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CURRICULUM VITAE
NAME: Chen Liu, MD, Ph.D.
PRESENT TITLE: Professor and Chairman, Chancellor Scholar
Department of Pathology, Immunology and Laboratory Medicine
New Jersey Medical School
Professor and Chairman
Department of Pathology and Laboratory Medicine
Robert Wood Johnson Medical School
Chairman, Center for Dermatology (Department of Dermatology)
Robert Wood Johnson Medical School
Chief of Service, NJMS University Hospital in Newark and RWJ
University Hospital in New Brunswick
Chief, Division of Oncological Pathology
Cancer Institute of New Jersey
Rutgers University, New Jersey, USA
OFFICE ADDRESS: Rutgers – New Jersey Medical School
185 South Orange Avenue, MSB C 671
Newark, NJ 07103
Rutgers – Robert Wood Johnson Medical School
One Robert Wood Johnson Place, MEB 212
New Brunswick, NJ 08901
E-MAIL ADDRESS:
CITIZENSHIP: USA
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EDUCATION:
A. Undergraduate Graduate and Professional
Tong Liao Medical College (Inner Mongolia University of Nationality),
Tong Liao, China
Degree (Discipline): B.M./M.D. (Medicine) Date Awarded: July, 1985
B. Graduate and Professional
University of Pennsylvania School of Medicine, Philadelphia, PA
Degree (Discipline): Ph.D. (Pathology) Date Awarded: December, 1993
POSTGRADUATE TRAINING:
A. Internship and Residencies
Hahnemann U. Hospital, Philadelphia, Pennsylvania
Anatomical and Clinical Pathology
01/01/1996 to 06/30/1999
UT MD Anderson Cancer Hospital, Houston, Texas
Surgical Oncological Pathology
07/01/1999 to 06/30/2000
B. Postdoctoral Appointments
Scripps Clinic, La Jolla, California
Oncovirology
01/01/1994 to 12/31/1995
ACADEMIC APPOINTMENTS:
Department of Pathology, Immunology and Laboratory Medicine
Rutgers - New Jersey Medical School
Professor and Chair, Tenured
2015 – Present
Department of Pathology and Laboratory Medicine
Rutgers – Robert Wood Johnson Medical School
Professor and Chair, Tenured
2015 – Present
Center for Dermatology
Rutgers – Robert Wood Johnson Medical School
Professor and Chairman
2017 – Present
Department of Pathology and Immunology, Laboratory Medicine
University of Florida
Associate Chair
2012 – 2015
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Department of Pathology and Immunology, and Laboratory Medicine
University of Florida
Professor (Tenured)
2010 – 2015
Department of Pathology, Immunology, and Laboratory Medicine
University of Florida
Endowed Chair in Gastrointestinal and Liver Research
2008 – 2015
Department of Pathology, Immunology, and Laboratory Medicine
University of Florida
Associate Professor (Tenured)
2006 – 2015
Department of Pathology, Immunology, and Laboratory Medicine
University of Florida
Assistant Professor
2000 – 2015
HOSPITAL APPOINTMENTS:
University Hospital
Attending Physician
December 2015 – Present
Robert Wood Johnson University Hospital
Attending Physician
December 2015 – Present
Newark Beth Israel Medical Center
Attending Physician
December, 2017 - Present
University of Florida Shands Hospital
Attending Physician
July 2000 – November 2015
MD Anderson Cancer Center, University of Texas,
Clinical Fellow
July 1999 – June 2000
MCP Hahnemann University Hospital
House Staff
January 1996 – June 1999
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OTHER EMPLOYMENT OR MAJOR VISITNG APPOINTMENTS: None
LICENSURE: Medical License #ME80099 State of Florida. Expire: Jan 31, 2020
Medical License #25MA09724000 State of New Jersey. Expire: June 30, 2021
DRUG LICENSURE:
CDS: N/A
DEA: N/A
CERTIFICATION: American Board of Pathology, AP/CP, indefinite (No expiration)
MEMBERSHIPS, OFFICES AND COMMITTEE ASSIGNMENTS IN
PROFESSIONAL SOCIETIES:
College of American Pathologists (CAP)
Lifetime Fellow
2000 - Present
Association of Pathology Chairs (APC)
Council, Chair-Practice and Management Committee
2019 - Present
American Association for the Study of Liver Diseases (AASLD)
2000 - Present
Association of Pathology Chairs (APC)
Member
2012 - Present
American Gastroenterology Association (AGA)
Member and nomination committee
2000 - Present
American Society of Investigative Pathology (ASIP)
Member
2002 - Present
United States & Canadian Academy of Pathology (USCAP)
Member
2003 - Present
Hans Popper Hepatopathology Society
Member and Educational Committee
2005 - Present
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Rodger Haggitt Gastrointestinal Pathology Society
Member
2005 - Present
American Association for Cancer Research (AACR)
Member
2009 - Present
HONORS AND AWARDS:
Faculty of the year, Rutgers University 2019
Alpha Omega Alpha member 2017
Technology Innovator Award, University of Florida 2015
University of Florida Research Foundation Professorship 2014
Technology Innovator Award, University of Florida 2013
Pathology Resident Teaching Award, University of Florida 2011
Howard Hughes Medical Institute Undergraduate Mentor Award 2010
Mid-career Mentor Award, National Institute of Health 2009
Liver Research Scholar, American Liver Foundation 2002
Clinical Fellow Research Award, M.D. Anderson Cancer Center 1999
Award from Gastrointestinal Pathology Society 1998
House Staff Research Award, MCP Hahnemann University 1997
Individual National Research Award, National Cancer Institute, NIH 1994
Scientific Merit Award, Ministry of Health, China 1988
Honored Outstanding Medical Graduate, Tong Liao Medical College 1985
BOARDS OF DIRECTORS/TRUSTEES POSITIONS:
Member, Board of Trustee, Rutgers Health
2016 - Present
Board of Governors, Robert Wood Johnson Medical School
2016 – Present
Board of University Physicians, New Jersey Medical School
2015 – Present
Chair, Board of Trustee, Chinese Hua-Gen School, Gainesville, Florida
2008 – 2011
SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS,
COMMITTEES:
Member of National Institutes of Health Study Sections (ad hoc): 2003, 2005, 2006,
2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019
NIH Clinical Oncology Study Section (CONC, Regular Member) 2015-2021
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SERVICE ON MAJOR COMMITTEES:
A. International:
American Association for the Study of Liver Diseases (AASLD)
Basic Science Committee
2004 - 2008
American Gastroenterology Association (AGA)
Nomination Committee
2011 - 2014
Hans Popper Hepatopathology Society
Educational Committee
2010 - 2013
B. National:
Association of Pathology Chairs (APC)
Council, Chair-Practice and Management Committee
2019 – Present
Annual Princeton Integrated Pathology Symposium (PIPS)
Advisory Committee
2013 – Present
Alpha-1 Foundation
Member of Tissue Bank Committee,
2005 – 2008.
