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The N I H Guide announces scientific initiatives and provides pdiqand administrative information t o individuals and orginizations who need t o bt. kept inhrrned ofopponunlties. requiremcnu. and changes in extrarnucti programs administered by the National Institutes ot'llealth.

Vol. 2 0 , No. 9 March 1, 1991

NIH GUIDE - Vol. 20, No. 9, March 1 , 1991

NOTICES

WORLD AIDS FOUNDATION ...................................................... 1 Fogarty International CenterIndex: FOGARTY INTERNATIONAL CENTER

NEW WORLD MONKEYS AVAILABLE FOR BIOMEDICAL RESEARCH ........................ 1 Public Health Service Index: PUBLIC HEALTH SERVICE

NATIONAL WORKSHOPS ON "PROTECTION OF HUMAN SUBJECTS" ....................... 2 National Institutes of Health Food and Drug Administration Index: NATIONAL INSTITUTES OF HEALTH, FOOD AND DRUG ADMINISTRATION

ANNUAL REPORT AND ASSURANCE ON POSSIBLE SCIENTIFIC MISCONDUCT . . . . . . . . . . . . . . 3 Public Health ServiceIndex: PUBLIC HEALTH SERVICE

NOTICES OF AVAILABILITY (RFPs AND RFAs)

VACCINE PRODUCTION FACILITY (RFP) .......................................... 4 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES

ROLE OF HERPES SIMPLEX VIRUS IN THE PATHOGENESIS OF ORAL MUCOSITIS ASSOCIATED WITH CANCER CHEMOTHERAPY (RFP) .................................. 4National Institute of Dental Research Index: DENTAL RESEARCH

DRUG ABUSE TREATMENT EVALUATION RESEARCH CENTER GRANTS (RFA DA-91-05) ...... 5 National Institute on Drug Abuse Index: DRUG ABUSE

DRUG DISCOVERY GROUPS FOR THE TREATMENT OF COGNITIVE IMPAIRMENT ASSOCIATED WITH ALZHEIMER'S DISEASE (RFA AG-91-09) ......................... 7 National Institute on AgingIndex: AGING

MEDICAL INFORMATICS RESEARCH TRAINING (RFA LM-91-01) ....................... 8 National Library of Medicine Index: NATIONAL LIBRARY OF MEDICINE

W

EXPLORATORY CENTERS FOR HEALTH BEHAVIOR RESEARCH WITH CHILDREN AND ADOLESCENTS (RFA NR-91-02) ................................................. 10 National Center for Nursing Research National Institute of Child Health and Human Develotment National Institute of Mental HealthIndex: NURSING RESEARCH, CHILD HEALTH, HUMAN DEVELOPMENT, MENTAL HEALTH

ONGOING PROGRAM ANNOUNCEMENTS

THE NCI OUTSTANDING INVESTIGATOR GRANT (PA-91-28) .......................... 1 1 National Cancer Institute Index: CANCER

ACADEMIC AWARD IN ENVIRONMENTAL/OCCUPATIONAL MEDICINE (PA-91-29) ........... 13 National Institute of Environmental Health SciencesIndex: ENVIRONMENTAL HEALTH SCIENCES

SHORT-TERM TRAINING FOR MEDICAL STUDENTS IN ENVIRONMENTAL/OCCUPATIONALHEALTH (PA-91-30] .......................................................... 1 4 National Institute of Environmental Health Sciences Index: ENVIRONMENTAL HEALTH SCIENCES

ERRATA

CLINICAL TREATMENT AND CORRELATES OF UPPER GI CARCINOMA (RFA CA-91-03) .....15 National Cancer Institute Index: CANCER

PREDOCTORAL FELLOWSHIP AWARDS FOR MINORITY STUDENTS (RFA GM-91-01) .........16 National Institute of General Medical Sciences \vIndex: GENERAL MEDICAL SCIENCES

RESEARCH AND DEMONSTRATION GRANTS RELATING TO OCCUPATIONAL SAFETY AND HEALTH.16 National Institute for Occupational Safety and Health (PA-91-27)Index: OCCUPATIONAL SAFETY, OCCUPATIONAL HEALTH

NOTICES

WORLD AIDS FOUNDATION

P.T. 44; K.W. 0715008, 0502000--' Fogarty I n t e r n a t i o n a l Center

The World AIDS Foundation (WAF), j o i n t l y sponsored by t h e U.S. Department o f Heal th and Human S e r v i c e s and t h e I n s t i t u t P a s t e u r o f P a r i s , France, announces i t s i n t e n t t o suppor t r e s e a r c h and e d u c a t i o n r e l a t i n g t o AIDS i n t h e developing world. The g o a l o f t h e WAF is t o f ac i l i t a t e i n f o r m a t i o n exchangeand t o a s s i s t deve loping c o u n t r i e s t o respond t o t h e AIDS pandemic.

The WAF i s p a r t i c u l a r l y i n t e r e s t e d i n p r o j e c t s t h a t are c a t a l y t i c , and, once i n p l a c e , could have a m u l t i p l i c a t i v e e f fec t . The WAF is s p e c i f i c a l l yi n t e r e s t e d i n s u p p o r t i n g :

A ) shor t - te rm, in-country t r a i n i n g f o r c l i n i c i a n s , a l l i e d h e a l t h p r o f e s s i o n a l s , and t e c h n i c i a n s ;

B ) f e l l o w s h i p s t o suppor t t r a i n i n g f o r n a t i o n a l e x p e r t s ;

C ) development and t e s t i n g of new concepts and demonst ra t ions f o r p r e v e n t i n g t h e s p r e a d o f H I V ; and

D ) h i g h l y focused workshops t h a t enhance t h e s c i e n t i f i c p r o c e s s and t r a n s f e r knowledge needed i n t h e e f f o r t a g a i n s t H I V i n f e c t i o n s and AIDS.

The l i m i t o f any s i n g l e funding r e q u e s t t o t h e WAF is $200,000.

A p p l i c a t i o n Procedures:

Concept l e t t e r s and a p p l i c a t i o n s may be prepared i n e i t h e r E n g l i s h o r French. A p p l i c a n t s should submit concept l e t t e r s f o r i n i t i a l c o n s i d e r a t i o n . Followingreview o f concept l e t t e r s , a p p l i c a n t s may b e i n v i t e d t o submit completep r o p o s a l s . The annual d e a d l i n e f o r r e c e i p t o f concept l e t t e r s is A p r i l 1 .

1- Concept l e t t e r s , f u l l a p p l i c a t i o n s , and i n q u i r i e s concerning t h e programs o f t h e WAF should b e d i r e c t e d t o e i t h e r :

World AIDS Foundation A s s i s t a n t S e c r e t a r y f o r Heal th c /o D i r e c t o r , Fogarty I n t e r n a t i o n a l Center Nat iona l I n s t i t u t e s of Heal th Bui ld ing 31, Room B2C39 Bethesda, MD 20892 U.S.A.

o r

World AIDS Foundation c /o D i r e c t o r I n s t i t u t P a s t e u r 28 r u e du Docteur Roux 75724 P a r i s , Cedex 15 FRANCE

FEW WORLD MONKEYS AVAILABLE FOR BIOMEDICAL RESEARCH

P.T. 34; K.W. 0780000

P u b l i c Heal th S e r v i c e

The I n t e r a g e n c y Research Animal Committee, c h a r t e r e d by t h e U . S . P u b l i c Heal th S e r v i c e (PHS), s u p p o r t s and c o o r d i n a t e s a program w i t h t h e Pan American Heal th Organiza t ion t h a t makes p o s s i b l e t h e i m p o r t a t i o n of N e w World monkeys i n t o t h e United S t a t e s f o r use i n biomedical r e s e a r c h p r o j e c t s . Transfers are l i m i t e d t o a f e w s p e c i e s , n e i t h e r t h r e a t e n e d nor endangered. For informat ion on q u a l i f i c a t i o n s for p a r t i c i p a t i o n , s p e c i e s , purchase procedures , and o t h e r matters, c o n t a c t :

N I H G U I D E - Vol. 20, No. 9, March 1 , 1991 - Page 1

I n t e r a g e n c y Research Animal Committee M s . Suzanne Moore N a t i o n a l I n s t i t u t e s o f Heal th B u i l d i n g 14A, Room 100 9000 R o c k v i l l e P ike Bethesda, MD 20892 Telephone: ( 3 0 1 ) 496-5424

NATIONAL WORKSHOPS ON "PROTECTION OF HUMAN SUBJECTS"

P.T. 42; K.W. 0783005

N a t i o n a l I n s t i t u t e s o f Heal th Food and Drug A d m i n i s t r a t i o n

The N a t i o n a l I n s t i t u t e s o f Heal th ( N I H ) and t h e Food and Drug Adminis t ra t ion (FDA) a r e c o n t i n u i n g t o sponsor a ser ies o f workshops on t h e r e s p o n s i b i l i t i e s of r e s e a r c h e r s , I n s t i t u t i o n a l Review Boards ( I R B s ) , and i n s t i t u t i o n a l o f f i c i a l s f o r t h e p r o t e c t i o n of human s u b j e c t s i n r e s e a r c h . The workshops a r e open t o everyone w i t h an i n t e r e s t i n r e s e a r c h i n v o l v i n g human s u b j e c t s . The meetings should be o f s p e c i a l i n t e r e s t t o t h o s e persons c u r r e n t l y s e r v i n g o r about t o begin s e r v i n g as a member of an I R B . I s s u e s d i s c u s s e d a t t h e s e workshops are r e l e v a n t t o a l l o t h e r P u b l i c Heal th S e r v i c e a g e n c i e s . The

schedule i n c l u d e s t h e fo l lowing:c u r r e n t

I . MIDEAST WORKSHOP

DATES: March 4-5, 1991

WORKSHOP SITE: Fr iday Center Laurel Hill ParkwayChapel H i l l , NC 27599-1020

SPONSORS: U n i v e r s i t y o f North C a r o l i n a 3 0 0 Bynum H a l l Chapel H i l l , NC 27599-4100

Shaw U n i v e r s i t y 118 E . South S t r e e t Rale igh , NC 27611

REGISTRATION CONTACT: Mr. A 1 Dawson D i r e c t o r Fr iday Center Laure l H i l l Parkwav C . B . 1020 Chapel H i l l , NC 27599-1020 Telephone: (919) 962-1106

a t Chapel H i l l

TOPIC: " I n t e r p r e t i n g t h e F e d e r a l Code f o r t h e P r o t e c t i o n

