University of Groningen
Modifications of collagen and chromatin in ECM-related diseaseGjaltema, Rutger Almer Friso
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Citation for published version (APA):Gjaltema, R. A. F. (2016). Modifications of collagen and chromatin in ECM-related disease: Uncoveringtherapeutic targets for fibrosis and cancer. [Groningen]: Rijksuniversiteit Groningen.
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Rutger Almer Friso Gjaltema
2016
Modifications of collagen and chromatin in ECM-related disease
Uncovering therapeutic targets for fibrosis and cancer
The research in this thesis was performed at the Graduate School of Medical Sciences (GSMS) at the University of Groningen.
This Ph.D project was financially supported by:Netherlands Institute of Regenerative MedicineDutch Kidney FoundationStichting de Cock-Hadders
Modifications of chromatin and collagen in ECM-related disease: Uncovering therapeutic targets for fibrosis and cancer
Gjaltema, R.A.F.
Proefschrift Groningen
ISBN (printed): 978-90-367-9195-3ISBN (digital): 978-90-367-9194-6
Cover design: Rutger A.F. GjaltemaLay-out: Rutger A.F. Gjaltema
Printed by: Ipskamp drukkers
Printing of this thesis was kindly supported by:University of GroningenUniversity Medical Center Groningen
© Copyright 2016 R.A.F. GjaltemaAll rights reserved. No part of this thesis may be reproduced, stored on a retrieval system, or transmitted in any form or by any means, without written permission of the author.
Modifications of collagen and chromatin in ECM-related disease
Uncovering therapeutic targets for fibrosis and cancer
Proefschrift
ter verkrijging van de graad van doctor aan deRijksuniversiteit Groningen
op gezag van de rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdedigen zal plaatsvinden op
woensdag 9 november 2016 om 14:30 uur
door
Rutger Almer Friso Gjaltema
geboren op 29 maart 1982te Zwolle
PromotoresProf. dr. R.A. BankProf. dr. M.G. Rots
BeoordelingscommissieProf. dr. F.J. Dekker Prof. dr. H. van GoorProf. dr. G.J.V.M. van Osch
Paranimfen:Bram PiersmaMendel Kaelen
Voor mijn vader
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Contents
Chapter 1: Introduction and aims
PARt I: NOVEL FEAtURES OF COLLAGEN MODIFYING ENZYMES
Chapter 2: Molecular Insights Into Prolyl And Lysyl Hydroxylation Of Fibrillar Collagens In Health And Disease
Chapter 3: Disentangling Mechanisms Involved In Collagen Pyridinoline Cross-linking: The Immunophilin FKBP65 Is Critical For Dimerization Of Lysyl Hydroxylase 2
Chapter 4: Lysyl hydroxylase 2 splice variants are chromatin-associated proteins that regulate transcription of target genes
PARt II: tRANSCRIPtIONAL REGULAtION OF PRO-FIBROtIC PROCESSES
Chapter 5: Procollagen Lysyl Hydroxylase 2 Expression is Regulated by an Alternative Downstream Transforming Growth Factor Beta-1 Activation Mechanism
Chapter 6: Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22 alpha expression in endothelial cells in response to interleukin-1 beta and transforming growth factor-beta 2
Chapter 7: Targeting TET methylcytosine dioxygenases induces a wide spectrum of anti-fibrotic effects
PARt III: tRANSCRIPtIONAL MODULAtION BY tARGEtED REwRItING OF thE EPIGENOME
Chapter 8: KRAB-induced heterochromatin is more effective than targeted DNA methylation in achieving efficient and mitotically stable gene repression
Chapter 9: Writing of H3K4Me3 permanently overcomes silencing in a context-dependent manner
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Chapter 10: Summary & general discussion
Chapter 11: Nederlandse samenvatting
Appendices:AbbreviationsCurriculum vitae and list of publicationsDankwoord
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