tinyurl.com/epiffany International Forum on Quality and Safety in Healthcare, 21-24 April 2015, ExCel London
Using the ‘Team Sky’ approach to reduce medication errors among junior doctors
Dr. Rakesh PatelNIHR Academic Clinical Lecturer in Medical Education, Department of Medical and Social Care Education, University of LeicesterHonorary Specialist Registrar in Renal Medicine, University Hospitals of Leicester NHS Trust
Dr. William GreenLecturer in Innovation, Operations and Knowledge ManagementSchool of Management, University of Leicester
Thank you
• Health Education East Midlands
• University of Leicester
• University Hospitals of Leicester NHS Trust
• Leicester Kidney Patient Association
• Patient and Carer Community, Leeds Institute of Medical Education
• Pfizer Pharmaceuticals
• UpToDate®, Wolters Kluwer Health
• Lexicomp®, Wolters Kluwer Health
• BNF on Formulary Complete, Pharmaceutical Press
• StudioCode, StudiocodeBusiness Group
• Anova Technology Ltd
• Hark2
Outline
• Case to contextualise and set the scene
• The wider problem of prescribing and patient safety
• Prescribing interventions
• EPIFFany
– Effective Prescribing Insight For the Future
• Discussion
Background
• 72-year-old female
– ESRF on haemodialysis since 2006
– Left leg DVT – 15 years prior to presentation
– Type 2 diabetes
– Hypertension
– Hypothyroidism
– Hysteroscopy and polipectomy 1 week prior to admission
• 4 day history of shortness of breath and cough
– Yellow sputum
– Streaks of blood
– Left sided chest pain
• Fever at presentation but otherwise observation trends and examination was normal
• Insert CXR image
0
20
40
60
80
100
120
140
26/06/2011 28/06/2011 30/06/2011 02/07/2011 04/07/2011 06/07/2011 08/07/2011 10/07/2011
Axi
s Ti
tle
Axis Title
BP SYSTOLIC
BP DIASTOLIC
HR
H
LJul 1 Jul 8
LJul 2 Jul 3 Jul 4 Jul 5 Jul 6 Jul 7Jun 30Jun 29Jun 28 Jul 9
CRP
warfarin dose
8
7
6
5
4
3
2
1
Wed 15Jun 2011
Wed 22 Jul 1 Jul 15 Jul 22
INR PE on CT
Fistulogram5mg Vitamin K Fistuloplasty
1.0
1.5
2.0
2.5
3.0
3.5
4.0
4.5
5.0
5.5
Jul 8
Questions raised but never answered
1. Could the pulmonary embolus have been diagnosed earlier?
2. To what extent does the poor monitoring and maintainence of an appropriate INR constitute a prescribing error?
Rationale
• Government pledge to reduce avoidable harm in the NHS from activities such as poor prescribing to save an extra 6000 lives each year
• The National Patient Safety Agency (NPSA) estimates avoidable harm from medication errors cost more than £750 million each year in England
• The GMC’s EQUIP study suggested junior doctors were more likely to make prescriptions errors compared to other healthcare professionals
What is a prescribing error?
• “An unintentional significant (1) reduction in the probability of treatment being timely and effective or (2) increase in the risk of harm when compared with generally accepted practice1”
1. Dean B, Barber N, Schachter M. What is a prescribing error? Quality in Health Care. 2000 December 1, 2000;9(4):232-7.
Prescribing errors
• Affect 7% of medication orders
• Contribute to 2% of patient days and 50% of hospital admissions1,2
1 Smith J. Building a Safer NHS for Patients: Improving Medication Safety. London: Department of Health, 2004.
http://webarchive.nationalarchives.gov.uk/20130107105354/http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_4084961.pdf
(19 February 2014, date last accessed).
2 Lewis P, Dornan T, Taylor D et al. Prevalence, incidence and nature of prescribing errors in hospital inpatients. Drug Safety 2009; 32: 379–89.
