Vol. 269, No. 14 The Journal of April 8, 1994

Biological Chemistry Copyright 0 1994 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 U.S.A.

CONTENTS

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MINIREVIEW Sorting of membrane proteins in the yeast secretory pathway. Steven F. Nothwehr and Tom H. Stevens

COMMUNICATIONS Differences between lumen targeting domains of chlo- roplast transit peptides determine pathway specificity for thylakoid transport. Ralph Henry, Aliki Kapazoglou, Michael McCaffery, and Kenneth Cline

A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. Steven D. Leidich, Darren A. Drapp, and Peter Orlean

Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. Joseph El Khoury, Christian A. Thomas, John D. hike, Suzanne E. Hickman, Long Cao, and Samuel C. Silverstein

Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2a (eIF-Sa) kinase.

M. Flowers, Scot R. Kimball, and Leonard S. Jefferson Evidence for multitissue expression. Harry Mellor, Kevin

properties of Alzheimer amyloid protein analogues., Racemization of Asp” residue affects the aggregation

Takami Tomiyama, Satoshi Asano, Yoshiko Furiya, Takuy Shirasawa, Noriaki Endo, and Hiroshi Mori

Phospholipid-stimulated autophosphorylation acti- vates the G protein-coupled receptor kinase GRK5. Priya Kunupuli, Vsevolod V. Gurevich, and Jeffrey L. Benouic

Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter. Bruno Doiron, Marie-Heline Cuif, Axel Kahn, and Maria-Jose M. Diaz-Gwrro

Binding of G protein By-subunits to pleckstrin homol-

Pitcher, Gerry Shaw, and Robert J. Lefkowitz ogy domains. Kazushige Touhara, James Inglese, Julie A.

driven H+ translocation in uncoupled Q42E subunit c Suppressor mutations in F, subunit c recouple ATP-

Zhang, Mary Oldenburg, and Robert H. Fcllcngame mutant of Escherichia coli FIFo ATP synthase. Ying

DNA polymerase a overcomes an error-prone pause site in the presence of replication protein-A. Motoshi Suzuki, Shunji Izuta, and Shonen Yoshida

ARTICLES

pendent exocytosis from adrenal chromaffin cells. Ron- Evidence for the involvement of Rab3A in Caz+-de-

ald W. Holz, William H. Brondyk, Ruth A. Senter, Luzette Kuizon, and Ian G. Macara

Protein kinase A phosphorylation and G protein regu- lation of purified renal Na channels in planar bilayer

Dale J. Benos membranes. Iskander I. Ismailou, James H. McDuffie, and

tuted into liposomes acts as an iron transporter. The H+-ATPase from reticulocyte endosomes reconsti-

Cai- Yuan Li, J . Abra Watkins, and Jonathan Glass

Accessibility of the c-Src SH2-domain for binding is

Laudano, and David Shalloway increased during mitosis. Shubha Bagrodia, Andrew P.

promoter and its activation by the POU domain factor Characterization of an acetylcholine receptor a3 gene

SCIPjTst-1. Xiangdong Yang, Jennifer McDonough, Dmitry Fyodorov, Mark Morris, Feng Wang, and Evan S. Deneris

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10319

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The a/B subunit interaction in H+-ATPase (ATP syn- thase). An Escherichia coli a subunit mutation (Arg- a296 + Cys) restores coupling efficiency to the delete-

Mi- Yeon Park, Masatomo Maeda, and Masamitsu Futai rious B subunit mutant (Ser-B174 + Phe). Hiroshi Omote,

Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand- induced cellular response. Lisha Zhang, Masahiro Higmhi, Klara Totpal, Madan M. Chaturvedi, and Bhurat B. Aggarwal

Luminal communication between intracellular calcium

Hajndczky, Chi Lin, and Andrew P. Thomas stores modulated by GTP and the cytoskeleton. Gyorgy

Localization of an apolipoprotein A-I epitope critical for lipoprotein-mediated cholesterol efflux from mon- ocytic cells. Carole L. Banka, Audrey S. Black, and Linda K. Curtiss

The influence of apolipoproteins on the structure and function of spheroidal, reconstituted high density lipo- proteins. Kerry-Anne Rye and Philip J . Barter

On the role of groES in the chaperonin-assisted folding

Buchner, Matthew J. Todd, George H. hrimer, and Paul V. reaction. Three case studies. Marion Schmidt, Johannes

Viitanen

Regulation of phosphoprotein p18 in leukemic cells.

By Xiang-Nong Luo, Bijoyesh Mmkerjee, Anna Ferrari, Cell cycle regulated phosphorylation by p34- kinase.

Sucharita Mistry, and George F. Atweh

Lipoprotein lipase domain function. Howard Wong, Rich- ard C. Davis, Tom Thuren, John W. Goers, Judith Nikazy, Moseley Waite, and Michael C. Schotz

Interaction of desacetamidocolchicine, a fast binding analogue of colchicine with isotypically pure tubulin dimers abn, a&, and ab^. Asok Banerjee, A n D’Hoore, and Yves Engelborghs

Developmental expression of trout egg polysialoglyco- proteins and the prerequisite a2,6-, and a2,8-sialyl and a2,8-polysialyltransferase activities required for their synthesis during oogenesis. Shinobu Kitazum, Ken Kita- jima, Sadako Inoue, Yasua Inoue, and Frederic A. Troy II

Identification of a novel determinant for basic domain- leucine zipper DNA binding activity in the acute-phase inducible nuclear factor-interleukin-6 transcription factor. Allan R. Brasier and Amalendra Kumar

Intracellular Mgl+ movement during muscarinic stim- ulation. M e uptake by the intracellular Cap+ store in rat sublingual mucous acini. Guo H. Zhang and James E. Melvin

Subtype-specific signaling mechanisms of somatostatin

and Diane L. Barber receptors SSTRl and SSTR2. Cuifen Hou, Robin L. Gilbert,

Phenotypic alterations in Fos-transgenic mice corre- late with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloprotein- ases by carcinogens, tumor promoters, CAMP, and Fos oncoprotein. Sabine Gack, Riidiger Vallon, Jorg Schoper, Ulrich Ruther, and Peter Angel

Mutational analysis of the traffic ATPase (ABC) trans- porters involved in uptake of eye pigment precursors in Drosophila melanogaater. Implications for struc- ture-function relationships. Gary D. Ewart, David Cannell, Graeme B. Cox, and Anthony J. Howells

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1994) J. Biol. Chem. 269, 777-785, and reprints may be obtained from the editorial office.

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Expression in Escherichia coli of genes encoding the Ela and Elg subunits of the pyruvate dehydrogenase complex of Bacillus stearothermophilus and assembly

Lessard and Richard N. Perhum of a functional El component (ad.) in vitro. Ivan A. D.

