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Valve reconstruction/replacement

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    I.INTRODUCTION

    Healthy heart valves are important for good blood circulation and for

    maintaining a healthy heart. Healthy heart keeps the blood flowing and prevents

    the blood from backing up. Unfortunately sometimes the valves can be damaged

    not allowing enough blood to flow through them or allowing blood to leak back

    against the flow. In such case valve repair or valve replacement become

    necessary to preserve the functions of heart.

    II.DEFINITION OF VALVULAR HEART DISEASE

    Valvular heart disease encompasses those diseases charecterized by abnormal

    mobility or closure of the heart valves,causing obstruction or regurgitation of

    flow through the valve.

    III.RELATED ANATOMY

    The heart is a pump made of muscle tissue. The heart has four pumping

    chambers: two upper chambers, called atria, and two lower chambers, called

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    ventricles. The right atrium pumps blood into the right ventricle, which then

    pumps the blood into the lungs .

    From the lungs, the blood flows back into the left atrium, is pumped into the leftventricle, and then is pumped through the aorta out to the rest of the body and

    the coronary arteries. Once the atria have pumped their entire blood load into

    the ventricles, they relax while the ventricles pump the blood out to the lungs

    and to the rest of the body.

    In order to keep the blood flowing forward during its journey through the heart,

    there are valves between each of the heart's pumping chambers.

    tricuspid valve - located between the right atrium and the right ventricle pulmonary (or pulmonic) valve - located between the right ventricle and

    the pulmonary artery

    mitral valve - located between the left atrium and the left ventricle aortic valve - located between the left ventricle and the aorta

    IV.INDICATIONS OF VALVULAR SURGERY

    Valves are very delicate structures that can be damaged for variety of reasons.

    Inflammation of valves , as seen indisease such as rheumatic heart disease Infections of valve as endocarditis Calcification and stiffness of valves due to chronic or continual long

    term wear and tear

    Defects from birth or congenital malformations Changes in heart valve causing major heart symptoms, such as chest pain

    (angina), shortness of breath, fainting spells (syncope), or heart failure.

    Tests show that the changes in your heart valve are beginning to seriouslyaffect heart function

    http://www.nlm.nih.gov/medlineplus/ency/article/001107.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003092.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/003092.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001107.htm
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    Aortic insufficiency Aortic stenosis Mitral regurgitation - acute Mitral regurgitation - chronic Mitral stenosis Mitral valve prolapse Pulmonary valve stenosis Tricuspid regurgitation

    V.VALVE RECONSTRUCTION

    The repair of a cardiac valve is referred to as valvuloplasty.

    TYPES OF VALVULOPLASTY

    The type of valvuloplasty depends on the cause and type of valve dysfunction.

    1.Commissurotomy

    Repair may be made to the commissures between the leaflets in a procedure

    known as commissurotomy.

    2.Annuloplasty

    Repair to the annulus of the valve is known as annuloplasty.

    3.Chordoplasty

    Repair to theleaflets, or to the chordae is known as chordoplasty

    1.COMMISSUROTOMY

    The most common valvuloplasty procedure is commissurotomy.Each valve has

    leaflets, the site where the leaflets meet is called the commissure. The leaflets

    may adhere to one another and close the commissure (ie, stenosis). Less

    commonly, the leaflets fuse in such a way that, in addition to stenosis, the

    http://www.nlm.nih.gov/medlineplus/ency/article/000179.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000178.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000177.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000176.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000175.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000180.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001096.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000169.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000169.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/001096.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000180.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000175.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000176.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000177.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000178.htmhttp://www.nlm.nih.gov/medlineplus/ency/article/000179.htm
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    leaflets are also prevented from closing completely, resulting in a backward

    flow of blood (ie, regurgitation). A commissurotomy is the procedure performed

    to separate the fused leaflets.

    A.TYPES OF COMMISSUROTOMY

    (a)Closed commissurotomyClosed commissurotomies do not require cardiopulmonary bypass.

    The valve is not directly visualized. The patient receives a general anesthetic, a

    midsternal incision is made, a small hole is cut into the heart, and the surgeons

    finger or a dilator is used to break open the commissure. This type of

    commissurotomy has been performed for mitral, aortic, tricuspid, and

    pulmonary valve disease.