Prescribing errors and junior doctors
• 124,260 prescriptions made by Foundation doctors across 19 hospitals over seven days contained 11,077 (8.9% of all prescriptions) errors1
– Foundation Year doctors were twice as likely as consultants to make a prescribing error
– New prescribers (i.e. nurses and pharmacists) had similar error rates to consultants
1. An in depth investigation into causes of prescribing errors by foundation trainees in relation to their medical education. The EQUIP Study, The General Medical Council 2009.
www.gmc-uk.org
Interventions
Interventions
Brennan, N; Mattick, K. A systematic review of educational interventions to change behaviour of prescribers in hospital settings, with a particular emphasis on new prescribers.
BJCP 2012;75:2: 359-72
Prescribing
• What is it?
Prescribing
• The task of writing or ordering a prescription
•
•
Prescribing
•
• The skills necessary for completing prescribing tasks
•
Prescribing
‘Prescribing’ is used to describe many related activities, including supply of prescription only medicines, prescribing medicines, devices and dressings on the NHS and advising patients on the purchase of over the counter medicines and other remedies. It may also be used to describe written information provided for patients (information prescriptions) or advice given1.
1. The General Medical Council. Good practice in prescribing and managing medicines and devices (2013)
Prescribing
•
•
• The behaviours and environmental support required for safe prescribing
Current perceived environmental support
• “I knew I should've looked it up cos I didn’t really know it, but I, I think I just convinced myself I knew I because I felt it was something that I should've known….because it is very easy to get caught up in, in being, you know, ‘Oh I'm a Doctor now, I know stuff,’ and with the pressure of people who are maybe, sort of, a little bit more senior than you thinking ‘what’s wrong with him…you don’t wannaalways be seen to be in, you know, ‘what’s the dose of paracetamol?’ Interviewee 2 (medical school H)
An in depth investigation into causes of prescribing errors by foundation trainees in relation to their medical education. The EQUIP Study, The General Medical Council 2009.
www.gmc-uk.org
Current absence of safe behaviours associated with prescribing• The notion of ‘safety’ was conspicuous by its absence from
FY respondents’ discourses of their prescribing errors, the reported culture of their working environments, and the reported actions of other doctors1
• When lack of knowledge led to errors, those errors might have been prevented by better support in the working environment1
• ‘Just-in-time’ education in practical prescribing during the FY1 year, when offered, was valued by trainees and more would have been appreciated1
1. An in depth investigation into causes of prescribing errors by foundation trainees in relation to their medical education. The EQUIP Study, The General Medical Council 2009.
www.gmc-uk.org
Aggregation of marginal gains
• A new age solution for an age old problem?
• “The whole principle came from the idea that if you broke down everything you could think of that goes into riding a bike, then improved it by 1%, you will get a significant increase when you put them all together”.
Aggregation of marginal gains
Gastone Nencini (Italy) 1960 Bradley Wiggins (2012)
Aggregation of marginal gains
• Wilhelm Steinitz described the gradual gain of advantages that are not decisive individually but collectively may be so
• Been considered in anaesthesia
• Improvements already made but where to go next?
Human factors
• “Human Factors is the scientific discipline concerned with the understanding of interactions among humans & other elements of a system, & the profession that applies theory, principles, data & methods to design in order to optimise human well-being & overall system performance” (IEHF, UK)
• “Enhancing clinical performance through an understanding of the effects of teamwork, tasks, equipment, workspace, culture, organisation on human behaviour & abilities, & application of that knowledge in clinical settings” (CHFG, UK).
Prescribing as a task
Overview HistoryPhysical
ExaminationDifferential
diagnosisInvestigations Results Management
Prescribing as a situated task embedded in the process of clinical enquiry
Prescribing as a situated task embedded in the clinical enquiry from the SRL perspective
Prescribing as a situated task embedded in the clinical enquiry from the SRL perspective
Zimmerman BJ. Attaining self-regulation. A
social cognitive perspective. In: Boekaerts
M, Pintrich PR, Z eidner M, editors.
Handbook of self-regulation. San Diego, CA:
Academic Press; 2000. p. 13-39.
