Presented by,T.SHIVA RAM

Vanillin is a herbal drug obtained from

the dried pods of Vanilla planifolia

synonym:vanilla beans, vanilla pods

Family: Orchidaceae

Chemically vanillin is, 4-hydroxy 3-methoxy benzaldehyde.

To synthesise the semisynthetic

derivatives of vanillin which are used in

our daily biological activities.

To optimize the biological activity of the compounds selected in the study.

The compounds selected for the study are volatile in nature, formation of non volatile derivative with a better activity avoids the wastage through vaporization and also increases the potency.

The compounds to be synthesized in this study are very simple derivatives and follow one or two step reactions, thus there is very less chance for the degradation of the starting compound.

The compounds synthesized in this study will be subjected for TLC, physical and spectral analysis in order to identify purity, and to interpret the structure of the derivatives synthesized.

Based on this concept the present work

was designed to synthesize semisynthetic

derivatives of some commonly used

phytoconstituent’s. In the present study

semisynthetic derivatives of vanilla are

synthesized. These derivatives are chosen

due to their wide pharmacological activity

and are used in our day to day life.

Experimental work procedure Take about 1 gm of hydrazine sulphate, 0.8 gm of sodium acetate in little quantity of distilled water and shaken well, added 2 gm of vanillin and shaken well till it becomes clear solution, if necessary add ethanol to dissolve the contents.

The thoroughly dried substance is to be subjected for analytical work

In this experiment vanillin is treated with semicarbazide in the presence of sodium acetate.

The resulted product is Hydrazine methylidene vanillin

The entire mixture warmed on water bath continuously for about 1 hour under reflux and allowed to cool to get the compound hydrazine di methyl vanillin, which is filtered and subjected for recrystallization with suitable solvent like alcohol.

uses

The uses of the newly generated product are

Analgesic

Antibacterial

Anti helmenthic

Flavouring agent Perfumary Masking agent

The literature survey reveals that some

activities like Antibacterial, Antioxidant

& analgesic activities etc… which are

found weak, to increase its biological

activity,a modification of functional

groups in the structure/ modification of

structure, may increase their

pharmacological actions.

Satyajit D Sarker, Lutfun Nahar, “Chemistry For Pharmacy students General , Organic and natural Product Chemistry”, Nat prod chem, John Wiley & Sons Ltd, chapter 6,pg no.283-289, 2004.

Dr. C. K. Kokate, A. P. Purohit, S. B. Gokhale, “Pharmacognosy”,Nirali prakashan ; Pune, thirty eighth edition, p.no:1-6,2007

Newman DJ, Cragg GM. “Natural products as sources of new drugs over the last 25 years” J Nat Prod, 70, 461-477 (2007).

Dan Bensky, Steven Clavey, Erich Stoger, and Andrew Gamble “Chinese Herbal Medicine: Materia Medica” Third Edition 2004.