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The New England Journal of Medicine as published by New England Journal of Medicine. Downloaded from www.nejm.org on August 10, 2010. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

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The New England Journal of Medicine as published by New England Journal of Medicine.Downloaded from www.nejm.org on August 10, 2010. For personal use only. No other uses without permission.

Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine as published by New England Journal of Medicine.Downloaded from www.nejm.org on August 10, 2010. For personal use only. No other uses without permission.

Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine as published by New England Journal of Medicine.Downloaded from www.nejm.org on August 10, 2010. For personal use only. No other uses without permission.

Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine as published by New England Journal of Medicine.Downloaded from www.nejm.org on August 10, 2010. For personal use only. No other uses without permission.

Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine as published by New England Journal of Medicine.Downloaded from www.nejm.org on August 10, 2010. For personal use only. No other uses without permission.

Copyright 1991 Massachusetts Medical Society. All rights reserved.
The New England Journal of Medicine as published by New England Journal of Medicine.Downloaded from www.nejm.org on August 10, 2010. For personal use only. No other uses without permission.

Copyright 1991 Massachusetts Medical Society. All rights reserved.

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