11. MIDWEST WORKSHOP

DATES: A p r i l 11-12, 1991

WORKSHOP S I T E : Ramada Inn , Lakeshore 4900 South Lake Shore Drive Chicago, I L 60615

SPONSORS : U n i v e r s i t y o f Chicago 970 E a s t 5 8 t h S t r e e t Chicago, I L 60637

Chicago S t a t e U n i v e r s i t y 9 5 t h S t r e e t a t King Drive Chicago, I L 60628

of Human Subjec ts"

N I H GUIDE - V o l . 20, No. 9, March 1 , 1991 - Page 2

REGISTRATION CONTACT: M r . Arnold L . Aronoff Assoc ia t e D i r e c t o r Facu l ty and A d m i n i s t r a t i v e S e r v i c e s U n i v e r s i t y Research Admin i s t r a t ion U n i v e r s i t y o f Chicago

-d 970 East 58 th S t r e e t Chicago, I L 60637 Telephone: (312) 702-8669

TOPIC: " C u l t u r a l D i v e r s i t y , E t h i c s , and Research: A Workshop on Human Sub jec t P r o t e c t i o n "

N I H l F D A have planned n a t i o n a l human s u b j e c t p r o t e c t i o n s workshops i n o t h e r p a r t s o f t h e United S t a t e s . For f u r t h e r in format ion r e g a r d i n g t h e s e workshops c o n t a c t :

Darlene Marie Ross Execut ive A s s i s t a n t f o r Educat ion D i v i s i o n o f Human S u b j e c t P r o t e c t i o n s Office f o r P r o t e c t i o n from Research R i sks Nat iona l I n s t i t u t e s of Hea l th 9000 Rockv i l l e P ike Bui ld ing 31, Room 5B59 Bethesda, MD 20892 Telephone: (301) 496-8101

ANNUAL REPORT AND ASSURANCE ON POSSIBLE SCIENTIFIC MISCONDUCT

P.T. 34; K . W . 1014006, 1014004

P u b l i c Heal th S e r v i c e

E f f e c t i v e Date: March 5, 1991

The P u b l i c Hea l th S e r v i c e (PHS) s c i e n t i f i c misconduct r e g u l a t i o n s , 42 CFR 50 Subpar t A, " R e s p o n s i b i l i t i e s o f PHS Awardee and Appl icant I n s t i t u t i o n s f o r Deal ing With and Repor t ing P o s s i b l e Misconduct i n Science", r e q u i r ei n s t i t u t i o n s r e p o r t annua l ly t o t h e Office o f S c i e n t i f i c I n t e g r i t y (OSI) ,

'I' about t h e i r hand l ing of a l l e g a t i o n s , i n q u i r i e s and i n v e s t i g a t i o n s i n t o p o s s i b l e s c i e n t i f i c misconduct , i n connec t ion wi th r e s e a r c h f o r which PHS funds have been r e q u e s t e d o r r e c e i v e d . An annual update o f t h e i r i n s t i t u t i o n a l a s su rance a l s o must be r e p o r t e d t o t h e OSI.

The annual r e p o r t forms were mailed by t h e OS1 i n December 1990 t o t h e s i g n a t o r y o f f i c i a l o f 2,600 i n s t i t u t i o n s t h a t had f i l e d an I n i t i a l Assurance with OS1 f o r 1990. Most i n s t i t u t i o n s d i d r e t u r n t h e completed form by t h e January 1991 d e a d l i n e ; o t h e r s r ece ived c a l l s o r l e t t e r s about t h e i r r e p o r t s . However, annual r e p o r t s f o r approximate ly 500 of t h e smaller i n s t i t u t i o n s have still n o t been r e c e i v e d by t h e OSI. They are needed now.

An updated, a c t i v e a s su rance is a requi rement f o r an i n s t i t u t i o n t o remain e l i g i b l e t o apply f o r o r receive g r a n t s , f e l l o w s h i p s , and c o o p e r a t i v e agreements f o r r e s e a r c h funds from t h e PHS i n 1991. The OS1 S t a f f w i l l be upda t ing t h e approved a s su rance f i l e i n mid-March t o change t h e a s su rance s t a t u s t o " i n a c t i v e " f o r t h o s e i n s t i t u t i o n s t h a t have n o t y e t submi t t ed annual r e p o r t s .

For f u r t h e r i n fo rma t ion , p l e a s e c a l l immediately:

D r . Alan P r i c e , M s . Carolyn Bowman, o r M r . John A l l i s o n O f f i c e o f S c i e n t i f i c I n t e g r i t y N I H Bu i ld ing 31, Room BlC39 9000 Rockv i l l e P ike Bethesda, MD 20892 Telephone: (301) 496-2624 ( t h i s is n o t a t o l l - f r e e number)FAX: (301) 402-0238

N I H GUIDE - Vol. 20, No. 9, March 1, 1991 - Page 3

NOTICES OF AVAILABILITY (RFPs AND RFAs)

VACCINE PRODUCTION FACILITY

RFP AVAILABLE: NIAID-91-36

P.T. 34; K.W. 0740075, 1002045

Na t iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases

The D i v i s i o n o f Microbiology and I n f e c t i o u s Diseases, Na t iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases, r e q u i r e s one Vaccine Product ion F a c i l i t y .T h i s c o n t r a c t o r must have t h e p r o f e s s i o n a l c a p a b i l i t i e s and f a c i l i t i e s t o o p e r a t e a vacc ine p roduc t ion l a b o r a t o r y t o p r e p a r e l i v e v i r a l , i n a c t i v a t e d v i r a l , and s u b u n i t c a n d i d a t e vacc ines f o r e v a l u a t i o n i n humans. The vacc ines must be p repa red i n accordance wi th t h e r e g u l a t i o n s and g u i d e l i n e s e s t a b l i s h e d by t h e Food and Drug Admin i s t r a t ion f o r materials t o be t e s t e d i n humans. Candidate v a c c i n e s t o be produced inc lude , bu t are n o t l i m i t e d t o , i n f l u e n z a v i r u s e s , r e s p i r a t o r y s y n c y t i a l v i r u s , p a r a i n f l u e n z a v i r u s e s , r o t a v i r u s e s , and subun i t p r e p a r a t i o n s from t h e s e a g e n t s . The o f f e r o r ' s f a c i l i t y must meet requi rements l i s t e d i n t h e Code o f Fede ra l Regu la t ions f o r an e s t ab l i shmen t engaged i n t h e p r e p a r a t i o n o f l i v e and i n a c t i v a t e d v i r u s vacc ines l i c e n s e d f o r human u s e by t h e Office o f B i o l o g i c s and p rov ide adequate documentation o f such q u a l i f i c a t i o n s . If no t i n f u l l compliance, t h e o f f e r o r must d e s c r i b e what e f f o r t s have been made t o b r i n g t h e f a c i l i t y i n t o compliance. The o f f e r o r is s u b j e c t t o i n s p e c t i o n under t h e "Good Labora tory P r a c t i c e s A c t t 1 and t h e "Good Manufactur ing A c t . " It is expec ted t h a t t h e c o n t r a c t w i l l have a f i v e (5) yea r p e r i o d of performance. Any r e s p o n s i b l e o f f e r o r may submit a p roposa l , which w i l l be cons ide red by t h e Government.

The i s suance d a t e o f t h e RFP w i l l be on March 11 , 1991 and p r o p o s a l s w i l l be due by t h e c l o s e o f b u s i n e s s on April 26, 1991.

Reques ts f o r t h e RFP must be d i r e c t e d t o r

Merilee Rahe-Stol ine Cont rac t Management Branch Nat iona l I n s t i t u t e o f A l l e r g y and I n f e c t i o u s Diseases Nat iona l I n s t i t u t e s o f Heal th Cont ro l Data Bu i ld ing , Room 326P Bethesda, MD 20892

P l e a s e p rov ide t h i s o f f i c e wi th two se l f - addres sed ma i l ing l a b e l s . T h i s adve r t i s emen t does n o t commit t h e Government t o award a c o n t r a c t .

ROLE OF HERPES SIMPLEX VIRUS I N THE PATHOGENESIS OF ORAL MUCOSITIS ASSOCIATED WITH CANCER CHEMOTHERAPY

RFP AVAILABLE: NIH-NIDR-2-91-5R

P.T. 34; K.W. 0745005, 0740012, 0755015

Na t iona l I n s t i t u t e o f Dental Research

The Na t iona l I n s t i t u t e o f Denta l Research ( N I D R ) h a s a requi rement t o s t u d yt h e r o l e o f h e r p e s s implex v i r u s (HSV) i n t h e pa thogenes i s of o r a l m u c o s i t i s a s s o c i a t e d wi th i n t e n s i v e chemotherapy, and t o de te rmine whether t h e a n t i v i r a l agen t a c y c l o v i r can reduce t h e inc idence and s e v e r i t y o f m u c o s i t i s i n s e v e r e l yimmunocompromised p a t i e n t s . The s t u d y w i l l c o n s i s t o f a double-b l ind ,p l acebo-con t ro l l ed t r i a l o f d a i l y o r a l a c y c l o v i r f o r t h e p r e v e n t i o n o f HSV i n f e c t i o n and m u c o s i t i s i n HSV-seroposit ive p a t i e n t s undergoing i n t e n s i v e chemotherapy f o r t h e t r e a t m e n t o f leukemias o r lymphomas. A t t h e complet iono f t h i s two-year s tudy , an a n a l y s i s w i l l be made o f t h e s e v e r i t y and f requencyo f o r a l u l c e r a t i o n s and t h e a s s o c i a t i o n o f HSV culture/antigen-posit ivel e s i o n s i n p a t i e n t s on a c y c l o v i r and t h o s e on p l acebo . If t h e s t u d ydemonst ra tes t h a t he rpes s implex v i r u s i s involved i n t h e pa thogenes i s o f o r a l m u c o s i t i s and t h a t a c y c l o v i r can reduce t h e f requency and/or s e v e r i t y o f mucos i t i s , t h e n an informed recommendation can be made t h a t a l l HSV s e r o p o s i t i v e p a t i e n t s undergoing i n t e n s i v e chemotherapy f o r a c u t e leukemia o r lymphoma r e c e i v e r o u t i n e p r o p h y l a c t i c a c y c l o v i r t h e r a p y f o r each cour se o f chemotherapy.

The N I D R e x p e c t s t o make one award from t h i s s o l i c i t a t i o n .

RFP NIH-NIDR-2-91-5R w i l l be a v a i l a b l e on o r about March 18, 1991, with p r o p o s a l s due on o r about A p r i l 30, 1991.