The human chorionic somatomammotropin gene en- hancer is composed of multiple DNA elements that are

and Norman L. Eberhardt homologous to several SV40 enhansons. Shi- Wen Jiang

Molecular mechanism of regulation of yeast plasma membrane H+-ATPase by glucose. Interaction between domains and identification of new regulatory sites. Pilar Eraso and Francisco Portilh

The dephosphorylation reaction of the Ca*+-ATPase from plasma membranes. Claudia J . Herscher, Alcides F. Regs and Patricio J . Garrahun

Monoclonal antibodies FKl and WF6 define two neigh- boring ligand binding sites on Torpedo acetylcholine receptor u-polypeptide. Bernd Schnider, Sigrid Rein- hardt-Maelicke, Andre Schrattenholz, Kathryn E. McLane, Axel Kretschmer, Bianca M. Conti-Tronconi, and Alfred Maelicke

Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers. Lan-bo Shi, William R. Skoch, and A. S. Verkman

Autocrine stimulation of the Xmrk receptor tyrosine kinase in Xiphophorus melanoma cells and identifica-

Malitschek, Joachim Wittbrodt, Petra Fischer, Reiner Lam- tion of a source for the physiological ligand. Barbara

mers, Axel UUrich, and Manfred Schartl

Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomoncrs aeruginosa

Mende-Mueller, Joseph T. Barbieri, and Dara W. Frank strain 388. Scott M. Kulich, Timothy L. Yahr, Liane M.

cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an en-

Eriksson, Dagmr Sandbirck, Bo Ek, Ulf Lindahl, and Lena zyme involved in the biosynthesis of heparin. Znger

Kjefin

The third helix of the Antennapedia homeodomain translocates through biolo 'cal membranes. Daniek De- rossi, Aloin H. Joliot, Gerard phassaing, and A k i n Prochiantz

The sequences of human and bovine genes of the phos- phate carrier from mitochondria contain evidence of

Ferdinand0 Palmieri, and John E. Walker alternatively spliced forms. Vincenza Dolce, Vito Iacobazzi,

Functional a-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-termi-

Lataro. Jesus Aparecido Ferro, and Fernando de Castro nal acetyl group. Patricia Brant Monteiro, Renata Crktina

Reinach

SH-PTP2/Syp SH2 domain binding specificity is de- fined by direct interactions with platelet-derived growth factor &receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. Randi D. Case, Elizabeth Piccione, Gert Wolf, Anton M. Benett, Robert J . Lechleider, Benjamin G. Neel, and Steven E. Shoelson

Roles of CCAAT/enhancer-binding protein and its binding site on repression and derepression of acetyl-

Ki-Han Kim CoA carboxylase gene. Hyi-Jeong Tae, Xiuochun L w , and

shrinkage is counteracted by an enhanced active trans- Response of human fibroblasts to hypertonic stress. Cell

Rossi, Ovidio Bussolati, and Gian C. Gazzolo port of neutral amino acids. Valeria Dall'Asta, Patrizia A.

Asymmetrical topology of diether- and tetraether-type polar lipids in membranes of Methanobacterium ther- moautotrophicum cells. Hiroyuki Morii and Yosuke Koga

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10517

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10538

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10559

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10574

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10590

10597

Identification of protein receptor for C~ostridium bot- ulinum type B neurotoxin in rat brain synaptosomes. Tei-ichi Nkhiki, Yoichi Kamta , Yasw Nemoto, Akira Omori, Tomoko Ito, Masami Takahashi, and Shunji Kozaki

Spectroscopic properties of desulfoferrodoxin from De- sulfovibrio desulfuricans (ATCC 27774). Pedro Tavares, Natarajan Ravi, Jose J . G. Moura, Jean LeGaU, Yun-Huo Huang, Brian R. Crouse, Michael K. Johnson, Boi Hanh Huynh, and Isabel Moura

Protein kinase C. mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby ca- nine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-spe-

Balboa, Bonnie L. Firestein, Catherine Godson, Kelly S. Bell, cific phospholipase C and phospholipase A*. Maria A.

and Paul A. Insel

Regulation of fluorescent fatty acid transfer from adi- pocyte and heart fatty acid binding proteins by acceptor membrane lipid composition and structure. Margo G. Wootan and Judith Storch

Multiple forms of the human tyrosine phosphatase

Gunter Daum, Stephan Regenass, Jan Sap, Joseph Schlessin- RPTPa. Isozymes and differences in glycosylation.

ger, and Edmond H. Fischer

Identification of phosphorylation sites in rat liver

MacDonald and Claudia Kent CTP:phosphocholine cytidylyltransferase. James I. S.

Microsomal retinoic acid metabolism. Effects of cellu- lar retinoic acid-binding protein (Type I) and C18- hydroxylation as an initial step. Paul D. Fiorella and Joseph L. Napoli

Identification of a vitamin D-responsive element in the 6'-flanking region of the rat 26-hydroxyvitamin Ds

Motoyuki Uchida, Toshimasa Shinki, Shigeaki Kato, Tatsw 24-hydroxylase gene. Yoshihiku Ohyama, Keiichi Ozono,

Suda, Osamu Yamamoto, Mitsuhide Noshiro, and Yukio Kat0

Modulation of transforming growth factor 6 receptors of rat lipocytes during the hepatic wound healing re- sponse. Enhanced binding and reduced gene expression

Scoff L. Friedman, Glenn Yamasaki, and Linda Wong accompany cellular activation in culture and in vivo.

Induction of dolichyl-saccharide intermediate biosyn- thesis corresponds to increased long chain cis-isopren- yltransferase activity during the mitogenic response in mouse B cells. Dean C. Crick, Jane R. Scocca, Jeffrey S. Rush, David W. Frank, Sharon S. Krag, and Charles J . Waechter

Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. Timothy L. Cover, Murali K. R. Tummuru, Ping Cao, Stuort A. Thomp- son, and Martin J. B h e r

Misfolded human chorionic gonadotropin @ subunits are secreted from transfected Chinese hamster ovary cells. Elliott Bedows, Sheila E. Norton, Jeffrey R. Huth, Nobuhiko Suganuma, Irving Boime, and Raymond W. Ruddon

Regulation by nerve growth factor and protein phos- phorylation of Na/K/2Cl cotransport and cell volume in PC12 cells. Sara h u n g , Martha E. O'Donnell, Anthony Mar- tinez, and H. Clive Palfrey

Isolation and characterization of a mutant dihydrofo- late reductase-thymidylate synthase from methotrex- ate-resistant Leishmania cells. Rosalia Arrebolo, Asuncion Olmo, Pedro Reche, Edward P. Garvey, Daniel V. Santi, Luis M. Ruiz-Perez, and Dolores Gonzalez-Pacanowskn

Selenophosphate synthetase. Enzyme properties and

D. Scholz, and Thressa C. Stadtman catalytic reaction. Zsuzsa Veres, Ick Young Kim, Thomas

The Journal of Biological Chemistry (ISSN 0021-9258) is published aeekly by the American Society for Biochemistry and Molecular B io lop Inc., 428 East Preston Street, Baltimore, MD 21202, U.S.A. Volume 269 for 1994: Institutions: United States, $790; Foreign, $980. Students/Post octoral Fellows: United States, $140; Foreign, $330. CD-ROM (available only with printed subscription): United States, $60; Foreign, $65. (Note: Maryland, Pennsylvania, and Canada add applicable taxes, unless a tax-exempt certificate number is shown.) The GST number for Canadian subscribers is 130369721. Second class postage paid at Baltimore, MD 21202, U.S.A. and at additional mailing offices. Printed in the U S A . P O S T M A S T E R Send address changes to THE JOURNAL OF BIOLOGICAL CHEMISTRY at 428 East Preston Street, Baltimore, MD 21202, U.S.A.

