６.【参考】研究果発表

(１) 原著論文（査読付き）

①抗体創薬・エピゲノム創薬・核内受容体創薬

1) Kuwahara A, Hirabayashi Y, Knoepfler PS, Taketo MM, Sakai J, Kodama T, Gotoh Y: Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development 137: 1035-1044, 2010【国外誌】

2) Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T: Sterol regulatory element-binding protein 2 and nuclear factor Y controls human farnesyl diphosphate synthase expression and affects cell proliferation in hepatoblastoma cells. Biochem J 429(2):347-57,2010【国外誌】

3) Okamura M, Inagaki T, Tanaka T, Sakai J.: Role of histone methylation and demethlaion in a dipogenesis and obesity. Organogenesis 6, 24-32,2010【国外誌】

4) Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, and Takakura N: PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties. Cancer. Res. 70: 1215-24, 2010【国外誌】

5) Suehiro J, Hamakubo T, Kodama T, Aird WC, and Minami T: Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. Blood 115: 2520-32, 2010【国外誌】

6) Papantonis A, Larkin J D, Wada Y, Ohta Y, Ihara S, Kodama T, and *Cook P R :2010

Active RNA polymerases: mobile or immobile molecular machines? PLoS biology 8, e1000419,2010【国外誌】

7) Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H, Kaneda A: Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma.Cancer Sci. 2010 Jun,101:1501-10, Epub 2010 Feb 27【国外誌】

8) Seki M, Watanabe A, Enomoto S, Kawamura T, Ito H, Kodama T, Hamakubo T, Aburatani H: Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells. FEBS Lett. 584:2909-15, 2010【国外誌】

9) International Cancer Genome Consortium. International network of cancer genome projects. Nature 464:993-8, 2010【国外誌】

10) Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H, Kaneda A: Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci. 101:1501-10, 2010【国外誌】

11) Yamamoto S, Midorikawa Y, Morikawa T, Nishimura Y, Sakamoto H, Ishikawa S, Akagi K, Aburatani H: Identification of chromosomal aberrations of metastatic potential in colorectal carcinoma. Genes Chromosomes Cancer. 49:487-96, 2010【国外誌】

12) Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H: Genome-wide single nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in PI3-kinase pathway. Oncogene 29:1897-908, 2010【国外誌】

13) Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, Isagawa T, Midorikawa Y, Nishimura Y, Sakamoto H, Seto Y, Aburatani H, Kaneda A. :Three DNA Methylation Epigenotypes in Human Colorectal Cancer. Clin Cancer Res. 16:21-33, 2010【国外誌】

14) Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, Doi T: Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARalpha-independent mechanisms. Eur J Cell Biol 90, 657-664,2011【国外誌】

15) Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J (corresponding author), Aburatani H, Kadowaki T :Global mapping of cell type–specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation. PLoS Genet 7, e1002311,2011【国外誌】

16) Fox R, Kim H S, Reddick R L, Kujoth G C, ProllaT A, Tsutsumi S, WadaY, Smithies O, and *Maeda N: Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite. Proceedings of the National Academy of Sciences of the United States of America 108, 8779-8784,2011 【国外誌】

17) Wada Y, Li D, Merley A, Zukauskas A, Aird W C,　Dvorak H F, and *Shih S C 2011:A multi-gene transcriptional profiling approach to the　discovery of cell signature markers. Cytotechnology 63, 25-33, 2011 【国外誌】

18) Mimura I, Tanaka T, Wada Y, Kodama T, and *NangakuM. : Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug　discovery: epigenetic regulation of the hypoxic response via　hypoxia-inducible factor and histone modifying enzymes. Journal of pharmacological sciences 115, 453-458, 2011【国外誌】

19) Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, and *Minami T: Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. The EMBO journal 30, 2582-2595, 2011【国外誌】

20) Kaneda A, Fujita T, Anai M, Yamamoto S, Nagae G, Morikawa M, Tsuji S, Oshima M, Miyazono K, Aburatani H: Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence. PLoS Genetics 7:e1002359, 2011【国外誌】

21) Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M: Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res. 71:7187-97, 2011【国外誌】

22) Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K: ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res. 39:8712-27, 2011【国外誌】

23) Watanabe A, Ogiwara H, Ehata S, Mukasa A, Ishikawa S, Maeda D, Ueki K, Ino Y, Todo T, Yamada Y, Fukayama M, Saito N, Miyazono K, Aburatani H: Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc Natl Acad Sci U S A. 108:12384-9, 2011【国外誌】

24) Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H: Tissue-specific demethylation in CpG-poor promoters during cellular differentiation. Hum Mol Genet. 20:2710-21, 2011【国外誌】

25)Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, Ishikawa S, Tsutsumi S, Sonoda K, Totsuka H, Shirakihara T, Sakamoto H, Wang L, Ojima H, Shimada K, Kosuge T, Okusaka T, Kato K, Kusuda J, Yoshida T, Aburatani H, Shibata T :High-resolution characterization of a hepatocellular carcinoma genome. Nature Genetics 43:464-9,2011【国外誌】

26) Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro J, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y: Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A. Mol Cell Biol 32:3018-3032,2012【国外誌】

27) Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S, Itoh H.: Novel repressor regulates insulin sensitivity through interaction with Foxo1. The Embo Journal 31:2275-2295, 2012【国外誌】

28) Tsuji S, Ihara S, Aburatani H.: A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network. BMC Syst Biol. 6: 124, 2012【国外誌】

29) Kaneda A, Matsusaka K, Aburatani H, Fukayama M: Epstein-barr virus infection as an epigenetic driver of tumorigenesis. Cancer Res. 72:3445-50, 2012【国外誌】

30) Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H:Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Research 22:208-19, 2012 【国外誌】

31) Yagi K, Takahashi H, Akagi K, Matsusaka K, Seto Y, Aburatani H, Nakajima A, Kaneda A: Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma. Am J Pathology 180:616-25, 2012【国外誌】

32) Tsuji S, Midorikawa Y, Takahashi T, Yagi K, Takayama T, Yoshida K, Sugiyama Y, Aburatani H: Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis. Br J Cancer. 106:126-32, 2012 【国外誌】

33) Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H :ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis. Lung Cancer. 75:119-25, 2012【国外誌】

34) Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro JI, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M.: Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Cancer Res. 2013 Mar 14. [Epub ahead of print] 【国外誌】

35)Young-Hun Lee, Mariko Iijima, Yuji Kado, Eiichi Mizohata, Tsuyoshi Inoue, Akira Sugiyama, Hirofumi Doi, Yoshikazu Shibasaki, Tatsuhiko Kodama:Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies,Biochem. Biophys. Res. Commun. 441 (2013) 1011-1017.【国外誌】

36)Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S: Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat Genet. 2014 Jun;46(6):583-7.Epub 2014 May 11. 【国外誌】

37)Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Johan A, J. GF, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J:「PPAR beta/delta activation of CD300a controls intestinal immunity.」Scientific Reports 4, 5412, (2014).【国外誌】