N I H G U I D E - Vol. 20, No. 9, March 1, 1991 - Page 4

W

- r

The RFP package w i l l be a v a i l a b l e upon w r i t t e n r e q u e s t t o :

Marilyn R . Zuckerman, C o n t r a c t i n g Officer Cont rac t Management S e c t i o n , N I D R Nat iona l I n s t i t u t e s o f Heal th Westwood Bui ld ing , Room 521 5333 Westbard Avenue Bethesda, MD 20892

DRUG ABUSE TREATMENT EVALUATION RESEARCH CENTER GRANTS

RFA AVAILABLE: DA-91-05

P .T . 0 4 ; K.W. 0404009, 0795005

Nat iona l I n s t i t u t e on Drug Abuse

A p p l i c a t i o n Rece ip t Date: May 22, 1991

PURPOSE

The purpose o f t h i s i n i t i a t i v e is t o e s t a b l i s h and suppor t C e n t e r s t o conduct i n t e r d i s c i p l i n a r y r e s e a r c h on t h e e f f e c t i v e n e s s o f drug abuse t r e a t m e n t .

RESEARCH OBJECTIVES

The Abuse Treatment E v a l u a t i o n Research Center Grant Program is des igned t o complement t h e i n v e s t i g a t o r i n i t i a t e d r e s e a r c h g r a n t s program o f t h e N a t i o n a l I n s t i t u t e on Drug Abuse ( N I D A ) by p r o v i d i n g long-term suppor t f o r i n t e r d i s c i p l i n a r y e v a l u a t i v e r e s e a r c h on drug abuse t r e a t m e n t . The program is in tended t o a t t r ac t i n v e s t i g a t o r s i n t h e b e h a v i o r a l , s o c i a l , and biomedical s c i e n c e s t o conduct e v a l u a t i v e r e s e a r c h on t h e t r e a t m e n t o f drug abuse, and t o provide a s t a b l e environment f o r such persons t o engage i n t r e a t m e n t r e s e a r c h . A Center is expec ted t o become a s i g n i f i c a n t r e g i o n a l o r n a t i o n a l r e s e a r c h r e s o u r c e . C e n t e r s funded under t h i s announcement w i l l conduct t r e a t m e n t e v a l u a t i o n r e s e a r c h and p a r t i c i p a t e a c t i v e l y i n and c o o p e r a t e wi th N I D A ' s programmatic e f f o r t s t o s y s t e m a t i c a l l y review, c o o r d i n a t e , and i n t e g r a t er e s e a r c h on t rea tment p o p u l a t i o n s p r o c e s s , and outcomes.

A v a r i e t y o f d e s i g n s and r e s e a r c h s t r a t e g i e s may be employed t o e v a l u a t e e x i s t i n g t r e a t m e n t programming and r e l a t e d i n t e r v e n t i o n s . Both f i e l d s t u d i e s and c o n t r o l l e d (randomized) s t u d i e s may be used, as w e l l as secondary a n a l y s e s t o i n v e s t i g a t e i s s u e s of i n t e r e s t t o t r e a t m e n t e v a l u a t i o n s . Areas f o r i n v e s t i g a t i o n p o t e n t i a l l y i n c l u d e comparat ive e f f e c t i v e n e s s o f t r e a t m e n t program t y p e s f o r wel l -def ined c l i e n t groups, t r e a t m e n t process , t h e s t r u c t u r e o f t r e a t m e n t , s t u d i e s of s p e c i f i c m o d a l i t i e s , o u t r e a c h , d i f f e r e n t i a l a t t r a c t i v e n e s s o f t r e a t m e n t , c l i e n t - t r e a t m e n t matching, t h e r o l e o f non-treatment f a c t o r s , c o r r e c t i o n a l t reatment , treatment o f drug abuse i n pr imary h e a l t h care d e l i v e r y systems, e f f e c t i v e n e s s o f a l t e r n a t i v e t r e a t m e n t s ,( i . e . , n o t des igned p r i m a r i l y for drug a b u s e r s ) t r e a t m e n t improvement,treatment for s p e c i f i c drugs of abuse, aftercare and r e l a p s e p r e v e n t i o n ,t r e a t m e n t c a r e e r s , and cohort-based s t u d i e s o f long-term outcomes. Methodological ly o r i e n t e d s t u d i e s may a l s o be a p p r o p r i a t e a c t i v i t i e s f o r t h e Center under t h i s program.

SPECIAL IMPLEMENTATION OF ADAMHA POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES I N C L I N I C A L RESEARCH STUDY POPULATIONS

A p p l i c a t i o n s / p r o p o s a l s f o r ADAMHA g r a n t s and c o o p e r a t i v e agreements are r e q u i r e d t o i n c l u d e both women and m i n o r i t i e s i n s t u d y p o p u l a t i o n s f o r c l i n i c a l r e s e a r c h , u n l e s s compell ing s c i e n t i f i c o r o t h e r j u s t i f i c a t i o n f o r n o t i n c l u d i n g e i t h e r women o r m i n o r i t i e s is provided . T h i s requirement is in tended t o e n s u r e t h a t r e s e a r c h f i n d i n g s w i l l be o f b e n e f i t t o a l l persons a t r i s k o f t h e d i s e a s e , d i s o r d e r , o r c o n d i t i o n under s t u d y . For t h e purpose o f t h e s e p o l i c i e s , c l i n i c a l r e s e a r c h i n v o l v e s human s t u d i e s o f e t i o l o g y , t r e a t m e n t , d i a g n o s i s , p r e v e n t i o n , o r epidemiology o f d i s e a s e s , d i s o r d e r s o r c o n d i t i o n s , i n c l u d i n g but n o t l i m i t e d t o c l i n i c a l t r i a l s ; and m i n o r i t i e s i n c l u d e U.S. r a c i a l l e t h n i c m i n o r i t y p o p u l a t i o n s ( s p e c i f i c a l l y : American I n d i a n s o r Alaskan Nat ives , A s i a n / P a c i f i c I s l a n d e r s , Blacks, and H i s p a n i c s ) .

ADAMHA r e c o g n i z e s t h a t it may n o t be f e a s i b l e o r a p p r o p r i a t e i n a l l c l i n i c a l r e s e a r c h p r o j e c t s t o i n c l u d e r e p r e s e n t a t i o n o f t h e f u l l a r r a y o f U.S. r a c i a l / e t h n i c m i n o r i t y p o p u l a t i o n s . However, a p p l i c a n t s are urged t o a s s e s s c a r e f u l l y t h e f e a s i b i l i t y o f i n c l u d i n g t h e broades t p o s s i b l e r e p r e s e n t a t i o n o f m i n o r i t y groups.

N I H G U I D E - Vol. 20, No. 9, March 1 , 1991 - Page 5

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A p p l i c a t i o n s should i n c l u d e a d e s c r i p t i o n o f t h e composi t ion o f t h e proposeds t u d y p o p u l a t i o n by gender and r a c i a l / e t h n i c group, and t h e r a t i o n a l e f o r t h e numbers and k i n d s o f people s e l e c t e d t o p a r t i c i p a t e . T h i s in format ion should be inc luded i n t h e form PHS 398 i n S e c t i o n 2 , A-D o f t h e Research P lan AND summarized i n S e c t i o n 2 , E , Human S u b j e c t s .

A p p l i c a t i o n s should i n c o r p o r a t e i n t h e i r s t u d y d e s i g n gender and/or m i n o r i t yr e p r e s e n t a t i o n a p p r o p r i a t e t o t h e s c i e n t i f i c o b j e c t i v e s of t h e work proposed.If r e p r e s e n t a t i o n o f women o r m i n o r i t i e s i n s u f f i c i e n t numbers t o permi t assessment o f d i f f e r e n t i a l effects is n o t f e a s i b l e o r is n o t a p p r o p r i a t e , t h e r e a s o n s f o r t h i s must be expla ined and j u s t i f i e d . The r a t i o n a l e may re la te t o t h e purpose o f t h e r e s e a r c h , t h e h e a l t h o f t h e s u b j e c t s , o r o t h e r compell ingc i rcumstances ( e . g . , i f i n t h e only s t u d y p o p u l a t i o n a v a i l a b l e , t h e r e is a d i s p r o p o r t i o n a t e r e p r e s e n t a t i o n i n terms o f age d i s t r i b u t i o n , r i s k f a c t o r s , o r inc idence /preva lence o f one gender o r m i n o r i t y / m a j o r i t y g r o u p ) . If t h e r e q u i r e d i n f o r m a t i o n is n o t c o n t a i n e d w i t h i n t h e a p p l i c a t i o n , t h e a p p l i c a t i o nw i l l be r e t u r n e d . Peer rev iewers w i l l a d d r e s s s p e c i f i c a l l y whether t h e r e s e a r c h p l a n i n t h e a p p l i c a t i o n conforms t o t h e s e p o l i c i e s . If gender and/orm i n o r i t y representation/justification are judged t o b e inadequate , rev iewers w i l l c o n s i d e r t h i s as a d e f i c i e n c y i n a s s i g n i n g t h e p r i o r i t y s c o r e t o t h e a p p l i c a t i o n .

APPLICATION PROCEDURES

A p p l i c a n t s must u s e t h e s t a n d a r d PHS 398 ( r e v . 10188) g r a n t a p p l i c a t i o n form. When apply ing , t y p e i n i t e m 2 o f face page o f PHS 398, t h e name o f t h i s announcement, "Drug Abuse Treatment Research Center Program, RFA DA-91-05." A p p l i c a t i o n k i t s are a v a i l a b l e from u n i v e r s i t y g r a n t o f f i c e s and from t h e D i v i s i o n o f Research Grants , N a t i o n a l I n s t i t u t e s o f Heal th , Westwood Bui ld ing ,Room 240, 5333 Westbard Avenue, Bethesda, Maryland 20892; Telephone ( 3 0 1 )496-7441.

A p p l i c a n t s must a f f i x t h e RFA l a b e l a v a i l a b l e i n t h e PHS 398 to the bot tom of t h e face page. F a i l u r e t o use t h i s l a b e l could r e s u l t i n delayed p r o c e s s i n go f t h e a p p l i c a t i o n such t h a t it may n o t r e a c h t h e review committee i n t i m e for review.

The o r i g i n a l and s i x ( 6 ) c o p i e s o f t h e a p p l i c a t i o n must be submi t ted t o :

D i v i s i o n o f Research Grants N a t i o n a l I n s t i t u t e s o f Heal th Westwood B u i l d i n g , Room 240 Bethesda, MD 20892XX

ELIGIBILITY

A p p l i c a t i o n s f o r r e s e a r c h g r a n t s may be made by any p u b l i c o r p r i v a t en o n - p r o f i t o r f o r - p r o f i t i n s t i t u t i o n s such as u n i v e r s i t i e s , c o l l e g e s , and h o s p i t a l s . Women and m i n o r i t y i n v e s t i g a t o r s are encouraged t o a p p l y .