    (i)Balloon valvuloplasty

    Balloon valvuloplasty is a form of closed commissurotomy.

    Procedure

    Balloon valvuloplasty is most commonly used for mitral and aortic valve

    stenosis, Balloon valvuloplasty also has been used for tricuspid and pulmonic

    valve stenosis.

    Mitral balloon valvuloplasty involves advancing one or two catheters into the

    right atrium, through the atrial septum into the left atrium, across the mitral

    valve into the left ventricle, and out into the aorta. A guide wire is placed

    through each catheter, and the original catheter is removed. A large balloon

    catheter is then placed over the guide wire and positioned with the balloon

    across the mitral valve. The balloon is then inflated with a dilute angiographic

    solution. When two balloons are used, they are inflated simultaneously. The

    advantage of two balloons is that they are each smaller than the one large

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    balloon often used, making smaller atrial septal defects. As the balloons are

    inflated, they usually do not completely occlude the mitral valve, thereby

    permitting some forward flow of blood during the inflation period.

    Some possible complications include

    Regurgitation bleeding from the catheter insertion sites emboli resulting in complications such as strokes left-to-right atrial shunts through an atrial septal defect caused by the

    procedure Restenosis

    (b) Open commissurotomy

    Open commissurotomies are performed with direct visualization of the valve.

    Procedure

    The patient is under general anesthesia, and a median sternotomy or left

    thoracic incision is made. Cardiopulmonary bypass is initiated, and an incision

    is made into the heart. A finger, scalpel, balloon, or dilator may be used to open

    the commissures. An added advantage of direct visualization of the valve is that

    thrombus may be identified and removed, calcifications can be seen, and if the

    valve has chordae or papillary muscles, they may be surgically repaired.

    Most commonly used for mitral and aortic valve stenosis, balloon valvuloplasty

    also has been used for tricuspid and pulmonic valve stenosis.

    2.ANNULOPLASTY

    Annuloplasty is the repair of the valve annulus (ie, junction of the valve leaflets

    and the muscular heart wall).

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    Procedure

    General anesthesia and cardiopulmonary bypass are required for all

    annuloplasties.The procedure narrows the diameter of the valves orifice and is

    useful for the treatment of valvular regurgitation. There are two annuloplasty

    techniques.

    One technique uses an annuloplasty ring . The leaflets of the valve are sutured

    to a ring, creating an annulus of the desired size. When the ring is in place, the

    tension created by the moving blood and contracting heart is borne by the ring

    rather than by the valve or a suture line, and progressive regurgitation is

    prevented by the repair.

    The other technique involves tacking the valve leaflets to the atrium with

    sutures or taking tucks to tighten the annulus. Because the valves leaflets and

    the suture lines are subjected to the direct forces of the blood and heart muscle

    movement, the repair may degenerate more quickly than with the annuloplasty

    ring technique.

    3.LEAFLET REPAIRDamage to cardiac valve leaflets may result from stretching, shortening,or

    tearing. Leaflet repair is for elongated, ballooning, or other excess tissue leaflets

    and removal of the extra tissue. The elongated tissue may be folded over onto

    itself (ie, tucked) and sutured (ie, leaflet plication). A wedge of tissue may be

    cut from the middle of the leaflet and the gap sutured closed (ie., leaflet

    resection). Short leaflets are most often repaired by chordoplasty. After theshort chordae are released, the leaflets often unfurl and can resume their normal

    function of closing the valve during systole. A piece of pericardium may also be

    sutured to extend the leaflet. A pericardial patch may be used to repair holes of

    the leaflet.

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    Chordoplasty

    Chordoplasty is the repair of the chordae tendineae. The mitral valve is involved

    with chordoplasty (because it has the chordate tendineae), seldom is

    chordoplasty required for the tricuspid valve.

    Regurgitation may be caused by stretched, torn, or shortened chordae tendineae.

    Stretched chordae tendineae can be shortened, torn ones can be reattached to the

    leaflet, and shortened ones can be elongated. Regurgitation may also be caused

    by stretched papillary muscles, which can be shortened.