C. Medical School/University:
Clinical Leadership Committee, Robert Wood Johnson Medical School
2015 – Present
Chairs Committee, Rutgers Health
2016 – Present
Academic Affair Committee of Faculty Senate
University of Florida
2010 – 2014
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D. Hospital:
Medical Executive Committee, University Hospital
2015 – Present
Medical Executive Committee, RWJ University Hospital
2015 - Present
IT and LIS Steering Committee
University of Florida Shands Hospital
2013 - 2015
E. Department:
University of Florida Department of Pathology, Immunology and Lab
Medicine
Faculty Search Committee
2011 – 2015
Patient outcome and population research committee
2013 - 2015
F. Editorial Boards:
Associate Editor, Laboratory Investigation (USCAP Official Journal)
2010 – Present
Editorial Board, Archives of Pathology &Laboratory Medicine
Section Editor: Precision Medicine
(College of American Pathologists Official Journal) 2014 – Present
G. AdHoc Reviewer:
J. Virology 2002 to present
Hepatology 2004 to present
Gastroenterology 2006 to present
Oncogene 2008 to 2009
American J. Pathology 2004 to present
Human Pathology 2010 to present
Cancer Research 2010 to 2011
J. Infectious Disease 2012 to 2014
Modern Pathology 2011 to present
PlosOne 2013 to present
Plos Pathogen 2012 to present
SERVICE ON GRADUATE SCHOOL COMMITTEES: None
SERVICE ON HOSPITAL COMMITTEES:
See Service on Major Committees, D.
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SERVICE TO THE COMMUNITY:
Member of Advisory Board, Eastside High School, Gainesville, Florida
2011 – 2015
Chair, Board of Trustee, Chinese Hua-Gen School, Gainesville, Florida
2008 – 2011
SPONSORSHIP (Primary Mentorship) OF CANDIDATES FOR
POSTGRADUATE DEGREE:
Jennifer Bess (Immunology and Microbiology, UF) PhD. 2004 – 2009
Erika Eksioglu (Immunology and Microbiology, UF) PhD. 2005 – 2010
Thin Le (Immunology and Microbiology, UF) PhD. 2010 – 2014
Aesis Luna (Biomedical Science, Rutgers) PhD. 2016 – Present
Saiaditya Badeti (Biomedical Science, Rutgers)
MD. Ph.D 2018-present
SPONSORSHIP (Primary Mentorship) OF POSTDOCTORAL FELLOWS:
Olorunseun Ogunwobi, Ph.D, Postdoctoral fellow 2009 – 2014
Elaine Salazar, M.D., Postdoctoral fellow 2011 – 2012
Hongyan Liu, Ph.D., Postdoctoral fellow 2007 – 2011
Frank Zhao, Ph.D., Postdoctoral fellow 2007 – 2012
Houda Darwiche, Ph.D., Postdoctoral fellow 2009 – 2011
Liping Sun, Ph.D. Postdoctoral fellow 2009 – 2011
Jun Hu, M.D., Postdoctoral fellow 2011 – 2012
Rafal Witak, Ph.D., Postdoctoral fellow 2005 – 2007
John Elyar, Ph.D., Postdoctoral fellow 2003 – 2006
Jane Dong, Ph.D., Postdoctoral fellow 2005 – 2007
Qi Su, M.D., Ph.D., Postdoctoral fellow 2005 – 2006
Chaohui Zuo, M.D., Postdoctoral fellow 2014 – 2015
William Puszyk, Ph.D., Postdoctoral Fellow 2009 – 2011
Kien Pham, Ph.D. Postdoctoral fellow 2013 – present
Frank Wu, Ph.D. Postdoctoral fellow 2014 – present
TEACHING RESPONSIBILITIES: A. Lectures or Course Directorships
Rutgers University
GI-Liver section for 2nd year-medical students 2016 –Present
GI-Liver Pathology Fellowship, Co-Diector 2018 –Present
University of Florida
Fellowship Director, Gastrointestinal and Liver Pathology 2004 – 2015
Pathology Resident Teaching 2000 – 2015
Teaching Director, Molecular Pathology 2001 – 2008
Course Director, Systemic pathology:
GI-Liver section for 2nd year-medical students (40 hrs per year) 2003 – 2010
Mentor, IDP graduate program at the University of Florida 2002 – 2015
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Mentor, NIH-T32 training program in Autoimmunity 2005 – 2015
Mentor, NIH-T32 training program in Cancer Biology 2008 – 2013
Lecture Graduate school:
Courses: Liver pathophysiology (10 hrs per year) 2001 – 2012
Mechanisms of Oncogenesis (6 hrs per year) 2009 – 2015
CLINICAL RESPONSIBILITIES: As the Chair of the Department of Pathology, Immunology and Laboratory Medicine, I
oversee the day-to-day operations of the entire department in both Newark and New
Brunswick as well as other locations.
As the Chief of Service for Gastrointestinal and Liver Pathology Service at University
Hospital in Newark, I provide pathology specialty service, consultation service for
patients and clinical practitioners, and administration. As a well-recognized GI/liver
pathologist I also provide a large number of expert consultations for many
physicians/patients.US
GRANT SUPPORT:
Active: A. Principal Investigator
1. NIH, NIDDK, R01DK110024-01, Liu & Robertson (MPI)
Epigenetic Mechanisms Underlying Hepatitis C-Induced
Hepatocarcinogenesis
The major goal of this project is to define changes to the epigenome
and transcriptome in HCV infection and HCV-associated
carcinogenesis.
09/30/2017-06/30/2021
2. NIH, NIAAA, R01 AA027179-01, Liu & Robertson (MPI)
Epigenetic Heterogeneity as a Driver of Liver Disease and Cancer
The major goal of this project is to define how epigenomic
heterogeneity plays a role in alcohol and HCV-associated liver
diseases and cancer.