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10675

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10691

10699

10706

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10720

10729

Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mi- togen-activated protein kinase. Long Pang, Kim L. Milar- ski, Masa Ohmichi, Yasumitsu Takata, Jerrold M. Olefsky, and Alan R. Saltiel

Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity. Wengang Zhang, Thomas A. Gustafson, William J . Rutter, and Jeffrey D. Johnson

On the relationship between the mitochondrial inner membrane anion channel and the adenine nucleotide translocase. Mary F. Powers, Lisa L. Smith, and Andrew D. Beavis

Intestinal absorption of peptides by coupling to bile acids. Werner Kramer, Gunther Wess, Georg Neckermann, Gerrit Schubert, Jurgen Fink, Frank Girbig, Ulrike Gutjahr,

fons Enhsen, Eugen Falk, Michael Friedrich, Heiner Glombik, Simone Kowalewski, Karl-Heinz Baringhaus, Georg Boger, Al-

Axel Hoffmann, Christoph Pittius, and Matthios Urmann

The oligosaccharide binding specificities of CD22@, a

Ajit Varki sialic acid-specific lectin of B cells. Leland D. Powell and

Cytokine-induced &galactoside a-2,6-sialyltransfer-

of adhesion molecules and CD22 ligands. Kohji Hanosaki, ase in human endothelial cells mediates a2,6-sialylation

Ajit Varki, Ivan Stamenkouic, and Michael P. Bevilacqua

Factor X-activating glycoprotein of Russell's viper venom. Polype tide composition and characterization of the carbohytrate moieties. D. Channe Gowda, Craig M. Jackson, Preston Hensley, and Eugene A. Davidson

skeletal muscle troponin I gene. Shari J . Corin, Ondrej Structure and expression of the human slow twitch

Juhasz, Lei Zhu, Pam Conky, Larry Kedes, and Robert Wade

GATA-type zinc finger motif-containing sequences and chorion gene transcription factors of the silkworm Bombyx mori. J&l R. Dreuet, Yasir A. W. Skeiky, and Kostas Zatrou

platelet-derived growth factor-AA and a potent neu- Structural coincidence of aPDGFR epitopes binding to

tralizing monoclonal antibody. Jin-Chen Yu, Daruka Ma- hndeuan, William J . LaRochelle, Jacalyn H. Pierce, and Mo- h a m d A. Heidaran

Intermediate filament-like network formed in vitro by

Eeua-Liisa Nurmiaho-Lussila, and Mikael Rhen a bacterial coiled coil protein. Reini Hurme, Ellen Namork,

Cloning and expression of a novel acidic calponin iso-

Applegate, Waldo Feng, Robert S. Green, and Mark B. form from rat aortic vascular smooth muscle. Dianne

Taubman

I n vitro characterization of nonpeptide irreversible in- hibitors of HIV proteases. Rafael Salto, Lilia M. Babe, Jia Li, Jason R. Ros& Zhonghua Yu, Alma Burlingame, James J. De Voss, Zhihua Sui, Paul Ortiz de Montellano, and Charles S. Craik

The mouse y-glutamyl transpeptidase gene is tran- scribed from at least five separate promoters. Antonio R. Sepulueda, Bing Z. Carter, Geetha M. Habib, Russell M. Lebovitz, and Michael W. Lieberman

Clostridium difFicile toxin B acts on the GTP-binding protein Rho. Zngo Just, Gerhard Fritz, Klaus Aktories, Mu- rielle Giry, Michel R. P o p f f , Patrice Boquet, S i l k Hegenbarth, and Chrrstoph won Eichel-Stretber

High affinity interaction of dipteran high mobility group (HMG) proteins 1 with DNA is modulated by COOH-terminal regions flanking the HMG box domain. Jacek R. Wiiniewski and Ekkehard Schulze

rse, a novel receptor-type tyrosine kinase with homol- ogy to Axl/Ufo, is expressed at high levels in the br+ Melanie R. Mark, David T. Scadden, Zhengyu Wang, Qtmtn Gu, Audrey Goddard, and Paul J . Godowski

Autocrine regulation of rat chondrocyte proliferation by natriuretic peptide C and its receptor, natriuretic peptide receptor-B. Hiromi Hagiwara, Hajime Sakaguchi, Makoto Ztakura, Takanobu Yoshtmoto, Mayumi Furuya, Shoji Tanaka, and Shigehisa Hirose

10734

10739

10747

10753

10758

10764

10771

10776

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10790

10797

10804

10813

10820

10830

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10864

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21"GTP formation. Toshiyasu

and JerroM M. Olefsky Sasaoka, Boris Draznin, J. Wayne Leitner, W. John Lunglois,

Reversible transcriptional activation of mdrl by so- dium butyrate treatment of human colon cancer cells.

Mary Jane Madden, and Kenneth H. Cowan Charles S. Morrow, Masayuki Nakagawa, Merrill E. Goldsmith,

Cytokines that associate with the signal transducer gp130 activate the interferon-induced transcription factor p 9 l by tyrosine phosphorylation. Gerald M. Feld- man, Emanuel F. Petricoin ZZZ, Michael David, Andrew C. Larner, and David S. Finbloom

Regulation of keratinocyte growth factor gene expres- sion by interleukin 1. Marcw Chedid, Jeffrey s. Rubin, Karl G. Csaky, and Stuart A. Aaronson

ent on both an ADP-ribosylation factor GTPase-acti- GTP hydrolysis by ADP-ribosylation factor is depend-

vating protein and acid phospholipids. Paul A. Randazzo and Richard A. Kahn

The cytoplasmic domain of myelin glycoprotein Po in- teracts with negatively charged phospholipid bilayers. Yungao Ding and Kurt R. Brunden

A mutational study of the C-terminal zinc-finger motif of the Escherichia coli UvrA protein. Jinting Wang, Kenneth L. Mueller, and Lawrence Grossman

Membrane cofactor protein (CD46) of complement. Processing differences related to alternatively spliced cytoplasmic domains. M. Kathryn Liszewski, Zndriati Tedja, and John P. Atkinson

Evidence that the cation occlusion domain of Na/K- ATPase consists of a complex of membrane-spanning segments. Analysis of limit membrane-embedded tryp- tic fragments. A h Shainskaya and Steven J. D. Karlish

A + U content rather than a particular nucleotide order

J . McDowall, Sue L i n - C b , and Stanley N . Cohen determines the specificity of RNase E cleavage. Kenneth

Effects of nucleotide sequence on the specificity of rne- dependent and RNase E-mediated cleavages of RNA I encoded by the pBR322 plasmid. Sue L i n - C b , Ten-Tsao Wong, Kenneth J . McDowaU, and Stanley N. Cohen

Remodeling of the transmembrane segment in human

Hung , Marion E. Reid, and Olga 0. Blumenfeld glycophorin by aberrant RNA splicing. Cheng-Han

Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may reg- ulate superoxide production by neutrophils stimulated with a phorbol ester. John T. Curnutte, Richard W. Erick- son, Jiabing Ding, and John A. Badwey

A novel transcriptional suppressor located within a downstream intron of the BCR gene. Mark J . Stewart, Gregory Cox, Anne Reifel-Miller, Su Young Kim, Carol A. Westbmk, and David S. Leibowitz

Retention and degradation of proteins containing an uncleaved glycosylphosphatidylinositol signal. Mark C. Field, Paul Moran, Wenlu Li, Gilbert-Andk Keller, and Ingrid W. Caras

Evidence that an &O-kDa mammalian plasma mem- brane protein with receptor-like properties mediates

perfringens enterotoxin. Ewa U. Wieckowski, Andrew P. the amphiphilicity of specifically bound Clostridium

Wnek, and Bruce A. McClane

Ranalexin. A novel antimicrobial peptide from bullfrog

bacterial antibiotic, polymyxin. Dough P. Clark, Stewart (Ram catesbeiam) skin, structurally related to the

Durell, W. Lee Maloy, and Michael Zasloff

Identification of a novel integrin binding site in fibro- nectin. Differential utilization by 83 integrins. Ron D. Bowditch, Meena Hariharan, Eiman F. Tominna, Jeffr W. Smith, Kenneth M. Yamoda, Elizabeth D. Getzoff, andgark H. Ginsberg

Identification and cellular localization of unique inter- feron mRNA from human placenta. Amy E. Whu.ley, C. s. Reddy Meka, Lisa A. Harbison, Joan S. Hunt, and Kazuhiko Imakawa

vii

10869 An altered specificity mutation in the X repressor in- duces global reorganization of the protein-DNA inter- face. James M. Benevides, Michael A. We&, and George J. Thomas, Jr.

