanderbilt Inst. for Clinical and Translational Research $2000 Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH “Genetics of Aging in Down Syndrome” $2,000. Role: Principal Investigator

2009-2011 National Library of Medicine R01 LM010040-01 “Analysis Tool for Heritable and Environmental Network Associations” PI: Marylyn Ritchie Role: Co-Investigator (Statistical Genetics)

2009-2013 National Human Genome Research Institute 5U01 HG004798-02 “Epidemiologic Architecture for Genes Linked to Environment (EAGLE)” PI: Dana Crawford Role: Co-Investigator (Statistical Genetics)


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2009-2014 National Institute of Mental Health Mentored Clinical Scientist Research Career Development Award, K08 MH085810-01 “A Computational Analysis of Psychiatric Genetics Data: Pathways and Architecture” PI: Kathleen Askland Role: Statistical Genetics Consultant

2010-2012 National Institute on Aging 1P30AG036445-01 “Recruitment of Faculty for Genetic Aging Research” PI: Jonathan Haines Role: Faculty Recruitment Recipient

2010-2011 National Human Genome Research Institute 5U01HG004608-04 “Genome-wide Study of Cataract and Low HDL” PI: Marylyn Ritchie Role: Statistical Geneticist

2011 Vanderbilt Inst. for Clinical and Translational Research $2000 Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH “Novel 3T MRI Scans for Detection of Alzheimer Disease” $2,000. Role: Principal Investigator

2011 Vanderbilt Inst. for Clinical and Translational Research Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH “MRI studies in Williams syndrome: Structure, function and physiology” Role: Co-Investigator

2011-2012 Vanderbilt Inst. for Clinical and Translational Research $1,872 Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH “Exome Genotyping in Caucasians with Alzheimer’s Disease from BioVU” Role: Principal Investigator

2011-2012 Vanderbilt Inst. for Clinical and Translational Research $1,684 Vanderbilt CTSA Grant 1 UL1 RR024975 from NCRR/NIH “Exome Genotyping in African Americans and Hispanics with Alzheimer’s Disease from BioVU” Role: Principal Investigator

2011-2012 Vanderbilt Inst. for Clinical and Translational Research Investigator-Initiated (Type A) Resource Request VR1982, $23,090

“Genetic Polymorphisms and Pain” PI: Stephen Bruehl Role: Co-Investigator

2011-2013 National Institute on Aging 5RC2AG036528-03 “Genome Wide Associate Analysis of Alzheimer’s Disease” PI: Gerard Schellenberg Role: Statistical Geneticist 2012-2013 Vanderbilt Inst. for Clinical and Translational Research Investigator-Initiated (Type A) Resource Request VR4752, $2,000 “A neural basis for atypical auditory processing in Williams syndrome”

Role: Co-Investigator (PI’s Mentor)


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2012-2013 Vanderbilt Inst. for Clinical and Translational Research Investigator-Initiated (Type A) Resource Request VR4752, $5,000 “Neuroimaging of Alzheimer Disease in African Americans”

Role: Principal Investigator 2012-2014 Vanderbilt Inst. for Clinical and Translational Research Investigator-Initiated (Type A) Resource Request VR2610, $48,400 “MRI Biomarkers and Genetic Risk Factors for Alzheimer Disease”

Role: Principal Investigator

PUBLICATIONS AND PRESENTATIONS

PUBLICATIONS: Articles in Refereed Journals (in Chronological Order):

1. Thornton TA, Hakim RM. Meaningful Rehabilitation of the End-Stage Renal Disease Patient. Seminars in Nephrology. 17: 246-252, 1997. PMID: 9165654

2. Thornton TA, Hakim RM. The Relationship Between Quality of Care and Financial Performance in Dialysis: “Doing Well by Doing Good”. Advances in Renal Replacement Therapy. 4: 350-358, 1997. PMID: 9356687

3. Hagan MC, Thornton TA, Zald DH, Pardo JV. Somatosensory processing in the human interior prefrontal cortex. Journal of Neurophysiology 88: 1400-1406, 2002. PMID: 12205161

4. Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Application of Genetic Algorithms to the Discovery of Complex Models for Simulation Studies in Human Genetics. In Langdon WB, Cantu-Paz E, Mathias K, Roy R, Davis D, Poli R, Balakrishnan K, Honavar V, Rudolph G, Wegener J, Bull L, Potter MA, Schultz AC, Miller JF, Burke E, Jonoska N (eds): Proceedings of the Genetic and Evolutionary Computation Conference. New York, Morgan Kaufmann, 1150-1155, 2002. PMID: 23413413, PMC3569849

5. Thornton TA, Haines JL. PowerTrim: An Automated Decision Support Algorithm for Preprocessing Family-Based Genetic Data. American Journal of Human Genetics 72: 1280-1281, 2003. PMID: 12677557, PMC1180279

6. Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Routine discovery of high-order epistasis models for computational studies in human genetics. Applied Soft Computing 4: 79-86, 2004. PMID: 20948983, PMC2952957

7. Thornton-Wells TA, Moore JH, Haines JL. Genetics, statistics and human disease: analytical retooling for complexity. Trends in Genetics 20: 640-647, 2004. PMID: 15522460

8. Thornton-Wells TA, Moore JH, Haines JL. Dissecting trait heterogeneity: A comparison of clustering methodologies applied to genotypic data. BMC Bioinformatics 7: 204, 2006. PMID: 16611359, PMC1525209

9. Bush WS, Thornton-Wells TA, and Ritchie MD. Association Rule Discovery has the ability to Model Complex Genetic Effects. Proceedings of the 2007 IEEE Symposium on Computational Intelligence and Data Mining: 624-629, 2007. PMID: 20953276, PMC2954594


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10. Thornton-Wells TA, Moore JH, Martin ER, Pericak-Vance MA, Haines JL. Confronting Complexity in Late-Onset Alzheimer Disease: Application of Two-Stage Analysis Approach Addressing Heterogeneity and Epistasis. Genetic Epidemiology 32: 187-203, 2008. PMID: 18076107, PMC2804868

