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GENETICS AUGUST 2008 • VOLUME 179 • ISSUE 4 • www.genetics.org Histone acetylation and genome stability Chromosomal breaking news: Half-crossovers SURly models for QTL Tracing visual pigment evolution NEW GENETICS WEBSITE VISIT www.genetics.org
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  • GENETICSAUGUST 2008 • VOLUME 179 • ISSUE 4 • www.genetics.org

    GE

    NE

    TIC

    SV

    OL

    UM

    E 179 • IS

    SU

    E 4 • P

    AG

    ES

    1735–2342A

    UG

    US

    T 2008

    ••••••••••••

    Histone acetylation and genome stability

    Chromosomal breaking news: Half-crossovers

    SURly models for QTL

    Tracing visual pigment evolution

    NEW GENETICS W

    EBSITE

    VISIT www.genetics.org

  • b o a r d o f d i r e c t o r s

    Trudi M. Schüpbach, President 2008 (2009)Princeton University

    Fred Winston, Vice President 2008 (2010)Harvard Medical School

    Allan C. Spradling, Past President (2008)Carnegie Institution for Science

    Trudy F. Mackay, Treasurer (2010)North Carolina State University

    James E. Haber, Secretary (2009)Brandeis University

    Mark Johnston, Acting Editor-in-ChiefWashington University School of Medicine

    Victor R. Ambros (2009)Dartmouth Medical School

    Kathryn M. Barton (2008)Carnegie Institution for Science

    Nancy M. Bonini (2009)University of Pennsylvania

    Sally A. Camper (2010)University of Michigan Medical School

    Charles H. Langley (2010)University of California, Davis

    Susan T. Lovett (2010)Brandeis University

    Tim Schedl (2009)Washington University School of Medicine, St. Louis

    Michael P. Snyder (2008)Yale University

    Mariana F. Wolfner (2008)Cornell University

    Jeff J. Sekelsky, Web Content EditorUniversity of North Carolina

    The Genetics Society of America is organized to provide forassociation and conference among students of heredity and toencourage close relationships between workers in genetics and those in related sciences. Genetics is its official journal.All persons interested in genetics are eligible for activemembership. Application for membership may be made on theform in this journal or obtainable from the address below.

    Genetics ISSN 0016-6731 is published monthly by the GeneticsSociety of America, 9650 Rockville Pike, Bethesda, Maryland20814-3998. The 2008 subscription price for nonmembers(including postage) is $900 per year domestic, $920 Canada andMexico, and $990 all other countries and includes online access($800 for online-only access). Contact the Genetics Society ofAmerica for consortia pricing, expedited mail service, and multi-site pricing. Copyright © 2008 by the Genetics Society of America.

    Correspondence about membership, nonmember subscrip-tions, changes of address, missing issues, and other noneditorialmatters should be directed to the appropriate address below,according to whether the inquirer is (or would be) a GSAmember or nonmember subscriber. Claims for missing issuesshould be made within 30 days of the date of mailing, which isgenerally on or near the first of the month; missing issues willbe supplied free only if they have been lost in the mail.

    gsa members only:GSA Administrative Office9650 Rockville PikeBethesda, Maryland 20814-3998(301) 634-7300

    nonmember subscriptions:FASEB Subscription Department9650 Rockville PikeBethesda, Maryland 20814-3998(301) 634-7029

    Back issues of Genetics from 1992 (Volume 130) can beobtained through the nonmember subscriber address above.Genetics is also available in microform from UniversityMicrofilms International, 300 North Zeeb Road, Ann Arbor, MI48106; European inquiries may be directed to 30-32 MortimerStreet, Dept. PR, London, W1N 7RA, England.

    permission to photocopy: The Genetics Society ofAmerica permits unlimited photocopying of any article,without fee, from this or any previous issue of Genetics foreducational purposes or for individual use. Students mayincorporate any portion of their research published inGenetics into a dissertation without further specificpermission. These permissions do not extend to copying forother purposes, such as for advertising or promotionalpurposes, for creating new collective works, or for resale; suchrequests should be addressed to the Editor-in-Chief.

    postmaster: Send address changes to Genetics, 9650 Rockville Pike, Bethesda, MD 20814-3998. Periodicalspostage paid at Bethesda, Maryland 20814-3998 and additionalmailing offices. (Publication No. 215860.)