38)Inagaki T1,2, Iwasaki S1, Matsumura Y, Kawamura T, Tanaka T, Abe Y, Yamasaki A, Tsurutani Y, Yoshida A, Chikaoka Y, Nakamura K, Magoori K, Nakaki R, Osborne TF, Fukami K, Aburatani H, Kodama T, Sakai J2 (1 equal contribution, 2 corresponding authors):「The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis」, J Biol Chem,Feb 13;290(7), 4163-77, (2015) 【国外誌】

39)Abe Y1, Rozqie R1, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki* T, Sakai* J. (1 equal contribution, * corresponding authors):「JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.」, Nature Comm. 6-7052, (2015) 【国外誌】

40)Raza-Iqbal S, Tanaka T, Anai M, Inagaki T, Matsumura Y, Ikeda K, Taguchi A, Gonzalez FJ, Sakai J, Kodama T.：「Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.」, J Atheroscler Thromb., Aug 26-22(8), 754-72, (2015) 【国外誌】

41)Matsumura Y*, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J* (* corresponding authors):「H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-specific DNA Methylation Pauses Adipocyte Differentiation」, Mol Cell., Nov 19;60(4), 584-96, (2015) 【国外誌】

42)Inagaki T, Sakai J, Kajimura S.:「Transcriptional and epigenetic control of brown and beige adipose cell fate and function」, Nature Reviews Molecular Cell Biology, 6, 17, 480-495, (2016) 【国外誌】

43)Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro JI, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M.: Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages. Cancer Res. 2013 Mar 14. [Epub ahead of print] 【国外誌】

44)Kazuki Yamamoto, Yoko Chikaoka, Gosuke Hayashi, Ryosuke Sakamoto, Ryuji Yamamoto, Akira Sugiyama, Tatsuhiko Kodama, Akimitsu Okamoto, and Takeshi Kawamura.： Middle-Down and Chemical Proteomic Approaches to Reveal Histone H4 Modification Dynamics in Cell Cycle: Label-Free Semi-Quantification of Histone Tail Peptide Modifications Including Phosphorylation and Highly Sensitive Capture of Histone PTM Binding Proteins Using Photo-Reactive Crosslinkers. Mass Spectrometry Vol. 4 (2015) No. 1 p. A0039 Published online July 14, 2015 【国外誌】

45)Fukuda T, Hike H, Usui F, Bando Y, Nishimura T, Kodama T, Kawamura T.: An improvement on mass spectrometry-based epigenetic analysis of large histone-derived peptides by using the Ionization Variable Unit interface. Anal Biochem. 2015 Jun 5;486:14-16. [Epub ahead of print]PMID: 26050628【国外誌】

46)Yohei Abe, Royhan Rozqie, Yoshihiro Matsumura, Takeshi Kawamura, Ryo Nakaki, Yuya Tsurutani, Kyoko Tanimura-Inagaki, Akira Shiono, Kenta Magoori, Kanako Nakamura, Shotaro Ogi, Shingo Kajimura, Hiroshi Kimura, Toshiya Tanaka, Kiyoko Fukami, Timothy Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, Takeshi Inagaki, and Juro Sakai. :JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nat Commun. 2015 May 7;6:7052. doi: 10.1038/ncomms8052. PMID: 25948511　【国外誌】

47)Takeshi Inagaki, Satoshi Iwasaki, Yoshihiro Matsumura, Takeshi Kawamura, Toshiya Tanaka, Yohei Abe, Ayumu Yamasaki, Yuya Tsurutani, Ayano Yoshida,Yoko Chikaoka, Kanako Nakamura, Kenta Magoori, Ryo Nakaki, Timothy F. Osborne, Kiyoko Fukami, Hiroyuki Aburatani, Tatsuhiko Kodama, and Juro Sakai. The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis. J. Biol. Chem., 290, 4163-4177 (2015). 【国外誌】

48)Sana Raza-Iqbal, Toshiya Tanaka, Motonobu Anai, Takeshi Inagaki, Yoshihiro Matsumura, Kaori Ikeda, Akashi Taguchi, Frank J. Gonzalez, Juro Sakai, and Tatsuhiko Kodama. Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver. J. Atherosclero. Thromb.,22: 754-772 (2015). 【国外誌】

49)Yoshihiro Matsumura, Ayano Yoshida, Ryo Nakaki, Yuka Kano, Hiroshi Kimura, Toshiya Tanaka, Takeshi Inagaki, Yoichi Shinkai, Kiyoko Fukami, Takefumi Doi,8 Timothy F. Osborne, Tatsuhiko Kodama, Hiroyuki Aburatani, Juro Sakai. H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-specific DNA Methylation Pauses Adipocyte Differentiation. Mol. Cell, 60: 584-596 (2015). 【国外誌】

50)Yuji Kado, Eiichi Mizohata, Satoru Nagatoishi, Mariko Iijima, Keiko Shinoda, Takamitsu Miyafusa, Taisuke Nakayama, Takuma Yoshizumi, Akira Sugiyama, Takeshi Kawamura, Young-Hun Lee, Hiroyoshi Matsumura, Hirofumi Doi, Hideaki Fujitani, Tatsuhiko Kodama, Yoshikazu Shibasaki, Kouhei Tsumoto and Tsuyoshi Inoue:Epiregulin recognition mechanisms by anti-epiregulin antibody 9E5,Journal of Biological chemistry, 291 (2016) 2319-2330.【国外誌】

51)Mariko Iijima, Motonobu Anai, Tatsuhiko Kodama, Yoshikazu Shibasaki: Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling,Biochem. Biophys. Res. Commun. (2017)　【国外誌】

2 低侵襲・高精度診断・治療機器

52)Koizumi N, Warisawa S, Hashizume H, and Mitsuishi M: Continuous path controller for the remote ultrasound diagnostic system. IEEE/ASME Trans. on Mechatronics 13: 206-218, 2008【国外誌】

53)Koizumi N, Warisawa S, Nagoshi M, Hashizume H, Mitsuishi M: Construction methodology for a remote ultrasound diagnostic system. IEEE Trans. on Robotics 25: 522-538, 2009【国外誌】

54)Seo J, Koizumi N, Yoshinaka K, Sugita N, Nomiya A, Homma Y, Matsumoto Y, Mitsuishi M：Three-dimensional computer controlled acoustic pressure scanning and quantification of focused ultrasound. IEEE Trans. on Ultrasonics, Ferroelectrics, and Frequency Control 57: 883-891,2010【国外誌】

55)Ando T, Kobayashi E, Liao H, Maruyama T, Muragaki Y, Iseki H, Kubo O, Sakuma I: Precise Comparison of Protoporphyrin IX Fluorescence Spectra with Pathological Results for Brain Tumor Identification, Brain Tumor Pathology 28: 43-51, 2011 Published online Dec. 25, 2010【国外誌】

56)Liao H, Inomata T, Sakuma I, Dohi T: 3-D Augmented Reality for MRI-guided Surgery using Integral Videography Autostereoscopic Image Overlay. IEEE Transactions on Biomedical Engineering 57: 1476-1486, 2010【国外誌】

57)Liao H, Ishihara H, Tran HH, Masamune K, Sakuma I, Dohi T: Precision-guided Surgical Navigation System using Laser Guidance and 3-D Autostereoscopic Image Overlay. Computerized Medical Imaging and Graphics 34: 46-54, 2010【国外誌】