11. Thornton-Wells TA, Kim CY, Cannistraci CJ, Eapen M, Anderson A, Gore JC, Blake RR, Dykens EM. Auditory Attraction: Activation of visual cortex to music and sound in Williams syndrome. Am J Intellect Dev Disabil 115: 172-189, 2010. PMID: 20440382, PMC2862007

12. Thornton-Wells TA, Avery SN, Blackford JU. Using novel control groups to dissect the amygdala’s role in Williams syndrome. DevCogn Neurosci 1: 295-304, 2011. PMID: 21731599, PMC3124852

13. Tang B, Thornton-Wells TA, Askland K. Comparative linkage meta-analysis reveals regionally-distinct, disparate genetic architectures: application to biopolar disorder and schizophrenia. PLoS ONE 6(4): e19073, 2011. PMID: 21559500, PMC3084739

14. Arlinghaus LR, Thornton-Wells TA, Dykens EM, Anderson AW. Alterations in diffusion properties of white matter in Williams syndrome phenotype. Magn Reson Imaging 29: 1165-1174, 2011. PMID: 21907520, PMC3199335

15. Avery SN, Thornton-Wells TA, Blackford JU. White matter integrity deficits in prefrontal-amygdala pathways in Williams Syndrome. Neuroimage 59: 887-894, 2012. PMID: 22008369, PMC3254058

16. Han Z, Thornton-Wells TA, Gore JC, Dawant BM. Effect of non-rigid registration algorithms on deformation based morphometry: a comparative study with control and Williams syndrome samples. Magn Reson Imaging 2012. PMID: 22459439

17. Meda SA, Pryweller JR, Thornton-Wells TA. Regional brain differences in cortical thickness, surface area and subcortical volume in individuals with Williams syndrome. PLoS ONE 7(2):e31913, 2012. PMID: 22355403, PMC3280212

18. Pryweller JR, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA. The effect of intellectual ability on functional activation in a neurodevelopmental disorder: preliminary evidence from multiple fMRI studies in Williams syndrome. Journal of Neurodevelopmental Disorders 4: 24, 2012. PMID: 23102261, PMC3502608

19. Meda SA, Koran MEI, Pryweller JR, Vega JN, Thornton-Wells TA. Genetic interactions associated with 12-month atrophy in hippocampus and entorhinal cortex in ADNI. Neurobiology of Aging 34(5): 1518.e9-1518.518, 2013. PMID: 23107432, PMC2570748

20. Rane S, Ally BA, Hussey EP, Wilson TL, Thornton-Wells TA, Gore JC, Donahue MJ. Inverse correspondence between hippocampal perfusion and verbal memory performance in older adults. Hippocampus 23(3): 213-220, 2013. PMID: 23109214, PMC3878078

21. Koran ME, Hohman TJ, Thornton-Wells TA, for ADNI. Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. Human Genetics 133:85-93, 2014. PMID:24026422, PMC3815519

22. Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA. Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes. PAIN 154(12): 2853-2859, 2013. PMID: 23994450, PMC3845348


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23. Koran ME, Hohman TJ, Meda SA, Thornton-Wells TA, for ADNI. Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. Journal of Alzheimer’s Disease 38(1):145-54, 2014. PMID: 24077433, PMC3815519

24. Hohman TJ, Koran ME, Thornton-Wells TA, for ADNI. Interactions between GSK3β and amyloid genes explain variance in amyloid burden. Neurobiology of Aging 35:460-465, 2014. PMID:24112793, PMC3864626

25. Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease (GERAD); Alzheimer's Disease Genetic Consortium (ADGC); Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nature Genetics 45(12): 1452-8, 2013. PMID: 24162737, PMC3896259

26. Samuels DC, Li C, Li B, Song Z, Torstenson E, Clay HB, Rokas A, Thornton-Wells TA, Moore JH, Hughes TM, Hoffman RD, Haines JL, Murdock DG, Mortlock DP, Williams SM. Recurrent tissue-specific mtDNA mutations are common in humans. PLOS Genetics 9: e1003929, 2013. PMID:24244193, PMC3820769

27. Hohman TJ, Koran MEI, Thornton-Wells TA, for ADNI. Epistatic effects among Alzheimer’s Candidate Genes. PLoS ONE 8(11): e80839, 2013. PMID: 24260488, PMC3832488

28. Hohman TJ, Koran MEI, Thornton-Wells TA, for ADNI. Genetic modification of the relationship between phosphorylated tau and neurodegeneration. Alzheimer’s & Dementia 2014 Mar 20. pii: S1552-5260(14)00013-2. PMID:24656848, PMC4169762


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29. Koran ME, Hohman TJ, Vega JN, Pryweller JR, Slosky LE, Crockett G, Villa de Rey L, Edwards CM, Meda SA, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA. Differences in age-related effects on brain volume in Down syndrome as compared to Williams syndrome and typical-development. Journal of Neurodevelopmental Disorders 6(1): 8, 2014. PMID:24713364, PMC4022321.

30. Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M1; United Kingdom Brain Expression Consortium, Johnson AD, Ruiz A, Bihoreau MT, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Hernández I, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, George-Hyslop PS, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Scarpini E, Bonuccelli U, Mancuso M, Siciliano G, Moebus S, Mecocci P, Zompo MD, Maier W, Hampel H, Pilotto A, Frank-García A, Panza F, Solfrizzi V, Caffarra P, Nacmias B, Perry W, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Haines JL, Lathrop M, Pericak-Vance MA, Launer LJ, Van Broeckhoven C, Farrer LA, van Duijn CM, Ramirez A, Seshadri S, Schellenberg GD, Amouyel P, Williams J. Gene-wide analysis detects two new susceptibility genes for Alzheimer’s disease. PLoS ONE 9(6): e94661, 2014. PMID: 24922517, PMC4055488.