10879 Specificity of coenzyme binding in thiamin diphos- phate-dependent enzymes. Crystal structures of yeast transketolase in complex with analogs of thiamin di- phosphate. Stephun Konig, Alfred Schellenberger, Holger Neef, and Gunter Schneider

10883 The crystal structure o succinyl-CoA synthetase from Escherichia coli at 2.5-1 resolution. William T. Wobdko, Marie E. Fraser, Michael N . G. James, and William A. Bridger

10891 Characterization of the chromosomal gene and pro- moter for human insulin-like growth factor binding protein-5. Susanne V. Allander, Cathurina Larsson, Ewa Ehrenborg, Adisak Suwanichkul, Gunther Weber, Sheila L. Morris, Svetlana Bajalica, Michnel C. Kiefer, Holger Luthmn, and David R. Powell

10899 On the role of the bithiazole moiety in sequence-selec- tive DNA cleavage by Fe-bleomycin. Stefanie A. Kane, Anand Natrajan, and Sidney M. Hecht

10905 Structure of the gene encoding the a subunit of the

factor receptor. Implications for the evolution of the human granulocyte-macrophage colony stimulating

shi Kosugi, Atsushi Miyajima, Ken-ichi Ami, and Takashi cytokine receptor superfamily. Yasushi Nakugawa, Hiro-

Yokota

10913 RNA/protein interactions in the 5”untranslated leader of HSP70 mRNA in Drosophila lysates. Lack of evi- dence for specific protein binding. Mark A. Hess and Roger F. Duncan

10923

10935

10940

10946

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10964

10965

10966

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Reconstitution of complete SV40 DNA replication with purified replication factors. S h u Waga, Glenn Bauer, and Bruce Stillman

Angiotensin I1 stimulates tyrosine phosphorylation of phospholipase C-yl in vascular smooth muscle cells.

ford C. Berk, and Kenneth E. Bernstein Maria E . Marrero, William G. Paxton, Jennifer L. Dufi Brad-

the FLP recombinase with the FLP recognition target Interaction of the NH,- and COOH-terminal domains of

sequence. Gagan E . Panigrahi and Paul D. Sadowski

Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine a-amidating

and Betty A. Eipper monooxygenase. Hye-Young Yun, Henry T. Keutmnn,

Oncogenic activation of ~ 5 9 ” ” tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528. Dominique Dauidson, Mar- ielle Fournel, and Andre Veillette

ADDITIONS AND CORRECTIONS

with monoclonal antibodies as probes. Does a renatured Unfolding/refolding studies on bovine &lactoglobulin

protein completely refold? Vol. 268 (1993) 22414- 22419. Makoto Hattori, Akw Ametani, Yoshinori Katakura, Makoto Shimizu, and Shuichi Kamimgawa

Inactivation of phytochrome- and phycobiliprotein- chromophore precursors by rat liver biliverdin reduc- tase. Vol. 268 (1993) 26099-26106. Matthew J . Terry, Mahin D. Maines, and J . Clark Lagarins

The active site substrate specificity of protein kinase C. Vol. 269 (1994) 4839-4844. Young-Guen Kwon, Mar- lanne Mendelow, and Davld S. Lawrence

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Vol. 269, No. 14

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The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

April 8, 1994

MINIREVIEW

pathway. Steven F. Nothwehr and Tom H. Stevens Sorting of membrane proteins in the yeast secretory

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. Steven D. Leidich, Darren A. Drapp, and Peter Orlean

Localization of an apolipoprotein A-I epitope critical

ocytic cells. Carole L. Bankn, Audrey S. Block, and Linda K. for lipoprotein-mediated cholesterol efflux from mon-

CurtLss

The influence of apolipoproteins on the structure and function of spheroidal, reconstituted high density lipo- proteins. Kerry-Anne Rye and Philip J . Barter

Developmental expression of trout egg polysialoglyco- proteins and the prerequisite a2,6-, and a2,8-sialyl and a2,8-polysialyltransferase activities required for their

jima, Sadako Imue, Yasua Imue, and Frederic A. Troy, I1 synthesis during oogenesis. Shimbu Kitazume, Ken Kita-

Asymmetrical topology of diether- and tetraether-type polar lipids in membranes of Methanobacterium ther- moautotrophicum cells. Hiroyuki Morii and Yosuke Koga

sialic acid-specific lectin of B cells. Leland D. Powell and The oligosaccharide binding specificities of CD228, a

Ajit Varki

Cytokine-induced &galactoside a-2,6-sialyltransfer- ase in human endothelial cells mediates a2,6-sialylation

Ajit Varki, Ivan Stamenkouic, and Michael P. Bevilocqua of adhesion molecules and CD22 ligands. Kohji Hanasaki,

CELL BIOLOGY AND METABOLISM Differences between lumen targeting domains of chlo- roplast transit peptides determine pathway specificity

Michael McCaffery, and Kenneth Cline for thylakoid transport. Ralph Henry, Aliki Kapazoglou,

Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. Joseph El Khoury, Christian A. Thomas, John D. h i k e , Suzanne E. Hickman, Long Cao, and Samuel C. Silverstein

Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter. Bruno Doiron, Marie-H6Dne Cuif, Axel Kahn, and Maria-Jose M. Dmz-Guerra

Evidence for the involvement of Rab3A in Cas+-de- pendent exocytosis from adrenal chromaffin cells. Ron- ald W. Holz, William H. Brondyk, Ruth A. Senter, Luzette Kuizon, and Ian G. Macara

Accessibility of the c-Src SH2-domain for binding is increased during mitosis. Shubha Bagrodia, Andrew P. Laudam, and David Shalloway

Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-

Klara Totpal, Madan M. Chaturuedi, and Bharat B. Aggarwal induced cellular response. Lisha Zhang, Masahiro Higuchi,

Luminal communication between intracellular calcium stores modulated by GTP and the cytoskeleton. Gyorgy Hajndczky, Chi Lin, and Andrew P. Thomas

On the role of groES in the chaperonin-assisted folding reaction. Three case studies. Marion Schmidt, Johannes Buchner, Matthew J. Todd, George H. Lorimer, and Paul V. Viitanen

Subtype-specific signaling mechanisms of somatostatin receptors SSTRl and SSTR2. Cuifen Hou, Robin L. Gilbert, and Dmne L. Barber

10363

10423

10467

10485

10498

10511

10529

10538

10551

10559

10604

10706

10729

10747

Phenotypic alterations in Fos-transgenic mice corre- late with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloprotein- ams by carcinogens, tumor promoters, CAMP, and Fos oncoprotein. Sabine Gack, Riidiger VaUon, Jorg Schaper, Ulrich Ruther, and Peter Angel

Autocrine stimulation of the Xmrk receptor tyrosine

tion of a source for the physiological ligand. Barbara kinase in Xiphophorus melanoma cells and identifica-

Malitschek, Joachim Wittbrodt, Petra Fischer, Reiner Lam- mers, Axel Ullrich, and Manfred Schurtl

SH-PTP2/Syp SH2 domain binding specificity is de- fined by direct interactions with platelet-derived

receptor, and insulin receptor substrate-1-derived growth factor &receptor, epidermal growth factor

phosphopeptides. Randi D. Case, Elizabeth Piccione, Gert

Neel, and Steven E. Shoelson Wol/, Anton M. Benett, Robert J . Lechleider, Benjamin G.