58) Shimazoe K, Takahashi H, Fujita K, Mori H, Momose T: Development of positron sensor for multi-modal endoscopy. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 648: Supplement 1, 21 August 2011, S116-S118【国外誌】

59)Shi B, Shimazoe K, Wang Y, Fujiwara T, Takahashi H, Iyomoto N: Development of Waveform Multiplexing Method With Decay Time Modulation for Front-End ASIC of Pixelated Detectors. IEEE Transactions on Nuclear Science 58, 2019-2023, Aug. 2011【国外誌】

60)Orita T, Takahashi H, Shimazoe K, Fujiwara T, Boxuan S: A new pulse width signal processing with delay-line and non-linear circuit (for ToT). Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 648: Supplement 1, 21 August 2011, S24-S27【国外誌】

61)Seo J, Koizumi N, Funamoto T, Sugita N, Yoshinaka K, Nomiya A, Ishikawa A, Homma Y, Matsumoto Y, Mitsuishi M： Biplane US guided real-time volumetric target pose estimation method for theragnostic HIFU system. Journal of Robotics and Mechatronics 23: 400-407, 2011【国外誌】

62)Seo J, Koizumi N, Funamoto T, Naohiko S, Yoshinaka K, Nomiya A, Ishikawa A, Homma Y, Matsumoto Y, Mitsuishi M：Visual Servoing for a US-guided therapeutic HIFU system by coagulated lesion tracking: a phantom study. International Journal of Medical Robotics and Computer Assisted Surgery 7: 237-247,2011【国外誌】

63)Wang J, Ohya T, Liao H, Sakuma I, Wang T, I Tohnai I, T Iwai T: Intravascular Catheter Navigation Using Path Planning and Virtual Visual Feedback for Oral Cancer Treatment. The International Journal of Medical Robotics and Computer Assisted Surgery 7: 214-224, 2011【国外誌】

64)Ando T，Taniguchi K, Kim H, Joung S, Kobayashi E, Liao H, Sakuma I: High Sensitive Fluorescence Endoscope using Electrocardiography-Synchronized Multiple Exposure. International Journal of Computer Assisted Radiology and Surgery 6: 73-81, 2011【国外誌】

65) 廖洪恩，山下紘正，正宗賢，佐久間一郎，土肥健純：三次元画像技術を活用した低侵襲高精度診断治療用手術支援システム. 生体医工学49: 641-646, 2011【国内誌】

66)Shimazoe K, Takahashi H, Boxuan Shi, Orita T, Furumiya T, Ooi J, Kumazawa Y: Dynamic Time Over Threshold Method. IEEE Transactions on Nuclear Science 59: 3213-3217, Dec. 2012【国外誌】

67)Damayanthia RMT, Ohno M, Hatakeyama S, Takahashi H, Maehata K, Yasumune T, Iyomoto N: Observation of very fast response signals from Pb absorber coupled transition edge sensor gamma-ray microcalorimeter. Nucl. Instr. and Meth. A. 691: 30-33, 2012【国外誌】

68)Koizumi N, Seo J, Funamoto T, Nomiya A, Ishikawa A, Yoshinaka K, Sugita N, Homma Y, Matsumoto Y, Mitsuishi M： Technologizing and Digitalizing Medical Professional Skills for a Non-Invasive Ultrasound Theragnostic System. Journal of Robotics and Mechatronics. 24: 379-388,2012【国外誌】

69)Zhang Y, Tachibana R, Okamoto A, Azuma A, Sasaki A, Yoshinaka K, Osada K, Kataoka K, Takagi S, Matsumoto Y: Ultrasound-Mediated Gene Transfection in vitro: Enhanced Efficiency by Complexation of Plasmid DNA. Jpn. J. of Appl. Phys. 51: 07GF29-33, 2012【国内誌】

70)Zhang YW, Tachibana R, Okamoto R, Azuma A, Sasaki A, Yoshinaka K, Tei Y, Takagi S, Matsumoto Y: Ultrasound-Mediated Gene Transfection in vitro: Effect of Ultrasonic Parameters on Efficiency and Cell Viability. Int. J. Hyperthermia 28: 290-299, 2012【国外誌】

71)Gooya A, Liao H, Sakuma I: Generalization of Geometrical Flux Maximizing Flow on Riemannian Manifolds for Improved Volumetric Blood Vessel Segmentation. Computerized Medical Imaging and Graphics 36: 474-483, 2012 【国外誌】

72)Liao H, Noguchi M, Maruyama T, Muragaki Y, Kobayashi E, Iseki H, Sakuma I: An Integrated Diagnosis and Therapeutic System using Intraoperative 5-Aminolevulinic-Acid-Induced Fluorescence Guided Robotic Laser Ablation for Precision Neurosurgery. Medical Image Analysis 16: 754-766, 2012【国外誌】

73) Shimazoe K, Takahashi H, Yeom JY, Furumiya T, Ohi J: Multi-channel Waveform Sampling ASIC for radiation detection and measurement. Radiation Measurements, Available online 6 February 2013, ISSN 1350-4487, 10.1016/j.radmeas.2013.01.022【国外誌】

74)Hatakeyama S, Ohno M, et al.: Development of hard X-ray and γ-ray spectrometer using superconducting transition edge sensor. IEEE TRANS. ON APPL. SUPERCONDUCTIBITY23: 2100804, 2013【国外誌】

75) Narumi R, Matsuki K, Mitarai S, Azuma T, Okita K, Sasaki A, Yoshinaka K, Takagi S, Matsumoto Y: Focus Control Aided by Numerical Simulation in Heterogeneous Media for High-Intensity Focused Ultrasound Treatment. Jpn. J. of Appl. Phys. 52: 07HF01, 2013【国内誌】

76)Ayumu Ishijima, Jun Tanaka, Takashi Azuma, Kosuke Minamihata, Satoshi Yamaguchi,Etsuko Kobayashi, Teruyuki Nagamune, Ichiro Sakuma:「The lifetime evaluation of vapourised phase-change nano-droplets」, Ultrasonics 69 ,pp97 - 105, (2016) 【国外誌】

77)Liangjing Yang, Junchen Wang, Takehiro Ando, Akihiro Kubota, Hiromasa Yamashita, Ichiro Sakuma, Toshio Chiba, and Etsuko Kobayashi：「Towards scene adaptive image correspondence for placental vasculature mosaic in computer assisted fetoscopic procedures」,The International Journal of Medical Robotics and Computer Assisted Surgery,pp375-386(2016) 【国外誌】

78)Liangjing Yang, Junchen Wang, Takehiro Ando, Akihiro Kubota, Hiromasa Yamashita, Ichiro Sakuma, Toshio Chiba, and Etsuko Kobayashi：「Self-contained image mapping of placental vasculature in 3D ultrasound-guided fetoscopy」, Surgical Endoscopy,pp4136-4149, (2015) 【国外誌】

79)L. Yang, J. Wang, T. Ando, H. Yamashita, I. Sakuma, T. Chiba, E. Kobayashi：「Vision-based endoscope tracking for 3D ultrasound image-guided surgical navigation」,Computerized Medical Imaging and Graphics, Volume 40, Pages 205–216（2015）【国外誌】