31. Koran ME, Thornton-Wells TA, Jahanshad N, Glahn DC, Thompson PM, Blangero J, Nichols TE, Kochunov P, Landman BA. The impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using SOLAR. SPIE J Med Imag 1(1): 014005. doi: 10.1117/1.JMI.1.1.014005

32. Hohman TJ, Koran ME, Thornton-Wells TA, for ADNI. Genetic variation modifies risk for neurodegeneration in biomarker positive individuals. Frontiers in Aging Neuroscience 6:183, 2014. PMID:25140149, PMC4121544

33. Lense MD, Dankner N, Pryweller JR, Thornton-Wells TA, Dykens EM. Neural correlates of amusia in Williams syndrome. PLoS ONE (Accepted).

Books, Book Chapters, Invited Review Articles:

1. Thornton TA, Hakim RM. Rehabilitation of Dialysis Patients: Reexamining the Barriers and the Benefits, in Malluche H, Sawaya P, Hakim RM, Sayegh MH (eds): Updated


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Textbook of Clinical Nephrology, Dialysis and Transplantation. Desenhofen, Germany, Dustri-Verlag, 1999.

2. Moore JH, Thornton TA, Ritchie MD. Basic statistics. In: Dracopoli NC, Haines JL, Korf BR, Moir DT, Morton CC, Seidman CE, Seidman JG, Smith DR (eds): Current Protocols in Human Genetics, New York: Wiley-Liss, Inc., 2003. PMID: 18428338

3. Thornton TA. The DNA donation project. In Lorenzi NM, Ash JS, Einbinder J, McPhee W, Einbinder L (eds): Implementing Health Informatics Systems: Case Studies. New York: Springer Science+Business Media, Inc., 2005.

4. Hodapp RM, Thornton-Wells TA, Dykens EM. Intellectual Disabilities. In Zeneah C (Ed): Handbook of Infant Mental Health, New York: The Guilford Press, 2009.

5. Key APF, Thornton-Wells TA. Brain-based Methods in the Study of Developmental Disabilities: Examples from Event-related Potentials and Magnetic Resonance Imaging Research. In Burack JA, Hodapp RM, Zigler, E (Eds): Handbook of Intellectual Disabilities and Development, Oxford University Press, 2011.

Letters to Editor, Book Reviews, Editorials:

Thornton TA, Johnson KB. Book review: PERL programming for biologists. Journal of the American Medical Informatics Association 11: 173, 2004.

Abstracts (in Chronological Order)

1. Thornton TA, Nicodimus K, Saunders AM, Mennold MM, Pericak-Vance MA, Haines JL, Moore JH. A genetic algorithm-optimized clustering methodology for the identification of multilocus genotypes that define disease subtypes. Graduate Student Research Day, Vanderbilt University, Nashville, TN, 2002.

2. Thornton TA, Haines JL. PowerTrim: An automated decision support algorithm for preprocessing family-based genetic data. American Journal of Human Genetics 71 Suppl: 570, 2002.

3. Thornton TA, Kenealy SJ, Haines JL. Power Study of a Novel Approach to Identifying a Minimum Candidate Gene Region in Complex Diseases. American Society of Human Genetics Annual Meeting, Los Angeles, CA, November 4-8, 2003.

4. Thornton TA, Kenealy SJ, Haines JL. Power Study of a Novel Approach to Identifying a Minimum Candidate Gene Region in Complex Diseases. International Genetic Epidemiology Society 12th Annual Meeting, Redondo Beach, CA, November 2-4, 2003.

5. Thornton TA, Moore JH, Haines JL. Clustering Methodologies for Discovery of Trait Heterogeneity Using Multilocus Genotypes. Vanderbilt-Meharry Genetics Symposium, Nashville, TN, September 4, 2003.

6. Thornton-Wells TA, Moore JH, Haines JL. Clustering Methodologies for Discovery of Trait Heterogeneity Using Multilocus Genotypes. Vanderbilt-Meharry Genetics Symposium, Nashville, TN, September 23, 2004.

7. Thornton-Wells TA, Moore JH, Haines JL. Dissecting Trait Heterogeneity: A Comparison of Clustering Methodologies Using Multilocus Genotypes. Middle Tennessee Chapter of the Society for Neuroscience, Nashville, TN, August 26, 2005.

8. Thornton-Wells TA, Moore JH, Haines JL. Dissecting Trait Heterogeneity: A Comparison of Clustering Methodologies Using Multilocus Genotypes. Vanderbilt-


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Meharry Genetics Symposium, Nashville, TN, September 21, 2005.

9. Martin ER, Thornton-Wells TA, Edward TL, Hahn LW, Bronson P, Gilbert JR, Haines JL, Pericak-Vance MA. Joint analysis of candidate genes in AD through data reduction. International Conference on Alzheimer’s Disease and Related Disorders, Madrid, Spain, June 15-20, 2006.

10. Thornton-Wells TA, Kim CY, Cannistraci CJ, Eapen M, Anderson A, Gore JC, Blake RR, Dykens EM. Music magnetism: An fMRI study on music processing in Williams Syndrome reveals recruitment of non-auditory sensory cortical region. Society for Neuroscience, San Diego, CA, November 3-7, 2007.

11. Thornton-Wells TA, Moore JH, Martin ER, Pericak-Vance MA, Haines JL. Confronting Complexity in Late-Onset Alzheimer Disease: Application of Two-Stage Analysis Approach Addressing Heterogeneity and Epistasis. International Genetic Epidemiology Society, York, England, September 7-10, 2007.

12. Thornton-Wells TA, Moore JH, Martin ER, Pericak-Vance MA, Haines JL. Confronting Complexity in Late-Onset Alzheimer Disease: Application of Two-Stage Analysis Approach Addressing Heterogeneity and Epistasis. American Society for Human Genetics, San Diego, October 23-27, 2007.