Response of human fibroblasts to hypertonic stress. Cell shrinkage is counteracted by an enhanced active trans- port of neutral amino acids. Valeria Dall’Asta, Patrizia A. Rossi, Ovidio Bussolati, and Gian C. Garzola

Identification of protein receptor for Clostridium bot- ulinum type B neurotoxin in rat brain synaptosomes. Tei-ichi Nishiki, Yoichi Kamata, Yasua Nemoto, Akira Omori, Tomoko Ito, Masami Takahnshi, and Shunji Kozaki

Protein kinase C, mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby ca- nine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-spe- cific phospholipase C and phospholipase An. Maria A. Balboa, Bonnie L. Firestein, Catherine Godson, Kelly S. Bell, and Paul A. Insel

Identification of phosphorylation sites in rat liver CTP:phosphocholine cytidylyltransferase. James I. S. MacDonuld and Claudia Kent

Microsomal retinoic acid metabolism. Effects of cellu- lar retinoic acid-binding protein (Type I) and C18-

Joseph L. Napoli hydroxylation as an initial step. Paul D. Fiorella and

Modulation of transforming growth factor @ receptors of rat lipocytes during the hepatic wound healing re- sponse. Enhanced binding and reduced gene expression accompany cellular activation in culture and in uiuo. Scott L. Friedman, Glenn Yamusaki, and Linda Wong

Induction of dolichyl-saccharide intermediate biosyn- thesis corresponds to increased long chain cis-isopren- yltransferase activity during the mitogenic response in mouse B cells. Dean C. Crick, Jane R. Scocca, Jeffrey S. Rush, David W. Frank, Sharon S. Krag, and Charles J . Waechter

Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mi- togen-activated protein kinase. Long Pang, Kim L. Milar-

Alan R. Saltlel ski, Masa Ohmichi, Yasumitsu Taknta, Jerrold M. Olefsky, and

Clostridium difficile toxin B acts on the GTP-binding protein Rho. Ingo Just, Gerhard Fritz, Klaus Aktories, Mu-

and Christoph won Eichel-Streiber rielle Giry, Michel R. Popoff, Patrice Boquet, Silke Hegenbarth,

Autocrine regulation of rat chondrocyte proliferation by natriuretic peptide C and its receptor, natriuretic peptide receptor-B. Hiromi Hagiwara, Hajime Sakoguchi,, Makoto Itakura, Taknmbu Yoshimoto, Mayumi Furuya, S ~ O J ~ Tanukn, and Shigehisa Hirose

Cytokines that associate with the signal transducer gp130 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation. Gerald M. Feld- man, Emanuel F. Petricoin, I l l , Michael David, Andrew C. Lurner. and David S. Finbloom

Indicates a Communication viii

ix

10776

10830

10838

10935

-10209

10242

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10590

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10720

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10771

10813

10879

10956

10965

10966

'10221

Membrane cofactor protein (CD46) of complement. Processing differences related to alternatively s p l i c e cytoplasmic domains. M. Kathryn Lwewskr, Indrmti Tedla, and John P. Atkinson

Retention and degradation of proteins containing an uncleaved glycosylphosphatidylinositol signal. Mark C. Field, Paul Moran, Wenlu Li, Gilbert-Andre Keller, and Ingrid W. Caras Evidence that an =5O-kDa mammalian plasma mem- brane protein with receptor-like properties mediates

perfringens enterotoxin. Ewa U. Wieckowski, Andrew P. the amphiphilicity of specifically bound Clostridium

Wnek, and Bruce A. McClane

Angiotensin I1 stimulates tyrosine phosphorylation of phospholipase C-71 in vascular smooth muscle cells. Marw B. Marrero, William G. Paxton, Jennifer L. Duff, Brad- ford C. Berk, and Kenneth E. Bernstein

ENZYMOLOGY Phospholipid-stimulated autophosphorylation acti-

Priya Kunqpuli, Vsevolod V. Gurevich, and Jeffrey L. Benovic vates the G protein-coupled receptor kinase GRK5.

The H+-ATPase from reticulocyte endosomes reconsti- tuted into liposomes acts as an iron transporter. Cai-Yuan Li, J . Abra Watkins, and Jonathan Glass

Expression in Escherichia coli of genes encoding the Ela and El@ subunits of the pyruvate dehydrogenase complex of Bacillus stearothermophilus and assembly

Lessard and Richard N. Perham of a functional El component (a&) in vitro. Ivan A. D.

Isolation and characterization of a mutant dihydrofo- late reductase-thymidylate synthase from methotrex- ate-resistant Leishmania cells. Rosalia Arrebola, Asuncwn Olmo, Pedro Reche, Edward P. Garvey, Daniel V. Santi, Luis M. Ruiz-Perez, and Dolores Gonzalez-Pacanowska

Selenophosphate synthetase. Enzyme properties and catalytic reaction. Zsuzsa Veres, Ick Young Kim, Thomas D. Scholz, and Thressa C. Stadtman

rse, a novel receptor-type tyrosine kinase with homol- ogy to Axl/Ufo, is expressed at high levels in the brain. Melanie R. Mark, David T. Scadden, Zhengyu Wang, Qimin Gu, Audrey Goddard, and Paul J . Godowski

ent on both an ADP-ribosylation factor GTPase-acti- GTP hydrolysis by ADP-ribosylation factor is depend-

and Richard A. Kahn vating protein and acid phospholipids. Paul A. Randazzo

A mutational study of the C-terminal zinc-finger motif of the Escherichia coli UvrA protein. Jinting Wang, Kenneth L. Mwller, and Lawrence Grossman

Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may reg- ulate superoxide production by neutrophils stimulated

son, Jiubing Ding, and John A. Badwey with a phorbol ester. John T. Curnutte, Richard W. Erick-

phate-dependent enzymes. Crystal structures of yeast Specificity of coenzyme binding in thiamin diphos-

phosphate. Stephan Konig, Alfred Schellenberger, Holger transketolase in complex with analogs of thiamin di-

Neef, and Gunter Schneufer

Oncogenic activation of ~ 5 9 ~ " tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528. Dominique Dauldson, Mar- ielle Fournel, and Andre Veillette

Inactivation of phytochrome- and phycobiliprotein- chromophore precursors by rat liver biliverdin reduc- tase. Vol. 268 (1993) 26099-26106. Matthew J . Terry, Mahin D. Maines, and J . Clark Lagarb

The active site substrate specificity of protein kinase C. Vol. 269 (1994) 4839-4844. Young-Gum Kwon, Mar- mnne Mendelow, and David s. Lawrence

MEMBRANES AND BIOENERGETICS Suppressor mutations in F1 subunit c recouple ATP- driven H+ translocation in uncoupled Q42E subunit c mutant of Escherichia coli FIFO ATP synthase. Ying Zhang, Mary Oldenburg, and Robert H. FiUingame

10235

10265

10352

10393

10400

10451

10581

10614

10621

10780

Protein kinase A phosphorylation and G protein regu- lation of purified renal Na channels in planar bilayer membranes. Iskander I. Ismailov, James H. McDufjSe, and Dale J . Benos The a/@ subunit interaction in H+-ATPase (ATP syn- thase). An Escherichia coli a subunit mutation (Arg- a296 + Cys) restores coupling efficiency to the delete-

Mi- Yeon Park, Masatomo Mae&, and Masamitsu Futai rious @ subunit mutant (Ser-,3174 Phe). Hiroshi Omote,

Intracellular MgP+ movement during muscarinic stim- ulation. MgP+ uptake by the intracellular Ca'+ store in

Melvin rat sublingual mucous acini. Guo H. Zhang and J a m s E.