    B.COMPLICATIONS OF VALVULOPLASTY

    Ventricular perforation Acute aortic regurgitation Atrial septal defect Embolism Heart failure Damage to the heart valve Hemorrhage

    VI.VALVE REPLACEMENT

    Prosthetic valve replacement began in the 1960s. When valvuloplasty or valve

    repair is not a viable alternative, such as when the annulus or leaflets of the

    valve are immobilized by calcifications, valve replacement is performed.

    A.SELECTION OF PROSTHESIS

    Durability-The prosthetic valve should last for the probable life span ofthe patient. At the present time an unmounted homograft in the aortic

    position is the most durable. Mechanical valves endure for up to 10 yrs

    while biological valves calcify within 6 yrs.

    Hemodynamic efficiency-The valves should be sensitive to low gradientsfor easy flow at the atrioventricular sites.The blood flow area should be

    adequate with minimal turbulence.

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    Thrombogenicity- Mechanical valves are highly thrombogenic because ofblood turbulence at its interface with the device.Life long administration

    of anticoagulant such as warfarin is mandatory after insertion of

    mechanical valves.Tissue valves are less thrombogenic and do not require

    anticoagulant therapy.

    Tissue compatibility- There is no problem with rejection orincompatibility with any of the three categories of valve prosthesis.

    Ease of insertion-Mechanical and biological valves require the sametechnical approach in their surgical implantation.The implantation of

    homografts requires specialized experience and skill.

    Cost effective- There is less difference in the cost of the differentvarieties of prosthesis.

    Free of infection-There should be rare chance to develop infection likeendocarditis.

    Silence-The click sound of the mechanical valve does not appear to worrypatients.Tissue valves are totally silent.

    B.TYPES OF VALVULAR PROSTHESIS

    There are two types of prosthetic valves used.They are

    1,Mechanical valves

    2.Biological or tissue valves

    1.Mechanical valves

    Ball and cage valveA ball moves freely within a 3 or 4 sided metallic cage mounted on a circular

    sewing ring. These have the disadvantage of cage protrusion with possible

    irritation of the ventricular septum and obstruction of the left ventricular

    outflow tract.

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    Eg:Starr-Edwards,Smeloff-Cutter.

    Pivoting disc or Tilting discA freefloating , lens shaped disk mounted on a circular sewing ring. There is

    less hemolysis and less likelihood of outflow tract obstruction.

    Example:Medtronic -Hall, Bjork-shiley.

    Bi-leafnersTwo semicircular leaflets mounted on a circular sewing ring that opens

    centrally. It is functionally efficient with lowest index of thrombogenicity

    amongst the mechanical valves.

    Example:St.Jude medical,Carbomodics.

    Advantages of mechanical valves

    Long term durability Good hemodynamics

    Disadvantages of mechanical valves

    Lifetime anticoagulation therapy Audible click Risk of thromboembolism Infections are harder to treat.

    2.Biological or tissue valves

    Calf pericardium,dura matter or pig valve are mounted on a titanium farme

    covered in Dacron. The tissues are fixed in glutar aldehyde and sterility is

    maintained by formaldehyde.The deleterious effects of sterilization include

    disintegration or calcification of the valve within 5 to 7 years. Improvement in

    durability has accompanied glutaraldehyde fixation sterilization methods.

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    Tissue valves are less likely to generate thromboemboli, and long-term

    anticoagulation is not required.Tissue valves are not as durable as mechanical

    valves and require replacement more frequently.

    Example:Ionescu-Shiley valve-calf pericardium

    Hancock or carpentier Edwards valve:pig valves

    Tissue (ie, biologic) valves are of three types

    Xenografts Homografts Autografts

    (1)Xenografts

    Xenografts are tissue valves, most are from pigs (porcine), but valves from

    cows (bovine) may also be used. Their viability is 7 to 10 years. They do not

    generate thrombi, thereby eliminating the need for longterm anticoagulation.

    They are used for women of childbearing age because the potential

    complications of long-term anticoagulation associated with menses, placental

    transfer to a fetus.Xenografts also are used for patients older than 70 years of

    age, patients with a history of peptic ulcer disease,and others who cannot

    tolerate long-term anticoagulation. Xenografts are used for all tricuspid valve

    replacements.

