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UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir-...

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UNCLASSIFIED AD NUMBER AD840535 NEW LIMITATION CHANGE TO Approved for public release, distribution unlimited FROM Distribution authorized to U.S. Gov't. agencies and their contractors; Administrative/Operational Use; JUN 1968. Other requests shall be referred to Department of The Army, Fort Detrick, Attn: Technical Release Branch/TID, Frederick, MD 21701. AUTHORITY Smufd, D/A ltr, 17 Feb 1972 THIS PAGE IS UNCLASSIFIED
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Page 1: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

UNCLASSIFIED

AD NUMBER

AD840535

NEW LIMITATION CHANGE

TOApproved for public release, distributionunlimited

FROMDistribution authorized to U.S. Gov't.agencies and their contractors;Administrative/Operational Use; JUN 1968.Other requests shall be referred toDepartment of The Army, Fort Detrick,Attn: Technical Release Branch/TID,Frederick, MD 21701.

AUTHORITY

Smufd, D/A ltr, 17 Feb 1972

THIS PAGE IS UNCLASSIFIED

Page 2: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

TRANSLATION NO. 61C

DATE:

DDC AVAILABILITY NOTICE

Reproduction of this publication in whole or in part

is prohibited. However, DDC is authorized to

reFroduce the publication for United States

Government purposes.

D D )-

Best Available Copy

STATEMENT t2 UNCLASSIFIED

Th.S doCum"ent is subject to special export

,,trols.and each transmittal to forei% egoverrans or ford gn ation ay b

qoenly wth pri aproa of Dept. of Army,onl with Prlor appro .' V,,i Release Branch/