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    The Genetics Society of America wishes to thank CarnegieMellon University and the Department of Biological Sciences forproviding space and amenities for the Genetics Editorial Office.

    Genetics Society of America

    About the Cover Loss of mitotic synchrony in Drosophila early embryo due toreduction in phosphatase inhibitor 2 (I-2). This embryo from anI-2 mutant mother was fixed and stained to visualize microtubules(immunostain for �-tubulin: green) and chromosomes (DAPIstain for DNA: magenta). Nuclei are in various stages of mitosis:from metaphase at the extreme anterior end (left) to late anaphaseat the posterior end (right). See Wang et al. (pp. 1823–1833).

  • 2008 APPLICATION FOR MEMBERSHIP

    THE GENETICS SOCIETY OF AMERICA

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    Mail completed application and remittance to the above address.

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    21. Volume 1 (5 DVDs: Hartwell, Jacob, Lewis, Motulsky, Witkin) $102 US, $104 Canada/Mexico, $112 elsewhere (includes shipping/handling) .......................... $ ____________ 21

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    ADVANTAGES OF MEMBERSHIP

    • Receive a subscription to Genetics (print and/or online)

    • Be listed in the online membership directory

    • Vote in GSA elections

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    • Pay discounted rate for Genetics Journal publication fees and use of color

    • Pay lower registration fees for GSA-sponsored meetings

    • Post free employment ad on GSA Web site

    • Order GSA discounted subscriptions and Conversations in Genetics

    • Participate in opportunities to purchase discount reagents and antibodies

    • Receive meeting information for Yeast, Drosophila, Chlamydomonas, fungal genetics, C. elegans, Zebrafish, or Genetic Analysis: Model Organisms to Human Biology

    • Purchase the abstract book(s) of GSA-sponsored meetings for a nominal sum unless you register, in which case the books are free

    • Receive the GSA newsletter, GENEtics

    • Support advocacy for genetics research through the efforts of the Joint Steering Committee for Public Policy

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    • Promote the intellectual heritage of genetics through a variety of initiatives and projects

    • Enjoy fellowship with over 4000 colleagues and scholars in genetics

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    will begin mailing issues to you one or two months after your order is received in the Administrative Office. Annual Reviews will be mailed at the book rate in the

    month of issue.

    Line Journal Issues/Yr.

    2 BioEssays 12

    3 Chromosoma 6

    4 Current Biology 24

    5 Current Opinion in Cell Biology 6

    6 Current Opinion in Genetics & Development 6

    7 Genes & Development 24

    8 genesis: The Journal of Genetics & Development 12

    9 Genetic Testing 4

    10 Genetica 9

    11 Genome Research 12

    12 Journal of Computational Biology 10

    13 OMICS: A Journal of Integrative Biology 4

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    Maryland residents add 5% sales tax. Canadian residents add 6% GST on total.

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    Please be sure to enter on line 25 the total amount reflected in your payment. Payment may be made via money order; a check drawn on a U.S. bank, in U.S. currency

    only, and made payable to The Genetics Society of America; MasterCard, VISA, American Express (AMEX) or Discover credit card. Checks drawn on foreign banks

    cannot be accepted. Persons in countries with currency restrictions may apply to the Administrative Office for assistance.

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  • Announcement

    Dear Colleagues,

    Our journal has gone through some significant changesin the past few years. Most were planned, of course, andare decidedly positive; one was unexpected and tragic.We are now carrying the baton of progress handed to usby our esteemed and very dedicated Editor-in-Chief,the late Elizabeth W. Jones. We intend to be good stew-ards of Beth’s legacy of excellence while we search forher successor.

    Over the next months we will tell you about several sub-stantive enhancements that have recently been made toour editorial process. Here we describe significantimprovements in the appearance and accessibility ofthe journal.

    We are pleased to announce the launch of Genetics’snew website. Nearly a year ago a group of dedicatedGenetics Society of America members1 took on thechallenge of redesigning the journal website. Underthe very capable leadership of Suzanne Sandmeyer, our colleagues responded to the need to redesign thejournal’s web pages to reflect the journal’s steadilyincreasing standards and to showcase our content witha contemporary aesthetic and clean form and delivery.In 2007, 613 articles appeared in over 7200 pages of thejournal, an average of 51 articles each issue. Such vol-ume and breadth demands that our readers be able toswiftly locate and use these articles.