08/15/2018-05/31/2023
3. Clinical trial: Epigenomics Inc. www.clinicaltrials.gov
Trial Number: NCT03218423
Colon cancer screening using Epi ProColon test based on circulating
DNA methylation
1/15/2018 – 1/14/2021
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B. Co-Investigator
1. R01 HL125571, National Institute of Health Hanash (PI)
“Regulation of the intestinal stem cell compartment after
hematopoietic transplantation”
07/01/2015-04/30/2020
2. R01 HL124112, National Institute of Health Jenq (PI)
“Microbiota-focused strategies to mitigate GVHD”
08/15/2015-05/31/2020
3. R01 AI118305, National Institute of Health, Yu (PI)
“MicroRNA Regulates Graft-versus-Host Disease”
08/01/2015-01/31/2020
5. 2P30CA72720-20 , NIH/NCI
“ Cancer Center Support Grant (CCSG)”, Libutti (PI)
03/07/2019-02/29/2024
Director, Biospecimen and Histopathology Core
6. UL1TR003017, National Institute of Health, Panettieri (PI)
“Clinical and Translational Science Award (CTSA)”
03/11/19-02/29/2024
Director, Pilot Development Core Program
Completed:
1. National Institute of Health, R01 NCI
Principal Investigator
“Molecular targets for liver cancer diagnosis and therapy”
06/01/2009 – 08/31/2016
2. James &Ester King Biomedical Research Program
Principal Investigator
"Small molecule inhibitors for Alppha-1 antitrypsin deficient
treatment"
05/25/2015 – 05/24/2018
3. R01 National Institute of Health, R01 NIAAA
Principal Investigator
“Developmental pathways, environmental agents, and epigenetics in
liver disease”
09/20/2011 – 07/30/2017
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4. National Institute of Health, R01 NCI
Co-Investigator
"Cellular and Molecular Studies of Bone Marrow Transplants"
07/01/2010 – 04/30/2015
5. National Institute of Health, R01 NIAAA
Co-Investigator
“Acute Alcohol and Calcium-Dependent LPS-Triggered Activation of
Microphages”
09/01/2009 – 08/31/2014
6. University of Florida Research Foundation
Experimental models for human pancreatic cancer
05/01/2014 – 02/28/2016
Role: PI
7. Hamner Institute
Principal Investigator
“Hepatic Tissue Registry”
05/01/2014 – 04/30/2017
8. National Institute of Health, R01 NCI
Co-Investigator
"TH1/TH17 cell differentiation in GVHD and GVL"
06/01/2010 – 04/30/2015
9. American Association for Cancer Research
Mentor
“Mechanisms of metastasis in pancreatic cancer”
03/01/2012 – 02/28/2014
10. National Institute of Health, K24 NCRR
Principal Investigator
“Mouse Immunopathology”
04/01/2009 – 12/31/2014
11. National Institute of Health, R01 NIAID
Principal Investigator
"Innate and adaptive immune response in HCV patients"
04/01/2005 – 03/31/2011
12. University of Florida Cancer Center
Principal Investigator
Team Science Project: “Immunotherapy for Liver Cancer”
Total 4 projects and 6 project leaders
01/10/2012 – 02/28/2014
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13. Juvenile Diabetes Research Foundation
Co-Investigator
“Organ Processing and Pathology Core”
12/01/2006 – 12/31/2017
14. R01 CA173878, National Institute of Health Reddy (PI)
"Role of noncoding RNA in Regulating GVHD"
03/01/2013-05/28/2019
15. Bayer Testing Group
Co-Investigator
“Bayer testing services agreement”
02/01/2013 – 12/31/2015
16. University of Florida Research Foundation
Principal Investigator
"Nanozymes in cancer therapy"
07/01/2010 – 06/30/2012
17. National Institute of Health, R01 NHLBI
Co-Investigator
"Gene Therapy Using Viral Vector for Lung and Cardiovascular
Disease"
09/01/2008 – 06/30/2013
18. National Institute of Health, NCI
Principal Investigator
"TCGA program: Pathogenesis of hepatocellular carcinoma"
09/01/2010 – 08/31/2013
19. National Institute of Health, R01 NIDDK
Co-Investigator
"Transduction of hepatocytes with rAAV for correction of genetic
abnormalities"
08/01/2006 – 07/31/2011
20. UF/Moffitt Cancer Center
Principal Investigator
“Immunotherapy for liver cancer”
2009 – 2010
21. Florida Legislature 00079010
Principal Investigator
"Adaptive Cell Therapy for Liver Cancer Using Bone Marrow
Transplantation Platform"
03/01/2009 – 03/31/2011
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22. BANYAN BIOMARKERS, Inc.
Co-Investigator
" Liver Serodiagnostic Panel of Liver Inflammation and Fibrosis in
Patients."
2008 – 2010
23. National Institute of Health, NHLBI
Principal Investigator
“Small molecules to treat alpha-1 antitrypsin deficiency”
2005 – 2008
24. Alpha-one Foundation
Principal Investigator
“Therapeutic small molecules for alpha-1 antitrypsin deficiency”
2007 – 2009
25. Geyer Foundation for Cancer Research
Principal Investigator
“Liver Cancer Biomarkers”
2008 -- 2009
26. National Institute of Health, R21, NIAID
Principal Investigator
“Murine model for hepatitis C virus”
2005 – 2008
27. National Institute of Health, K08 NIDDK
Principal Investigator
“Role of liver cytokine expression in hepatitis C viral infection”
2002 – 2007
28. Florida Biomedical Research Program
Co-Principal Investigator
Biomarker discovery of liver cancer.
2007 – 2008
29. National Institute of Health, R03 NIDDK
Principal Investigator
“Role of SOCS3 in Interferon Resistance”
2005 – 2008
30. CellzDirect Corporation (Invitrogen Inc.)
Principal Investigator
“Hepatic Registry Program.”
2005 – 2007
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31. Howard Hughes Medical Institute
Principal Investigator
Startup Program
2000 – 2002
32. Howard Hughes Medical Institute
Principal Investigator
Pilot Project
2000 – 2003
33. University of Florida Research Foundation
Principal Investigator
Opportunity research fund
2002 – 2003
34. American Liver Foundation
Principal Investigator
“Establishment and characterization of PiZZ liver cell lines.”
2003 – 2005
35. American Liver Foundation
Principal Investigator
Liver scholar award
2002 – 2005
36. Children’s Miracle Network
Principal Investigator
“Novel treatment for hepatoblastoma.”
2005 – 2006
37. Wyeth Research
Co-Investigator
"A randomized, open-label, comparative evaluation of conversion
from calcineurin inhibitor treatment to Sirolimus treatment versus"
2003 -- 2007
PUBLICATIONS:
A. Refereed Original Article in Journal
1. Liu C, Condreay LD, Burch JB, Mason WS (1991)
Characterization of the core promoter and enhancer of duck
hepatits B virus. Virology 184:242-252. PMID: 1871970
Page 15 of 53
2. Mason WS, Cullen J, Saputelli J, Wu TT, Liu C, London WT,
Lusterbader E, Shaffer P, O’connell, Aldrich CE, Jilbert AR
(1994) Characterization of the antiviral effects of
2’carbodeoxyguanosine in duck chronically infected with duck
hepatitis B virus Hepatology 19:398-411. PMID: 8294097
3. Liu C, Mason WS, Burch JBE (1994) Identification of factor
binding sites in duck hepatitis B virus and in vivo effects of
enhancer mutations. Journal of Virology. 68:2286-2296. PMID:
8139013
4. Liu C, Smith BC, Nicolaou BM, Vogt P (1996) Sequence selective
carbohydrate DNA interaction: Dimeric and monomeric forms of
the calicheamicin aryltetrasacchride interfere with transcription
factor function. Proceeding of National Academy of Science.
U.S.A, 93:940-944. PMID: 8570664
5. Guo JT, Liu C, Mason WS, Pugh JC (1998) Cloning and
expression of a cDNA encoding the large subunit of duck
replication factor C. Biochimica et Biophysica Acta 1395:293-300.
PMID: 9512663
6. Ayala G, Liu C, Nicosia R (2000) Microvasculature and VEGF
expression in cartilaginous tumors. Human Pathology. 31:341-346.
PMID: 10746677
7. Guo JT, Zhou H, Liu C, Aldrich C, Saputelli J, Whitaker T,
Barrasa I, Mason WS, Seeger C. (2000) Viral clearance and
hepatocyte turnover during hepatitis B infection in woodchucks.
Journal of Virology. 74:1495-1505. PMID: 10627561
8. Reddy P, Teshima T, Lowler K, Kukuruga M, Liu C, Cooke K,
Ferrara J (2001) Interleukin-18 regulates acute graft versus host
disease by enhancing Fas mediated donor T cell apoptosis. Journal
of Experimental Medicine. 194:1433-1440. PMID: 11714750
9. Teshima T, Liu C, Lowler KP, Dranoff G, Ferrara J. (2002) Donor
leukocyte infusion from immunized donors increases tumor
vaccine efficiency after allogenic bone marrow transplantation.
