Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 -...

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Update on influenza vaccine development

Transcript

Update on influenza vaccine development

Recent advances in influenza vaccine R&D

• Novel delivery system: microneedle • Cell culture-based vaccine • Quadrivalent vaccine • Broadly protective vaccine

Page 3: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Microneedle

• Intradermal vaccination targets dendritic cells • Antigen sparing • Possibility of self administration • Increased vaccine stability

Page 4: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Page 5: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Dissolvable microneedle patch

Page 6: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

, 2015

Page 7: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

, 2015

Page 8: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

, 2015

Page 9: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Cyrille Dreyfus et al. Science 2012;337:1343-1348

Page 10: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Page 11: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

HA epitopes

Page 12: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Nabel & Fauci, 2010

Page 13: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Li, 2012

Page 14: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Hai, 2012

Page 15: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Page 16: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

Page 17: Update on influenza vaccine development - NVInvi.ddc.moph.go.th/Download/vc7/010.pdf · 2011 - Number of infleunza B cases 250 200 150 ... Rong Hal,a Florian Krammer,a Gene S. Tan,a

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