80)T. Suzuki, F. Isa, L. Fujii, K. Hirosawa, K. Nakagawa, K. Goda, I. Sakuma, F. Kannari：「Sequentially timed all-optical mapping photography (STAMP) utilizing spectral filtering」, Optics Express, vol. 23, pp. 30512-30522, （2015）【国外誌】

81)T. Zhou, T. Ando, K. Nakagawa, H. Liao, E. Kobayashi and I. Sakuma：「Localizing fluorophore (centroid) inside a scattering medium by depth perturbation」, Journal of Biomedical Optics 20,　pp017003, (2015) 【国外誌】

82)R. Tachikawa, A. Tsukamoto, Y. Monden, K. Nakagawa, T. Ando, E. Kobayashi, T. Ushida and I. Sakuma：「Development of Cavitation Bubble Observation System and Application to Study Expansion Waves and Shock Waves」, Advanced Biomedical Engineering 4,pp 96-104, (2015) 【国外誌】

83)Xiaolei Qu, Takashi Azuma, Haruka Imoto, Riaz Raufy, Hongxiang Lin, Hirofumi Nakamura, Satoshi Tamano, Shu Takagi, Shin-ichiro Umemura, Ichiro Sakuma:「Novel automatic first-arrival picking method for ultrasound sound-speed tomography」, Jpn. J. Appl. Phys. 54 ,07HF10（2015）【国外誌】

84)M. Tamamitsu, K. Nakagawa, R. Horisaki, A. Iwasaki, Y. Oishi, A. Tsukamoto, F. Kannari, I. Sakuma, and K. Goda:「Design for sequentially timed all-optical mapping photography with optimum temporal performance」, Optics letters, vol. 40, pp. 633-636, （2015）【国外誌】

85)Kazuki Hashimoto, Hikaru Mizuno, Keiichi Nakagawa, Ryoichi Horisaki, Atsushi Iwasaki, Fumihiko Kannari, Ichiro Sakuma, Keisuke Goda:「High-speed multispectral videography with a periscope array in a spectral shaper」, OPTICS LETTERS Vol. 39, No. 24 , pp6942-6945,（2014）【国外誌】

86)K. Nakagawa, A. Iwasaki, Y. Oishi, R. Horisaki, A. Tsukamoto, A. Nakamura, K. Hirosawa,H. Liao, T. Ushida, K. Goda, F. Kannari, I. Sakuma: Sequentially timed all-optical mapping photography (STAMP)」, NATURE PHOTONICS VOL 8, pp695-700, （2014）【国外誌】

87)Lianging Yang, Junchen Wang, Etsuko Kobayashi, Takehiro Ando, Hiromasa Yamashita, Ichiro Sakuma, Toshio Chiba: 【Image mapping of untracked free-hand endoscopic views to an ultrasound image-constructed 3D placenta model】, Int J Med-Robotics Comput Assist Surg,pp223-234,（2015）【国外誌】

88)Tuo ZHOU, Takehiro ANDO,Hongen LIAO, Etsuko KOBAYASHI, Ichiro SAKUMA：「Piecewise Weighted Tikhonov Regularization for Reconstructing Fluorophore Distribution in Tissue using Mesoscopic Epifluorescence Tomography」,Advanced Biomedical Engineering vol.2, pp84-94, （2013）【国外誌】

89)K. Nakagawa, A. Tsukamoto, T. Arafune, H. Liao, E. Kobayashi, T. Ushida and I. Sakuma, 「A Miniaturized Shock-Wave Device for Mounting on Forceps」, J. Biomechanical Science and Engineering 8,pp17-26 (2013) 【国外誌9089)Montagne K., Uchiyama H., Furukawa K.S. and Ushida T：「Hydrostatic pressure decreases membrane fluidity and lipid desaturase expression in chondrocyte progenitor cells」,Journal of Biomechanics,47(2),354-359,（2014）【国外誌】

91)Montagne K., Oh D., Kim J.H., Ushida T. and Furukawa K.S.：「Involvement of the mTOR pathway in redifferentiation of bovine chondrocytes under dynamic hydrostatic loading」,Japanese Journal of Clinical Biomechanics,37,1-8,（2016）【国内誌】

92)S. Yamaguchi, M. Ura, S. Izuta, A. Okamoto: 「Chemically activatable alkyne tag for low pH-enhanced molecular labeling on living cells」, Bioconju. Chem., 27, 1976-1980, (2016) 【国外誌】

93) A. Ishijima, K. Minamihata, S. Yamaguchi, S. Yamahira, R. Ichikawa, E. Kobayashi, M. Iijima, Y. Shibasaki, T. Azuma, T. Nagamune, I. Sakuma, 「Selective intracellular vaporisation of antibodyconjugated phasechange nanodroplets in vitro」, accepted in Sci. Rep (2017) 【国外誌】

94) X. Qu, T. Azuma, R. Sugiyama, K. Kanazawa, M. Seki, A. Sasaki, H. Takeuchi, K. Fujiwara, K. Itani, S. Tamano, S. Takagi, I. Sakuma, and Y. Matsumoto, 「Improved highly accurate localized motion imaging for monitoring high-intensity focused ultrasound therapy」, Jpn. J. Appl. Phys., 55, 07KF04, (2016) 【国外誌】

95) R. Sugiyama, K. Kanazawa, M. Seki, T. Azuma, A. Sasaki, H. Takeuchi, K. Fujiwara, K. Itani, S. Tamano, K. Yoshinaka, S. Takagi, and Y. Matsumoto, 「Real-time feedback control for high-intensity focused ultrasound system using localized motion imaging」, Jpn. J. Appl. Phys. 54, 07HD15, (2015) 【国外誌】

96) K. Okita, R. Narumi, T. Azuma, S. Takagi, Y. Matumoto, 「The role of numerical simulation for the development of an advanced HIFU system」, Comput. Mech.　54, 1023-1033, (2014) 【国外誌】

97) R. Narumi, K. Matsuki, S. Mitarai, T. Azuma, K. Okita, A. Sasaki, K. Yoshinaka, S. Takagi, and Y. Matsumoto, 「Focus Control Aided by Numerical Simulation in Heterogeneous Media for High-Intensity Focused Ultrasound Treatment」, Jpn. J. Appl. Phys. 52, 07HF01-1-9, (2013) 【国外誌】

98) Y. Zhang, R. Tachibana, A. Okamoto, T. Azuma, A. Sasaki, K. Yoshinaka, K. Osada, K. Kataoka, S. Takagi, Y. Matsumoto「Ultrasound-Mediated Gene Transfection in vitro: Enhanced Efficiency by Complexation of Plasmid DNA」, Jpn. J. of Appl. Phys., 51, 07GF29-33, (2012) 【国外誌】

99) Y. W. Zhang, R. Tachibana, A. Okamoto, T. Azuma, A. Sasaki, K. Yoshinaka, Y. Tei, S. Takagi, and Y. Matsumoto, 「Ultrasound-Mediated Gene Transfection in vitro: Effect of Ultrasonic Parameters on Efficiency and Cell Viability」, Int. J. Hyperthermia, 28, 290-299, (2012) 【国外誌】