Cancer Research. 62:796-800. PMID: 11830535
10. Teshima T, Reddy P, Lowler K, Kukuruga M, Liu C, Cooke K,
Ferrara JM (2002) Flt3 ligand modulates immune responses
through expansion of CD8 + dentritic cells. Blood. 99:1825-
1832. PMID: 11861301
Page 16 of 53
11. Ordemann R, Hutchinson R, Friedman J, Burakoff SJ, Reddy P,
Duffner U, Braun TM, Liu C, Teshima T, Ferrara J. (2002)
Enhanced allostimulatory activity of host antigen-presenting cells
in old mice intensifies acute graft-versus-host disease Journal of
Clinical Investigation. 109:1249-56. PMID: 11994414
12. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Reed A, Hemming A,
Howard R, Van Der Werf W, Lauwers G, Liu C, Crawford JM,
Davis GL, Nelson DR. Combination of interferon alfa-2b and
ribavirin in liver transplant recipients with histological recurrent
hepatitis C. Liver Transplantation 2002 Nov;8(11):1000-1006.
PMID: 12424712
13. Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke KR &
Ferrara JM (2002) Acute graft-versus-host disease does not require
alloantigen expression on host epitheLium. Nature Medicine
8:575-581. (Cover article). PMID: 12042807
14. Hildebrandt, G.C., Duffner, U.A., Olkiewicz, K.M., Willmarth,
N.E., Corrion, L.A., Clouthier, S., Williams, D.L., Reddy, P.R.,
Moore, B.B., Liu, C., and K.R. Cooke. (2003). A Critical Role for
CCR2 in the development of idiopathic pneumonia syndrome after
allogeneic bone marrow transplantation. Blood, 2004 103:2417-
2426. PMID: 14615370
15. Duffner, U., Lu, B., Teshima, T., Williams, D.L., Hildebrandt, G.,
Reddy, P., Ordemann, R., Lowler, K., Liu, C., Cooke, K.R., and
Ferrara J.L.M. (2003) Role of CXCR3-induced donor T-cell
migration in acute GVHD. Experimental Hematolology. (10):897-
902. PMID: 14550805
16. Nelson DR, Tu Z, Soldevila-Pico C, Abdelmalek M, Zhu H, Xu
YL, Liu, C, Davis GL (2003) Long-term interleukin 10 therapy in
chronic hepatitis C patients has a proviral and anti-inflammatory
effect. Hepatology, 38(4):859-68. PMID: 14512873
17. Clouthier S, Cooke KR, Teshima T, Lowler KP, Liu C, Connolly
K, Ferrara JL (2003) Repifermin (Keratinocyte Growth Factor-2),
delays onset of graft-versus-host disease while preserving a graft-
versus-leukemia effect. Biology of Bone marrow, Blood and
Transplantation. (9):592-603. PMID: 14506661
18. Reddy P, Teshima T, Hildebrandt G, Williams DL, Liu C, Cooke
KR, Ferrara JL. (2003) Pretreatment of donors with interleukin-18
attenuates acute graft-versus-host disease via STAT6 and preserves
graft-versus-leukemia effects. Blood 101(7):2877-85. PMID:
12433681
Page 17 of 53
19. Teshima T, Reddy P, Liu C, Williams D, Cooke KR, Ferrara JL.
(2003) Impaired thymic negative selection causes autoimmune
graft-versus-host disease. Blood 102(2):429-35. PMID: 12663438
20. Ichiba T, Teshima T, Kuick R, Misek DE, Liu C, Takada Y,
Maeda Y, Reddy P, Williams DL, Hanash S, Ferrara JL. (2003)
Early changes in gene expression profiles of hepatic GVHD
uncovered by oligonucleotid microarrays. Blood 102(2):763-71.
PMID: 12663442
21. Petrovic, A; Alpdogan, O; Willis, LM; Eng, JM; Greenberg, AS;
Kappel, BJ; Liu, C; Murphy, G; Heller, G and van den Brink, MR
(2004) LPAM ( / integrin) is an important homing integrin on
alloreactive T cells in the development of intestinal Graft-Versus-
Host Disease. Blood.103: 1542-1547. PMID: 14563643
22. Zhu, HZ; Liu, C. (2003) Interleukin 1 inhibits hepatitis C viral
RNA replication by activation of extracellular regulated kinase
pathway. Journal of Virology. 77:5493-5498. PMID: PMC153991
23. Zhu, H.Z; Zhao, HS; Collins, CD; Eckenrode, SE; Run, Q;
McIndoe, RA; Crawford, JM; Nelson, DR; She, JX; Liu, C. Gene
expression associated with IFN alpha antiviral activity in an HCV
replicon cell line. (2003) Hepatology, 37:1180-1188.
EDITORIAL: on page 975. PMID: 12717400
24. Hassanein A, Glanz S, Kessler H, Eskin T, Liu C (2003) Beta
catenin is aberrantly expressed in tumors expression shadow cells:
pilomatricoma, craniopharyngioma, and calcifying odontogenic
tumor. American J Journal of Clinical Pathology. 120(5):732-6.
PMID: 14608900
25. Liu, C; Zhu, HZ; Xu, YL; Nelson, DR. (2003) CD8+ T cell
interaction with HCV replicon cells: evidence for both cytokine-
and cell-mediated antiviral activity. Hepatology, 37:1335-1342.
PMID: 12774012
26. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Cabrera R, Shuster JJ,
Theriaque D, Reed AI, Hemming AW, Liu C, Crawford JM, and
Nelson DR.(2004) One-year Protocol Liver Biopsy Can Stratify
Fibrosis Progression In Liver Transplant Recipients With
Recurrent Hepatitis C Infection. Liver Transplantation. 40:1062-
71. PMID: 15376304
Page 18 of 53
27. Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D,
Boyd A, Kupper TS, Burakoff SJ. (2004) Increasing T-cell age
reduces effector activity but preserves proliferative capacity in a
murine allogeneic major histocompatibility complex-mismatched
bone marrow transplant model. Biology of Blood Marrow
Transplantation.10:448-60. PMID: 15205666
28. Hildebrandt, GC; Olkiewicz, KM; Chang, Y; Liu, C; Cooke, KR
(2004) Donor-dreived TNF regulates pulmonary chemokine
expression and the development of idiopathic pneumonia
syndrome after allogenic bone marraow transplantation. Blood,
104:586-93. PMID: 15069018
29. Persad, R; Liu, C; Wu, TT; Houlihan, PS; Hamilton, SR; Diehl,
AM, Rashid, A (2004) Overexpression of caspase 3 in
hepatocellular carcinoma. Modern Pathology, 17(8) 1026. PMID:
15098015
30. Abdelmalek MF, Firpi RJ, Soldevila-Pico C, Reed AI, Hemming
AW, Liu C, Crawford JM, Davis GL, Nelson DR (2004) Sustained
viral response to interferon and ribavirin in liver transplant
recipients with recurrent hepatitis C. Liver Transplantation.
10(2):199-207. PMID: 14762857
31. Hildebrandt GC, Corrion, LA, Olkiewicz, KM, Lowler, K, Moore,
BB, Kuziel, WA, Liu, C and Cooke, KR. (2004) Blockade of
CXCR3 receptor:ligand interactions reduces leukocyte recruitment
to the lung and the severity of experimental idiopathic pneumonia
syndrome Journal of Immunology, 173:2050-9. PMID: 15265940
32. Duffner, UA; Maeda, Y; Cooke, KR; Reddy, P; Ordemann, R; Liu,
C; Ferrara, JL. (2004) Host dendritic cells alone are sufficient to
initiate acute graft-versus-host-disease. Journal of Immunology.