    We first watched, listened, and learned: We conductedinterviews, focus groups, and questionnaires withauthors, readers, non-readers, and GSA members. Wethen retained one of the finest designers—ElizabethKairys Design from San Francisco—with a wealth ofexperience working with academic journals and non-profit organizations. We collaborated with the designerson minute aspects of color, usability, readability, andform to provide a website design that reflects the excite-ment of modern genetics while holding true to ouridentity, integrity, and our long and illustrious history of “investigations bearing on heredity and variation.” To

    implement our ideas, we partnered with our technologyprovider, HighWire Press, a division of StanfordUniversity Libraries and a well-respected host of thelargest repository of online scholarly content, represent-ing over 1100 journals and 140 scholarly publishers.

    Most important, we redesigned the website primarily tohighlight what lies between the virtual covers ofGenetics: its content. We’ve made it easier for you tofind, read, and use research articles. The table of con-tents is organized by section subheading; distinct colorsquickly orient the reader. We provided issue highlightswith summaries targeted to our diverse readership,hoping to foment the good fortune of serendipity thatmight arise as a population geneticist happens upon arelevant article published in our Genome Transmissionand Integrity section.

    With one click, you can access article collections likeReviews, Genetics Education, and Most-Read or Most-Cited articles. The new web interface enables easydownloading of figures for use in teaching. We offercover-to-cover PDFs for a more accurate historicalrecord. Our color covers—started just two years ago—form a stunning collection of visually arresting imagesthat also highlight individual articles.

    We are grateful to Suzannne Sandmeyer and the mem-bers of her committee for achieving this significantimprovement in our journal. Whether you’ve not seenus in years or you published an article last week—takeanother look. We expect you’ll be back.

    Beginning with the first paper published in the journal—Calvin Bridges’s classic demonstration in 1916 that chro-mosomes carry genes—Genetics has led the way in ourfield. From Beadle, Haldane, and Luria and Delbrück toHartwell, Kimura, and Sulston and Brenner, the leadersof our field have chosen Genetics to present some oftheir best work. We expect to attract the papers of tomor-row’s leaders, in part by providing an online forum forthe presentation of their newest, most-exciting findings.

    Visit the NEW Genetics online at www.genetics.org!Tell us what you think—we welcome your commentsand questions as our journal continues to evolve.

    Sincerely,

    Mark Johnston, Acting Editor-in-Chief

    Tracey DePellegrin Connelly, Managing Editor

    Visit the NEW GENETICS online at www.genetics.org

    1Board of Senior Editors, 2006–2007:Suzanne Sandmeyer, Chair; Vicki Chandler; Andy Clark; R. ScottHawley; Mark Johnston; Terry Magnuson; Paul Sternberg.

  • Executive Director, Genetics Society of America

    The Genetics Society of America (GSA) is an organization of 5,000 scientists, edu-cators, and students who are involved in the research and teaching of genetics atall levels. The GSA sponsors the major annual meetings of researchers workingon the genetics of many model organisms as well as a new meeting on the role ofmodel organisms in the study of human disease. The GSA is now seeking a newExecutive Director to provide leadership and initiative in overseeing the missionof the GSA. The responsibilities of the individual in this position include the fol-lowing:

    • Facilitate the GSA’s scientific meetings as Executive Organizer

    • Serve as the Executive member of the Committees of the Board

    • Develop new programs and initiatives in conjunction with the GSA Board

    • Oversee publication of the GSA’s journal, Genetics, and the newsletter,GENEtics

    • Administer the GSA website

    • Direct membership recruitment and retention

    • Represent the GSA in public and private venues

    • Manage an office that carries out the day-to-day activities of the GSA

    • Oversee maintenance of financial records of the GSA

    Candidates should have prior experience in organizational management andhave demonstrated the ability to conceptualize and implement new projects.Postgraduate training in science and knowledge of genetics is desirable.Familiarity with the non-profit sector and advocacy activities will be an advantage.

    Please send a letter of application, resume, and three references to:

    Susan ScalcoFASEB Human Resources 9650 Rockville Pike Bethesda, MD 20814 301-634-7000, [email protected].

    Deadline for receipt is September 30, 2008.

    The office of the Society is located in Bethesda, Maryland. Please refer to ourwebsite at http://www.genetics-gsa.org/ for more information about the GSA, inparticular, the mission statement for search of executive director (http://www.genetics-gsa.org/pages/gsamission.shtml).


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