13. Thornton-Wells TA, Cannistraci CJ, Eapen E, Gore JC, Blake RR, Dykens EM. Music magnetism: An fMRI study of music processing in Williams Syndrome reveals recruitment of non-auditory sensory cortex. Society for Neuroscience Annual Meeting, San Diego, CA, November 3-7, 2007.

14. Thornton-Wells TA, Cannistraci CJ, Eapen E, Gore JC, Dykens EM. fMRI responses to emotionally charged images and faces in Williams syndrome. Gatlinburg Conference on Research & Theory in Intellectual & Developmental Disabilities, San Diego, CA, March 26-28, 2008.

15. Anderson AW, Tumuklu MN, Arlinghaus LR, Thornton-Wells TA, Hong X, Meltzer HY. Effects of genetic polymorphisms on white matter structure in schizophrenia measured with diffusion tensor imaging. International Society for Magnetic Resonance in Medicine, Toronto, Ontario, Canada, May 3-9, 2008.

16. Thornton-Wells TA, Cannistraci CJ, Eapen E, Gore JC, Dykens EM. fMRI responses to emotionally charged images and faces in Williams syndrome. Society for Neuroscience, Washington, DC, November 15-19, 2008.

17. Han Z, Thornton-Wells TA, Dykens EM, Srivastava A, Ding Z, Gore JC, Dawant B. Comparison of Group Average and Individual Differences in Brain Morphometry in Williams Syndrome. International Society for Magnetic Resonance in Medicine, Honolulu, Hawaii, April 18-24, 2009.

18. Thornton-Wells TA, Dykens EM, Blackford JU. The paradox of Williams syndrome: A functional MRI study of the dissociation of response to social and non-social stimuli. Society for Neuroscience, Chicago, IL, October 17-21, 2009.

19. Thornton-Wells TA, Dykens EM, Blackford JU. The paradox of Williams syndrome: An imaging genetics study of the genetic basis of non-social anxiety and hypersociability. International Imaging Genetics Conference, Irvine, CA, January 18-19, 2010.

20. Thornton-Wells TA, Pryweller JR, Solus LT, Dykens EM. The neural basis of heightened empathy in Williams syndrome: An fMRI study of the auditory mirror neuron system. Vanderbilt Kennedy Center Science Day, February 16, 2010.


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21. Thornton-Wells TA, Pryweller JR, Solus LT, Dykens EM. The neural basis of heightened empathy in Williams syndrome: An fMRI study of the auditory mirror neuron system. Gatlinburg Conference on Research & Theory in Intellectual & Developmental Disabilities, Annapolis, MD, March 17-19, 2010.

22. Blackford JU, Dykens EM, Thornton-Wells TA. The paradox of Williams syndrome: An imaging genetics study of the genetic basis of non-social anxiety and hypersociability. American Society of Human Genetics Annual Meeting, Washington, D.C., November 2-5, 2010.

23. Glenn K, Gentry-Brown K, Allen M, Mayo P, Schnetz-Boutaud N, Crawford DC, Thornton-Wells TA. Replication and generalization of genetic risk factors for depression, anxiety and panic attack in a population-based cohort with African, European and Mexican ancestries. American Society of Human Genetics Annual Meeting, Washington, D.C., November 2-5, 2010.

24. Thornton-Wells TA, Torstenson ES, Turner SD, Dudek SM, Bush WS, Ritchie MD, Pericak-Vance MA, Haines JL. Gene-gene interactions associated with Alzheimer disease replicate in independent Alzheimer Disease Genetics Consortium datasets. American Society of Human Genetics Annual Meeting, Washington, D.C., November 2-5, 2010.

25. Koran ME, Thornton-Wells TA. Gene-gene interactions are associated with baseline MRI measures in Alzheimer’s Disease Neuroimaging Initiative (ADNI). Vanderbilt Kennedy Center Science Day, Vanderbilt University, Nashville, TN, February 15, 2011.

26. Pryweller JR, Choo MJ, Dykens EM, Cascio CJ, Thornton-Wells TA. Sensory modulation in Williams syndrome. Vanderbilt Kennedy Center Science Day, Vanderbilt University, Nashville, TN, February 15, 2011.

27. Pryweller JR, Dykens EM, Thornton-Wells TA. The effect of intellectual ability on functional brain activation in Williams syndrome. Vanderbilt Kennedy Center Science Day, Vanderbilt University, Nashville, TN, February 15, 2011.

28. Wright AF, Blackford JU, Thornton-Wells TA. GTF2IRD1: Temperamental or not? Copy number variation in WS and controls. Vanderbilt Kennedy Center Science Day, Vanderbilt University, Nashville, TN, February 15, 2011.

29. Restrepo N, Thornton-Wells TA. Regional brain atrophy measurements are associated with gene-gene interaction models in Alzheimer Disease Neuroimaging Initiative. Vanderbilt Kennedy Center Science Day, Vanderbilt University, Nashville, TN, February 15, 2011.

30. Avery S, Thornton-Wells TA, Blackford JU. Altered white matter integrity in prefrontal-amygdala pathways in Williams syndrome. Vanderbilt Kennedy Center Science Day, Vanderbilt University, Nashville, TN, February 15, 2011.

31. Pryweller JR, Dykens EM, Thornton-Wells TA. The effect of intellectual ability on functional brain activation in Williams syndrome: an fMRI study. Gatlinburg Conference on Intellectual and Developmental Disabilities, San Antonio, TX, March 2-5, 2011.

32. Thornton-Wells TA, Pryweller JR, Solus LT, Dykens EM. The neural basis of heightened empathy in Williams syndrome: an fMRI study of the auditory mirror neuron system. Gatlinburg Conference on Intellectual and Developmental Disabilities, San Antonio, TX, March 2-5, 2011.


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33. Thornton-Wells TA, Brown-Gentry KD, Torstenson ES, Dudek SM, Ritchie MD, Martin ER, Pericak-Vance MA, Haines JL. Discovery and replication of gene-gene interactions in multiple independent Alzheimer Disease Genetics Consortium datasets. Alzheimer’s Association International Conference on Alzheimer’s Disease (AAICAD), Paris, France, July 16-21, 2011.