172:7393-7398 PMID: 15178116
33. Min CK, Maeda Y, Lowler K, Liu, C, Clouthier S, Lofthus D,
Weisiger E, Ferrara JL, Reddy P. (2004) Paradoxical effects of
interleukin-18 on the severity of acute graft-versus-host disease
mediated by CD4+ and CD8+ T cell subsets after experimental
allogeneic bone marrow transplantation. Blood, 104:3393-3399.
PMID: 15280194
34. Camp ER, Hochwald SN, Liu C. (2004) FAP with concurrent
duodenal adenomatous polyposis and carcinoid tumor. Journal of
Surgical Oncology. 87(4):187-90. PMID: 15334634
Page 19 of 53
35. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, Nelson DR.
(2004) An immunomodulatory role for CD4(+)CD25(+) regulatory
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197. Auletta JJ, Eid SK, Wuttisarnwattana P, Silva I, Metheny L, Keller
MD, Guardia-Wolff R, Liu C, Wang F, Bowen T, Lee Z, Solchaga
LA, Ganguly S, Tyler M, Wilson DL, Cooke KR. (2015) Human
mesenchymal stromal cells attenuate graft-versus-host disease and
maintain graft-versus-leukemia activity following experimental
allogeneic bone marrow transplantation. Stem Cells. Feb;33
(2):601-14. PMID: 25336340
198. Trinh TL, Zhu G, Xiao X, Puszyk W, Sefah K, Wu Q, Tan W, Liu
C. (2015) A Synthetic Aptamer-Drug Adduct for Targeted Liver
Cancer Therapy. PLoS One. Nov 2;10(11):e0136673. eCollection
2015. PMID: 26523833
199. Das DK, Naidoo MK, Ilboudo A, DuBois P, Durojaiye V, Liu C,
Ogunwobi OO. (2015) Isolation and Propagation of Circulating
Tumor Cells from a Mouse Cancer Model. J Vis Exp. 2015 Oct
9;(104). PMID: 26484891
Page 41 of 53
200. Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH,
Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM,
Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML,
O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo
T, Dow LE, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R,
van den Brink MR, Hanash AM. (2015) Interleukin-22 promotes
intestinal-stem-cell-mediated epithelial regeneration. Nature. Dec
24;528(7583):560-4. Epub 2015 Dec 9. PMID: 26649819
201. Nguyen HD, Chatterjee S, Haarberg KM, Wu Y, Bastian D,
Heinrichs J, Fu J, Daenthanasanmak A, Schutt S, Shrestha S, Liu
C, Wang H, Chi H, Mehrotra S, Yu XZ. (2016) Metabolic
reprogramming of alloantigen-activated T cells after hematopoietic
cell transplantation. J Clin Invest. 2016 Apr 1;126(4):1337-52
202. Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu C, Jin J,
Anasetti C, Yu XZ. (2016) T-bet Promotes Acute Graft-versus-
Host Disease by Regulating Recipient Hematopoietic Cells in
Mice. J Immunol. 2016 Apr 1;196(7):3168-79. Epub 2016 Feb 22
203. Zhou K, Xia M, Tang B, Yang D, Liu N, Tang D, Xie H, Wang X,
Zhu H, Liu C, Zuo C. (2016) Isolation and comparison of
mesenchymal stem cell‑like cells derived from human gastric
cancer tissues and corresponding ovarian metastases. (2015) Mol
Med Rep. Feb;13(2):1788-94. Epub 2015 Dec 30. PMID:
26718033
204. Pham K, Delitto D, Knowlton A, Hartlage ER, Madhavan R,
Gonzalo DH, Thomas R, Behrns KE, George T, Hughes S, Wallet
S, Trevino J, Liu C (2016) Isolation of Pancreatic Cancer Cells
from a Patient-Derived Xenograft Model, Allows for Practical
Expansion and Preserved Heterogeneity in Culture. Am. J.
Pathology. Jun;186(6):1537-46. Epub 2016 Apr 18. PMID:
27102771
205. Li W, Liu L, Gomez A, Zhang J, Ramadan A, Zhang Q, Choi SW,
Zhang P, Greenson JK, Liu C, Jiang D, Virts E, Kelich SL, Chu
HW, Flynn R, Blazar BR, Hanenberg H, Hanash S, Paczesny S.
(2016) Proteomics analysis reveals a Th17-prone cell population in
presymptomatic graft-versus-host disease. JCI Insight. 2016 May
5;1(6). pii: e86660.
Page 42 of 53
206. Delitto D, Black BS, Cunningham HB, Sliesoraitis S, Lu X, Liu C,
Sarosi GA, Thomas RM, Trevino JG, Hughes SJ, George TJ Jr,
Behrns KE. Standardization of surgical care in a high-volume
center improves survival in resected pancreatic head cancer. Am J
Surg. 2016 Aug;212(2):195-201.e1. Epub 2016 May 10. PMID:
27260793; PMCID: PMC4969126.
207. Heinrichs J, Li J, Nguyen H, Wu Y, Bastian D, Daethanasanmak
A, Sofi MH, Schutt S, Liu C, Jin J, Betts B, Anasetti C, Yu XZ.
(2016) CD8(+) Tregs promote GVHD prevention and overcome
the impaired GVL effect mediated by CD4(+) Tregs in mice.
Oncoimmunology. 2016 Mar 28;5(6):e1146842.
208. Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai
JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR,
Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M,
Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA,
Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss
EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink
MR, Jenq RR. Increased GVHD-related mortality with broad-
spectrum antibiotic use after allogeneic hematopoietic stem cell
transplantation in human patients and mice. Sci. Transl Med. 2016
May 18;8(339)
209. Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey
VM, Cammer M, Neil J, Dewan MZ, Lieberman SR, Lazrak A,
Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, van den
Brink MRM, Cadwell K. (2017) Autophagy protein ATG16L1
prevents necroptosis in the intestinal epithelium. J Exp Med. 2017
Dec 4;214(12):3687-3705. PMID: 29089374
210. Nieves EC, Toubai T, Peltier DC, Oravecz-Wilson K, Liu C,
Tamaki H, Sun Y, Reddy P. STAT3 Expression in Host Myeloid
Cells Controls Graft-versus-Host Disease Severity. Biol Blood
Marrow Transplant. 2017 Jul 8. pii: S1083-8791(17)30549-9.
[Epub ahead of print] PubMed PMID: 28694183.
211. Fischer JC, Bscheider M, Eisenkolb G, Lin CC, Wintges A, Otten
V, Lindemans CA, Heidegger S, Rudelius M, Monette S,
Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C,
Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y,
Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas
T, van den Brink MRM, Poeck H. RIG-I/MAVS and STING
signaling promote gut integrity during irradiation- and immune-
mediated tissue injury. Sci Transl Med. 2017 Apr 19;9(386). pii:
eaag2513. PubMed PMID: 28424327.
Page 43 of 53
212. Hlady RA, Zhou D, Puszyk W, Roberts LR, Liu C, Robertson
KD. (2017) Initiation of aberrant DNA methylation patterns and
heterogeneity in precancerous lesions of human hepatocellular
cancer. Epigenetics. 2017 Mar 4;12(3):215-225. PMID: 28059585;
PMCID: 5406211.
213. Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER,
Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM,
George TJ Jr, Brusko TM, Mathews CE, Liu C, Trevino JG,
Hughes SJ, Wallet SM.(2017) Human Pancreatic Cancer Cells
Induce a MyD88-Dependent Stromal Response to Promote a
Tumor-Tolerant Immune Microenvironment. Cancer Res. 2017
Feb 1;77(3):672-683.. Epub 2016 Nov 18. PMID: 27864347;
PMCID: PMC5290036.
214. Ramadan A, Griesenauer B, Adom D, Kapur R, Hanenberg H, Liu
C, Kaplan MH, Paczesny S. Specifically differentiated T cell
subset promotes tumor immunity over fatal immunity. (2017) J
Exp Med. 2017 Dec 4;214(12):3577-3596. doi:
10.1084/jem.20170041. Epub 2017 Oct 16.PMID: 29038366
215. Wu Q, Pi L, Le Trinh T, Zuo C, Xia M, Jiao Y, Hou Z, Jo S,
Puszyk W, Pham K, Nelson DR, Robertson K, Ostrov D,
Rameshwar P, Xia CQ, Liu C (2017). A Novel Vaccine Targeting
Glypican-3 as a Treatment for Hepatocellular Carcinoma. Mol
Ther. 2017 Oct 4;25(10):2299-2308. Epub 2017 Aug 10. PMID:
28865999
216. Toubai T, Rossi C, Oravecz-Wilson K, Zajac C, Liu C, Braun T,
Fujiwara H, Wu J, Sun Y, Brabbs S, Tamaki H, Magenau J, Zheng
P, Liu Y, Reddy P. Siglec-G represses DAMP-mediated effects on
T cells. JCI Insight. 2017 Jul 20;2(14). pii: 92293. [Epub ahead of
print] PMID: 28724800
217. Ghosh A, Smith M, James SE, Davila ML, Velardi E,
Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER,
Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young
LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC,
Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR.
Donor CD19 CAR T cells exert potent graft-versus-lymphoma
activity with diminished graft-versus-host activity. Nat Med. 2017
Feb;23(2):242-249. Epub 2017 Jan 9. PMID: 28067900
Page 44 of 53
218. Zhou D, Hlady RA, Schafer MJ, White TA, Liu C, Choi JH,
Miller JD, Roberts LR, LeBrasseur NK, Robertson KD. High fat
diet and exercise lead to a disrupted and pathogenic DNA
methylome in mouse liver. Epigenetics. 2017 Jan 2;12(1):55-69.
Epub 2016 Nov 18. PMID: 27858497
219. Wu Q, Jorgensen M, Song J, Zhou J, Liu C, Pi L. Members of the
Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic
Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma.
Gastroenterol Res Pract. 2016;2016:2313850. Epub 2016 Oct 18.
PMID: 27829832
220. Khodayari N, Wang RL, Marek G, Krotova K, Kirst M, Liu C,
Rouhani F, Brantly M. SVIP regulates Z variant alpha-1
antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78.
PLoS One. 2017 Mar 16;12(3):e0172983. eCollection 2017.
PubMed PMID: 28301499; PMCID: PMC5354272.
221. Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH,
Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR,
Hu CC, Yu XZ. (2018) Inhibition of the IRE-1α/XBP-1 pathway
prevents chronic GVHD and preserves the GVL effect in mice.
Blood Adv. 2018 Feb 27;2(4):414-427. PMID: 29483082
222. Betts BC, Bastian D, Iamsawat S, Nguyen H, Heinrichs JL, Wu Y,
Daenthanasanmak A, Veerapathran A, O'Mahony A, Walton K,
Reff J, Horna P, Sagatys EM, Lee MC, Singer J, Chang YJ, Liu C,
Pidala J, Anasetti C, Yu XZ.(2018) Targeting JAK2 reduces
GVHD and xenograft rejection through regulation of T cell
differentiation. Proc Natl Acad Sci U S A. 2018 Feb
13;115(7):1582-1587. PMID:29382747.
223. Iamsawat S, Daenthanasanmak A, Voss JH, Nguyen H, Bastian D,
Liu C, Yu XZ. Stabilization of Foxp3 by Targeting JAK2
Enhances Efficacy of CD8 Induced Regulatory T Cells in the
Prevention of Graft-versus-Host Disease. J Immunol. 2018 Sep 21.
[Epub ahead of print] PMID: 30242073
224. Fujiwara H, Docampo MD, Riwes M, Peltier D, Toubai T, Henig I,
Wu SJ, Kim S, Taylor A, Brabbs S, Liu C, Zajac C, Oravecz-
Wilson K, Sun Y, Núñez G, Levine JE, van den Brink MRM,
Ferrara JLM, Reddy P. Microbial metabolite sensor GPR43
controls severity of experimental GVHD. Nat Commun. 2018 Sep
10;9(1):3674.
Page 45 of 53
225. Clark VC, Marek G, Liu C, Collinsworth A, Shuster J, Kurtz T,
Nolte J, Brantly M. Clinical and histologic features of adults with
alpha-1 antitrypsin deficiency in a non-cirrhotic cohort.
Hepatology. 2018 Aug 21. [Epub ahead of print] PMID: 30138687
226. Hlady RA, Sathyanarayan A, Thompson JJ, Zhou D, Wu Q, Pham
K, Lee JH, Liu C, Robertson KD. Integrating the Epigenome to
Identify Novel Drivers of Hepatocellular Carcinoma. Hepatology.
2018 Aug 22. [Epub ahead of print] PMID: 30136421
227. Paratala BS, Chung JH, Williams CB, Yilmazel B, Petrosky W,
Williams K, Schrock AB, Gay LM, Lee E, Dolfi SC, Pham K, Lin
S, Yao M, Kulkarni A, DiClemente F, Liu C, Rodriguez-
Rodriguez L, Ganesan S, Ross JS, Ali SM, Leyland-Jones B,
Hirshfield KM. RET rearrangements are actionable alterations in
breast cancer. Nat Commun. 2018 Nov 16;9(1):4821. PMID:
30446652
228. Toubai T, Tamaki H, Peltier DC, Rossi C, Oravecz-Wilson K, Liu
C, Zajac C, Wu J, Sun Y, Fujiwara H, Henig I, Kim S, Lombard
DB, Reddy P. Mitochondrial Deacetylase SIRT3 Plays an
Important Role in Donor T Cell Responses after Experimental
Allogeneic Hematopoietic Transplantation. J Immunol. 2018 Dec
1;201(11):3443-3455. Epub 2018 Nov 2. PMID: 30389773
229. Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM,
Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young
LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF,
Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM.
Nrf2 regulates CD4+ T cell-induced acute graft-versus-host
disease in mice.Blood. 2018 Dec 27;132(26):2763-2774.. Epub
2018 Oct 31. PMID: 30381375
230. Iamsawat S, Daenthanasanmak A, Voss JH, Nguyen H, Bastian D,
Liu C, Yu XZ. Stabilization of Foxp3 by Targeting JAK2
Enhances Efficacy of CD8 Induced Regulatory T Cells in the
Prevention of Graft-versus-Host Disease. J Immunol. 2018 Nov
1;201(9):2812-2823. Epub 2018 Sep 21. PMID: 30242073
231. Daenthanasanmak A, Iamsawat S, Chakraborty P, Nguyen HD,
Bastian D, Liu C, Mehrotra S, Yu XZ. Targeting Sirt-1 controls
GVHD by inhibiting T-cell allo-response and promoting Treg
stability in mice. Blood. 2019 Jan 17;133(3):266-279. PMID:
30514750
Page 46 of 53
232. Zhang X, Pham K, Li D, Schutte RJ, Brantly M, Liu C, Ostrov
DA. Targeting the site encoded by SERPINA1*E342K for treating
alpha-1 antitrypsin deficiency-associated liver diseases. FEBS Lett.
