Vit B6 PYRIDOXINE

Rat antidematitis

Pyridoxine & pyridoxol (PN)

Pyridoxal (PL)

caa Pyridoxamine (PM)

STRUCTURE

Pyridoxal phosphate

PYRIDOXINE [B6]

Phosphorate •Intestine

alkaline

Deposohated •In blood

Phosphorate

Deposohated

In live by kinase

In blood Pl PLP Pyridoxine kinase

Alkaline phosphatase

Sensitive to high temperature

Transamination

Deamination

Decarboxylation

Desulfuration

Production of Niacin

Glycogenolysis

Healthy skin

Healthy mucous membrane

Metabolism and formation RBCs

In nervous and immune system

Maintain blood glucose level

Convert blood carbohydrate to glycose

Reaction type Example

Deamination Serine → pyruvate + NH3 Threonine → propionic acid + NH3

Decarboxylation glutamic → ϒ amino butyric acid (GABA)

-amino ẞ-keto adipic → ϒ amino levulonic acid

desulfuration cysteine → pyruvic acid

plpالسهم عليه

Abnormal growth

Anemia

High blood pressure

Dermatitis

Pellagra

Vomition of early progenance

Low vitamin intake

Pregnancy

Alcoholics & smoker

Older people

Antibiotic

Diabetes

For kidney stone Improve CNS Vomition during pregnancy

Vit B7(biotin ) Vit h

Coenzyme r Growth factor

Anti egg white injury factor

Heterocyclic sulfur Consist of imidazole ring + thiophene ring

It is widely distributed in the

foods

Liver, kidney, vegetables and egg yolk are important

source

Biotin also synthesized by

intestinal bacteria

Chocolate

Royal jelly

Yeast

Mushrooms

BIOTIN - SOURCES

BIOTIN - FUNCTIONS

Cell growth

Hair & skin & mucous membrane

Co2 fixation

Production of fatty acid

Maintains of blood sugar level

Acetyl coA → methyl coA → in synthesis of fatty acid

Propionyl COA → methyl malonl COA

Acetyl co carboxylase

Propionyl COA carboxylase

BIOTIN DEFICIENCY

1) Hair loss 2) Muscle pains 3) Dermatitis 4) Vomition

CAUSES

• Smoking

• Poor diet

• Kidney failure

• Older people

• Antibiotic

• Diabetes illness