USTAR SYNTHETIC BIOMANUFACTURING INSTITUTE · 2013. 2. 12. · USTAR Synthetic Bioproducts Center ....

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H. Scott Hinton SBI Science & Technology Review

USTAR SYNTHETIC

BIOMANUFACTURING INSTITUTE

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Outline

• Institute Overview

• USTAR Synthetic Bioproducts Center

• Sustainable Waste-to-Bioproducts Engineering Center

• USTAR BioEnergy Center

• USTAR Bioproduct Production Laboratory

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USTAR Synthetic Biomanufacturing Institute Interim Executive Director: H. Scott Hinton

Sustainable Waste-to-Bioproducts

Engineering Center

Co-Directors: Ron Sims & Issa Hamud

USTAR Synthetic Bioproducts

Center

Director: Randy Lewis

USTAR BioEnergy

Center

Director: Foster Agblevor

USTAR Bioproducts

Production Lab

Director: Reese Thompson

Business Development Officer Christian Iverson

Corporate Partners

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SBI Pathways to Products

Product Prototype

Development (USTAR, CE Group, Corporate Partners)

CE/USTAR Project Selection

Commercial Enterprises Business Development

Path

way

#1

Sales Agreement

Path

way

#2

Path

way

#3

Academic Research

(NSF, NIH, USDA, DOE, DOD, …)

Topi

c #

3

Topi

c #

4

Topi

c #

5

Topi

c #

n

Topi

c #

2

Path

way

#4

License

Topi

c #

1

Topi

c #

6 Start-up

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Outline






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USTAR Synthetic Bioproducts Center

Driven by today’s environmental, health and economic challenges, the goal of the Synthetic Bioproducts Center is to take advantage of the recent bio-scientific advances to enable living organisms (single-cell organisms, plants, and animals) to transform raw materials into environmentally friendly products such as low cost therapeutics, antimicrobials, biomaterials, and pharmaceuticals.

Spider on Spool of Synthetic Silk

Biliverdin Spider Silk Protein Bioplastic K20 Fungicide

Picture of K20

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SBC Affiliated Faculty

Ron Sims - BE -

Scott Hinton - ECE -

Charlie Miller - BE -

Randy Lewis - Biology -

Jixun Zhan - BE -

Tom Chang - CB -

Heng Ban - MAE -

Yue Cui - BE -

Nicholas Flann - CS -

Jon Takemoto - Biology -

Number of funded students - ~21 (9G/12UG) Number of funded staff - 3

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Current SBC Project Pathways

Product Prototype

Development


Commercial Enterprises Office

Ant

i-inf

lam

mat

ory

Sales Agreement

Fung

icid

es

Biop

last

ics

Spor

t Eq

uipm

ent

Spor

ts C

loth

ing

Academic Research

KISS

Pep

tide

s

Ant

imic

robi

als

E.co

li-ba

sed

PHB

Spid

er S

ilk

Biliv

erdi

n

Def

ense

Glue

Ther

mal

Lin

ks

License

Mod

elin

g

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International Genetically Engineered Machines (iGEM) Student Competition

2008: Bronze Medal Efficient Systems for Monitoring Polyhydroxybutyrate (PHB) Production in Microorganisms

2009: Gold Medal BioBricks without Borders

2010: Gold Medal CyanoBricks - Developing Cyanobacteria as a Biological Engineering Platform

2011: Gold Medal CyanoBricks - Expression Testing and Bioproduct Development

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iGEM 2012 – October, 2012

• Arachnicoli, Production and Purification of Spider Silk Proteins in Escherichia coli

• Won gold medal, 4th year in a row

• Won Best New BioBrick Device-Engineered Award, Americas West Regional (Stanford)

• Won Best Manufacturing Project Award, World Championship (MIT)

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Outline






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Sustainable Waste-to-Bioproducts Engineering Center (SWBEC)

Algae Biofilm Growth

Algae to Biodiesel Logan Lagoons

The Sustainable Waste-to-Bioproduct Engineering Center converts society’s wastes into valuable products to promote national energy independence, sustainable local production of bioproducts, new industries for new jobs and the protection of human health and the environment.