2019 May 22. [Epub ahead of print] PMID: 31116417
233. Sivaram N, McLaughlin PA, Han HV, Petrenko O, Jiang YP,
Ballou LM, Pham K, Liu C, van der Velden AW, Lin RZ. umor-
intrinsic PIK3CA represses tumor immunogenecity in a model of
pancreatic cancer. J Clin Invest. 2019 May 21;130. pii: 123540.
PMID: 31112530
234. Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A,
Heinrichs Voss J, Nguyen H, Bastian D, Iamsawat S, Selvam SP,
Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, Yu XZ.
Thioredoxin-1 confines T cell alloresponse and pathogenicity in
graft-versus-host disease. J Clin Invest. 2019 May 2;130:2760-
2774.
235. Toubai T, Fujiwara H, Rossi C, Riwes M, Tamaki H, Zajac C, Liu
C, Mathew AV, Byun J, Oravecz-Wilson K, Matsuda I, Sun Y,
Peltier D, Wu J, Chen J, Seregin S, Henig I, Kim S, Brabbs S,
Pennathur S, Chen G, Reddy P. Host NLRP6 exacerbates graft-
versus-host disease independent of gut microbial composition. Nat
Microbiol. 2019 May;4(5):800-81. Epub 2019 Mar 11. PMID:
30858572
236. Wang L, Marek GW 3rd, Hlady RA, Wagner RT, Zhao X, Clark
VC, Fan AX, Liu C, Brantly M, Robertson KD. Alpha-1
Antitrypsin Deficiency Liver Disease, Mutational Homogeneity
Modulated by Epigenetic Heterogeneity With Links to Obesity.
Hepatology. 2019 Jul;70(1):51-66. Epub 2019 Mar 20.
B. Books, Monographs and Chapters
1. Wu TT, Condreay LD, Liu C, Mason WS and Jibert JR (1991)
Hepadnavirus DNA synthesis. In: 1990 international symposium on
viral hepatitis and liver disease ed. Hollinger, B; Margolis H; William
and Wilkins. 114-121.
2. Mason WS, Summers J, Liu C, Condreay LD, Wu TT (1991) Chronic
hepadnavirus infection. In: international symposium on hepatitis delta
virus, ed. Gerin, J; Purcell; Rizetto, M Wiley-Liss, Inc. 235-242.
3. Liu C; Crawford JM. (2003) Liver anatomy. In: Madara ed.
“Encyclopedia of Gastroenterology.” pp 510-515.
Page 47 of 53
4. Liu C; Crawford JM. (2003) Liver biopsy. In: Madara ed.
“Encyclopedia of Gastroenterology.” pp. 516-522.
5. Liu C; Crawford JM. (2004) Chapter 17, Pathology of gastrointestinal
tract. In “Robbins Pathologic Basis of Disease”. 7 th edn. pp. 410-
474.
6. Liu C; Crawford JM. (2004) Graft-versus-Host Disease of the Liver.
In: Ferrara ed. “Graft-vs-Host Disease.” 3 rd edn. Marcel Dekker, New
Yrok. pp: 257-278.
7. Liu C; Crawford JM (2005) Chapter 17 and 18, in “Robbins and
Cotran Pathologic Basis of Disease.” Pocket book. pp. 516-522.
8. Liu C (2006) Hepatitis C Virology and Experimental Models. “Clinics
in Liver Disease”. 10:773-791.
9. Liu C (2009) Primary Hepatocyte Culture in HCV Research.
"Hepatitis C Protocols". Methods Mol Biol. 2009;510:373-82.
10. Liu C, Crawford JM (2009) Chapter 18, Liver Pathology, in Robbins
and Cotran Pathologic Basis of Disease, 8 th ed.
11. Liu C, Crawford JM. (2009) Pathological staging of biliary tract
cancers. In Biliary Tract and Gallbladder Cancers. Pp. 77-84 Ed.
Thomas and Fuller, Demos Medical, New York.
12. Kim Y, Liu C, Tan WH, (2009) Aptamers generated by cell-based
SELEX for biomarker discovery. Biomark Med. 2009 Apr;3(2):193-
202.
13. Ogunwobi O, Liu C. (2011) Therapeutic markers for liver cancer
metastasis. Critical Reviews in Oncology/Hematology. 2012
Sep;83(3):319-28, 2011 Dec 16. [Epub ahead of print].
14. Tan W, Wang H, Chen Y, Zhang X, Zhu H, Yang C, Yang R, Liu C.
(2011) Molecular aptamers for drug delivery. Trends Biotechnology.
2011 Dec;29(12):634-40.
15. Liu C (2012) Guardian and selective killer: the versatile functions of
TLR3 in hepatocellular carcinoma. J National Cancer Institute. 2012
Dec 5;104(23):1780-2
16. Fyfe B, Zaldana F, Liu C. The Pathology of Acute Liver Failure. Clin
Liver Dis. 2018 May;22(2):257-268. doi: 10.1016/j.cld.2018.01.003.
PMID: 29605065
Page 48 of 53
17. Liu C (2018) Precision Pathology of Liver Cancer, Editor
C. Patents Held
1. Human Liver Cancer Cell Line, US patent 8017391, issued September
2011
2. Compounds for alpha-1 antitrypsin deficiency treatment, US patent
6403646, issued May 2013
3. New polypeptide for alpha-1 antitrypsin deficiency, US patent
application, US12/522,958
4. Epigenetic markers for liver cancer, US patent application, filed in
January, 2011
5. Nanozyme as a new therapeutic agent for infection and cancer, US
patent application, filed in March 2011
D. Other Articles (Reviews, Editorials, etc.) In Journals; Chapters; Books; other
Professional Communications
See Section B
Abstracts (Representative)
1. Jose Varillas, Weian Sheng, Kangfu Chen, Thomas George, Liu C,
Hugh Fan. Capture of Circulating Tumor Cells (CTCs) in
Microfluidic Devices for Patient Treatment Monitoring. BMES
2015 Annual Meeting, scheduled for October 7-10, 2015
2. Thu Le Trinh, Guizhi Zhu, Xilin Xiao, Xiaokui Zhang, Kwame
Sefah, Weihong Tan, and Liu C. AS1411-Doxorubicin adduct for
targeted liver cancer therapy. 2013 AACR-NCI-EORTC Molecular
Targets and Cancer Therapeutics Conference, October 19-23,
Boston MA.
3. Olorunseun O. Ogunwobi, Thu L. Trinh, and Liu C. Human
glypican-3 promotes hepatocellular carcinoma progression via
induction of epithelial-mesenchymal transition. AACR 103rd
Annual Meeting 2012-- Mar 31-Apr 4, 2012; Chicago, IL
4. Thu Le Trinh, K. Safah, W. Tan, Liu C. AS1411 as a Potential
Anti-Cancer Reagent for Treatment of Hepatocellular Carcinoma.