3 生活習慣病の診断薬・治療薬

100)Kondo K, Kadowaki T: Colestilan monotherapy significantly improves glycaemic control and LDL cholesterol levels in patients with type 2 diabetes: a randomized double-blind placebo-controlled study. Diabetes Obes. Metab. 12: 246-251, 2010【国外誌】

101)Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T: Adiponectin and AdipoR1 regulate PGC1α and mitochondria by Ca2+ and AMPK/SIRT1. Nature 464: 1313-1319, 2010【国外誌】

102)Waki K, Terasaki PI, Kadowaki T: Long-term panocreas allograft survival in simultaneous pancreas-kidney transplantation by era: UNOS registry analysis. Diabetes Care 33: 1789-1791, 2010【国外誌】

103)Noda M, Kato M,Takahashi Y, Matsushita Y, Mizoue T, Inoue M, Tsugane S, Kadowaki T: Fasting plasma glucose and 5-year incidence of diabetes in the JPHC diabetes study - suggestion for the threshold for impaired fasting glucose among Japanese. Endocr. J. 57: 629-637, 2010【国外誌】

104)Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Grarup N, Cauchi S, Ng DPK, Ma RCW, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jørgensen T, Lauritzen T, Sandbæk A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So WY, Beury D, Chan JCN, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwag A, Kawamori R, Kasuga M, Frogue P, Pedersen O, Kamatani N, Nakamura Y, Kadowaki T: A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.

Nature Genetics 42: 864-868, 2010【国外誌】

105)Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T: Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms. Cell Metabolism 12: 619-632, 2010【国外誌】

106)Kadowaki T, Nishida T, Kaku K: 28-week, randomized, multicenter, open-label, parallel-group phase III trial to investigate the efficacy and safety of biphasic insulin aspart 70 thrice-daily injections vs twice-daily injections of biphasic insulin aspart 30 in patients with type 2 diabetes. J. Diabetes Invest. 1: 103-110, 2010【国外誌】

107)Takamoto I, Kadowaki T: Controversies about the importance of increased waist circumference.

International Diabetes Moniter.22: 10-17, 2010【国外誌】

108)Sakoda H, Ito S, Kanda H, Fujishiro M, Osuga JI, Tsukamoto K, Ueki K, Kadowaki T: Association between type 1 diabetes mellitus and remitting seronegative symmetrical synovitis with pitting edema: A case report. Diabetes Res. Clin. Pract. 91:e43-44, 2011【国外誌】

109)Kumagai K, Kubota N, Saito TI, Sasako T, Takizzawa R, Sudo K, Kurokawa M, Kadowaki T: Generation of transgenic mice on an NOD/SCID background using the conventional microinjiction technique. Biol. Reprod. 84:682-688, 2011【国外誌】

110)Iizuka Y, Ohashi K, Tsukamoto K, Ueki K, Kadowaki T: Education and management of diabetes at The University of Tokyo Hospital. J. Diabetes 3: 104-108, 2011【国外誌】

111)Kadowaki T and Yamauchi T: Adiponectin receptor signaling: a new layer to the current model.

Cell Metabolism 13: 123-124, 2011【国外誌】

112)Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, SasakoT, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue, K Kodama T, Ueki K, Kadowaki T: Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle. Cell Metabolism 13: 294-307, 2011【国外誌】

113)Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T: Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via macrophage-derived IL-6 dependent pathway. Cell Metabolism 13: 401-412, 2011【国外誌】

114)Endo Y, Suzuki M, Yamada H, Horita S, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T: Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARα-dependent non-genomic signaling. Cell Metabolism 13:550-561, 2011【国外誌】

115)Ueki K and Kadowaki T: The other sweet face of XBP1. Nature Medicine 17: 246-248, 2011【国外誌】

116)Kobayashi N, Ueki K, Okazaki Y, Iwane A, Kubota N, Ohsugi M, Awazawa M, Kobayashi M, Sasako T, Kaneko K, Suzuki M, Nishikawa Y, Hara K, Yoshimura K, Koshima I, Goyama S, Murakami K, Sasaki J, Nagai R, Kurokawa M, Sasaki T, Kadowaki T: Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. USA 108: 5753-5758, 2011【国外誌】

117)Kadowaki T: Our sympthies to the people affected by the Great East Japan Earthquake, and the activities of the Japan Diabetes Society. Diabetol. Int. 2: 45-46, 2011【国外誌】

118)Cho YS, Chen CH, Hu C, Long J, Ong RTH, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RCW, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJM, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DPK, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman AK, Morris AP, McCarthy MI, Diagram consortium, MuTHER consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JCN, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M: Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nature Genetics 44:67-72, 2011【国外誌】

119)Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H, Kadowaki T: Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation. PLoS Genet. 7:e1002311, 2011【国外誌】

120)Kadowaki T, Nishida T, Kaku K：Safety and efficacy of switching thrice-daily treatment with NovoRapid®70Mix (BIAsp70) to BIAsp70 before breakfast and lunch and NovoRapid®30Mix (BIAsp30) before dinner in patients with type 2 diabetes: subgroup analysis of a phase III trial.Diabetol. Int. 2:183–189, 2011【国外誌】

121)Kadowaki T, Yamauchi T, Waki H: Adiponectin, Adiponectin receptors, and Epigenetic Regulation of Adipogenesis. Cold Spring Harb. Symp. Quant. Biol. 76:257-265, 2011【国外誌】

122)Kadowaki T, Ueki K, Yamauchi T, Kubota N. SnapShot: Insulin Signaling Pathways. Cell 148:624-624, 2012【国外誌】

123)Kadowaki T, Kubota N, Ueki K, Yamauchi T. SnapShot: Physiology of Insulin Signaling. Cell 148:834-834, 2012【国外誌】

124)Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Iwata M, Hirose H, Kaku K, Ito C, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Kasuga M, Kamatani N, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y, Kadowaki T: A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.　Human Molecular Genetics 21:3042-3049, 2012【国外誌】

125)Oe M, Sanada H, Nagase T, Minematsu T, Ohashi Y, Kadono T, Ueki K, Kadowaki T: Factors associated with deep foot fissures in diabetic patients: a cross-sectional observational study.Int. J. Nurs. Stud. 49:739-746, 2012【国外誌】

126)Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R: Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metabolism15:518-533 , 2012【国外誌】

127)Kadowaki T, Ohtani T, Odawara M: Potential Formula for the Calculation of Starting and Incremental Insulin Glargine Doses: ALOHA Subanalysis.PLoS One 7:e41358. Epub, 2012【国外誌】

128)Odawara M, Ohtani T, Kadowaki T: Dosing of Insulin Glargine to Achieve the Treatment Target in Japanese Type 2 Diabetes on a Basal Suppoted Oral Therapy Regimen in Real Life: ALOHA Study Subanalysis.Diabetes Technol Ther. 14:635-643, 2012【国外誌】

129)Eto T, Inoue S, Kadowaki T:Effects of once-daily teneligliptin on 24-h blood glucose control and safety in Japanese patients with type 2 diabetes mellitus: a 4-week, randomized, double-blind, placebo-controlled trial. Diabetes, Obesity and MetabolismEarly View 14:1040-1046, 2012【国外誌】