Clinical Diagnostic Decision-Making
including Prescribing
Patel R, Sandars, J. Carr, S. Clinical diagnostic decision-making in real life contexts: A trans-theoretical approach for teaching: AMEE Guide No. 95. 2014, 1–17, Early Online
Clinical Diagnostic Decision-Making
Including Prescribing
Knowledge for the task
Patel R, Sandars, J. Carr, S. Clinical diagnostic decision-making in real life contexts: A trans-theoretical approach for teaching: AMEE Guide No. 95. 2014, 1–17, Early Online
Clinical Diagnostic Decision-Making
including Prescribing
Knowledge for the task
Skill: Gut feeling or a
more logical
approach
Patel R, Sandars, J. Carr, S. Clinical diagnostic decision-making in real life contexts: A trans-theoretical approach for teaching: AMEE Guide No. 95. 2014, 1–17, Early Online
Clinical Diagnostic Decision-Making
including Prescribing
Knowledge for the task
‘Self’ (Confidence Motivation)
Skill: Gut feeling or a
more logical
approach
Patel R, Sandars, J. Carr, S. Clinical diagnostic decision-making in real life contexts: A trans-theoretical approach for teaching: AMEE Guide No. 95. 2014, 1–17, Early Online
Clinical Diagnostic Decision-Making
including Prescribing
Knowledge for the task
‘Self’ (Confidence Motivation)
Self-regulation
of ‘Skill’
and ‘Self’
Skill: Gut feeling or a
more logical
approach
Patel R, Sandars, J. Carr, S. Clinical diagnostic decision-making in real life contexts: A trans-theoretical approach for teaching: AMEE Guide No. 95. 2014, 1–17, Early Online
Situated in context
Clinical Diagnostic Decision-Making
including Prescribing
Knowledge for the task
‘Self’ (Confidence Motivation)
Self-regulation
of ‘Skill’
and ‘Self’
Skill: Gut feeling or a
more logical
approach
Patel R, Sandars, J. Carr, S. Clinical diagnostic decision-making in real life contexts: A trans-theoretical approach for teaching: AMEE Guide No. 95. 2014, 1–17, Early Online
Situated in context
Clinical Diagnostic Decision-Making
including Prescribing
Knowledge for the task
‘Self’ (Confidence Motivation)
Self-regulation
of ‘Skill’
and ‘Self’
Skill: Gut feeling or a
more logical
approach
Authentic‘Real-life’
with sufficient challenge
Responsible‘Real’
decision to do
something
Patel R, Sandars, J. Carr, S. Clinical diagnostic decision-making in real life contexts: A trans-theoretical approach for teaching: AMEE Guide No. 95. 2014, 1–17, Early Online
Teaching prescribing as a situated task embedded in the clinical enquiry from the SRL perspective
1http://pixshark.com/zone-of-proximal-development-infographic.htm
Planning &
Audit
Control Study - no interventionRotation cohort A
Intervention - Blended learningRotation cohort B
Analyses &
reporting
Feb - Mar Apr - Jul Aug - Nov Dec - Jan
Simulation
eLearning
Simulation
Clinical Decision Support
Face-to-face
Teaching and
Feedback
Simulation Simulation
Error rates, Error severity,
Medication error types
Error rates, Error severity,
Medication error types
Planning &
Audit
Control Study - no interventionRotation cohort A
Intervention - Blended learningRotation cohort B
Analyses &
reporting
Feb - Mar Apr - Jul Aug - Nov Dec - Jan
Competence
Performance
Safe behaviours
and Attitudes
Change
Usefulness and usabilityFocus Group
Return on Investment
QALY
Simulation
Simulation
eLearning
Clinical Decision Support
Face-to-face
Teaching and
Feedback
CompetenceSignificant
change in the
competence of
junior doctors
for prescribing
from the start to
the end of the
rotation in the
intervention
group (p<0.05)
0
10
20
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40
50
60
70
Case Notes at Start Case Notes at End Drug Charts at Start Drug Charts at End
Control Cohort
Intervention Cohort
• 10,394 prescriptions across four wards on the renal unit over 8 months
• 368 (3.5% of all prescriptions) contained an error
Performance
Performance
• 20,543 prescriptions across four wards on the renal unit over 8 months
