Planet 2 /MATISSEUK – Dutch collaboration

RESEARCH STAFF

Karin (K) FijnvandraatPediatric hematologistAcademic Medical Center (Amsterdam) Sanquin blood supply

Enrico (E) LoprioreNeonatologistLeiden University Medical Center

Anske (JG) van der BomProfessor of Clinical EpidemiologyLeiden University Medical CenterSanquin Blood Supply

HISTORY OF MATISSE TRIAL• 2011 - 2012: Idea plus funding• 2013: PhD student + Planet-2 • Jan 2014: ethical approval• Feb 2014: start study in Amsterdam

Managing Thrombocyte transfusions In a Special Subgroup: nEonates

STUDY DESIGNS IDENTICAL

Transfusion thresholds

Inclusion criteria

Transfusion dose

?Outcome

PARTICIPATING CENTERSGroningen

Zwolle

Veldhoven

Nijmegen

Maastricht

RotterdamLeiden

Amsterdam

PARTICIPATING PI’S

…

E. Lopriore

A. Kroon

A. Van Kaam

W. de Boode M. vd Hoeven

A. Donker

E. D’Haens

C. Hulzebos

PARTICIPATING CENTERS• 8 level II/III neonatal intensive care units• 4000 admission per year• 2000 < 34 weeks GA

PLANNING• February 18 start in Amsterdam• February – september: start other centers• Datasharing• Expected inclusions: 65 / year

Inclusions

MONET: MONITORING OUTCOME IN NEONATAL THROMBOCYTOPENIA

• Retro/prospective observational cohort• Goal: prediction model neonatal bleeding• Design phase, 1000-2000 inclusions

Questions?