24th EORTC-NCI-AACR symposium on ‘Molecular targets and
cancer therapeutics’– 6-9 November 2012, Dublin, Ireland.
Page 49 of 53
5. Thu Le Trinh and Liu C. Glypican-3 as a potential therapeutic
target for hepatocellular carcinoma immunotherapy. Experimental
biology 2012– April 21-25, 2012; San Diego, CA
6. Jeung J, Patel R, Wakefield D, Liu C Characterization of HER2
Expression in Primary Gastroesophageal adenocarcinoma. USCAP
100th Annual Meeting, Feb. 2011, Modern Pathology, 24:153A.
7. Liu J, Zhu HZ, Liu HY, Nelson, DR, Liu C (2010) TRAIL agonist
resistance is associated with death receptor mutations. Digestive
Disease Week, May, 2010. (Oral Presentation)
8. Ogunwobi OO, Liu C. Hepatocyte growth factor upregulation and
signaling is associated with carcinogenesis and mesenchymal
characteristics in hepatocellular carcinoma. American Association
for Cancer Research Annual Meeting, Orlando, Florida, USA,
April 2011.
9. Ogunwobi OO, Zhang L, Liu C. Multiple growth factors induce
epithelial-mesenchymal transition in novel liver cancer cell lines.
American Association for Cancer Research Special Conference on
EMT and Cancer Progression and Treatment, Arlington, Virginia,
USA, February 2010.
10. Gilliland K, Dong, HJ, Hochwald, S, Liu C The role of k-ras
mutations in pancreatic neuroendocrine tumors. USCAP Annual
Meeting, March, 2010. Modern Pathology, 23:355A.
11. Liu C, Cardona D, Dong J K-ras mutations in hepatocellular
carcinoma. USCAP Annual Meeting, March, 2010, Modern
Pathology, 23:363A.
12. Zhao XX, Zhu HZ, Zhang XK, Liu J, Nelson DR, and Liu C
Cycloheximide sensitizes TRAIL-agonist-induced apoptosis in
liver cancer cells AACR Cell death mechanisms and cancer
therapy Feb, San Diego, CA, 2010 Culture and immortalization of
hepatitis C viral positive human hepatocytes. Poster, AASLD,
2003. Hepatology, 34: 462A
Reports
N/A
Page 50 of 53
PRESENTIONS:
A. Scientific (Basic Science):
2001 University of Michigan, Liver pathology in graft-versus-host
disease.
2003 Institute for Medicinal Biotechnology, Chinese Academy of
Medical Sciences. Interferon signaling in hepatitis C viral
infection.
2003 Institute for Infectious Diseases, Beijing, China. Functional
genomics in hepatitis C viral infection.
2004 Keynote speaker, Shandong University, China, Hepatitis C
diagnosis and therapy.
2005 Harvard Medical School, Innate and adaptive immunity in HCV
infection.
2005 Invited speaker, Alpha-1 Foundation International Scientific
Conference, Small molecules for AAT deficient therapy.
2007 Invited speaker, Chinese Academy of Medical Sciences, Innate
immunity in HCV.
2008 Invited speaker, China Medical University, Novel therapy for liver
cancer.
2008 Falk Symposium, Mainz, Germany, Trail agonists for liver cancer
therapy
2008 Invited speaker, Inner Mongolia Medical College. Liver disease
updated therapies.
2008 College of Veterinary Medicine, University of Florida. Innate
Immunity
2008 Harvard Medical School and Brigham and Women's Hospital,
TRAIL pathway in hepatitis C viral infection and liver cancer.
2008 Invited speaker, Moffitt Cancer Center. Immunotherapy for HCV
and liver cancer.
2008 Keynote speaker, Florida State University, Innate immunity in
hepatitis C infection
2008 Duke University Medical Center, "Apoptosis in HCV and Liver
cancer".
Page 51 of 53
2009 Invitrogen Inc. " Liver cell line and mouse model in liver disease
research.
2009 Keynote speaker and scientific session chair, 2nd World cancer
congress
2009 Invited speaker, Beijing University, "Hepatitis C animal models".
2009 Invited speaker, Hunan University "Liver cancer therapy, current
progress".
2009 Invited speaker, Chinese Academy of Sciences, "Aptamer in
translational medicine".
2010 Invited speaker, Penn State School of Medicine, "TRAIL-agonists
in liver cancer therapy".
2010 Invited speaker, Drexel University, Institute of Biotechnology.
Apoptosis and liver cancer therapy.
2011 Invited speaker, Medical College of Georgia. "Developing novel
therapeutic strategies for liver cancer."
2012 Invited speaker, University of Kentucky. "Immunotherapy for
Liver Cancer".
2012 Invited speaker, 5th International Symposium on Bioanalysis,
Biomedical Engineering and Nanotechnology. "Nanotechnology
application in cancer therapy".
2013 Invited speaker, 14th SCBA International symposium
“Epigenetic and genetic factors in hepatitis C infection and
treatment response”
2014 Invited speaker, Duke University Medical Center
“Liver Cancer in the Era of Personalized Medicine”
2014 Invited Speaker, Rutgers University New Jersey Medical School
“Immunotherapy for Liver Cancer”
2014 Invited Speaker, Dartmouth Medical School
“Therapeutic Strategies for Liver Cancer Therapy”
2016 Invited Speaker, New York Medical College
“Opportunities and Challenges in Cancer Immunotherapy”
Page 52 of 53
2017 Alpha Omega Alpha Keynote Speaker
“The Discovery of Hepatitis Viruses and the Current Challenges”
2018 Grand Rounds Speaker, McGill University, Canada
“Cancer Immunotherapy”
2019 Grand Rounds speaker, Geisinger Health
“Epigenetics in liver cancer”
B. Professional (Clinical): 2003 University of Florida, Cancer Center, Grand Round.
Pathogenesis of Liver Cancer.
2004 University of Florida, Division of Critical Care & Pulmonary
Medicine. Hepatic injury in alpha-1 antitrypsin deficiency.
2005 Grand rounds, University of Florida Cancer Center.
Liver Cancer Diagnosis and Therapy.
2007 Invited speaker, US-Canadian Academy of Pathology Annual
Meeting Hepatocellular Lesions: Diagnosis and differential
diagnosis.
2009 Invited speaker, Hunan University "Liver cancer therapy, current
progress".
2010 Invited speaker, Chinese pathology association annual conference,
Chongqing, China, Pathology of Liver Lesions
2011 Invited speaker, University of Louisville.
"Hepatocellular carcinoma in the era of personalized medicine."
2014 Grand Rounds, Department of Pathology, Tulane University
“Immunotherapy for Liver Cancer”.
2014 Grand Rounds, University of Florida Cancer Center
“Mechanisms of Cancer Metastasis”.
2014 Grand Rounds, Case Western Reserve University
“Liver Cancer, A Translational Approach”
2014 Grand Rounds, The Methodist Hospital, Houston, Texas
“Personalized Medicine for Liver Cancer Therapy”.
Page 53 of 53
2014 Invited Speaker, North America Neuroendocrine Tumor Society
meeting, Orlando
“Pathology of GI and Liver neuroendocrine tumor”.
2014 Grand Rounds, Tulane University
“Liver cancer immunotherapy”
2018 Grand Rounds Speaker, McGill University, Canada
“Cancer Immunotherapy”
2019 Grand Rounds speaker, Geisinger Health
“Epigenetics in liver cancer”