Uraniumanditsdecayproductsinthehumanbody:Wheredotheygoandwhatdotheydo?ByCindyFolkersUraniumisradioactive.Humanshavebeendigginguraniumoutoftheearthworldwideforoveracentury,usingitineverythingfrompotteryglazetoatomicbombproduction.Whilehealthimpactsofuraniumanditsdecayproductswereatfirstunknown,bythetimeoftheColdWaratomicarsenalbuildup,obvioushealthimpacts(lungcancer,forinstance,hadbecomeassociatedwithuraniumminingasearlyasthe1930s)wereignoredinfavorofnuclearwarheadproduction.UraniumminesandmillsspreadacrosstheU.S.IntheWesternU.S.,asinmostoftherestoftheworld,theminersandpeoplelivingnearthesefacilitieswerelargelyindigenous.Notonlywasthehealthofworkersimpacted,butbecauseuraniumindustrialprocessesleftradioactivecontaminationinsoilandwater,peoplelivingintheareaalsosufferedhealtheffects.Uraniumanddecayproductsstilllittertheselandscapes,posingacontinuingdanger,particularlywheninhaledoringested.Whiletheseradioisotopesoccurnaturally,theyareartificiallyavailableduetoindustrialprocessing.Althoughminingforuraniumisthemostobvioussource,goldandothermineprocessescanalsoreleasethesematerials.Minesitesandsurroundingareasposethegreatestdangerofexposuretouraniumandallofitsdecayproducts.Additionalsitesthatcouldposeadangerfromindividualdecayproductsincludethoriumwastedisposalsitesandfactoriesthatusedradiumpaintforcommercialandmilitaryitemssuchaswatchandairplanedials.ThesesitesdottheNorthAmericanlandscapeandalthoughanumberofthesefacilitieshavebeencleanedupaspartoftheSuperfundprogram,forsome,monitoringisongoing.Radongascanleachoutfromthegroundinmanyplaces,notjustfrommines,andbecometrappedinbuildings.Inthisinstance,however,radoncanbeeasily,safelyremovedbysimpletechnologyasrecommendedbytheU.S.EnvironmentalProtectionAgency(EPA),posingessentiallynodanger.1Whileallexposedareatrisk,radiationposesaparticulardangertowomen,childrenandpregnancy.Pregnancyisauniqueconcern,astheimpactsarenotaccountedforincurrentradiationexposurestandards.2Uraniumdecaystoanumberofradioactiveisotopes.Inthisarticle,wereviewtheimpactofuraniumandfiveofitsdecayproductsthatarethemostimpactfultohealth:thorium,radium,radongas,poloniumandradioactivelead.Weexaminewheretheytravelinthehumanbody,usingimagesrepresentingpregnancy.*AlthoughtheEPAhassomeexposurestandardsfortheseisotopes,ithasnotclassifiedradium,radonoruraniumforcarcinogenicity.3
*AllpregnancyimagesappearcourtesyofRadiationMonitoringProjectandarecopyrighted.
URANIUMmimicsthemineralcalciumandcanenteryourbodybyinhalationoringestion.Replacinghealthy,non-radioactivecalciumwithradioactiveuraniumcancauseahostofsubtleandnotsosubtlehealthimpacts.Thereisalsoevidencethattheelementuraniummimicstheessentialhormoneestrogen.Ifyouinhaleuraniumintothelung,itcantakeyearsforittoleavethelungandbeabsorbedintotherestofyourbody.Whenitleavesthelung,itgoesmostlytobonewithsometravelingtothekidneysandliver.4Ingesteduraniumwillendupinthesameorgansandtissues,butcanbeabsorbedfasterintheneonatalgastrointestinaltract.Fastingandirondeficiencywillincreaseuraniumabsorptionrates.5Inthebody,uraniumcancausekidneydamage,bonediseases,anddevelopmentalproblems.6ResearchindicatesthatevenatlevelsbelowEPA’sallowedlimitsinwater,uraniumcancausenegativereproductivehealthimpactsincludingdecreasedfertility,reductionintestosterone,decreasedfetalbodyweightandgrowthweightand7ovarianfailureinoffspring,8andsmallerplacentas.9IncidenceofgonadalcancerinNewMexicoNativeAmericanchildrenandteenagersis8-foldgreaterthanthatinnon-NativeAmericanindividuals.10
THORIUM11collectsinthesameplacesinthebodywhetherinhaledoringested.Thoriummimicsthemineraliron,whichisnecessaryforhealthybonesandblood.Targetorgansincludethelungs,lymphnodes,bones,12liverandspleen.13Athighermedicalandoccupationaldoses,thoriumisassociatedwithlungcancer,pancreaticcancer,colorectalcancers,chronicrespiratorydiseases,andliverdamage.14ResidentsinthevicinityofathoriumwastedisposalsiteinNewJerseyhaveincreasesinbirthdefectsandliverdisease,althoughspecifictestsforbodycontaminationhavenotbeenconducted.”15Evensmallamountsofthoriumintheplacentaincreaseitsweight.16