    (2)Homografts

    Homografts, or allografts (ie, human valves), are obtained from cadaver tissue

    donations. The aortic valve and a portion of the aorta or the pulmonic valve and

    a portion of the pulmonary artery are harvested and stored cryogenically.

    Homografts are not always available and are very expensive. Homografts

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    last for about 10 to 15 years, somewhat longer than xenografts.Homografts are

    not thrombogenic and are resistant to subacute bacterial endocarditis. They are

    used for aortic and pulmonic valve replacement.

    (3)Autografts

    Autografts (ie, autologous valves) are obtained by excising the patients own

    pulmonic valve and a portion of the pulmonary artery for use as the aortic valve.

    Anticoagulation is unnecessary because the valve is the patients own tissue and

    is not thrombogenic. The autograft is an alternative for children (it may grow as

    the child grows), women of childbearing age, young adults,patients with ahistory of peptic ulcer disease, and those who cannot tolerate anticoagulation.

    Aortic valve autografts have remained viable for more than 20 years.Most aortic

    valve autograft procedures are double valve replacement procedures.

    Advantages of biological valve

    Low incidence of thromboembolism No long-term anticoagulant therapy Good hemodynamics Silent Infections are easier to treat.

    Disadvantages of biological valves

    Prone to deterioration. Frequent replacement is reuired.

    C.PROCEDURE OF VALVE REPLACEMENT

    General anesthesia and cardiopulmonary bypass are used for all valve

    replacements. Most procedures are performed through a median sternotomy (ie,

    incision through the sternum), although the mitral valve may be approached

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    through a right thoracotomy incision. After the valve is visualized, the leaflets

    and other valve structures, such as the chordae and papillary muscles, are

    removed. Some surgeons leave the posterior mitral valve leaflet, its chordae,

    and papillary muscles in place to help maintain the shape and function of the

    left ventricle after mitral valve replacement. Sutures are placed around the

    annulus and then into the valve prosthesis. The replacement valve is slid down

    the suture into position and tied into place . The incision is closed, and the

    surgeon evaluates the function of the heart and the quality of the prosthetic

    repair. The patient is weaned from cardiopulmonary bypass, and surgery is

    completed.

    VII.NURSING MANAGEMENT

    Pre operative management

    Explain the procedure to patient and offer opportunities to ask anyquestions about the procedure.

    Patient is asked to sign a consent form that gives permission to do thetest.

    Complete physical examination to ensure that client is in good healthbefore undergoing the procedure.

    Blood tests and other diagnostic tests are performed. Fasting needed for eight hours before the procedure, generally after

    midnight.

    Notify physician if sensitive to or allergic to any medications, iodine,latex, tape, or anesthetic agents (local and general).

    Notify physician of all medications (prescription and over-the-counter)and herbal supplements that patient is taking.

    Notify physician if any history of bleeding disorders or if taking anyanticoagulant medications, aspirin, or other medications that affect blood

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    clotting. It may be necessary to stop some of these medications prior to

    the procedure.

    Blood test done prior to the procedure to determine the clotting time. Notify physician if patient has a pacemaker. Instruct patient to stop smoking as soon as possible prior to the

    procedure, if they have the habit of smoking. This may improve the

    chances for a successful recovery from surgery and this benefit overall

    health status.

    PREOPERATIVE NURSING MANAGEMENT

    1.Activity intolerance related to insufficient oxygenation and decreased cardiac

    output.

    Interventions

    Monitor cardiorespiratory response to activity (pulse rate,respiration andBP)

    Encourage alternative rest and activity periods to conserve energy. Encourage patients to choose activities that gradually build endurance to

    increase cardiac

    Assist the patient to establish realistic activity goals to promote feelingsof accomplishments.

    2.Excess fluid volume related to incompetent valves

    Interventions

    Monitor for any edema. Assess respiratory status for any dyspnea or other symptoms. Monitor vital signs. Check daily weight. Administer prescribed diuretics. Provide sodium restricted diet.

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    3.Decreased cardiac output related to valvular incompetence

    Interventions

    Monitor vital signs Assess cardiovascular status. Monitor for any cardiac dysrrhythmias. Administer inotrops as per order. Maintain head elevation to reduce venous return and reduce oxygen

    demand .