REVIEW PROCESS AND CRITERIA

The D i v i s i o n of Research Grants , N I H , s e r v e s as a central p o i n t f o r r e c e i p t of a p p l i c a t i o n s f o r most d i s c r e t i o n a r y HHS g r a n t programs. A p p l i c a t i o n s r e c e i v e d under t h i s announcement w i l l be a s s i g n e d t o an i n i t i a l review group ( I R G )convened by N I D A . The IRG w i l l review t h e a p p l i c a t i o n s f o r s c i e n t i f i c and t e c h n i c a l m e r i t . N o t i f i c a t i o n o f t h e review recommendations w i l l be s e n t t o t h e a p p l i c a n t a f t e r t h e i n i t i a l review. A p p l i c a t i o n s w i l l r e c e i v e a second-level review by t h e Nat iona l Advisory Counci l on Drug Abuse, whose review may be based on p o l i c y c o n s i d e r a t i o n s a s wel l a s s c i e n t i f i c meri t . Only a p p l i c a t i o n s recommended f o r approval by t h e Counci l may be c o n s i d e r e d f o r funding .

AWARD CRITERIAA

A p p l i c a t i o n s recommended f o r approval by t h e N a t i o n a l Advisory Counci l on DrugAbuse w i l l be c o n s i d e r e d f o r funding on t h e b a s i s o f o v e r a l l s c i e n t i f i c and t e c h n i c a l m e r i t o f t h e Center p r o p o s a l as determined by p e e r review,a p p r o p r i a t e n e s s o f budget estimates, N I D A program needs and ba lance , N I D A p o l i c y c o n s i d e r a t i o n s , adequacy of p r o v i s i o n s f o r t h e p r o t e c t i o n o f human s u b j e c t s , and a v a i l a b i l i t y o f f u n d s .

AVAILABILITY OF FUNDS

I n f i s c a l y e a r 1991, an e s t i m a t e d $2 m i l l i o n w i l l be a v a i l a b l e t o suppor t new g r a n t s under t h i s announcement. The a c t u a l amount o f funding a v a i l a b l e w i l l depend on a p p r o p r i a t e d funds and program p r i o r i t i e s a t t h e t i m e o f award.

I*

N I H G U I D E - Vol. 20 , No. 9, March 1 , 1991 - Page 6

INQUIRIES

P r o s p e c t i v e a p p l i c a n t s may o b t a i n a d d i t i o n a l in format ion r e g a r d i n g t h e development of Drug Abuse Treatment Evalua t ion Research Center g r a n ta p p l i c a t i o n s and advice r e g a r d i n g t h e feas ib i l i ty /appropriateness o f such a p p l i c a t i o n s by c o n t a c t i n g :

-1'

Frank M . T i m s , Ph.D. Deputy Chief , Treatment Research Branch D i v i s i o n o f C l i n i c a l Research Nat iona l I n s t i t u t e on Drug Abuse Parklawn Bui ld ing , Room 1 OA-30 5600 F i s h e r s Lane Rockvi l le , MD 20857 Telephone: ( 3 0 1 ) 443-4060

For f i sca l and a d m i n i s t r a t i v e matters,

Grants Management Branch Nat iona l I n s t i t u t e f o r Drug Abuse Parklawn Bui ld ing , Room 8A54 5600 F i s h e r s Lane Rockvi l le , MD 20857 Telephone: (301) 443-6710

c o n t a c t :

T h i s program is d e s c r i b e d i n t h e Cata log of Federa l Domestic A s s i s t a n c e No. 13.279. Grants w i l l be awarded under t h e a u t h o r i t y o f S e c t i o n s 301 and 515 o f t h e P u b l i c Heal th S e r v i c e A c t , as amended (42 USC 241 and 42 USC 2901, and adminis te red i n accordance w i t h t h e PHS Grants P o l i c y Statement and F e d e r a l Regula t ions a t 42 CFR P a r t 52, and 45 CFR P a r t 74. T h i s program i s n o t s u b j e c t t o t h e In te rgovernmenta l review requi rements o f Execut ive Order 12372 o r Heal th Systems Agency review.

DRUG DISCOVERY GROUPS FOR THE TREATMENT OF COGNITIVE IMPAIRMENT ASSOCIATED WITH ALZHEIMER'S DISEASE

RFA AVAILABLE: AG-91-09

P.T. 34; K.W. 0715180, 0740020, 0755025 '**I

N a t i o n a l I n s t i t u t e on Aging

A p p l i c a t i o n Receipt Date: May 21, 1991 Le t t e r o f I n t e n t Rece ip t Date: A p r i l 1, 1991

BACKGROUND

The Nat iona l I n s t i t u t e on Aging ( N I A ) i n v i t e s Program P r o j e c t a p p l i c a t i o n s(PO11 f o r t h e e s t a b l i s h m e n t o f Drug Discovery Groups f o r t h e Treatment o f Cogni t ive Impairment Assoc ia ted With Alzheimer 's Disease. The U.S. Congress, a s p a r t o f t h e F i s c a l Year 1991 a p p r o p r i a t i o n , h a s mandated t h a t N I A "explore new t r e a t m e n t and management methods, i n c l u d i n g t e s t i n g promising drugs , such as nerve growth f a c t o r and a c e t y l c a r n i t i n e , t h a t could s a f e l y and e f f e c t i v e l yslow o r r e v e r s e t h e symptoms o f Alzheimer's d i sease .""

RESEARCH OBJECTIVES AND SCOPE

The o b j e c t i v e of t h i s s o l i c i t a t i o n is t o s t i m u l a t e m u l t i - c e n t e r m u l t i - d i s c i p l i n a r y p r e c l i n i c a l r e s e a r c h i n t h e des ign , development and t e s t i n gof novel compounds aimed a t slowing, h a l t i n g , o r , i f p o s s i b l e , r e v e r s i n g t h e p r o g r e s s i v e d e c l i n e i n c o g n i t i v e f u n c t i o n i n Alzheimer 's d i s e a s e v i c t i m s . + T h i s i n i t i a t i v e is in tended t o s t i m u l a t e b a s i c r e s e a r c h and developmente f f o r t s which go beyond t h o s e a l r e a d y underway o r l i k e l y t o be undertaken bypharmaceut ical f i r m s i n t h e f o r e s e e a b l e f u t u r e . Compounds a r e needed t o c o r r e c t o r improve t h e f u n c t i o n i n g a t v a r i o u s s i t e s a l o n g t h e s i g n a lt r a n s d u c t i o n pathway; e . g . r e c e p t o r s , channels , membrane, second and t h i r d messenger, phosphoryla t ion , and s i g n a l a m p l i f i c a t i o n s t a g e s . The d i s c o v e r y o f compounds and t r e a t m e n t s should be aimed t o a m e l i o r a t e fundamental p r o c e s s e so f t h e n e u r a l d y s f u n c t i o n and c e l l d e a t h a s s o c i a t e d wi th t h e d i s e a s e . The aim is t o encourage i n n o v a t i v e approaches t o t h e treatment of AD.

MECHANISM OF SUPPORT

& Awards w i l l be made as Program P r o j e c t s ( P o l ) . Funding o f a t l eas t 3 awards i s a n t i c i p a t e d . Each award is l i m i t e d t o $750,000 t o t a l c o s t p e r y e a r . The amount s p e n t w i l l be dependent on t h e c o n t i n u i n g a v a i l a b i l i t y o f funds f o r


t h i s purpose and t h e q u a l i t y and d i v e r s i t y o f approved a p p l i c a t i o n s . The s t a r t d a t e w i l l be on or b e f o r e September 30, 1991.

APPLICATION AND REVIEW PROCEDURES

I n p r e p a r i n g a p p l i c a t i o n s , i n s t r u c t i o n s f o r PHS Form 398 (10/88 r e v i s i o n ,r e p r i n t e d 9/89), supplemental in format ion a v a i l a b l e from N I A program s t a f f ,and a d d i t i o n a l i n s t r u c t i o n s inc luded i n t h e f u l l RFA should be used . Proposa ls judged by s ta f f t o be nonresponsive t o t h e RFA w i l l be a d m i n i s t r a t i v e l y withdrawn and r e t u r n e d t o t h e a p p l i c a n t without review. Responsive p r o p o s a l s may t h e n r e c e i v e a p r e l i m i n a r y review by a subcommittee o f t h e review p a n e l t o e s t a b l i s h t h o s e a p p l i c a t i o n s deemed t o be c o m p e t i t i v e .Those judged noncompeti t ive w i l l be so d e s i g n a t e d , and an a b b r e v i a t e d summary s t a t e m e n t n o t i n g t h e major d e f i c i e n c i e s w i l l be s e n t t o t h e p r i n c i p a li n v e s t i g a t o r . A p p l i c a t i o n s judged t o be c o m p e t i t i v e w i l l be given f u l l review by a s p e c i a l review group convened by N I A . Following review by t h e i n i t i a l review group, t h e a p p l i c a t i o n s w i l l be cons idered by t h e Nat iona l AdvisoryCounci l on Aging.

A p p l i c a n t s should o b t a i n t h e f u l l RFA and supplemental in format ion and d i s c u s s t h e i r p l a n s w i t h and d i r e c t any o t h e r i n q u i r i e s t o :

Neil Buckhol tz , Ph.D. NNA, N I A , N I H B u i l d i n g 31, Room 5C35 9000 R o c k v i l l e P ike Bethesda, MD 20892 Telephone: (301) 496-9350 FAX: (301) 496-1494

I n q u i r i e s r e g a r d i n g f i s ca l matters may b e addressed

Mr . Joseph Ellis Grants Management Off iver N a t i o n a l I n s t i t u t e on AgingB u i l d i n g 31, Room 5C07 Bethesda, MD 20892

t o :

Although n o t a p r e r e q u i s i t e f o r apply ing , p o t e n t i a l a p p l i c a n t s are encouraged t o submit t o D r . Buckhol tz , a t t h e a d d r e s s i n d i c a t e d above, a non-bindingl e t t e r of i n t e n t t o apply by A p r i l 1, 1991. A p p l i c a t i o n s must be complete and -+-

r e c e i v e d by May 21, 1991.

