Turning TypeOne to

The Plan for a World without T1D

LESS UNTIL NONE

JDRF’s Vision for the Future

BurdenUNTIL NONE

DangerLESS

ComplexityLESS

InvasiveLESS

LESS

LESS UNTIL NONE

Delivery of Continuous Therapeutic Improvements

Side-EffectsComplicationsPatient Burden

Glycemic ControlSafety

Normal PhysiologyRestored

Easier, Safer, Less Worry, Better Life

Therapies Cure

The Plan: Work the Pipeline

Artificial Pancreas

A series of systems that will automate insulin dosing and additional hormone delivery

Artificial Pancreas Artificial PancreasSmart Insulin

A series of systems that will automate insulin dosing and additional hormone delivery

Single dose of insulin that delivers insulin only where and

when needed

Artificial Pancreas Smart Insulin

Single dose of insulin that delivers insulin only where and

when needed

Smart InsulinEncapsulation

Implantable, beta cell replacement therapies restoring insulin

independence without the need for intensive immune suppression

Artificial Pancreas Smart Insulin EncapsulationEncapsulation

Implantable, beta cell replacement therapies restoring insulin

independence without the need for intensive immune suppression

Prevention

Slow or stop the progression of T1D before insulin dependence and

ultimately eliminate the possibility of ever developing T1D

Artificial Pancreas Smart Insulin Encapsulation

Prevention

Prevention

Slow or stop the progression of T1D before insulin dependence and

ultimately eliminate the possibility of ever developing T1D

Restoration

Beta cell growth protected from immune attack restoring insulin

independence without immune suppression

Restoration

Smart Insulin Encapsulation

Prevention

Artificial Pancreas

Beta cell growth protected from immune attack restoring insulin

independence without immune suppression

Restoration

Continuous Therapeutic Improvements N

ear T

erm

Mid

Ter

mLo

ng T

erm

ComplicationsDiabetic Eye DiseasePredictive Diagnostics

Artificial PancreasLow Glucose SuspendTreat-to-Range

Artificial PancreasTreat-to-TargetMultihormone

EncapsulationImplantable Islets

Smart InsulinControl

PreventionSecondary Prevention

PreventionPrimary: Vaccine

ComplicationsComprehensivePrevention Therapy

RestorationNew Beta Cell GrowthProtected from Immune Attack

The Plan

Capabilities Across All Stages of the Pipeline

$500 Million Research PortfolioBroad and Diverse PortfolioResearch and Development ExpertiseVolunteer EngagementInternational ReachPartnerships

Your Support

Capabilities

Plan

Vision