130)Shojima N, Hara K, Fujita H, Horikoshi M, Takahashi N, Takamoto I, Ohsugi M, Aburatani H, Noda　M, Kubota　N, Yamauchi T, Ueki K, Kadowaki T:Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice.Diabetologia 55: 3318-3330, 2012【国外誌】

131)Waki H, Yamauchi T, Kadowaki T: The epigenome and its role in diabetes. Curr. Diab. Rep. 12:673-685, 2012 【国外誌】

132)Yamada T, Hara K, Kadowaki T: Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.PLoS One. 7:e42031, 2012 doi: 10.1371/journal.pone.0042031. Epub 2012 Jul 25【国外誌】

133)Yamada T, Hara K, Umematsu H, Suzuki R, Kadowaki T: Erectile dysfunction and cardiovascular events in diabetic men: a meta-analysis of observational studies. PLoS One. 7:e43673, 2012 doi: 10.1371/journal.pone.0043673. Epub 2012 Sep 4【国外誌】

134)Fujita H, Hara K, Shojima N, Horikoshi M, Iwata M, Hirota Y, Tobe K, Seino S, Kadowaki T : Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits.J Hum Genet. 57:776-779, 2012 doi: 10.1038/jhg.2012.110. Epub 2012 Sep 20【国外誌】

135) Isao Saito, Kazumasa Yamagishi, Choy-Lye Chei, Renzhe Cui, Tetsuya Ohira, Akihiko Kitamura, Masahiko Kiyama, Hironori Imano, Takeo Okada, Tadahiro Kato, Shinichi Hitsumoto, Yoshinori Ishikawa, Takeshi Tanigawa, Hiroyasu Iso: Total and high molecular weight adiponectin levels and risk of cardiovascular disease in individuals with high blood glucose levels Atherosclerosis 229: 222e227, 2013【国外誌】

136)Yamauchi T, Kadowaki T.: Adiponectin receptor as a key player in healthy longevity and obesity-related diseases.Cell Metabolism 17:185-196, 2013【国外誌】

137) Kadowaki T, Ohtani T, Odawara M :Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis. Diabetol Int.4:16-22,2013【国外誌】

138)Kadowaki T, Kondo K: Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus.Diabetes Obes Metab. 2013 Mar 6.12092. [Epub ahead of print]2013 【国外誌】

139)Nabeno M, Akahoshi F, Kishida H, Miyaguchi I, Tanaka Y, Ishii S, Kadowaki T: A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site. Biochem Biophys Res Commun. 2013 Mar 15.00407-5,2013.03.010. [Epub ahead of print] 2013【国外誌】

140)Yamauchi T, Kadowaki T: Adiponectin receptor as a key player in healthy longevity and obesity-related diseases.

Cell Metab. 17:185-196, 2013　【国外誌】

141)Kadowaki T, Ohtani T, Odawara M: Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis, Diabetol. Int.4:16-22, 2013 【国外誌】

142)Kadowaki T, Kondo K: Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus, Diabetes Obes. Metab. 15:810-818, 2013 【国外誌】

143)Kubota T, Kubota N, Kadowaki T: The role of endothelial insulin signaling in the regulation of glucose metabolism, Rev. Endocr. Metab. Disord. 14:207-216, 2013 【国外誌】

144)Kadowaki T, Tajima N, Odawara M, Nishii M, Taniguchi T, Juan Camilo Arjona Ferreira : Addition of sitagliptin to ongoing metformin monotherapy improves glycemic control in Japanese patients with type 2 diabetes over 52 weeks.

J. Diabetes Invest.4:174-181, 2013 【国外誌】

145)Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T: Small-molecule AdipoR agonist for type 2 diabetes and short life in obesity, Nature (Article) 503: 493-499, 2013 【国外誌】

146)Kadowaki T: Ensuring success for J-NIH. Science 342:670, 2013 【国外誌】

147)Nishimura S, Manabe I, Takaki S, Nagasaki M, Otsu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R: Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation.Cell Metab. 18:759-799, 2013 【国外誌】

148)Kadowaki T, Kondo K: Efficacy and safety of teneligliptin in combination with pioglitazone in Japanese patients with type 2 diabetes mellitus.J.Diabetes Investig. 4:576-584, 2013 【国外誌】

149)Yamauchi T, Iwabu M, Okada-Iwabu M, Kadowaki T: Adiponectin receptors: A review of their structure, function and how they work.Best Practice & Research Clinical Endocrinology & Metabolism 28:15-23, 2014 【国外誌】

150)Kadowaki T, Yamauchi T, Okada-Iwabu M, Iwabu M: Adiponectin and its receptors: implications for obesity-associated diseases and longevity.Lancet Diabetes Endocrinol. 2:8-9, 2014 【国外誌】

151)Kadowaki T, Haneda M, Inagaki N, Terauchi Y, Taniguchi A, Koiwai K, Rattunde H, Woerle HJ, Broedl UC: Empagliflozin monotherapy in Japanese patients with type 2 diabetes mellitus: a randomized, 12-week, double-blind, placebo-controlled, phase II trial.Adv.Ther. 31:621-638, 2014 【国外誌】

152)Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R: ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity.Diabetes 63: 4154-4164, 2014 【国外誌】

153)Kadowaki T, Haneda M, Inagaki N, Terauchi Y, Taniguchi A, Koiwai K, Rattunde H, Woerle HJ, Broedl UC: Efficacy and safety of Empagliflozin monotherapy for 52 weeks in Japanese patients with type 2 diabetes: A randomized, double-blind, parallel-group study.Adv. Ther. 32:306-318, 2015 【国外誌】

154)Kadowaki T, Marubayashi F, Yokota S, Katoh M, Iijima H: Safety and efficacy of teneligliptin in Japanese patients with type 2 diabetes mellitus: a pooled analysis of two Phase III clinical studies.Expert Opin. Pharmacother. 16:971-981, 2015【国外誌】

155)Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, Italiano JE Jr, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R: IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.J. Cell Biol. 209:453-466, 2015 【国外誌】

156)Okada-Iwabu M, Iwabu M, Ueki K, Yamauchi T, Kadowaki T: Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity. Diabetes Metab.J 39:363-372, 2015 【国外誌】

157)Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T: Adiponectin/adiponectin receptor in disease and aging.npj Aging and Mechanisms of Disease 1, 15013, 2015 【国外誌】

158)Ueki K, Sasako T, Kato M, Okazaki Y, Okahata S, Katsuyama H, Haraguchi M, Morita A, Ohashi K, Hara K, Morise A, Izumi K, Ohashi Y, Noda M, Kadowaki T, and the J-DOIT3 Study Group: Design of and Rationale for the Japan Diabetes Optimal Integrated Treatment Study for 3 Major Risk Factors of Cardiovascular Diseases (J-DOIT3): a Multicenter, Open-Label, Randomized, Parallel-Group Trial. BMJ Open Diabetes Research & Care 4:e000123. doi: 10.1136/bmjdrc-2015-000123. eCollection 2016 【国外誌】