MEDICAL INFORMATICS RESEARCH TRAINING

RFA AVAILABLE: LM-91-01

P.T. 22; K.W. 1004017, 1004000, 0720005, 0710030 N a t i o n a l L i b r a r y o f Medicine

Letter of I n t e n t Rece ip t Date: May 1, 1991 A p p l i c a t i o n Rece ip t Date: June 10, 1991

PURPOSE

The N a t i o n a l L i b r a r y o f Medicine (NLM) i n v i t e s t r a i n i n g g r a n t a p p l i c a t i o n s i n a s i n g l e c o m p e t i t i o n f o r p r e d o c t o r a l and p o s t d o c t o r a l r e s e a r c h t r a i n i n g i n medical i n f o r m a t i c s . A p p l i c a t i o n s may be f o r t h e c r e a t i o n o f new t r a i n i n g c e n t e r s or f o r t h e renewal o f e x i s t i n g NLM-supported t r a i n i n g programs. T h i s t r a i n i n g w i l l h e l p meet a growing need f o r q u a l i f i e d , t a l e n t e d i n v e s t i g a t o r s ,w e l l p repared t o a d d r e s s informat ion problems i n h e a l t h care, h e a l t h p r o f e s s i o n a l e d u c a t i o n , and biomedical r e s e a r c h .

A p p l i c a t i o n s must c l e a r l y i n d i c a t e t h a t t h e pr imary i n t e n t o f t h e program i s p r e p a r a t i o n f o r a n academic career i n Medical I n f o r m a t i c s . A p p l i c a t i o n s must d e s c r i b e t h e p r o c e s s by which t r a i n e e s w i l l become familiar w i t h t h e manyr e l e v a n t d i s c i p l i n e s . To p r e p a r e t r a inees f o r r e s e a r c h careers i n a demandingr e s e a r c h environment, t h e sponsorsh ip of a r e s e a r c h - o r i e n t e d , academic h e a l t h sciences i n s t i t u t i o n is c r i t i c a l . It is expected t h a t t h e c o r e o f t r a i n i n gw i l l emphasize t h e s y n t h e s i s , o r g a n i z a t i o n , r e t r i e v a l , and e f f e c t i v e management o f knowledge. The c u r r i c u l a should be i n t e r - d i s c i p l i n a r y byi n c l u d i n g t o p i c s i n medicine and t h e b i o l o g i c a l sciences, t h e c o g n i t i v esciences, informat ion science, and computer s c i e n c e . T r a i n i n g s i tes must o f f e r an e x c e l l e n t s e t t i n g f o r i n s t r u c t i o n , involvement i n important h e a l t h computer s c i e n c e r e s e a r c h , and o p p o r t u n i t i e s f o r meaningful t r a i n e e involvement i n such r e s e a r c h .


OBJECTIVES AND SCOPE

I n a d d i t i o n t o t h e g e n e r a l goa l o f a s s i s t i n g i n t h e educa t ion o f pe r sons t o be a b l e t o t a k e academic p o s i t i o n s t o conduct r e s e a r c h and t e a c h medical i n f o r m a t i c s , s e v e r a l more s p e c i a l i z e d a d d i t i o n s t o t h e t r a i n i n g programs are l i k e l y t o become a v a i l a b l e du r ing t h e next few y e a r s t o enhance r e s e a r c h

c C I r t r a i n i n g g r a n t s approved i n t h e FY 1991 compe t i t i on . Consequent ly , NLM i n v i t e s a p p l i c a n t i n s t i t u t i o n s t o i n c l u d e t h e i r p l a n s for such p o s s i b l eenhancements w i t h i n t h e a p p l i c a t i o n . Some p o t e n t i a l enhancement areas ( d e s c r i b e d i n t h e f u l l RFA) are h igh performance computing and communication,b io technology, cance r , and in fo rma t ion systems. Dental i n f o r m a t i c s is a n o t h e r area f o r which a d d i t i o n a l t r a i n i n g s l o t s may become a v a i l a b l e i n t h e f u t u r e .


T h i s RFA w i l l u s e t h e T15 g r a n t mechanism. NLM p l a n s t o make a v a i l a b l e approximate ly $3 m i l l i o n f o r t h i s program i n FY 1992. It is expec ted t h a t six t o t e n t r a i n i n g g r a n t s w i l l be awarded; however, a c t u a l award o f g r a n t s pursuant t o t h i s RFA is n e c e s s a r i l y c o n t i n g e n t upon r e c e i p t of funds a p p r o p r i a t e d f o r t h i s purpose . These awards are a u t h o r i z e d by t h e Medical L i b r a r y A s s i s t a n c e A c t and are n o t p a r t o f t h e Na t iona l Research S e r v i c e Awards Program o f t h e P u b l i c Heal th S e r v i c e . P r i o r t o i n i t i a l s c i e n t i f i c merit review, a t r i a g e mechanism may be employed t o s c r e e n o u t a p p l i c a t i o n st h a t are c l e a r l y noncompet i t ive or nonresponsive t o t h e RFA. Such a p p l i c a t i o n s would be r e t u r n e d t o t h e a p p l i c a n t .

APPLICATION SUBMISSION

Letter o f I n t e n t : P r o s p e c t i v e a p p l i c a n t s are asked t o submit by May 1, 1991, a l e t t e r o f i n t e n t t h a t i n c l u d e s a d e s c r i p t i v e t i t l e , t h e name and a d d r e s s o f t h e P r i n c i p a l I n v e s t i g a t o r , t h s names and a d d r e s s e s of any o t h e r keyi n v e s t i g a t o r s , and any o t h e r p a r t i c i p a t i n g i n s t i t u t i o n s .

App l i ca t ion form PHS-398 ( rev . 10/88) must be used i n app ly ing . To i d e n t i f y r e sponses t o t h i s announcement, check Ifyes" and t y p e t h e RFA number and t i t l e CRFA LM-91-01, MEDICAL INFORMATICS RESEARCH T R A I N I N G ] i n i t e m 2 on page 1 o f t h e g r a n t a p p l i c a t i o n . The RFA l a b e l provided wi th t h e i n s t r u c t i o n s must be a f f i x e d t o t h e bottom o f t h e f a c e page. F a i l u r e t o u s e t h i s l a b e l cou ld r e s u l t i n de layed p r o c e s s i n g o f your a p p l i c a t i o n such t h a t it may n o t r e a c h t h e review committee i n t i m e f o r review.

I

The completed o r i g i n a l a p p l i c a t i o n and s i x ( 6 ) c o p i e s must be mailed t o :

D i v i s i o n o f Research Grants Na t iona l I n s t i t u t e o f Heal th Westwood Bu i ld ing , Room 240 Bethesda, MD 20892XX

A p p l i c a t i o n s must be r e c e i v e d by June 10 , 1991. A p p l i c a t i o n s r e c e i v e d after t h a t d a t e w i l l be r e t u r n e d t o t h e a p p l i c a n t . The review p r o c e s s w i l l be completed i n October 1991. Funding around J u l y 1, 1992 is a n t i c i p a t e d .

INQUIRIES

A more d e t a i l e d RFA may be ob ta ined from:

Roger W . Dahlen, Ph.D. Chief ,. Biomedical In fo rma t ion Support Branch Extramural ProgramsNat iona l L i b r a r y of Medicine 8600 Rockv i l l e P ike Bui ld ing 3 8 A , Room 5S522 Bethesda, MD 20894 Telephone: ( 3 0 1 ) 496-4221 FAX: ( 3 0 1 ) 402-0421

For f i sca l and a d m i n i s t r a t i v e matters,

Ruth Bor t z Nat iona l L i b r a r y of Medicine 8600 Rockv i l l e P ike Bui ld inn 3 8 A , Room 5S522 Bethesda, MD 20892 Telephone: (301) 496-4253

N I H GUIDE - Vol. 20, No.

c o n t a c t :

9 , March 1 , 1991 - Page 9

EXPLORATORY CENTERS FOR HEALTH BEHAVIOR RESEARCH WITH CHILDREN AND ADOLESCENTS

RFA AVAILABLE: NR-91-02

P.T. 34, AA; K . W . 0404000, 0715020, 0745035

N a t i o n a l Center f o r Nursing Research Nat iona l I n s t i t u t e o f Chi ld Heal th and Human DevelopmentN a t i o n a l I n s t i t u t e o f Mental Heal th

Let t e r o f I n t e n t Rece ip t Date: A p r i l 15, 1991 A p p l i c a t i o n Rece ip t Date: May 2 0 , 1991

PURPOSE

The N a t i o n a l Center f o r Nursing Research ( N C N R ) , t h e Nat iona l I n s t i t u t e o f Chi ld Heal th and Human Development ( N I C H D ) and t h e Nat iona l I n s t i t u t e o f Mental Heal th ( N I M H ) i n v i t e a p p l i c a t i o n s from i n t e r e s t e d i n s t i t u t i o n s t o e s t a b l i s h m u l t i d i s c i p l i n a r y e x p l o r a t o r y c e n t e r s t o i n v e s t i g a t e h e a l t h behavior development i n c h i l d r e n and a d o l e s c e n t s ( a g e s 8-18). It is a n t i c i p a t e d t h a t approximately 6 e x p l o r a t o r y c e n t e r s w i l l be funded.

The P u b l i c Heal th S e r v i c e (PHS) is committed t o a c h i e v i n g t h e h e a l t h promotion and d i s e a s e p r e v e n t i o n o b j e c t i v e s o f Heal thy People 2000, a PHS-led n a t i o n a l a c t i v i t y f o r s e t t i n g p r i o r i t y a r e a s . T h i s RFA, l lExploratory Centers f o r Heal th Behavior Research w i t h Chi ldren and Adolescents , " i s r e l a t e d t o t h e p r i o r i t y area o f t h e development of s e v e r a l h e a l t h promotion b e h a v i o r s . P o t e n t i a l a p p l i c a n t s may o b t a i n a copy o f Heal thy People 2000 ( F u l l Report : Stock No. 017-001-00474-0) o r Heal thy People 2000 (Summary Report : S tock No. 017-001-00473-1) th rough t h e Super in tendent o f Documents, Government P r i n t i n g Office, Washington, D . C . 20402-9325 (Telephone 202-783-3238).