34. Porchak T, Thornton-Wells TA, Ally B, Hussey E, Smith S, Cobb J, Dula A, Rane S, Welch B, Anderson A, Gore J, Donahue M. Novel high-filed MRI applied to the early detection of Alzheimer’s disease-related pathology. Alzheimer’s Association International Conference on Alzheimer’s Disease (AAICAD), Paris, France, July 16-21, 2011.

35. Meda SA, Pryweller JR, Thornton-Wells TA. Exploring brain morphology changes in Williams syndrome and their relationships to anxiety and depression. Vanderbilt Institute of Imaging Science Frontiers in Biomedical Imaging Conference, Nashville, TN, June 14-16, 2011.

36. Pryweller JR, Dykens EM, Thornton-Wells TA. The effect of intellectual ability on functional brain activation in Williams syndrome: an fMRI study. Vanderbilt Institute of Imaging Science Frontiers in Biomedical Imaging Conference, Nashville, TN, June 14-16, 2011.

37. Meda SA, Pryweller JR, Thornton-Wells TA. Altered default-mode network connectivity in Williams syndrome. Society for Neuroscience Annual Meeting, Washington, D.C., November 12-16, 2011.

38. Pryweller JR, Dykens EM, Thornton-Wells TA. The effect of intellectual ability on functional brain activation in a neurodevelopmental disorder: fMRI studies in Williams syndrome. Society for Neuroscience Annual Meeting, Washington, D.C., November 12-16, 2011.

39. Meda SA, Koran ME, Restrepo NA, Thornton-Wells TA. Genetic interactions in diversified biological pathways predict hippocampal and entorhinal atrophy in Alzheimer disease. International Congress on Human Genetics, Montreal, Canada, October 11-15, 2011.

40. Thornton-Wells TA, Brown-Gentry KD, Torstenson ES, Dudek SM, Jiang L, Ritchie MD, Martin ER, Pericak-Vance MA, Haines JL, Alzheimer’s Disease Genetics Consortium. Discovery and replication of gene-gene interactions in multiple independent Alzheimer’s Disease Genetics Consortium datasets. International Congress on Human Genetics, Montreal, Canada, October 11-15, 2011.

41. Koran ME, Thornton-Wells TA. Gene-gene interactions associated with baseline brain volume and cortical thickness measurements in the Alzheimer’s Disease. Vanderbilt Medical Scientist Training Program Retreat, Lake Barley, KY, June 24, 2011.

42. Vega JN, Thornton-Wells TA. The relationship between regional brain atrophy and BMI in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Vanderbilt Neuroscience Graduate Program Retreat, Nashville, TN, September 19, 2011.

43. Koran ME, Meda SA, Thornton-Wells TA. Genetic interactions in biological pathways are associated with increase in ventricle size over time in the Alzheimer’s Disease Neuroimaging Initiative cohort. Vanderbilt Center for Human Genetics 12th Annual Genetics Symposium, Nashville, TN, October 5, 2011.

44. Vega JN, Thornton-Wells TA. The relationship between regional brain atrophy and BMI in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Vanderbilt


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Center for Human Genetics 12th Annual Genetics Symposium, Nashville, TN, October 5, 2011.

45. Meda SM, Wilson TP, Thornton-Wells TA. The serotonin-2A receptor gene (5-HTR2A) is associated with structural alterations in Williams syndrome: a preliminary DARTEL-VBM based study. International Imaging Genetics Conference, Irvine, CA, January 16-17, 2012.

46. Koran ME, Meda SM, Thornton-Wells TA. Genetic interactions in focal adhesion and extracellular matrix pathways are associated with increase in ventricle size over time in the Alzheimer’s Disease Neuroimaging Initiative cohort. International Imaging Genetics Conference, Irvine, CA, January 16-17, 2012.

47. Meda SM, Wilson TP, Thornton-Wells TA. The serotonin-2A receptor gene (5-HTR2A) is associated with structural alterations in Williams syndrome: a preliminary DARTEL-VBM based study. Vanderbilt Kennedy Center Science Day, February 28, 2012.

48. Koran ME, Meda SM, Thornton-Wells TA. Genetic interactions in focal adhesion and extracellular matrix pathways are associated with increase in ventricle size over time in the Alzheimer’s Disease Neuroimaging Initiative cohort. Vanderbilt Kennedy Center Science Day, February 28, 2012.

49. Vega JN, Thornton-Wells TA. The relationship between regional brain atrophy and BMI in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Vanderbilt Kennedy Center Science Day, February 28, 2012.

50. Slosky LS, Meda SM, Thornton-Wells TA. Examining the development of Alzheimer pathology: a focus on Down syndrome. Vanderbilt Kennedy Center Science Day, February 28, 2012.

51. Meda SA, Cobb JG, Porchak TL, Hussey EP, Ally BA, Rane SD, Donahue MJ, Thornton-Wells TA. Multi-slice 3T T1-rho quantitative imaging as an early biomarker of Alzheimer disease: preliminary voxel-based analysis in controls, at risk and MCI subjects. International Society for Magnetic Resonance in Medicine, Melbourne, Australia, May 5-11, 2012.

52. Pryweller JP, Dykens EM, Cascio CJ, Thornton-Wells TA. A neural basis for atypical auditory processing in Williams syndrome. Organization for Human Brain Mapping, Beijing, China, June 10-13, 2012. Accepted but unable to attend

53. Meda SA, Cobb JG, Wilson TL, Hussey EP, Ally BA, Rane SD, Gore JC, Donahue MJ, Thornton-Wells TA. Voxel-based analysis of multi-slice quantitative T1-rho MRI in MCI, At-Risk and Control Subjects. Alzheimer’s Association International Conference (AAIC), Vancouver, British Columbia, Canada, July 18, 2012.