159)Kadowaki T, Jinnouchi H, Kaku K, Hersløv ML, Hyllested-Winge J, Nakamura S: Efficacy and safety of once-daily insulin degludec dosed flexibly at convenient times vs fixed dosing at the same time each day in a Japanese cohort with type 2 diabetes: A randomized, 26-week, treat-to-target trial. J. Diabetes Investig.  2016 Feb 22. doi: 10.1111/jdi.12502. [Epub ahead of print] 【国外誌】

160)Kadowaki T, Jinnouchi H, Kaku K, Hersløv ML, Hyllested-Winge J, Nakamura S：Efficacy and safety of once-daily insulin degludec dosed flexibly at convenient times vs fixed dosing at the same time each day in a Japanese cohort with type 2 diabetes: A randomized, 26-week, treat-to-target trial. J. Diabetes Investig. 7:711-717, 2016 【国外誌】

161)Kadowaki T, Jinnouchi H, Kaku K, Hersløv ML, Hyllested-Winge J, Nakamura S: Insulin degludec in a simple or stepwise titration algorithm in a Japanese population of patients with type 2 diabetes: a randomized, 26-week, treat-to-target trial. Diabetology International 7:1-8, 2016 【国外誌】

162)Kubota T, Kubota N, Sato H, Inoue M, Kumagai H, Iwamura T, Takamoto I, Kobayashi T, Moroi M, Terauchi Y, Tobe K, Ueki K, Kadowaki T: Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways. Sci. Rep. 2016 Oct 5;6:34707 【国外誌】

163)Kubota N, Kubota T, Kajiwara E, Iwamura T, Kumagai H, Watanabe T, Inoue M, Takamoto I, Sasako T, Kumagai K, Kohjima M, Nakamuta M, Moroi M, Sugi K, Noda T, Terauchi Y, Ueki K, Kadowaki T: Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.Nat.Commun. 2016 Oct 6;7:12977 【国外誌】

4 In vivoイメージング技術・質量分析技術による新規診断技術

164) Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Sano M, Otsu K, Snider P, Conway SJ, Nagai R: Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest 120: 254-265, 2010【国外誌】

165) Fujiu K, Manabe I, Nagai R: Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice. J Clin Invest 121: 3425-3441, 2011【国外誌】

166) Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R: Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metabolism 15: 518-533, 2012【国外誌】

167) Fujiu K, Manabe I, Sasaki M, Inoue M, Iwata H, Hasumi E, Komuro I, Katada Y, Taguchi T, Nagai R: Nickel-free stainless steel avoids neointima formation following coronary stent implantation. Sci. Technol. Adv. Mater. 13: 064218, 2012【国外誌】

168) Fujimoto H, Suzuki T, Aizawa K, Sawaki D, Ishida J, Nagai R: Processed B-type natriuretic peptide is a biomarker of post-interventional restenosis in ischemic heart disease. Clin. Chem. in press. 2012【 国外誌】

169) Ishida J, Suzuki T, Aizawa K, Sawaki D, Nagai R: Comparison of Analytical Performance of Two Single-step Measurement Devices of B-type Natriuretic Peptide. Int. Heart J. 53: 320-323, 2012 【国内誌】

170) Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen Y-R, Sekine K, Kido T,　Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A: Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. PNAS 109:4263-8, 2012【国外誌】

171) Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R: In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates　contribution　ofi　nflammatory　cytokine　and　integrin　signaling. Blood 119: e45-56, 2012【国外誌】

172) Nishimura S, Nagasaki M, Sugita J: Adipose tissue remodeling associatedwith chronic inflammation and abnormal local immunity in obesity visualized by in vivo molecular imaging method. Inflammation and Regeneration 32, 165-170, 2012【国内誌】

173) Fujiu K, Nagai R：Contributions of cardiomyocyte-cardiac fibroblast-Immune cell interactions in heart failure development. Basic Res in Cardiol in press, 2013【国外誌】

174） Fujimoto H, Suzuki T, Aizawa K, Sawaki D, Ishida J, Ando J, Fujita H, Komuro I, Nagai R：Processed B-Type Natriuretic Peptide Is a Biomarker of Postinterventional Restenosis in Ischemic Heart Disease.　Clinical Chemistry published May 13, 2013.203406【国外誌】

175)Nishimura S, Manabe I, Takaki S, Nagasaki M, Otsu M, Yamashita H, Sugita J,Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R.：Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation. Cell Metab. 2013 Oct 22. pii: S1550-4131(13)00386-0. doi: 10.1016/j.cmet.2013.09.017. 【国外誌】

176)Fujiu K, Nagai R, Contributions of cardiomyocyte-cardiac fibroblast-Immune cell interactions in heart failure development, Basic Res in Cardiol, 108(4)357, 2013

177)Fujiu K, Nagai R, Contributions of cardiomyocyte-cardiac fibroblast-Immune cell interactions in heart failure development, Basic Res in Cardiol, 108(4)357, 2013 【国外誌】

178)Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R.:ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity.Diabetes. 2014 Dec;63(12):4154-64. doi: 10.2337/db13-1694. Epub 2014 Jun 26. 【国外誌】

179)Fujiu K, Wang J, Nagai R, Cardio-Protective Function of Cardiac Macrophage, Cardiovasc Res, 2014;102(2):232-9【国外誌】

180)Nishimura S:Frontiers in Live Bone Imaging Researches. In vivo vascular imaging of thrombosis and thrombopoiesis Clin Calcium. 2015 Jun;25(6):845-51. doi: CliCa1506845851.【国内誌】

181）Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H,Ohmori T, Manabe I, Italiano JE Jr, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R.:IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.J Cell Biol. 2015 May 11;209(3):453-66. doi:10.1083/jcb.201410052. 【国外誌】

182)Wang JH, Eguchi K, Matsumoto S, Fujiu K, Komuro I, Nagai R, Manabe I. The ω-3 polyunsaturated fatty acid, eicosapentaenoic acid, attenuates abdominal aortic aneurysm development via suppression of tissue remodeling. PLoS One 9:e96286, 2014.

183)Ogata F, Fujiu K, Koshim I, Nagai R, Manabe I., Phenotypic modulation of smooth muscle cells in lymphedema., Br J Dermatol. 2014 Oct 15. doi: 10.1111/bjd.13482.

184)Fujiu K, Nagai R, Fibroblast-mediated pathways in cardiac hypertrophy, J Mol Cell Cardiol.

185) Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I, A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation and cellular communication, Nat Med, in press.　