RADIUM,likeuranium,mimicsthenecessarymineralcalciumandcrossestheplacentainthesameratioasinthemother’sblood.Becauseofitssimilaritytocalcium,ingestedradiumlodgesinbone,causingrapidchangesinbonestructure,redbloodcellformation(hematopoiesis)inadditionitcausesbonesarcomas.17Throughtheburningoffossilfuels,wecaninhaleradiumintothelungs.Fromthereitgraduallyentersthebloodstream.18Chronicexposuretoradiuminhumans,byinhalation,hasresultedinadecreaseofwhitebloodcells(acuteleukopenia).Oralexposurehasresultedinanemia,necrosisofthejaw,abscessofthebrain,andterminalbronchopneumonia.Noinformationisavailableonthedevelopmentalorreproductiveeffectsofradiuminhumansoranimals.19
RADONGASisaradioactivegasthatitselfdoesn’taccumulateinorgans,butitsdecayproductscan.Whenitisinhaled,thedosefromradonisgivenmainlytothelung.20Radoncantraveltothebrainwhereitsdecayproductscanirradiatebraintissue.Itcanpassthroughtheplacentairradiatingthedevelopingembryoorfetus.Radonisthoughttobethesecondmajorcauseoflungcanceraftersmoking,21responsiblefor15Kto22KcancerdeathsperyearintheU.S.alone.22Whenradontravelstothebrain,itsdecayproductscancauseAlzheimer’sdiseaseandParkinson’sdisease.Someresearchindicatesthatradoncausesmultiplesclerosis.23Chronicexposurehasresultedinrespiratoryeffectsincludingchroniclungdisease,pneumonia,fibrosisofthelung,anddecreasedlungfunction.24RadoncanpassthroughtheplacentaandintothedevelopingembryowhereitsdecayproductscanproduceDNAlesionsthatwillmostlikelykillit.Ifthepregnancyisatthefetalstage,radonanddecayproductswillbedrawntolipids,whereitwillmostlikelynotkillthefetus,butmayhavesevereimpactsonbraindevelopment.25
POLONIUM’Smovementwithinourbodieshasbeenstudiedextensivelybutdespitethis,westilldon’tknowhowtointerpretthedatacorrectlyforanumberofreasons.Muchoftheimportantbiologicalandtoxicologicalresearchonpoloniumismorethanfourdecadesold.26Poloniumcanbeinhaledandingested,collectingintheliver,kidneys,bonemarrowandgonads,particularlytheradiosensitiveovaries.Poloniumalsoaccumulatesintheyolksacoftheembryoandinthefetalandplacentaltissues.27Poloniumistoxicbecauseofitsradioactivityratherthanitschemicalproperties.Low-levelexposuretopoloniummayhavesubtle,long-termbiologicaleffectsbecauseofitsaffinityforreproductiveandembryonicandfetaltissues.Poloniumcandamagetheplacenta.Littleisspecificallyknownabouttheeffectsofpoloniumexposuretotheembryoandfetus,butexposurecouldleadtosubfertilityandmiscarriage.28
RADIOACTIVELEADcandodamagebothfromitsradioactiveanditschemicalproperties.29Themajorityofleadcollectsinbonesandteeth.Therestcollectsinallorgansofthebody.Leadcollectsintheplacentaandcrossesintothedevelopingembryoorfetus.Ahighexposuretoleadcanleadtopoisoning.Symptomsincludeabdominalpain,constipation,fatigue,headaches,irritability,lossofappetite,memoryloss,painortinglinginthehandsorfeet,andweakness.Symptomsofchronic,lowerlevelleadexposureincludemiscarriage,stillbirths,maleandfemaleinfertility,behavioralproblems,nervoussystemdamage,reducedintelligence,neurologicaleffects,mentalretardation,highbloodpressure,heartdisease,kidneydisease,andcancer.Forradioactivelead,theriskofcancerincreasesovernon-radioactivelead,butthechemicaldiseaserisksremain.30,31
WewouldliketorecognizeandthankRadiationMonitoringProjectfortheimagesinthisarticle.RMPhostsworkshopsonunderstandingandmonitoringradioactivecontaminationintheenvironmentbypurchasinganddistributingradiationdetectorstocontaminatedandfrontlinecommunitiesintheU.S.RMPisacollaborationbetweenDinéNoNukes,NuclearEnergyInformationService&SlothsAgainstNuclearState.