Molecular mechanism of regulation of yeast plasma membrane H+-ATPase by glucose. Interaction between domains and identification of new regulatory sites. Pilar Eraso and Francisco Portillo

The dephosphorylation reaction of the Caa+-ATPase from plasma membranes. Claudw J . Herscher, Alcides F. Rega, and Patricw J. Garrahan The sequences of human and bovine genes of the phos- phate carrier from mitochondria contain evidence of alternatively spliced forms. Vincenza Doke, Vito Iacobazzi, Ferdinand0 Palmieri, and John E. Walker Regulation by nerve growth factor and protein phos- phorylation of Na/K/2CI cotransport and cell volume in PC12 cells. Sara Leung, Martha E. O'Donnell, Anthony Mar- tinez, and H. Clive Palfrey On the relationship between the mitochondrial inner membrane anion channel and the adenine nucleotide translocase. Mary F. Powers, Lisa L. Smith, and Andrew D. Beavis

Intestinal absorption of peptides by coupling to bile acids. Werner Kramer, Gunther Wess, Geog Neckermann, Gerrit Schubert, Jurgen Fink, Frank Girbig, Ulrike Gutjahr, Simone Kowalewski, Karl-Heinz Baringhaus, Geog Boger, Al- fons Enhsen, E en Falk, M+@l Friedrich, Heiner Glombik, Axel Hoffmnn,?hristoph Pzttlu, and Matthias Urmonn

Evidence that the cation occlusion domain of Na/K- ATPase consists of a complex of membrane-spanning segments. Analysis of limit membrane-embedded tryp- tic fragments. Aka Shainskaya and Steven J . D. Karlish

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

-10201

010225

10252

10312

10384

10431

10475

10545

Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2a (eIF-2a) kinase. Evidence for multitissue expression. Harry Mellor, Kevin M. Flowers, Scot R. Kimball, and Leonard S. Jefferson

DNA polymerase a overcomes an error-prone pause site

Shunji Izuta, and S h n e n Yoshida in the presence of replication protein-A. Motoshi Swuki,

promoter and its activation by the POU domain factor Characterization of an acetylcholine receptor a3 gene

SCIP/Tst-1. Xiungdong Yang, Jennifer McDonough, Dmitry Fyodomv, Mark Morris, Feng Wang, and Evan S. Deneris Regulation of phosphoprotein p l 8 in leukemic cells. Cell cycle regulated phosphorylation by p34- kinase. By Xiang-Nong Luo, Bijoyesh Mookerjee, Anna Ferrari, Sucharita Mistry, and George F. Atweh

The human chorionic somatomammotropin gene en- hancer is composed of multiple DNA elements that are homologous to several SV40 enhansons. Shi- Wen Jiang and Norman L. Eberhardt

exoenzyme S (exoS) from Pseudomonas aemginosa Cloning the structural gene for the 49-kDa form of

Mende-Mueller, Joseph T. Barbieri, and Dara W. Frank strain 388. Scott M. Kulich, Timothy L. Yahr, Liane M.

binding site on repression and derepression of acetyl- Roles of CCAAT/enhancer-binding protein and its

Ki-Han Kim CoA carboxylase gene. Hyi-Jeong Tae, Xiaochun Luo, and

Identification of a vitamin D-responsive element in the 5"flanking region of the rat 25-hydroxyvitamin Ds 24-hydroxylase gene. Yoshihiko Oh ama, Keiichi Ozono, Motoyuki Uchida, Toshimasa Shinki, ihigeaki Kato, Tatsuo Suda, Osamu Yamumoto, Mitsuhide Noshim, and Yukw Kat0

Indicates a Communication

X

10566

10651

10660

10699

10713

10739

10753

10790

10797

10804

10820

10864

10869

10891

10899

10905

10913

10923

Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. Timothy L. Cover, Murali K. R. Tummuru, Ping Cao, Stuart A. Thomp- son, and Martin J . Blaser

Structure and expression of the human slow twitch

J u h z , Lei Zhu, Pam Conky, Larry Kedes, and Robert Wade skeletal muscle troponin I gene. Shuri J. Corin, Ondrej

GATA-type zinc finger motif-containing sequences and

Bombyx mori. Joel R. Drevet, Yasir A. W. Skeiky, and chorion gene transcription factors of the silkworm

Kostas Iatrou

scribed from a t least five separate promoters. Antonia The mouse y-glutamyl transpeptidase gene is tran-

Lebovitz, and Michael W. Lieberman R. Sepulveda, Bing Z. Carter, Geethu M. Habib, Russell M.

High affinity interaction of dipteran high mobility group (HMG) proteins 1 with DNA is modulated by COOH-terminal regions flanking the HMG box domain. Jacek R. Wiiniewski and Ekkehurd Schulze

Reversible transcriptional activation of m d r l by so- dium butyrate treatment of human colon cancer cells.

Mary Jane Mada'en, and Kenneth H. Cowan Churles S. Morrow, Masayuki Nakagawa, Merrill E. Goldsmith,

Regulation of keratinocyte growth factor gene expres- sion by interleukin 1. Marcio Chedid, Jeffrey s. Rubin, Karl G. Csaky, and Stuart A. Aaronson

A + U content rather than a particular nucleotide order

J . McDowall, Sue Lin-Chao, and Stanley N. Cohen determines the specificity of RNase E cleavage. Kenneth

Effects of nucleotide sequence on the specificity of me-

encoded by the pBR322 plasmid. Sue Lin-Chao, Ten-Tsao dependent and RNase E-mediated cleavages of RNA I

Wong, Kenneth J . McDowaU, and Stanley N. Cohen

Remodeling of the transmembrane segment in human glycophorin by aberrant RNA splicing. Cheng-Han Huang, Marion E. Reid, and Olga 0. BlumenfeM

A novel transcriptional suppressor located within a downstream intron of the BCR gene. Mark J . Stewart, Gregory Cox, Anne Reifel-Miller, Su Young Kim, Carol A. Westbrook, and David S. Leibowib

Identification and cellular localization of unique inter-

Reddy Meka, Lisa A. Harbison, Joan s. Hunt, and Kozuhiko feron mRNA from human placenta. Amy E. Whuley, C. S.

Imakawa

An altered specificity mutation in the A repressor in- duces global reorganization of the protein-DNA inter- face. James M. Benevides, Michael A. Weiss, and George J . Thomas, Jr.

Characterization of the chromosomal gene and pro- moter for human insulin-like growth factor binding protein-6. Susanne V. Allander, Cathurina Larsson, Ewa Ehrenborg, Adisak Suwanichkul, Gunther Weber, Sheila L. Morris, Svetlana Bajalica, Michael C. Kiefer, Holger Luthman, and David R. Powell

On the role of the bithiazole moiety in sequence-selec- tive DNA cleavage b,y Fe-bleomycin. Stefanie A. Kane, Anand Natra~an, and Sulney M. Hecht

Structure of the gene encoding the a subunit of the human granulocyte-macrophage colony stimulating

cytokine receptor superfamily. Yasushi Nakagawa, Hiro- factor receptor. Implications for the evolution of the

shi Kosugi, Atsushi Miyajimn, Ken-ichi Arai, and Takmhi Yokota

RNA/protein interactions in the 6'-untranslated leader of HSP70 mRNA in Drosophila lysates. Lack of evi-

F. Duncan dence for specific protein binding. Mark A. Hess and Roger

Reconstitution of complete SV40 DNA replication with purified replication factors. Shou Woga, Glenn Bauer, and Bruce Stillman

10940

'10205

-10217

10319

10324

10341

10370

10407

10417

10438

10444

10461

10504

10517

10524

10574

10609

10644

Interaction of the NHn- and COOH-terminal domains of the FLP recombinase with the FLP recognition target sequence. Gagan B. Panigrahi and Paul D. Sadowski

PROTEIN CHEMISTRY AND STRUCTURE Racemization of AspPS residue affects the aggregation properties of Alzheimer amyloid @ protein analogues.