Fort Detrick, .A...n. 21R e h

TID, Frederlick, Maryland 21701

Page 3: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

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Page 4: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

~~~~~~-: 199 ) n:- 7~

Td-m *-- .r- ..

Z1cs ani .ls lomto *. :I to E 1et zzia tz* Li; .yA _"52=31ly d~owozed tI7_z=x bizt t~*eao =d~2~ no4 =td:'Gi.~zo Aa±rstA, iup of oýa s (ft~e~x-Z =d 4m rr 1962).

Razval of SZJns s rgic ' !"-a m~& e clar influenca o-, z*.tbodyaynthesis. Alz -•._- • t.r-'Ii "-l cl n'=r. -. zni. Co--.,_ 4. •-

Ot~Ir- &am.i4_:ns a-. B31 ga-m the sane.~1 (Uolf 19ý32 !.JJZar 19649,Gruitzer 1:963, 19 is63.

Qmr.rzty to t*= raszlts dascib*o,4 cabz:v ulth bacto:1-01 o ~~areZBSA and 12i J, t:-.- burza uas mv d ch a ~' nd __c -fca it

G0 j (B1erz&ý. :=mal rmtdibo:!y for.wti=~ was Ze~ Oho U5'63) concludace",.aa the b.a fabruii ilz not z3xsy i.'volved in ai.c,- .r-yio:., butthiat this i:cxp z :n wt:-. tpo of amt±Zen. it may be pos-cib-- t~iact :i:%fowl the t.yrnc i. -zorble for thc szythesis of cto• aa ci.

Ic o .3i7• triclz t cfefct of t!rjmocto,7 of chickc.• on ,tibody

for-ati=n it. mestie-tcei &x:-inZ nt-pic =iVad cIhicveen po:if t;4~

X-bthO3 zds ::&toiats

'Zia Vhoe we~re ;ae:Toz~od vithi "MZ EMZ chcV Svoro o"-otllc•d oý 'I'7 -=nd pox firc. coc: and ware hatchc in t•t in-stitute. For Ut =7 zxial 60 chick• waro uzod in croio o .J. Fortpax, trial & c.4c=s •, ero grouped per 16 an=m--". Half of the chicc= u-orotkr.-jctomi~cd at 3-6 d.V;, t!;z -rs vae c~ut-ols. All ch:!L~s we-e !a pt

in incubetrz and fed peliots of food.

Ornat : , =stZ-ctic af ta- 'reyan ý •163) with z~u--.Ll diluted1:6 vith =J=; da:o of 0,005 -_ per grm bo. might ZlX. -Nedian cutdorcai fron atlas to cheebt, tho thW= kmots ware rzovod •_i=h a bentforceps. -outearo wi'-a 4 t-itc1bas (not xo-oved).

e -1 insas Vr.ms: xi& r 13 straim of lID Cntor vnccinoC3n• c•) ,az wued. dose for i00 =Jms -; disolvzd in 1.0 =l

i{20 adc v~r =-.an rzcoivd 1 =1 by pipct~t i.to tm Gulls-P. '-r.0

_ , :50 -iztioz C Z-6 ID D').

Lth zbra-in 0 3'- 1 :-I !: 4 dibu1 oa r!. Titcar ns 15 cý. LD correspondi-nz320 coll nZlutiLn;ion Units ( xam-nide - =a armon 1961).

&ro': .cd obtainad. b.*y left-Sid-3 heart, P-me :.. L' ckroel vaccL=n--,ion and t'= weeks post infection. Seram: wac. zred at -20°Cand used zz: 1) he=.&=Je! nation (SI) nhxibition diluted !.5 - 1:20,340,

Best Available Copy

Page 5: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

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In-~v ~~tc~ i-4-4ct-cd, iAc -ctio Z c=' HI or

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Page 6: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

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Z1t (1:10, % 1:5, 1:5) 2.-$.,in th.e --9 5 onl 2 o 5 f-,:5,- D -. 2hi,3 zi-"- . i-s s-•tistically; m'•aa~dy giz..ttMc_.-+t. 2= '- .ft: ,:,:"..,: _ ;-_*on -+.- .+L I.- ,. p-L•/.ous VZacc2l .iOa.- _.," "-.: i • .-. ".+:.:.-.• •. -- ,,t,- .

Liv -- d 4 c:. no_-=!.a zave ;C-.itiva zz,. iznS•-aof a32. cL14cen•.. -alot'_-'.4- " ".kbI.r %an" .16:523).

asvaý -zsd tfh;t'Z% e~:nzn-- oi':D 7 is prob::- sol=tho HU tit,3r iL a a !ov'3. o-* 29i:. 1.,.. ' 1-63). 2..•.e. i"t+c~-+ v o." chii'.2. : "ch Z tit.rsa of 12.-, 1 ,r±-

=ta Zti:=--- zuled-I.* a Ug ty d llun J-3 a z~ al=A a3".:o ".;a u + " '--, .,. r.- - :. , • r a : _L m~i c t.. cd p := -emat a zr a Z • +,ll C..." ' ý O sc s o f

vyr.-z.i. ir."-ztAd .z.z =^! h. no,'ZO boon va.cc•natad hiih alitX)no sa~olor_.; vA.iiesa wa'co donna.

noral5 3 tT. -'cto.7=xcd w.n--21s. !a Al c.Z-0t V-1-Ctt_±-.S could "L1-,r=3r4 cai.zr on z' 7 -ý=t v•cc inacn. .i clinical jxic-ý,m __o loo:.C..thi ar.a. 'Zie L-.--t .c• pe-- m.--• 2:a cc:i on d.-y £ -- th vc-cc9-nadgroip, on &iy 16 t:o n-.l z!Zs co-.d b1 ac a -- 1 16 -- ls. Crt•2bctor.i . c zici-an -d'_d on day 33. Nome of the v azinatad icI&nsbacce ill lztý incttio w~ith r,

A ramv:y o:' theo rz-oloZic results are pz:ent:-d in table 5-. Tbfoll.cd.n .= b, cozci.Uod.

Ze o-- .t,..., tests weme n3gatiim in cont-rols vrjitr vac-cir.xt'.d =z infacd); aLso i'. tha vaccinated a -inals t•is u-s as ct, lutcd.

2tm woc'= o.r -e 17 i infec;ion v-ith 1i.eld '•_'as (afc' vaccLnAtion)a3l scra ot tc-i~ d n.,±-d.als gave .Pi-"ip.cijitLivP tst. Inco."t-•oi 3 of 6 c <n1 -s&ra pracpitatcd. t -, _s dlffa:%=O is notsig--icnt. C.- -lier ati' -as twe edLerance in .c-.n-vaccinn-cchickens; 2 iaeL.:- tc inia-ion zz..cipitiv3 zssts e .cr posi-zive in seraoz f~ 4 "- ....... L " Ia )r.or

zh•'!db ~t....o' .._.+ that i~n"ith =aah c-,,z-ec d.And.-t •"-.,cto:.vr of chiclce•

1.

Page 7: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

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Page 8: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

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Page 12: UNCLASSIFIED AD NUMBER - DTIC · Alz -•._- t.r-'Ii • "-l cl n'=r. -. zni. Co--.,_ 4. •-Ot~Ir- &am.i4_:ns a-. B31 ... trial & c.4c=s •, ero grouped per 16 an=m--". Half of

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