    Promote bed rest4.Knowledge deficit regarding surgery, post operative care and life style

    modifications

    Interventions

    Explain about the disease condition Explain the life style changes like smoking cessation. Explain about preoperative workups,surgery and post operative care. Introduce the patient to a post operative patient. Clarify doubts. Explain about the need of anticoagulant medication after surgery. Advice them to use medi alert card.

    POSTOPERATIVE MANAGMENT

    1.Decreased cardiac output related to blood loss and compromised myocardialfunction

    Intervention

    Assess for the cardiac status, BP, Heart rate, Central venouspressure, arterial pressure

    Assess for the capillary refill and any signs of cyanosis

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    Monitor vitals hourly Monitor intake and output. Administer blood transfusion if needed.

    2.Risk for impaired gas exchange related to trauma of extensive chest surgery

    Intervention

    Assess for the respiratory rate , rhythm and movements Monitor the oxygen saturation levels

    Assess for any signs of cyanosis and capillary refill Check for the ABG values. Provide fowlers position Administer oxygen as per the need

    3.Pain related to operative trauma and pleural irritation caused by chest tubes

    Intervention

    Record nature type location duration of pain Assist patient to differentiate between surgical and anginal pain. Provide diversional therapy Reassure the patient. Encourage routine medication, dosing for the 1st 24 to 72 hours andobserve for side effects of lethargy, hypertension, tachycardia and

    respiratory depression.

    4.Risk for impaired renal perfusion related to decreased cardiac output ,

    hemolysis or vasopressor drug therapy.

    Intervention

    Assess renal function

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    Measure urine output half to one hour Measure urine specific gravity Monitor and report lab results, blood urea nitrogen, serum creatine,

    urine and serum electrolytes.

    Administer rapid acting diuretics or inotropic drugs5.Risk for infection related to invasive procedure

    Interventions

    Maintain aseptic technique Check vital signs. Remove invasive lines as early as possible. Send blood for CBC and culture. Give antibiotics as per order.

    VIII.COMPLICATIONS OF VALVULAR REPLACEMENTS

    Early complications

    Prosthetic dislodgement due to suture disruption Embolism-Throbus,calcific debris,air Distortion of adjacent valve by too large prosthesis Myocardial perforation during insertion of prosthesis with serious

    haemorrhage

    MalfunctionEspecially in ball valve types prosthesis with protrusion of papillary

    muscles, chordate or Teflon margin of ring into the device

    Injury to adjacent structuresTrauma to conducting pathway,suture through coronary arteries

    StenosisAll prosthetic valve replacements create a degree of stenosis when they

    are implanted in the heart. Usually, the stenosis is mild and does not

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    affect heart function. If valve replacement was for a stenotic valve, blood

    flow through the heart is often improved.

    Change in intracardiac blood pressureBefore surgery, the heart gradually adjusted to the pathology,but the

    surgery abruptly corrects the way blood flows through the heart.

    Complications unique to valve replacement are related to the sudden

    changes in intracardiac blood pressures.

    Heart failureThe signs and symptoms of the backward heart failure resolve in a few hours

    or days. If valve replacement was for a regurgitant valve, it may take months

    for the chamber into which blood had been regurgitating to achieve its

    optimal postoperative function. The signs and symptoms of heart failure

    resolve gradually as the heart function improves.

    Late complications

    Thromboembolism Bacterial endocarditis Paravalvular leak Hemolytic anaemia if prosthesis becomes regurgitant in aortic position Loss of ball in ball valves,loss of valve

    IX.HEALTH EDUCATION

    Long-term anticoagulant therapy after valve replacement.-Montly check up for INR (it should maintain 2.5 to 3.5)

    -Advice them to take medicine at same time daily.

    -Notify physician for any sie effects like bleeding,hematurea,gum

    bleeding, severe headache or stomach pains, weekness, dizziness, altered

    mental status, heametemesis,palpitation or chest pain.

    -Avoid injuries

    -Avoid NSAID.

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    -Wear medi alert tag.

    Explain the need for frequent follow-up appointments and bloodlaboratory studies

    Provides teaching about any prescribed medication: the name of themedication, dosage,its actions, prescribed schedule, potential side effects,

    and any drug-drug or drug-food interactions.