54. Thornton-Wells TA, Brown-Gentry KD, Baker AR, Torstenson ES, Dudek SM, Jiang L, Ritchie MD, Martin ER, Pericak-Vance MA, Haines JL, Alzheimer’s Disease Genetics Consortium. Biological knowledge-driven approach to gene-gene interaction analysis in Alzheimer’s Disease Genetics Consortium. Alzheimer’s Association International Conference (AAIC), Vancouver, British Columbia, Canada, July 18, 2012.

55. Pryweller JP, Dykens EM, Cascio CJ, Thornton-Wells TA. A neural basis for atypical auditory processing in Williams syndrome. Society for Neuroscience, New Orleans, LA, Oct. 13-17, 2012.

56. Thornton-Wells TA, Meda SA, Sivley RM, Cobb JG, Wilson TL, Hussey EP, Ally BA, Rane SD, Gore JC, Koran MEI. Multi-slice 3T T1-rho quantitative imaging as an early


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biomarker of Alzheimer disease: a voxel-based analysis in MCI, at risk and control subjects. Society for Neuroscience, New Orleans, LA, Oct. 13-17, 2012.

57. Koran ME, Meda SM, Thornton-Wells TA. Genetic interactions in focal adhesion and extracellular matrix pathways are associated with increase in ventricle size over time in the Alzheimer’s Disease Neuroimaging Initiative cohort. Society for Neuroscience, New Orleans, LA, Oct. 13-17, 2012.

58. Vega JN, Gentry-Brown KD, Glenn K, Allen M, Mayo P, Schnetz-Boutaud N, Crawford DC, Thornton-Wells TA. Replication and generalization of genetic risk factors for depression, anxiety and panic attack in a population-based cohort with African, European and Mexican ancestries. American Society for Human Genetics, San Francisco, CA, Nov. 6-10, 2012.

59. Koran ME, Meda SM, Thornton-Wells TA. Genetic interactions in focal adhesion and extracellular matrix pathways are associated with increase in ventricle size over time in the Alzheimer’s Disease Neuroimaging Initiative cohort. American Society for Human Genetics, San Francisco, CA, Nov. 6-10, 2012.

60. Williams SM, Samuels DC, Li B, Song Z, Torstenson E, Rokas A, Thornton-Wells TA, Moore JH, Hughes TM, Hoffman RD, Haines JL, Mortlock DP, Li C. Recurrent tissue-specific mtDNA mutations are common in humans. American Society for Human Genetics, Nov. 6-10, 2012.

61. Koran MEI, Hohman TJ, Meda SA, Sivley RM, Cobb JG, Wilson TL, Hussey EP, Ally BA, Rane SD, Cobb JG, Welch EB, Gore JC, Thornton-Wells TA. Multi-slice 3T T1rho-weighted MRI as an early biomarker of Alzheimer pathology: a voxel-based analysis in MCI, At Risk and Control subjects. Human Amyloid Imaging Conference, Miami, FL, January 16-18, 2013.

62. Hohman TJ, Koran MEI, Thornton-Wells TA. Epistasis and amyloid burden in the Alzheimer’s Disease Neuroimaging Initiative. Human Amyloid Imaging Conference, Miami, FL, January 16-18, 2013.

63. Pryweller JR, Dykens EM, Cascio CJ, Thornton-Wells TA. The role of white matter microstructure in a neural basis for atypical auditory processing in Williams syndrome. Vanderbilt Kennedy Center Science Day, Nashville, TN, January 15, 2013.

64. Vega JN, Hohman TJ, Thornton-Wells TA. Resting state functional connectivity in individuals at risk for developing Alzheimer’s disease. Vanderbilt Kennedy Center Science Day, Nashville, TN, January 15, 2013.

65. Hohman TJ, Koran MEI, Thornton-Wells TA. Epistasis and amyloid burden in the Alzheimer’s Disease Neuroimaging Initiative. Vanderbilt Kennedy Center Science Day, Nashville, TN, January 15, 2013.

66. Koran MEI, Hohman TJ, Meda SA, Sivley RM, Wilson TL, Hussey EP, Ally BA, Rane SD, Cobb JG, Welch EB, Gore JC, Thornton-Wells TA. Multi-slice 3T T1rho-weighted MRI as an early biomarker of Alzheimer pathology: a voxel-based analysis in MCI, At Risk and Control subjects. Vanderbilt Kennedy Center Science Day, Nashville, TN, January 15, 2013.

67. Koran MEI, Hohman TJ, Meda SA, Sivley RM, Cobb JG, Welch EB, Gore JC, Thornton-Wells TA. Amyloid burden measured by T1rho-weighted MRI in Down syndrome. Alzheimer’s Association International Conference, Boston, MA, July 13-18, 2013.


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68. Vega JN, Hohman TJ, Thornton-Wells TA. Age-dependent default mode network functional connectivity in individuals with Down syndrome. Alzheimer’s Association International Conference, Boston, MA, July 13-18, 2013.

69. Hohman TJ, Koran ME, Thornton-Wells TA. Genetic Resilience to amyloid-related neurodegeneration in older adulthood. Alzheimer’s Association International Conference, Boston, MA, July 13-18, 2013.

70. Hohman TJ, Koran MEI, Thornton-Wells TA. Genetic resilience to neurodegeneration in the presence of tau pathology. American Society for Human Genetics Annual Meeting, Boston, MA, October 21-25, 2013.

71. Koran MEI, Hohman TJ, Thornton-Wells TA. Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. American Society for Human Genetics Annual Meeting, Boston, MA, October 21-25, 2013.

72. Thornton-Wells TA, Hohman TJ, Koran MEI. Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. American Society for Human Genetics Annual Meeting, Boston, MA, October 21-25, 2013.

73. Hohman TJ, Koran ME, Thornton-Wells TA. Interactions between GSK3B and amyloid genes explain variance in amyloid burden. Society for Neuroscience Annual Meeting, San Diego, CA, November 9-13, 2013.