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SWBEC Affiliated Faculty

Number of funded students – ~20 (9G/11UG) Number of funded staff - 2

Ron Sims - BE -

Charlie Miller - BE -

Issa Hamud - BE -

Byard Wood - MAE -


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Current SWBEC Project Pathways

Product Prototype

Development



Wat

er C

lean

-up

RABR

Ace

tone

Biop

last

ics

Academic Research

Alg

ae B

iofi

lms

Alg

ae P

HB

Alg

ae B

iodi

esel

Alg

ae M

eal

Bior

emed

iati

on

Buta

nol

Etha

nol

Met

hane

Start-up

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Outline






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USTAR BioEnergy Center Research at the BioEnergy Center focuses on lignocellulosic biofuel and biodiesel production, pyrolysis, algal strain selection, nutrient optimization and management by focusing specifically on the needs and resources of Utah and the Intermountain West.

Pilot Plant for Fractional Catalytic Pyrolysis Hybrid poplar FCP oil

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BEC Affiliated Faculty

Foster Agblevor - BE -

Byard Wood - MAE -

Bruce Bugby - PSC -

Lance Sefeldt - CB -

Number of funded students - ~11 (7G/4UG) Number of funded staff - 4

Ron Sims - BE -

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Current BEC Project Pathways

Product Prototype

Development



Bio-

oil

Bioj

etfu

els

Bioe

than

ol

Biod

iese

l Con

v.

Academic Research

Pyr.

Mat

eria

ls

Biof

oam

Lipi

ds -

> Fue

l

Pyro

lysi

s Fu

els

CO2

Mgm

t.

License

CO2

-> F

uel

HT

Biop

last

ics

Phar

mac

euti

cals

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Outline






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USTAR Bioproducts Production Lab The Bioproducts Production Laboratory provides a multitude of shared resources and services to the SBI’s research centers and corporate partners. The BPL’s primary focus is to provide the prototyping and scale-up production capabilities for each of the Institute’s centers as well as bioproduction contract services for industry.

New Brunswick 125 L Fermentor

USU Algae Processing and Products Facility

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BPL Affiliated Faculty

Ron Sims - BE -


Randy Lewis - Biology -

Foster Agblevor - BE -

Byard Wood - MAE -

Lance Sefeldt - CB -

Bruce Bugbee - PSC -

Number of funded staff - 2

Reese Thompson - Director -

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USTAR Synthetic Biomanufacturing Institute Interim Executive Director: H. Scott Hinton

Sustainable Waste-to-Bioproducts

Engineering Center

Co-Directors: Ron Sims & Issa Hamud

• Waste water treatment

• Profitable bioremediation

USTAR Synthetic Bioproducts

Center

Director: Randy Lewis

• Pharmaceuticals

• Therapeutics

• Antimicrobials

• Cosmetics

• Biomaterials

• Specialty Chemicals

USTAR BioEnergy

Center

Director: Foster Agblevor

• Bio-oil

• Bio-Jet Fuel

• Biofoam

• Bioplastics

• CO2 -> Fuel

• Pharmaceuticals

Business Development Officer Christian Iverson

USTAR Bioproducts

Production Lab

Director: Reese Thompson

• Large-scale

Bioproduction

• Contract

Services

Corporate Partners

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Agenda Welcome and Introduction – Dean Scott Hinton Pyrolysis-based Bioproducts – Dr. Foster Agblevor BioEnergy Research at USU – Dr. Lance Seefeldt Break Sustainable Waste-to-Bioproducts – Dr. Ronald Sims iGEM 2012 – Dr. Charles Miller Lunch & Poster Session Biliverdin and Mesobiliverdin – Dr. Jon Takemoto Antifungals – Dr. Tom Chang Break Pathway Pioneer – Dr. Nick Flann Spider Silk – Dr. Randy Lewis Commercialization at USU – Dr. Rob Behunin and Curt Roberts Partners Roundtable Lab Tours

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Thank You

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USTAR SYNTHETIC BIOMANUFACTURING INSTITUTE · 2013. 2. 12. · USTAR Synthetic Bioproducts Center ....

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