BACKGROUND

Recent r e p o r t s h i g h l i g h t t h e s i g n i f i c a n c e of b e h a v i o r s r e l a t i n g t o d i e t ,p h y s i c a l a c t i v i t y , a l c o h o l and tobacco u s e , i n j u r i e s , and s e x u a l behaviors t h a t begin i n chi ldhood and adolescence , compromise h e a l t h i n t h e s h o r t term and have major long-range i m p l i c a t i o n s f o r t h e o n s e t o f c h r o n i c d i s e a s e i n c l u d i n g c a r d i o v a s c u l a r d i s e a s e and c a n c e r . T h i s RFA s e e k s empir ica l ly-basedm u l t i d i s c i p l i n a r y r e s e a r c h t h a t w i l l form t h e foundat ion f o r biomedical ,b e h a v i o r a l and n u r s i n g i n t e r v e n t i o n s i n h e a l t h promotion and d i s e a s e p r e v e n t i o n , and f a c i l i t a t e heal th-enhancing p a t t e r n s o f behavior i n c h i l d r e n and a d o l e s c e n t s .

SPECIFIC OBJECTIVES AND AREAS OF INTEREST

A p p l i c a n t s are i n v i t e d t o apply f o r suppor t o f p r o j e c t s t o a d d r e s s i s s u e s i n c l u d i n g b u t n o t l i m i t e d t o :

A Behaviora l Epidemiology-Ident i f i ca t i o n and D i s t r i b u t i o n o f Behaviora l Risk F a c t o r s .

B Es tab l i shment , Change and Maintenance of Heal th Rela ted Behaviors . Basic Behaviora l B i o l o g i c a l Mechanisms.

E L I G I B I L I T Y

I n s t i t u t i o n s o r c o n s o r t i a o f i n s t i t u t i o n s are e l i g i b l e t o apply i f t h e y have a t least two P r i n c i p a l I n v e s t i g a t o r s wi th any PHS agency o r comparable p e e rreviewed r e s e a r c h p r o j e c t ( R o l l g r a n t s t h a t a r e c u r r e n t l y a c t i v e i n h e a l t h and behavior r e s e a r c h .


The s u p p o r t mechanism f o r t h i s RFA i s t h e Explora tory Center Grant (P20) . The E x p l o r a t o r y Center Grant c o n s i s t s o f ( 1 ) an a d m i n i s t r a t i v e and p lanning c o r e p r o v i d i n g a d m i n i s t r a t i v e , c o o r d i n a t i n g , r e s e a r c h p lanning , l o g i s t i c a l , and/ormethodological ( e . g . , r e s e a r c h des ign , d a t a a n a l y s i s ) suppor t and (2)small-scale s t u d i e s . The i n i t i a l award p e r i o d i s f o r t h r e e y e a r s , and t h e award may n o t be renewed. Grants will be a d m i n i s t e r e d i n accordance with t h e PHS Grants P o l i c y Statement (10/01/90).

SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES I N CLINICAL RESEARCH STUDIES

For p r o j e c t s i n v o l v i n g c l i n i c a l r e s e a r c h , N I H r e q u i r e s a p p l i c a n t s t o g i v es p e c i a l a t t e n t i o n t o t h e i n c l u s i o n o f women and m i n o r i t i e s i n s t u d yp o p u l a t i o n s . If women o r m i n o r i t i e s a r e n o t inc luded i n t h e s t u d y p o p u l a t i o n sf o r c l i n i c a l s t u d i e s , a s p e c i f i c j u s t i f i c a t i o n f o r t h i s e x c l u s i o n must be


C

r e

provided . A p p l i c a t i o n s without such documentation w i l l n o t be accepted f o r review.

METHOD OF APPLYING

I P r i o r t o submission o f t h e formal a p p l i c a t i o n , c o n s u l t a t i o n wi th NCNR, N I C H D and/or N I M H concerning t h e t e c h n i c a l and s u b s t a n t i v e a s p e c t s o f p r e p a r i n g t h e a p p l i c a t i o n is recommended. Copies o f t h e complete RFA can be o b t a i n e d from t h e program s t a f f l i s t e d below:

Direct i n q u i r i e s t o :

NCNR N I C H D Shar lene M . Weiss, PhD, RN P e t e r S c h e i d t , MD, MPH Chief , Heal th Promotion/Disease Medical Officer Prevent ion Branch, NCNR, N I H Human Learning and Behavior 9000 Rockvi l le P ike Branch, N I C H D , N I H , Bui ld ing 31, Room 5B09 9000 Rockvi l le P ike Bethesda, MD 20892 Bethesda, MD 20892 Telephone: (301) 496-0523 Telephone: (301) 496-6591

N I M H Leonard Mitnick, Ph.D. Chief , B a s i c Prevent ion and Behaviora l Medicine Research Branch, N I H Room 11C-06 5600 F i s h e r s Lane Rockvi l le , MD 20857 Telephone: (301) 443-4337

O N G O I N G PROGRAM ANNOUNCEMENTS

THE N C I OUTSTANDING INVESTIGATOR GRANT

PA: PA-91-28

- P.T. 34; K.W. 0715035, 0710030

N a t i o n a l Cancer I n s t i t u t e

A p p l i c a t i o n Rece ip t Date: June 1, 1991

SUMMARY AND PURPOSE

The Nat iona l Cancer I n s t i t u t e ( N C I ) w i l l c o n t i n u e t o a c c e p t new a p p l i c a t i o n sf o r t h e Outstanding I n v e s t i g a t o r Grant ( O I G ) , as w e l l as competingc o n t i n u a t i o n a p p l i c a t i o n s from c u r r e n t l y funded O I G r e c i p i e n t s i n t h e f i f t h y e a r o f t h e i n i t i a l award p e r i o d . The purpose o f t h e O I G is t o encouragei n v e s t i g a t o r s to c o n t i n u e or embark on projects of unusual p o t e n t i a l i n cancer r e s e a r c h . Emphasis w i l l be p laced on evidence of recent s u b s t a n t i v e c o n t r i b u t i o n s ( i . e . , seminal i d e a s and i n n o v a t i v e approaches t o r e s i s t e n t problems) and t h e p o t e n t i a l f o r cont inued work o f h i g h c a l i b e r .

T h i s announcement s i g n i f i c a n t l y modi f ies a v a i l a b l e a p p l i c a b l e g u i d e l i n e s f o r t h e O I G . S p e c i a l a t t e n t i o n should be given t o t h e requi rements f o r " E l i g i b i l i t y t 1 and t o t h e "General Requirements" f o r p r e p a r a t i o n o f new and competing c o n t i n u a t i o n a p p l i c a t i o n s as noted below.

ELIGIBILITY

A p p l i c a t i o n s may be submi t ted o n l y by domest ic i n s t i t u t i o n s on b e h a l f o f i n v e s t i g a t o r s who have r e c e n t l y demonstrated o u t s t a n d i n g r e s e a r c h p r o d u c t i v i t yf o r a t l e a s t f i v e y e a r s . There are no age r e s t r i c t i o n s . Only United S t a t e s c i t i z e n s , n a t i o n a l s o r permanent r e s i d e n t s may be p r e s e n t e d as c a n d i d a t e s f o r t h i s g r a n t .

A p p l i c a t i o n s w i l l be accepted by t h e N C I on ly when t h e y a r e c a n c e r - r e l a t e d as d e f i n e d by t h e D i v i s i o n of Research Grants (DRG) g r a n t referral g u i d e l i n e s .I n v e s t i g a t o r s whose cu r ren t r e s e a r c h suppor t is d e r i v e d predominant ly from s o u r c e s o t h e r t h a n t h e N C I may n o t be e l i g i b l e a s O I G awardees. A s a g e n e r a lr u l e , I n v e s t i g a t o r s w i l l be allowed t o c o n s o l i d a t e ONLY N C I suppor ted a c t i v e c a n c e r - r e l a t e d p e e r reviewed g r a n t s i n t o t h e O I G r e s e a r c h e f f o r t . I n t h i s

I r e g a r d a p p l i c a n t s are encouraged t o d i s c u s s t h e i r r e s e a r c h o b j e c t i v e s w i t h a p p r o p r i a t e N C I o f f i c i a l s b e f o r e apply ing .

N I H GUIDE - Vol. 20, No. 9, March 1, 1991 - Page 1 1

--

The O I G P r i n c i p a l I n v e s t i g a t o r is r e q u i r e d t o commit 75 p e r c e n t o f h i s o r h e r t i m e and e f f o r t t o cance r r e s e a r c h suppor ted by t h e O I G , and t h e i n s t i t u t i o n sponsor ing t h e O I G a p p l i c a t i o n i s r e q u i r e d t o commit i t s e l f t o p rov id ing 25 p e r c e n t o f t h e I n v e s t i g a t o r r s s a l a r y s u p p o r t . However, t h e N C I w i l l e n t e r t a i n r e q u e s t s , on a case-by-case b a s i s , f o r t i m e and e f f o r t commitments o f less t h a n 75 p e r c e n t ( w i t h a proposed minimum of 50 p e r c e n t ) t o t h e O I G p r o j e c tbased upon a l lowab le r e t e n t i o n o f o t h e r ongoing pee r reviewed g r a n t s .

A p p l i c a t i o n s t h a t do no t meet a l l o f t h e above e l i g i b i l i t y c r i t e r i a o r t h a t have n o t had approva l from t h e N C I as e x c e p t i o n s t o t h e above c r i t e r i a w i l l be r e t u r n e d t o t h e a p p l i c a n t .

GENERAL REQUIREMENTS

N e w (Type 1 ) and competing c o n t i n u a t i o n (Type 2 ) O I G a p p l i c a n t s w i l l be r e q u i r e d t o p rov ide a d e t a i l e d ("eva luable l ' ) p roposa l emphasizing h i s / h e raccomplishments p r i o r t o (Type 1 ) and dur ing (Type 2) t h e f irst g r a n t p e r i o dand a d e t a i l e d d e s c r i p t i o n o f t h e a c t i v i t i e s t o be suppor ted under t h e nex t competing award p e r i o d . The budget r e q u e s t must be i n s p e c i f i c te rms and a zero-based budgetx should be developed t o assist r ev iewers i n making e x p l i c i tbudget recommendations.

REVIEW PROCEDURES

A p p l i c a t i o n s w i l l be a s s igned t o an a p p r o p r i a t e s u b s e t o f a na t ionwide panelo f recognized cance r i n v e s t i g a t o r s convened by t h e D i v i s i o n o f Extramural a c t i v i t i e s , N C I and reviewed f o r s c i e n t i f i c and t e c h n i c a l merit. Fol lowingreview by t h e i n i t i a l review group, t h e a p p l i c a t i o n s w i l l r e c e i v e a second- leve l review by t h e Na t iona l Cancer Advisory Board (NCAB) p r i o r t o a f i n a l funding d e c i s i o n by t h e N C I .

HOW TO APPLY

The d a t e o f r e c e i p t o f a l l O I G a p p l i c a t i o n s , i n c l u d i n g competingc o n t i n u a t i o n a p p l i c a t i o n s h a s been changed t o June 1 of each y e a r .They w i l l be p rocessed f o r review a t t h e e a r l i e s t p o s s i b l e meet ingof t h e NCAB.