74. Pryweller JR, Dykens EM, Cascio CJ, Thornton-Wells TA. A neural basis for atypical auditory processing in Williams syndrome. Society for Neuroscience Annual Meeting, San Diego, CA, November 9-13, 2013.

75. Koran ME, Hohman TJ, Vega JN, Pryweller JR, Slosky LE, Crockett G, Villa de Rey L, Edwards CM, Meda SA, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA. Differences in age-related effects on brain volume in Down syndrome as compared to Williams syndrome and typical development.” Vanderbilt Kennedy Center Science Day, Nashville, TN, January 14, 2014.

76. Vega JN, Hohman TJ, Pryweller JR, Thornton-Wells TA. “Characterizing resting state functional connectivity in individuals with Down syndrome and Williams syndrome compared to typically developing controls.” Vanderbilt Kennedy Center Science Day, Nashville, TN, January 14, 2014.

77. Hohman TJ, Koran MEI, Thornton-Wells TA, for ADNI. Genetic variation modifies risk for neurodegeneration in biomarker positive individuals. Human Amyloid Imaging Conference, Miami, FL, January 15-17, 2014.

78. Koran ME, Li B, Jahanshad N, Thornton-Wells TA, Glahn DC, Thompson PM, Blangero J, Nichols TE, Kochunov P, Landman BA. Neuroimaging Genetics Study Design: A Comparison of the OpenMX and SOLAR Software Packages for Estimating Heritability of Neuroimaging Traits, International Imaging Genetics Conference, Irvine, CA, January 20-21, 2014.

79. Hohman TJ, Koran ME, Thornton-Wells TA, for ADNI. Genetic Resilience to Neurodegeneration in the Presence of Tau Pathology, International Imaging Genetics Conference, Irvine, CA, January 20-21, 2014.

80. Koran ME, Li B, Jahanshad N, Thornton-Wells TA, Glahn DC, Thompson PM, Blangero J, Nichols TE, Kochunov P, Landman BA. The impact of family structure on


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estimating heritability for neuroimaging genetics studies using SOLAR. International Imaging Genetics Conference, Irvine, CA, January 20-21, 2014.

81. Li B, Jahanshad N, Koran ME, Thornton-Wells TA, Nichols TE, Kochunov P, Landman BA. On study design in neuroimaging heritability analyses. In Proceedings of the SPIE Medical Imaging Conference, San Diego, CA, February 15-20, 2014.

82. Thornton-Wells TA, Koran ME, Vega JN, Edwards CM, Pryweller JR, Hohman TJ. Age-related functional and structural MRI effects in Down syndrome. Wellcome Trust Conference on Alzheimer’s Disease in Down syndrome: from molecules to cognition. Hinxton, Cambridge, UK, March 27-29, 2014.

83. Thornton-Wells TA, Fennema-Notestine C, Hulgan T, Letendre S, Ellis R, Kallianpur AR, for the CHARTER Group. Iron-regulatory genes are associated with aging-related neuroimaging traits in HIV-infected persons: a CHARTER study. International Workshop on HIV & Aging, Baltimore, MD, October 20, 2014.

83. Thornton-Wells TA, Fennema-Notestine C, Hulgan T, Letendre S, Ellis R, Kallianpur AR, for the CHARTER Group. Iron-regulatory genes are associated with neuroimaging traits in HIV-infection. Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, February 23-26, 2014. Submitted

PRESENTATIONS AT SCIENTIFIC MEETINGS: Invited Presentations

1998 “Patient Satisfaction and Quality of Life Surveys,” Renal Care Group Annual Research Meeting, New Orleans, LA.

1999 “Renal Care Group Biomedical Survey,” Renal Care Group Annual Research Meeting, Chicago, IL.

2006 "Confronting Complexity: A Comprehensive Statistical and Computational Strategy for Identifying the Missing Link Between Genotype and Phenotype," Neuroscience Program Retreat, Nashville, TN.

2007 "Williams Syndrome: An fMRI Study on Affinity for Music," Neurodevelopmental Disorders Grand Rounds, Vanderbilt Kennedy Center for Research on Human Development, Nashville, TN.

2008 "Neuroimaging in Williams Syndrome,” Speaker Series on Developmental Psychology, Vanderbilt University, Nashville, TN.

2009 "Functional Neuroimaging in Williams Syndrome," The School for Science and Math at Vanderbilt, Vanderbilt University, Nashville, TN.

2009 "Cross-Modal Sensory Processing in Williams Syndrome: Hints at a Spectrum for Typical Development?” Psychiatric Neuroimaging Program Research Meeting, Vanderbilt University, Nashville, TN.

2010 “Neuroimaging and Genetics in Developmental and Psychiatric Disorders” Seminar & Chalk Talk Series, Department of Biological Sciences, Tennessee State University, Nashville, TN, February 12, 2010.


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2010 Co-Moderator, Neuropsychiatric Genetics Session, American Society for Human Genetics Annual Meeting, Washington, D.C., November 2-6, 2010.

2011 Co-Moderator, “Quantitative Traits in NeuroGenetics: The Future of Phenotyping in Neurological, Psychiatric and Developmental Disorders,” International Congress on Human Genetics Meeting, Montreal, Quebec, Canada, October 11-15, 2011.

2011 “Combining Complexity in Neurogenetics: Better Phenotypes + Better Analyses = Better Translational Science,” External Review Presentation, Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, October 21, 2011.

2012 “Dementia in Down Syndrome,” in A Window into Human Development and Disabilities, Vanderbilt University Osher Lifelong Learning Institute, Nashville, TN, February 16, 2012.

2012 “Combining Complexity in Neurogenetics: Better Phenotypes + Better Analyses = Better Translational Science,” Institute for Quantitative Biomedical Sciences, Dartmouth Medical School, Lebanon, NH, February 20, 2012.