Shirasawa, Noriaki Endo, and Hiroshi Mori Takami Tomiyama, Satoshi Asano, Yoshiko Furiya, Takuji

Binding of G protein @?-subunits to pleckstrin homol- ogy domains. Kazushige Touhura, James Inglese, Julie A. Pitcher, Gerry S h w , and Robert J. Lefkowitz

Lip0 rotein lipase domain function. Howard Wong, Rich- ard 8 Dave, Tom Thuren, John W. Goers, Judith Nikazy, Moseky Warte, and Michael C. Schotz

Interaction of desacetamidocolchicine, a fast binding analogue of colchicine with isotypically pure tubulin dimers a h , a@=. and a&. Asok Banerjee, A n D'Hoore, and Yves Engelborghs

Identification of a novel determinant for basic domain- leucine zipper DNA binding activity in the acute-phase inducible nuclear factor-interleukin-6 transcription factor. Allan R. Brasier and Amalendra Kumar

Mutational analysis of the traffic ATPase (ABC) trans- porters involved in uptake of eye pigment precursors in Drosophila melanogaeter. Implications for struc- ture-function relationships. Gary D. Ewart, David Cannell, Graeme B. Cox, and Anthony J . Howelk

boring ligand binding sites on Torpedo acetylcholine Monoclonal antibodies FK1 and WF6 define two neigh-

receptor a-polypeptide. Bernd Schroder, Sigrid Rein-

Axel Kretschmer, Bianca M. Conti-Tronconi, and Alfred hurdt-Maelicke, Andre Schrattenholz, Kathryn E. McLane,

Maelicke

Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers. Lan-bo Shi, William R. Skoch, and A. S. Verkman

cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an en-

Eriksson, Dagmar Sandbick, Bo Ek, Ulf Lindahl, and Lena zyme involved in the biosynthesis of heparin. Inger

Kjelkn

The third helix of the Antennapedia homeodomain translocates through biological membranes. Daniele De- rossi, Alain H. Joliot, Gerard Chnssaing, and Alain Prochiantz

Functional a-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-termi- nal acetyl group. Patricia Brant Monteiro, Renata Cristina Lataro, Jesus Aparecido Ferro, and Fernando de Castro R e i m h

Spectroscopic properties of desulfoferrodoxin from De-

Natarajan Ravi, Jose J . G. Moura, Jean LeGaU, Yun-Hua sulfovibrio desulfuricans (ATCC 27774). Pedro Tavares,

Huang, B r i m R. Crouse, Michael K. Johnson, Boi Hanh Huynh, and Isabel Moura

Regulation of fluorescent fatty acid transfer from adi- pocyte and heart fatty acid binding proteins by acceptor membrane lipid composition and structure. Margo G. Wootan and Judith Storch

Multiple forms of the human tyrosine phosphatase RPTPa. Isozymes and differences in glycosylation.

ger, and Edmond H. Fischer Gunter Daum, Stephun Regenass, Jan Sap, Joseph Schlessin-

Misfolded human chorionic gonadotropin @subunits are secreted from transfected Chinese hamster ovary cells. Elliott Bedows, Sheila E. Norton, Jeffrey R. Huth, Nobuhiko Suganuma, Irving Boime, and Raymond W. Ruddon

Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity. Wengang Zhung, Thomas A. Gustafson, William J . Rutter, and Jeffrey D. Johnson

venom. Polypeptide composition and characterization Factor X-activating glycoprotein of Russell's viper

Jackson, Preston Hensley, and Eugene A. Davidson of the carbohydrate moieties. D. Channe Gowda, Craig M.

Indicates a Communication

xi

10764 The cytoplasmic domain of myelin glyco rotein Po in- teracts with negatively char ed phosphoEpid bilayers. Yungao Ding and Kurt R. B r u d e n

10849 Ranalexin. A novel antimicrobial peptide from bullfrog (Ram coteebeiana) skin, structurally related to the bacterial antibiotic, polymyxin. Dough P. Clurk, Stewart D u d , W . Lee Maloy, and Michael Zasloff

10856 Identification of a novel integrin binding site in fibro-

Bowditch, Meena Hariharan, Eiman F. Tominno, Jeffr W. nectin. Differential utilization by 83 integrins. Ron D.

Smith, Kenneth M. Yamuda, Elizabeth D. Getzoff, andgark H. Ginsberg

10883 The crystal structure o succinyl-CoA s nthetase from Escherichia coli at 2.5-f4 resolution. Wi&um T. Wolodko, Marie E. Fraser, Michael N. G. James, and WiUiam A. Brrdger

10946 Alternative licing governs sulfation of tyrosine or oligosacchar8e on peptidylglycine a-amidating monooxygenase. Hye-Young Yun, Henry T. Keutmann, and Betty A. Eipper

10964 Upfolding/refolding.studies on bovine @-lactoglobulin wlth monoclonal anthxhes as probes. Does a renatured protein completely refold? Vol. 2.68 (1993) 22414-

Makoto Shimizu, and Shuichi Kaminogawa 22419. Makoto Hattort, Aku, Ametanz, Yoshznorr Katakura,

10668 Structural coincidence of aPDGFR epitopes binding to platelet-derived growth factor-AA and a potent neu- tralizing monoclonal antibody. Jin-Chen Yu, Daruka Ma- hadevan, WiUiam J . LaRocheUe, Jacalyn H. Pierce, and Mo- hammod A. Heidaran

10675 Intermediate filament-like network formed in vitro by

Eeva-Liisa Nurmiaho-Lassila, and Mikael Rhen a bacterial coiled coil protein. Reini Hurme, Ellen Namork,

10683 Cloning and expression of a novel acidic calponin iso-

Applegate, Waldo Feng, Robert S. Green, and Mark B. form from rat aortic vascular smooth muscle. Dianne

Taubman

10691 In vitro characterization of nonpeptide irreversible in- hibitors of HIV proteases. Rafael Salto, Lilia M. Babi, Jia Li, Jason R. Rose, Zhonghua Yu, Alma Burlingame, James J. De Voss, Zhihua Sui, Paul Ortiz de Montellano, and Charles S. Craik

10734 She is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21"GTP formation. Toshiyasu Sasaoka, Boris Draznin, J. Wayne Leitner, W. John Langlois, and Jerrold M. Olefsky

Aaronson, Stuart A,, 10753 Aggarwal, Bharat B., 10270 Aktories, Klaus, 10706 Allander, Susanne V., 10891 Ametani, Akio, 10964 Angel, Peter, 10363 Applegate, Dianne, 10683 Arai, Ken-ichi, 10905 Arrebola, Rosalia, 10590 Asano, Satoshi, 10205 Atkinson, John P., 10776 Atweh, George F., 10312 B a k , Lilia M., 10691 Badwey, John A,, 10813 Bagrodia, Shubha, 10247 Bajalica, Svetlana, 10891 Balboa, Maria A,, 10511 Banerjee, Asok, 10324 Banka, Carole L., 10288 Barber, Diane L., 10357 Barbieri, Joseph T., 10431 Baringhaus, Karl-Heinz,

Barter, Philip J., 10298 Bauer, Glenn, 10923

Bedows, Elliott, 10574 Beavis, Andrew D., 10614

Bell, Kelly S., 10511 Benett, Anton M., 10467 Benevides, James M., 10869 Benos, Dale J., 10235 Benovic, Jeffrey L., 10209 Berk, Bradford C., 10935 Bernstein, Kenneth E., 10935 Bevilacqua, Michael P.,