A p p l i c a t i o n s f o r t h i s award should be made on Form PHS 398 ( r e v .10/88) i n accordance wi th i n s t r u c t i o n s i n t h i s Announcement. These forms are a v a i l a b l e a t most academic o r r e s e a r c h i n s t i t u t i o n a l b u s i n e s s o f f i c e s and from t h e Office o f Grants I n q u i r i e s , D i v i s i o n of Research Grants , Na t iona l I n s t i t u t e s o f Hea l th , Room 449 Westwood Bu i ld ing , 5333 Westbard Avenue, Bethesda, Maryland 20892.

The t i t l e " N C I OUTSTANDING INVESTIGATOR GRANT, PA-91-28'' must be typed i n s e c t i o n 2 on t h e f irst page o f t h e a p p l i c a t i o n .

A l e t t e r i n d i c a t i n g clear and c o n t i n u a l i n s t i t u t i o n a l commitment byt h e I n s t i t u t i o n t o t h e a p p l i c a n t must accompany t h e a p p l i c a t i o n i n o r d e r f o r t h e N C I t o beg in t h e review p r o c e s s .

A p p l i c a t i o n s must be accompanied by a cur r icu lum v i t a e and a complete b i b l i o g r a p h y . Abbrevia ted c u r r i c u l a v i t a e o f a l l p r o f e s s i o n a l pe r sons ( d o c t o r a l l e v e l o r e q u i v a l e n t ) l i s t e d on t h e pe r sonne l page should be inc luded . R e p r i n t s o f no more t h a n f i v e p u b l i c a t i o n s may be submi t t ed . For a new a p p l i c a t i o n t h a t proposesp r i m a r i l y t h e c o n s o l i d a t i o n o f e x i s t i n g NCI-supported r e s e a r c h g r a n t s , t h e p r o s e p o r t i o n may no t exceed t e n t y p e w r i t t e n pages .For t h e s e a p p l i c a t i o n s , d e t a i l e d d e s c r i p t i o n s o f methods are n o t r e q u i r e d because t h e e v a l u a t i o n o f t h e new O I G a p p l i c a t i o n w i l l be based most ly on t h e a p p l i c a n t ' s t r a c k r e c o r d i n t h e c o n t e x t of c u r r e n t peer-reviewed s u p p o r t . However, t h e s e new a p p l i c a t i o n s must o u t l i n e t h e main o b j e c t i v e s t o be pursued and d i s c u s s t h e s i g n i f i c a n c e o f t h e r e s e a r c h . When o b j e c t i v e s are proposed t h a t are o u t s i d e t h e c o n t e x t o f c u r r e n t peer-reviewed a c t i v i t i e s ,p o r t i o n s o f t h e a p p l i c a t i o n a d d r e s s i n g t h o s e aims should be w r i t t e n i n more d e t a i l . Therefore , f o r a p p l i c a t i o n s propos ing new r e s e a r c h areas, and f o r competing renewal a p p l i c a t i o n s , up t o 18 pages o f p r o s e are a l l o w a b l e .

The a p p l i c a n t i n v e s t i g a t o r and h i s l h e r i n s t i t u t i o n must p r e s e n t a workable p l a n f o r c o n s o l i d a t i o n o f t h e a p p l i c a n t ' s c u r r e n t r e s e a r c h suppor t and conve r s ion o f s t a f f and f a c i l i t i e s t o be suppor t ed byt h e O I G . T h i s must be submi t ted as a s e p a r a t e s e c t i o n o f t h e g r a n ta p p l i c a t i o n immediately fo l lowing t h e budget s e c t i o n .


*d

W

4’

o The o r i g i n a l and s i x l e g i b l e c o p i e s o f t h e a p p l i c a t i o n should be submi t ted t o DRG, N I H , as d i r e c t e d i n t h e i n s t r u c t i o n s o f t h e g r a n ta p p l i c a t i o n .

INQUIRIES

A l l p o t e n t i a l a p p l i c a n t s o f t h i s award are advised t h a t t h e fclll t e x t of t h i s Program Announcement, c o n t a i n i n g c u r r e n t l y a p p l i c a b l e g u i d e l i n e s , is now a v a i l a b l e and should b e r e q u e s t e d p r i o r t o s u b m i t t i n g an a p p l i c a t i o n f o r t h e June 1 , 1991 r e c e i p t d a t e .

P l e a s e d i r e c t i n q u i r i e s f o r f u r t h e r in format ion on a p p l i c a t i o n development t o :

Barbara S . BynumD i r e c t o r D i v i s i o n o f Extramural A c t i v i t i e s Nat iona l Cancer I n s t i t u t e Bui ld ing 31, Room 10A03 Bethesda, MD 20892 Telephone: (301) 496-5147

For f i s ca l and a d m i n i s t r a t i v e matters, c o n t a c t :

C r y s t a l E l l i o t t Grants Management S p e c i a l i s t N a t i o n a l Cancer I n s t i t u t e Execut ive P l a z a South, Room 243 Bethesda, MD 20892 Telephone: (301) 496-7800 x19

W Budget r e q u e s t should j u s t i f y each item f o r which suppor t i s r e q u e s t e d and should n o t be presumed t o i n c l u d e a l l funds c u r r e n t l y a v a i l a b l e t o t h e P r i n c i p a l I n v e s t i g a t o r under a c t i v e g r a n t awards.

ACADEMIC AWARD I N ENVIRONMENTAL/OCCUPATIONAL MEDICINE

PA: PA-91-29

P.T. 34; K.W. 0725020, 0725000, 0720005

N a t i o n a l I n s t i t u t e o f Environmental Heal th S c i e n c e s

A p p l i c a t i o n Rece ip t Date: June 1 , 1991

The Nat iona l I n s t i t u t e of Environmental Heal th S c i e n c e s (NIEHS) announces i t s second n a t i o n a l compet i t ion f o r Environmental/Occupational Medicine Academkc Awards which f i r s t appeared i n t h e N I H Guide, Vol. 19, No. 8, February 23, 1990, Page 9 . The award w i l l have t h e d u a l purpose o f improving t h e q u a l i t yof environmental/occupational medicine c u r r i c u l a and o f f o s t e r i n g g r a d u a t er e s e a r c h careers i n environmental/occupation medicine. Each school of medicine o r os teopathy i n t h e United S t a t e s and i ts p o s s e s s i o n s o r t e r r i t o r i e s is e l i g i b l e t o compete f o r Environmental/ Occupat ional Medicine Academic Award for a p r o j e c t p e r i o d t h a t does n o t exceed f i v e y e a r s and, i f success fu l , t o r e c e i v e t h e Award once o n l y . The number o f new awards made each y e a r w i l l depend on t h e a v a i l a b i l i t y o f funds .

For t h e purposes of t h e Environmental/Occupational Medicine Academic Award,t h e term environmental/occupational medicine refers t o t h e a r e a o f medicine concerned w i t h t h e development o f knowledge and t h e a p p l i c a t i o n o f knowledged i r e c t e d a t t h e d i a g n o s i s , t r e a t m e n t , and p r e v e n t i o n o f adverse human h e a l t h e f f e c t s from environmental/occupational exposures t o t o x i c a g e n t s . This i n c l u d e s adverse h e a l t h e f fec ts i n i n f a n t s , c h i l d r e n , and a d u l t s who a r e a t r i s k of developing such h e a l t h problems and t h e r e d u c t i o n o f p r e v e n t a b l ecompl ica t ions o r d i s a b i l i t y i n persons of a l l a g e s who have a l r e a d y developedsuch d i s e a s e s .

NIEHS i n i t i a t e d t h e Environmental/Occupational Medicine Academic Award Program t o provide a s t i m u l u s f o r development of an environmental/occupationalmedicine cur r icu lum i n t h o s e s c h o o l s t h a t do n o t have one and t o s t r e n g t h e nand improve the environmental/occupational medicine cur r icu lum i n s c h o o l s t h a t do. Awards provide suppor t t o a p p l i c a n t f a c u l t y members f o r t h e i r e d u c a t i o n a l development and f o r implementation o r expansion o f t h e cur r icu lum i n environmental/occupational medicine.

N I H G U I D E - V o l . 20, No. 9, March 1, 1991 - Page 13

---

HEALTHY PEOPLE 2000

The P u b l i c Heal th S e r v i c e (PHS) i s committed t o a c h i e v i n g t h e h e a l t h promotion and d i s e a s e p r e v e n t i o n o b j e c t i v e s o f Heal thy People 2000, a PHS-led n a t i o n a l a c t i v i t y f o r s e t t i n g p r i o r i t y a r e a s . T h i s Program Announcement, Academic Award i n Environmental/Occupational Medicine, is r e l a t e d t o t h e p r i o r i t y area o f environmental h e a l t h . P o t e n t i a l a p p l i c a n t s may o b t a i n a copy o f Heal th Ill*r*

People 2000 ( F u l l Report : S tock No. 017-001-00474-0) o r Heal thy People 2000 (Summary Report : S tock No. 017-001-00473-1) th rough t h e Super in tendent o f Documents, Government P r i n t i n g Office, Washington, D . C . 20402-9325 (Telephone 202-783-3238).

A p p l i c a t i o n s must b e r e c e i v e d by June 1, 1991, f o r review a t t h e January meeting o f t h e N a t i o n a l Environmental Heal th S c i e n c e s Advisory Counci l . Awards w i l l be made w i t h a beginning d a t e o f J u l y 1, 1992. Copies o f t h e Program G u i d e l i n e s are c u r r e n t l y a v a i l a b l e from:

Annet te Ki rshner , Ph.D. S c i e n t i f i c Programs Branch D i v i s i o n o f Extramural Research and T r a i n i n g N a t i o n a l I n s t i t u t e o f Environmental Heal th S c i e n c e s N a t i o n a l I n s t i t u t e o f Heal th P. 0 . Box 12233 Research T r i a n g l e Park, NC 27709 Telephone: (919) 541-0488

For f i s ca l and a d m i n i s t r a t i v e matters, c o n t a c t :

David L . Mineo Grants Management Officer Grants Management Branch D i v i s i o n o f Extramural Research and T r a i n i n g N a t i o n a l I n s t i t u t e of Environmental Heal th S c i e n c e s N a t i o n a l I n s t i t u t e s o f Heal th P.O. Box 12233 Research T r i a n g l e Park, NC 27709 Telephone: (919) 541-1373

The programs o f t h e N a t i o n a l I n s t i t u t e of Environmental Heal th S c i e n c e s are i d e n t i f i e d i n t h e C a t a l o g o f F e d e r a l Domestic A s s i s t a n c e , Number 93.894.Awards w i l l b e made under t h e a u t h o r i t y o f t h e P u b l i c Heal th S e r v i c e A c t , a

S e c t i o n 301 (42 USC 241) and a d m i n i s t e r e d under PHS g r a n t p o l i c i e s and Federa l r e g u l a t i o n s , most s p e c i f i c a l l y 42 CFR P a r t 52 and 45 CFR P a r t 74. T h i s program is n o t s u b j e c t t o t h e in te rgovernmenta l review requi rements o f Execut ive Order 12372 o r t o review by a Heal th Systems Agency.