• 542 (2.6% of all prescriptions) contained an error
Antibacterial drugs, 108
Vitamins, 41
Minerals, 40
Analgesics, 35
Anaemias and some other blood disorders, 32
Drugs used in diabetes, 26
Drugs affecting the immune response, 19
Anticoagulants and protamine, 16
Corticosteroids and other anti-inflammatory preparations, 15
Drugs used in nausea and vertigo, 14
nitrates, calcium-channel blockers, and other antianginal drugs, 12
Antiepileptic drugs, 11
Lipid-regulating drugs, 10
Oral preparations for fluid and electrolyte imbalance, 9
Antisecretory drugs and mucosal protectants, 8
Antiviral drugs, 8
Hypnotics and anxiolytics, 8
Laxatives, 8
Phosphorous, 8
Antihistamines, hyposensitisation, and allergic emergencies, 7
Beta-adrenoceptor blocking drugs, 7
Bronchodilators, 7
Hypertension and heart failure, 7
Thyroid and antothyroid drugs, 7
Antiplatelet drugs, 6
Antispasmodics and other drugs altering gut motility, 5
Diuretics, 5
Nutritional supplements (non-disease specific), 5
Others, 59
Medication error categorised by class of drug as listed in the BNF
Performance
15
9
7
4
3
1
7
4
9
4
1
00
2
4
6
8
10
12
14
16
FY1 FY2 Core Trainee Specialisttrainee
Consultant Nurse
Error Rate Per Prescriber
Control Cohort
Intervention Cohort
Significant
acceleration in
prescribing
performance of
novices in the
intervention
cohort
compared to
more
experienced
peers in the
control cohort
Performance
162
148
50
1
71
98
12
0
20
40
60
80
100
120
140
160
180
Minor Significant Serious Lethal
Control Cohort
Intervention Cohort
Significant
reduction in the
errors across
categories of
severity across
all prescribers
C
Face-to-Face
feedback
Clinician
D
Face-to-Face
Pharmacist
education
B*
eLearning &
mLearning
A
Simulation
Aug Sept Oct Nov Dec
AA C C
B*
DD
Engagement
Participated in both Simulations
High engager with CDS Attended two clinical feedback and education sessions
Attended two pharmacy feedback and education sessions
C
Face-to-Face
feedback
Clinician
D
Face-to-Face
Pharmacist
education
B*
eLearning &
mLearning
A
Simulation
Aug Sept Oct Nov Dec
AA C
B*
Engagement
Participated in both Simulations
Average engager with CDS
Attended one clinical feedback and education sessions
No pharmacy feedback and education sessions
It's really worth, I think, doing something like that, and going to
have some feedback from a specialist who can actually guide
you on what you have missed and you know... what you can
improve, brilliant... yeah
72% increase in drug chart
Performance 2 significant prescribing errors
Competence 7% increase in clinical notes
Safe behaviour change
Out performing FY1s, FY2s & CTs in the control group following ePIFFany
Competence, Performance & Safe Behaviour
34% decrease in drug chart
Performance 25 prescribing errors (6 minor, 17 significant, 2 serious)
Competence No change in clinical notes
Safe behaviour change
Under-performing compared to both the control and intervention groups following ePIFFany
Competence, Performance & Safe Behaviour
High-engagerLow-engager
High-performerLow-performer
“I've got a drug question I go to BNF... but if I've got a question about a condition I go to UpToDate... so... and then... the problem is though... I mean when you are working in a big Trust really... you should be following clinical guidelines that are available so... it's actually... I tend to actually go to the... Insite... and use that... but I find that [difficult] to use…”
“(I use) mostly BNF online (and) BNF paper copy...I’ve used UpToDate a few times…on the computer, but I don't use it as much, that often, to be honest”
High-engagerLow-engager
High-performerLow-performer
“I don’t what is was but the second group seemed better at greetings and goodbyes … A conversation with patients about their [medication] should have a beginning, middle and end. I know it’s a little thing but it makes a big difference”
Dr. Margaret Ince, Past Chair, Leicester Kidney Patients Association