1https://www.epa.gov/radon2https://beyondnuclearinternational.files.wordpress.com/2018/07/radiation-and-harm-to-human-health_27-july.pdf3Radionuclides(includingRadon,RadiumandUranium)HazardSummary.EPA.2000,2016?4Craftetal.DEPLETEDANDNATURALURANIUM:CHEMISTRYANDTOXICOLOGICALEFFECTS.JournalofToxicologyandEnvironmentalHealth,PartB,7:297–317,2004.
5Craft2004.6Craft2004.7Raymond-Whish,etal.DrinkingWaterwithUraniumbelowtheU.S.EPAWaterStandardCausesEstrogenReceptor–DependentResponsesinFemaleMice.EnvironmentalHealthPerspectives.VOLUME115.NUMBER12.December2007.8Mirderikvandetal.EmbryoToxicEffectsofDepletedUraniumontheMorphologyoftheMouseFetus.IranianJournalofPharmaceuticalResearch :IJPR.2014;13(1):199-206.9Mirderikvandetal.10Whish2007.11http://hpschapters.org/northcarolina/NSDS/thorium.pdf12Ulsh,etal.RetrospectiveDoseReconstructionforThorium,232ActivitiesattheMoundLaboratory,PreliminaryReport,NIOSH,2012.13Thorium-232andUranium-238:TheToxicologyofRadioactiveSubstances.editedbyA.A.Letavet,197014Najem,etal.HealthEffectsofaThoriumWasteDisposalSite.AJPH.April1990.15Najem.1990.16Rakhmanbek,etal.Theeffectoflowconcentrationsofradioactivenuclidesonmorphometriccharacteristicsofhumanplacenta.EHPabstracts.2013.17Canuetal.HealthEffectsofNaturallyRadioactiveWaterIngestion:TheNeedforEnhancedStudies.EnvironHealthPerspect119:1676-1680(2011)18TOXICOLOGICALPROFILEFORRADIUM.AgencyforToxicSubstancesandDiseaseRegistryU.S.PublicHealthServiceincollaborationwith:U.S.EnvironmentalProtectionAgency.1990.19Radionuclides(includingRadon,RadiumandUranium)HazardSummary.EPA.2000,2016?20Field,R.William(1999)."RadonOccurrenceandHealthRisk"(PDF).21CatelinoisO,RogelA,LaurierD,etal.(2006)."Lungcancerattributabletoindoorradonexposureinfrance:effectoftheriskmodelsanduncertaintyanalysis".Environ.HealthPerspect.114(9):1361–6.22"RadonandCancer:QuestionsandAnswers".NationalCancerInstitute.23Groves-Kirkbyetal.EnvironmentalRadonGasandDegenerativeConditions–AnOverview.IRPA,Paris.2006.24Radionuclides(includingRadon,RadiumandUranium)HazardSummary.EPA.2000,2016?25Radon:MolecularActionandGeneticEffects.UniversityofMinnesotaSchoolofPublicHealth.26Leggettetal.Asystemicbiokineticmodelforpolonium.TheScienceoftheTotalEnvironment275.2001.109-125.27Seiler,etal.Occurrenceof210PoandBiologicalEffectsofLow-LevelExposure:TheNeedforResearchEnvironHealthPerspect.2012.28Seiler2012.29HealthProblemsCausedbyLead.CDC.2013.30TOXICOLOGICALPROFILEFORLEADU.S.DEPARTMENTOFHEALTHANDHUMANSERVICESPublicHealthServiceAgencyforToxicSubstancesandDiseaseRegistry.2007.31CDC2013.