2012 “What Role Does Genetics Play in Alzheimer’s Disease,” in 26th Annual Alzheimer’s Disease Symposium, Alzheimer’s Tennessee, Inc., Knoxville TN, June 14, 2012.

2012 Moderator, Neurogenetics Session, American Society for Human Genetics Meeting, San Francisco, CA, November 6-10, 2012.

2012 “Neuroimaging of functional connectivity in Williams syndrome,” First Annual Isabelle Rapin Communications Disorders Conference, Rose F. Kennedy IDDRC, Albert Einstein College of Medicine, Bronx, NY, December 6, 2012.

2013 “Imaging genetics of Alzheimer disease risk in Down syndrome,” Data Blitz: Systems Neuroscience, Vanderbilt Kennedy Center Science Day, Nashville, TN, January 15, 2013.

2013 “Chemo-Brain: Fact or Fiction,” Vanderbilt Cancer Imaging Group Seminar, Vanderbilt University Institute of Imaging Science, Nashville, TN, January 29, 2013.

2013 “Computational Methods for Integrative Analysis of Imaging and Genomic Data,” Invited Workshop Speaker, at IEEE International Symposium on Biomedical Imaging, San Francisco, CA, April 7-14, 2013.

2013 “Neuroimaging Genetics: How Genes Influence the Brain,” Adventure Science Center’s Science Café, Nashville, TN, April 19, 2013.

2013 “Personalized Medicine in Alzheimer’s Disease,” in 2013 Geriatric Update, Presented by Meharry Consortium Geriatric Education Center and Vanderbilt University Medical Center Nursing Education and Professional Development, Nashville, TN, September 28, 2013.

2013 “Unraveling Genetic Interactions in Alzheimer’s Disease using Neuroimaging Phenotypes,” Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA, November 11, 2013.

2013 “Neuroimaging genetics of Alzheimer disease in Down syndrome,” Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, December 5, 2013.


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2014 “Neuroimaging Genetics in Disorders of Cognitive Impairment,” Genetics Cluster Seminar, Carver College of Medicine, University of Iowa, Iowa City, IA, February 3, 2014.

2014 “Quantifying Anxiety and Sociability in Neurodevelopmental Disorders,” Data Blitz: Clinical, Behavioral and Intervention Research, Vanderbilt Kennedy Center Science Day, Nashville, TN, January 14, 2014

Peer-Reviewed Presentations

1998 “Quality of Life Indicators,” National Kidney Foundation Spring Clinical Nephrology Meeting, Nashville, TN.

2003 “Clustering Methodologies for Discovery of Trait Heterogeneity Using Multilocus Genotypes,” National Library of Medicine Informatics Trainee Annual Meeting, Bethesda, MD.

2003 “Power Study of a Novel Approach to Identifying a Minimum Candidate Gene Region in Complex Diseases,” International Genetic Epidemiology Society 12th Annual Meeting, Redondo Beach, CA.

2007 "Genetics and Functional Neuroimaging of Children with Prader-Willi Syndrome At-Risk for Psychosis," Vanderbilt University Institute of Imaging Science Annual Retreat, Birmingham, AL.

2007 "Music magnetism: An fMRI study of music processing in Williams Syndrome reveals recruitment of non-auditory sensory cortex," Annual Meeting of the Society for Neuroscience, San Diego, CA.

2008 “fMRI responses to emotionally charged images and faces in Williams syndrome,” Gatlinburg Conference On Research & Theory in Intellectual & Developmental Disabilities, San Diego, CA.

2009 "Music magnetism: An fMRI study of music processing in Williams Syndrome," Vanderbilt Kennedy Center Science Day, Vanderbilt University, Nashville, TN.

2010 “Gene-gene interactions associated with Alzheimer disease replicate in independent Alzheimer Disease Genetics Consortium datasets,” The American Society for Human Genetics Annual Meeting, Washington, D.C., November 5, 2010.

2011 “The neural basis of heightened empathy in Williams syndrome: an fMRI study of the auditory mirror neuron system.” Gatlinburg Conference on Intellectual and Developmental Disabilities, San Antonio, TX, March 2-5, 2011.

2014 “Iron-regulatory genes are associated with aging-related neuroimaging traits in HIV-infected persons: a CHARTER study.” International Workshop on HIV & Aging, Baltimore, MD, October 20, 2014.


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RESEARCH ARTICLES IN PROGRESS Research Papers Submitted:

1. Hohman TJ, Cooke-Bailey J, Reitz C, Jun G, Naj AC, Beecham G, Liu Z, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie HC, Hall KS, Goate AM, Lang-Walker R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA, for the Alzheimer Disease Genetics Consortium. Global and local ancestry in African Americans: Implications for Alzheimer’s disease risk. Revised & Resubmitted to Alzheimer’s & Dementia.

2. Hohman TJ, Brown-Gentry KD, Baker AR, Torstenson ES, Dudek SM, Jiang L, Ritchie MD, Martin ER, Pericak-Vance MA, Haines JL, Thornton-Wells TA, Alzheimer’s Disease Genetics Consortium. Biological knowledge-driven approach to gene-gene interaction analysis in Alzheimer’s Disease Genetics Consortium. Under Review at Biological Psychiatry.

3. Koran ME, Edwards CM, Ugochukwu U, Vega JN, Hohman TJ, Thornton-Wells TA. Age-related white matter hyperintensities in Down syndrome. Under Revision.

4. Vega JN, Hohman TJ, Pryweller JR, Dykens EM, Thornton-Wells TA. Resting state functional connectivity in Down syndrome versus typically-development and Williams syndrome. Under Revision for Brain Connectivity.

5. Hohman TJ, Pryweller JR, Solus LT, Dykens EM, Thornton-Wells TA. The auditory mirror neuron system in Williams syndrome. Under Revision.

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Tricia Ann Thornton-Wells Curriculum Vitae · 2010-2011 Vishal Gandi, Ph.D. Dissertation Committee...

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