    Patients with a mechanical valve prosthesis require education to preventbacterial endocarditis with antibiotic prophylaxis, which is prescribed

    before all dental and surgical interventions.

    Patients are discharged from the hospital in 3 to 7 days. Home care andoffice or clinic nurses reinforce all new information

    self-care instructions with the patient and family for 4 to 8 weeks after theprocedure.

    X.EVIDENCE BASED PRACTICE

    Karl E. Hammermeister, Gulshan K. Sethi, William G. Henderson, Charles

    Oprian, Tai Kim, and Shahbudin Rahimtoola for the Veterans AffairsCooperative Study on Valvular Heart Disease .med 1993; 328:1289-1296May

    6, 1993

    A Comparison of Outcomes in Men 11 Years after Heart-Valve

    Replacement with a Mechanical Valve or Bioprosthesis

    The study is to compare the outcomes of patients who receive two types of

    valves,They randomly assigned 575 men scheduled to undergo aortic-valve or

    mitral-valve replacement to receive either a mechanical or a bioprosthetic

    valve. The primary end points were death from any cause and any valve-related

    complication.During an average follow-up of 11 years, there was no difference

    between the two groups in the probability of death from any cause or in the

    probability of any valve-related complication .There was a much higher rate of

    structural valve failure among patients who received bioprosthetic valves than

    http://www.nejm.org/toc/nejm/328/18/http://www.nejm.org/toc/nejm/328/18/http://www.nejm.org/toc/nejm/328/18/http://www.nejm.org/toc/nejm/328/18/http://www.nejm.org/toc/nejm/328/18/
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    among those who received mechanical valves. However, this difference was

    offset by a higher rate of bleeding complications among patients with

    mechanical valves than among those with bioprosthetic valves and by a greater

    frequency of periprosthetic valvular regurgitation among patients with

    mechanical mitral valves than among those with mitral bioprostheses

    XI.CONCLUSION

    No artificial valve is perfect as the healthy functional natural valve. Each

    prosthetic valve has potential advantages and disadvantages which need to be

    considered. The lifespan depends upon the lifestyle modifications. So as nurses

    we should educate clients about post operative management.

    XII.REFERANCE

    1.Susan L. Woods etal, (2010),Cardiac Nursing, 6th

    edition, wolters Kluwer

    Lippincott Williams and wilkims publication, Philadelphia. Pg:-540-541

    2.Ignatavicius,D.D.,Workman,M.L.&Mishler,M.A.(1991)Medicalsurgicalnursing,(2nd

    ed),Philadelphia,Saunders publications.

    3.Smeltzer ,S.C. &Bare,B.G.(2001)Brunner and suddarths medical surgicalnursing,(10

    thed),Philadelphia,Lippincott.

    4.Graber,B.&Bucher,L.92007)Lewis medical and surgical nursing,(10th

    ed0,Misori,Elsvier publications,1102-1115.

    4.Donna,D.M.&workman,L.(2006)Medical surgical nursing(2nd

    ed),Philadelphia,Saunders publications,1665-1670.

    5.Susan,C.D,(2007)Medical surgical nursing,Philadelphia,Saunderspublications.

    6.Marks C and Marks P (1994) Fundamentals of cardiacsurgery.London.Chapman and Hall medical.

    7. http://www.medicinenet.com/ccf/page2.htm

    8.http://www.nejm.org/doi/full/10.1056/NEJM199305063281801

    http://www.medicinenet.com/ccf/page2.htmhttp://www.nejm.org/doi/full/10.1056/NEJM199305063281801http://www.nejm.org/doi/full/10.1056/NEJM199305063281801http://www.nejm.org/doi/full/10.1056/NEJM199305063281801http://www.medicinenet.com/ccf/page2.htm
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    9.http://stanfordhospital.org/healthLib/greystone/heartCenter/heartProcedures/heartValveRepairR

    eplacementSurgery.html

    http://www.nejm.org/doi/full/10.1056/NEJM199305063281801http://www.nejm.org/doi/full/10.1056/NEJM199305063281801http://www.nejm.org/doi/full/10.1056/NEJM199305063281801

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