Black, Audrey S., 10288 Blaser, Martin J., 10566

Boger, Georg, 10621 Blumenfeld, Olga O., 10804

Boime, Irving, 10574 Bcquet, Patrice, 10706 Bowditch, Ron D., 10856 Brasier, Allan R., 10341 Bridger, William A., 10883 Brondyk, William H., 10229 Brunden, Kurt R., 10764 Buchner, Johannes, 10304 Burlingame, Alma, 10691 Bussolati, Ovidio, 10485 Cannell, David, 10370 Cao, Long, 10197

10621

10637

Cao, Ping, 10566 Caras, Ingrid W., 10830 Carter, Bing Z., 10699 Case, Randi D., 10467 Chassaing, Gerard, 10444 Chaturvedi, Madan M., 10270 Chedid, Marcio, 10753 Clark, Douglas P., 10849 Cline, Kenneth, 10189 Cohen, Stanley N., 10790,

Conley, Pam, 10651 Conti-Tronconi, Bianca M.,

Corin, Shari J., 10651 Cover, Timothy L., 10566 Cowan, Kenneth H., 10739 Cox, Graeme B., 10370 Cox, Gregory, 10820 Craik, Charles S., 10691 Crick, Dean C., 10559 Crouse, Brian R., 10504 Csaky, Karl G., 10753 Cuif, Marie-Helene, 10213 Curnutte, John T., 10813 Curtiss, Linda K., 10288 Dall'Asta, Valeria, 10485 Daum, Gunter, 10524 David, Michael, 10747 Davidson, Dominique, 10956 Davidson, Eugene A,, 10644 Davis, Richard C., 10319 de Castro Reinach, Fernando,

Deneris, Evan S., 10252

De Voss, James J., 10691 Derossi, Daniele, 10444

DHoore, An, 10324 Diaz-Guerra, Maria-Jose M..

Ding, Jiabing, 10813 Ding, Yungao, 10764 Doiron, Bruno, 10213 Dolce, Vincenza, 10451 Drapp, Darren A., 10193 Draznin, Boris, 10734 Drevet, Joel R., 10660 Duff, Jennifer L., 10935 Duncan, Roger F., 10913 Durell, Stewart, 10849 Eberbardt, Norman L., 10384 Ehrenborg, Ewa, 10891

10797

10407

10461

10213

AUTHOR INDEX

Eipper, Betty A,, 10946 Ek, Bo, 10438 El Khoury, Joseph, 10197 Endo, Noriaki, 10205 Engelborghs, Yves, 10324 Enhsen, Alfons, 10621 Eraso, Pilar, 10393 Erickson, Richard W., 10813 Eriksson, Inger, 10438 Ewart, Gary D., 10370 Falk, Eugen, 10621 Feldman, Gerald M., 10747 Feng, Waldo, 10683 Ferrari, Anna, 10312 Ferro, Jesus Aparecido, 10461 Field, Mark C., 10830 Fillingame, Robert H., 10221 Finbloom, David S., 10747 Fink, Jiirgen, 10621 Fiorella, Paul D., 10538 Firestein, Bonnie L., 10511 Fischer, Edmond H., 10524 Fischer, Petra, 10423 Flowers, Kevin M., 10201 Fournel, Marielle, 10956 Frank, Dara W., 10431 Frank, David W., 10559 Fraser, Marie E., 10883 Friedman, Scott L., 10551 Friedrich, Michael, 10621 Fritz, Gerhard, 10706 Furiya, Yoshiko, 10205 Furuya, Mayumi, 10729 Futai, Masamitsu, 10265 Fyodorov, Dmitry, 10252 Gack, Sabine, 10363 Garrahan, Patricio J., 10400 Garvey, Edward P., 10590 Gazzola, Gian C., 10485 Getzoff, Elizabeth D., 10856 Gilbert, Robin L., 10357 Ginsberg, Mark H., 10856 Girbig, Frank, 10621 Giry, Murielle, 10706 Glass, Jonathan, 10242 Glombik, Heiner, 10621 Goddard, Audrey, 10720 Godowski, Paul J., 10720 Godson, Catherine, 10511 Goers, John W., 10319 Goldsmith, Merrill E., 10739 Gonzalez-Pacanowska,

Gowda, D. Channe, 10644 Green, Robert S., 10683 Grossman, Lawrence, 10771 Gu, Qimin, 10720 Gurevich, Vsevolod V., 10209 Gustafson, Thomas A,, 10609 Gutjahr, Ulrike, 10621 Habib, Geetha M., 10699 Hagiwara, Hiromi, 10729 Hajnkzky, Gyorgy, 10280 Hanasaki, Kohji, 10637 Harbison, Lisa A., 10864 Hariharan, Meena, 10856 Hattori, Makoto, 10964 Hecht, Sidney M., 10899 Hegenbarth, Silke, 10706 Heidaran, Mohammad A.,

Henry, Ralph, 10189 Hensley, Preston, 10644 Herscher, Claudio J., 10400 Hess, Mark A,, 10913 Hickman, Suzanne E., 10197 Higuchi, Masahiro, 10270

Hoffmann, Axel, 10621 Hirose, Shigehisa, 10729

Holz, Ronald W., 10229 Hou, Cuifen, 10357 Howells, Anthony J., 10370 Huang, Cheng-Han, 10804 Huang, Yun-Hua, 10504 Hunt, Joan S., 10864

Huth, Jeffrey R., 10574 Hurme, Reini, 10675

Huynh, Boi Hanh, 10504 Iacobazzi, Vito, 10451 Iatrou, Kostas, 10660 Imakawa, Kazuhiko, 10864 Inglese, James, 10217 Inoue, Sadako, 10330 Inoue, Yasuo, 10330 Insel, Paul A,, 10511 Ismailov, Iskander I., 10235 Itakura, Makoto, 10729 Ito, Tomoko, 10498 Izuta, Shunji, 10225 Jackson, Craig M., 10644 James, Michael N. G., 10883 Jefferson, Leonard S., 10201 Jiang, Shi-Wen, 10384 Johnson, Jeffrey D., 10609

Dolores, 10590

10668

Johnson, Michael K., 10504 Joliot, Alain H., 10444 Juhasz, Ondrej, 10651 Just, Ingo, 10706 Kahn, Axel, 10213 Kahn, Richard A,, 10758 Kamata, Yoichi, 10498 Kaminogawa, Shuichi, 10964 Kane, Stefanie A., 10899 Kapazoglou, Aliki, 10189 Karlish, Steven J. D., 10780 Katakura, Yoshinori, 10964 Kato, Shigeaki, 10545 Kato, Yukio, 10545 Kedes, Larry, 10651 Keller, Gilbert-An&, 10830 Kent, Claudia, 10529 Keutmann, Henry T., 10946 Kiefer, Michael C., 10891 Kim, Ick Young, 10597 Kim, Ki-Han, 10475 Kim, Su Young, 10820 Kimball, Scot R., 10201 Kitajima, Ken, 10330 Kitazume, Shinobu, 10330

Koga, Yosuke, 10492 Kjellen, Lena, 10438

Konig, Stephan, 10879 Kosugi, Hiroshi, 10905 Kowalewski, Simone, 10621 Kozaki, Shunji, 10498 Krag, Sharon S., 10559 Kramer, Werner, 10621 Kretschmer, Axel, 10407 Kuizon, Luzette, 10229 Kulich, Scott M., 10431 Kumar, Amalendra, 10341 Kunapuli, Priya, 10209 Kwon, Young-Guen, 10966 Lagarias, J. Clark, 10965 Lammers, Reiner, 10423 Langlois, W. John, 10734 Larner, Andrew C., 10747 LaRochelle, William J.,

Larsson, Catharina, 10891 Lataro, Renata Cristina,

Laudano, Andrew P., 10247 Lawrence, David S., 10966 Lebovitz, Russell M., 10699 Lechleider, Robert J., 10467

10668

10461