SHORT-TERM TRAINING FOR MEDICAL STUDENTS I N ENVIRONMENTAL/OCCUPATIONAL HEALTH

PA: PA-91-30

P.T. 34; K.W. 0725020, 0725000, 0720005 N a t i o n a l I n s t i t u t e of Environmental Heal th S c i e n c e s

A p p l i c a t i o n Rece ip t Date: May 10 , 1991

The purpose o f t h i s second announcement, which f irst appeared i n t h e N I H Guide, Vol. 19, No. 9, March 2, 1990, Page 10, i s t o s o l i c i t a p p l i c a t i o n s f o r shor t - te rm t r a i n i n g o f medical s t u d e n t s i n d i s c i p l i n e s r e l a t e d t o environmental and o c c u p a t i o n a l medicine. Two t y p e s of mechanisms are a v a i l a b l e .

Medical s c h o o l s a t which t h e r e i s a c u r r e n t l y a c t i v e N a t i o n a l I n s t i t u t e o f Environmental Heal th S c i e n c e s (NIEHS) I n s t i t u t i o n a l T r a i n i n g Grant (T32) maysubmit a supplemental a p p l i c a t i o n t o suppor t 3-5 medical s t u d e n t s f o r summer o r of f - te rm r e s e a r c h . The p e r i o d of suppor t may n o t exceed t h r e e months. Requests f o r shor t - te rm t r a i n i n g may be submi t ted only a t t h e time o f c o m p e t i t i v e renewal .

Medical s c h o o l s t h a t do n o t c u r r e n t l y have an NIEHS I n s t i t u t i o n a l T r a i n i n gGrant b u t do have ongoing b a s i c and/or c l i n i c a l r e s e a r c h a c t i v i t i e s i n areas r e l a t e d t o environmental/occupational h e a l t h may apply f o r a Nat iona l Research S e r v i c e Award f o r Short-Term T r a i n i n g ( T 3 5 ) t o suppor t 3-5 s t u d e n t s p e r y e a r as d e s c r i b e d above.


1d'

d

HEALTHY PEOPLE 2000

The P u b l i c Heal th S e r v i c e (PHS) is committed t o ach iev ing t h e h e a l t h promotionand d i s e a s e p reven t ion o b j e c t i v e s o f Heal thy People 2000, a PHS-led n a t i o n a l a c t i v i t y f o r s e t t i n g p r i o r i t y a r e a s . Th i s Program Announcement, Short-Term T r a i n i n g f o r Medical S t u d e n t s i n Environmental/Occupational Heal th , is r e l a t e d t o t h e p r i o r i t y a r e a o f environmental h e a l t h . P o t e n t i a l a p p l i c a n t s may o b t a i n a copy of Heal th People 2000 ( F u l l Report: S tock No. 017-001-00474-0) o r Heal thy People 2000 (Summary Repor t : S tock No. 017-001-00473-1) th rough t h e Supe r in t enden t o f Documents, Government P r i n t i n g Office, Washington, D . C . 20402-9325 (Telephone 202-783-3238).

For a d d i t i o n a l i n fo rma t ion and s p e c i a l i n s t r u c t i o n s , c o n t a c t :

Annet te K i r shne r , Ph.D. S c i e n t i f i c Programs Branch Div i s ion o f Extramural Research and T r a i n i n gNa t iona l I n s t i t u t e o f Environmental Heal th Sc iences Na t iona l I n s t i t u t e o f Hea l th P. 0 . Box 12233 Research T r i a n g l e Park, NC 27709 Telephone: ( 9 1 9 ) 541-0488

For f i s ca l and a d m i n i s t r a t i v e matters, c o n t a c t s

David L . Mineo Grants Management Officer Grants Management Branch D i v i s i o n o f Extramural Research and T r a i n i n g Nat iona l I n s t i t u t e o f Environmental Hea l th Sc iences Nat iona l I n s t i t u t e s o f Hea l th P.O. Box 12233 Research T r i a n g l e Park, NC 27709 Telephone: ( 9 1 9 ) 541-1373

ERRATA

CLINICAL TREATMENT AND CORRELATES OF UPPER G I CARCINOMA

RFA: CA-91-03

P.T. 34; K.W. 0715035, 0705025, 0745070

Nat iona l Cancer I n s t i t u t e

L e t t e r of I n t e n t Date: February 25, 1991 Appl i ca t ion Rece ip t Date: A p r i l 8 , 1991

The D i v i s i o n of Cancer Treatment of t h e Na t iona l Cancer I n s t i t u t e would l i k e t o c l a r i f y Request f o r A p p l i c a t i o n s (RFA) CA-91-03 wi th r e g a r d t o a p p r o p r i a t e upper g a s t r o i n t e s t i n a l ( G I ) tumor

sites. T h i s RFA t i t l e d " C l i n i c a l Treatment and C o r r e l a t e s o f Upper G I Carcinoma" w a s pub l i shed December 28 , 1990. Carcinoma o f t h e upper G I t ract is now d e f i n e d t o i n c l u d e " p a n c r e a t i c carcinoma" i n a d d i t i o n t o esophagus and stomach carcinomas. The RFA i n v i t e s r e s e a r c h g r a n t a p p l i c a t i o n s (Ro l l from i n t e r e s t e d i n v e s t i g a t o r s t o a s s e s s new c l i n i c a l c o r r e l a t e s and develop new t r e a t m e n t m o d a l i t i e s i n upper g a s t r o i n t e s t i n a l carcinoma.

Wr i t t en or t e l ephone i n q u i r i e s concern ing t h e o b j e c t i v e s and scope o f t h i s RFA i n q u i r i e s about whether s p e c i f i c r e s e a r c h would be r e spons iveo r o r n o t

encouraged and should be d i r e c t e d

Ms. Diane Bronzer t Program D i r e c t o r Cancer Therapy Eva lua t ion ProgramD i v i s i o n of Cancer Treatment Nat iona l Cancer I n s t i t u t e Executive Plaza North, Room 734 Bethesda, MD 20892 Telephone: (301) 496-8866 FAX: ( 3 0 1 ) 496-9384

are t o Ms. Diane Bronzer t a t t h e a d d r e s s below.

N I H GUIDE - Vol. 2 0 , No. 9 , March 1, 1991 - Page 15

II

For f i s ca l and a d m i n i s t r a t i v e m a t t e r s , c o n t a c t :

Mary N i e m i e c DCT Grants Grants A d m i n i s t r a t i o n Branch N a t i o n a l Cancer I n s t i t u t e Execut ive P l a z a South, Room 242 Bethesda, MD 20892 Telephone: ( 3 0 1 ) 496-7800

PREDOCTORAL FELLOWSHIP AWARDS FOR M I N O R I T Y STUDENTS

RFA: GM-91-01

P.T. 22, FF; K.W. 072005, 1014002

N a t i o n a l I n s t i t u t e o f General Medical S c i e n c e s

A p p l i c a t i o n Rece ip t Date: May 10, 1991

The E l i g i b i l i t y Requirements as p r i n t e d i n t h e N I H Guide f o r Grants and C o n t r a c t s on February 15, 1991, Vol . 20, No. 7, should be c o r r e c t e d t o r e a d :

ELIGIBILITY REQUIREMENTS

An a p p l i c a n t must c u r r e n t l y b e e n r o l l e d i n a Ph.D. o r M.D.1Ph.D. g r a d u a t e program i n t h e biomedical s c i e n c e s , o r have been a c c e p t e d by and agreed t o e n r o l l i n such a g r a d u a t e program t h e f o l l o w i n g academic y e a r .

E l i g i b i l i t y f o r t h e s e awards is l i m i t e d t o s t u d e n t s who are U.S. c i t i z e n s , n o n - c i t i z e n n a t i o n a l s , and permanent r e s i d e n t s from e t h n i c / r a c i a l groups t h a t are u n d e r r e p r e s e n t e d i n research i n the biomedical s c i e n c e s . For t h e purpose o f t h i s announcement, under represented m i n o r i t y s t u d e n t s are d e f i n e d as i n d i v i d u a l s be longing t o a p a r t i c u l a r e t h n i c o r racial group which h a s been determined by t h e a p p l i c a n t ' s g r a d u a t e i n s t i t u t i o n t o be under represented i n biomedical o r b e h a v i o r a l r e s e a r c h . I n making t h e s e awards, t h e N I H w i l l g i v e p r i o r i t y c o n s i d e r a t i o n t o a p p l i c a t i o n s from Black, Hispanic , Nat ive American,and P a c i f i c I s l a n d e r and o t h e r e t h n i c o r r a c i a l group members who have been found t o be u n d e r r e p r e s e n t e d i n biomedical o r b e h a v i o r a l r e s e a r c h n a t i o n a l l y .

B B PA: PA-91-27

P.T. 34; K.W. 0725020, 0403004, 0715027

C e n t e r s f o r Disease Cont ro l N a t i o n a l I n s t i t u t e f o r Occupat ional S a f e t y and H e a l t h

T h i s Program Announcement w a s p u b l i s h e d i n t h e N I H Guide f o r Grants and C o n t r a c t s on February 22, 1991, Vol. 20, No. 8 . , and c o n t a i n e d an i n c o r r e c t PA number. The c o r r e c t e d PA number i s PA-91-27. A p p l i c a t i o n s submi t ted i n response t o t h i s Program Announcement must i n s e r t t h e t i t l e o f t h i s announcement and PA-91-27 on l i n e 2 o f t h e a p p l i c a t i o n face page.

XXTHE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF RESEARCH GRANTS OR CONTACTING PROGRAM STAFF I N THE WESTWOOD BUILDING I S THE CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHO USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD BUILDING I S :

5333 Westbard Avenue Bethesda, Maryland 20816

*U~S.G.P~0:1991-261-138:20035

N I H GUIDE - Vol. 20, No. 9 , March 1 , 1991 - Page 16

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