(2)上記論文以外による発表国内誌（国内英文誌を含む）

　　①抗体創薬・エピゲノム創薬・核内受容体創薬

1)酒井寿郎、稲垣毅：エピゲノムと生活習慣病. 細胞工学 28: 806-811，2009

2)酒井寿郎：転写調節とエネルギー代謝. Annual Review糖尿病・代謝・内分泌2009:86-98，2009

3)酒井寿郎、油谷浩幸：大規模エピゲノム解析と生活習慣病. Annual Review循環器2010:79-88，2010

4)酒井寿郎、堤修一、稲垣毅、油谷浩幸：特集　網羅的解析―omics解析の現在と未来―次世代シーケンサーを用いたChlP-Seq法による網羅的エピゲノム解析と生活習慣病. 内分泌・糖尿病・代謝内科　30: 334-344, 2010

5)酒井寿郎、岡村将史、伊藤貞嘉：栄養状態が体質を変化させる分子基盤（脂肪形成時におけるエピゲノム解析）東北医誌122:44-47，2010

6)酒井寿郎：コレストロールフィードバック：LDLレセプタ－からSCAPのMELADLへ. The lipid, 21:p36(340)-50(354), 2010

7)酒井寿郎：転写因子SREBPとプロテアーゼによるプロセッシングとコレストロールフィードバック制御機構.日本臨床　増刊号メタボリックシンドローム（第2版）,241-258, 2011

8)酒井寿郎、稲垣毅：エピゲノムと肥満・糖尿病. Diabetes Frontier2:22, 2011，2011

9)Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J (corresponding author), Aburatani H, Kadowaki T: Global mapping of cell type-specific

10)酒井寿郎，稲垣毅：生活習慣病とエピゲノム.別冊 医学のあゆみ「エピゲノム　研究最前線」2011年11月

11)酒井寿郎：糖尿病のエピジェネティクス.チャイルドヘルス，3月号　15, 2012

12)酒井寿郎，稲垣毅：栄養とエピジェネティクス－エピゲノム変化と肥満インスリン抵抗性. 次世代シークエンス・ゲノミクス（第16回　東京肝臓シンポジウム講演集）, 2012年

13)酒井寿郎，稲垣毅：糖尿病発症にかかわるエピゲノムの役割. 最新臨床糖尿病学　上（日本臨床　70巻　増刊号3）, 2012年

14)酒井寿郎，稲垣毅：エピジェネティック制御と生活習慣病. エネルギー代謝転写因子ネットワークと生活習慣病（別冊・医学のあゆみ）, 2012年

15)酒井寿郎，稲垣毅：エピジェネティックと糖尿病・肥満. 糖尿病と代謝（DIABETES JOURNAL）, 第40巻　2012年

16)酒井寿郎，稲垣毅：エピゲノム変化と肥満・インスリン抵抗性. 栄養とエピジェネティクス（食による身体変化と生活習慣病の分子機構）, 4月10日　2012年

17)酒井寿郎，稲垣毅：エピジェネティクスと肥満・メタボリックシンドローム. 最新医学，第68巻, 2013年

18)Alexander S. Savchenko, Akira Inoue, Riuko Ohashi, Shuying Jiang, Go Hasegawa, Toshiya Tanaka, Takao Hamakubo, Tatsuhiko Kodama, Yutaka Aoyagi, Tatsuo Ushiki and Makoto Naito：Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis. Pathol. Int., 61, 290–297, 2011

19)Tetsuya Fujimura, Satoru Takahashi, Tomohiko Urano, Toshiya Tanaka, Weiguang Zhang, Kotaro Azuma, Kenich Takayama, Daisuke Obinata, Taro Murata, Kuniko Horie-Inoue, Tatsuhiko Kodama, Yasuyoshi Ouchi Yukio Homma, Satoshi Inoue：Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer. Cancer Sci. 103:176-180, 2012

20)油谷浩幸:大腸癌診療と遺伝子診断.　Medical Practice　27: 1361-1364, 2010

21)油谷浩幸:エピゲノム異常と癌.　医学のあゆみ　235 :1031-1037, 2010

22)油谷浩幸:次世代シーケンサーによるがんゲノム解析　癌と化学療法　38(1):1-6, 2011

23)辻真吾, 油谷浩幸:ゲノムネットワークを用いた網羅的実験データの解析技術.　実験医学　29: 186-193, 2011

24)油谷浩幸:がんとエピゲノム解析.　医学のあゆみ　236:585-592, 2011

25)油谷浩幸, Linghua Wang:膵がんの統合的ゲノム解析.　実験医学　30:33-38, 2012

26)油谷浩幸:エピゲノム研究と分子標的薬.　日本臨床　増刊号8:287-293, 2012

27)油谷浩幸:“ゲノム変異解析”雑感.　医学のあゆみ　245: 471-475, 2013

28)川村　猛：「プロテオミクスにおける分離技術と創薬標的としてのタンパク質翻訳後修飾」,　J. Mass Spectrom. Soc. Jpn,　Vol. 64（2）, 75-79頁,　（2016）

　　②低侵襲・高精度診断・治療機器

29)佐久間一郎：脳外科：脳神経外科における手術支援ロボット‐戦術ロボットと戦略ロボット‐. Pharma Medica 30: 29-32, 2012

30)Ichiro Sakuma: Computer Aides Surgery(CAS) and Surgical Robotics for Minimally Invasive Therapy. The Japan Society of Mechanical Engineers 22: December, 2011

31)廖洪恩、山下紘正、正宗賢、佐久間一郎、土肥健純：手術を支援する医用画像・表示三次元画像技術を活用した低侵襲高精度診断治療用手術支援システム. 生体医工学49:641-646, 2011

32)佐久間一郎：手術支援ロボットとその関連技術. KOSAKU 71, 2011 4

33)佐久間一郎：医用精密工学. 精密工学会誌 75:111-112, 2009

34)葭仲潔, 杵淵郁也, 竹内伸太郎, 高木周, 松本洋一郎: ソナゾイドによる加熱増強効果の検討. INNERVISION 　2009 in press

35)石島歩，東隆，南畑孝介，山口哲志，小林英津子，長棟輝行，佐久間一郎：相変化ナノ液滴気泡化時の周囲温度調節による気泡寿命制御、超音波Techno, Vol. 28, No. 6, pp.89-96 (2016)

36)中川桂一,佐久間一郎：「超高速イメージング「STAMP」：１兆分の１秒の世界へ」,自動車技術 Vol.69 No.2, pp:92-93, （2015）

37)JOURNAL OF THE VACUUM SOCIETY OF JAPAN Vol. 57, No.2, 2014, pp.66-pp.70 「Recent Developments in Pixelated Gamma Ray Detector and Imaging System」 Kenji SHIMAZOE

③生活習慣病の診断薬・治療薬

38)植木浩二郎、門脇孝：【脂質生物学】メタボリックシンドロームとリン脂質. 実験医学 28:3340-3347、2010.12

39)門脇孝：サイエンスとヒューマニズムを求めて. 糖尿病診療マスター8368‐381, 2010.07

40)窪田直人：遺伝子改変マウスを用いた糖尿病合併症の分子メカニズムの解明. 糖尿病合併症24:12-17、2010.06

41)高本偉碩、山内敏正、門脇孝：異所性脂肪とメタボリックシンドローム 異所性脂肪：メタボリックシンドロームの新常識. 日本医事新報社 3-22, 2010.12

42)山内敏正、門脇孝：糖尿病体質とは　糖尿病の分子生物学の最前線　分子から疾患へ基礎研究と臨床の統合　糖尿病の根本的治療法の開発に向けて. 日本体質医学会雑誌　72: 62-69, 2010.02

43)門脇孝：2型糖尿病の分子機構と治療戦略. 日本内科学100:57-64, 2011.02

44)窪田直人：生活習慣病　糖尿病治療最前線　毛細血管を標的とした新たな糖尿病治療に向けて. Astellas Square: 明日の医療を考える7:14-16, 2011.10

45)笹子敬洋、植木浩二郎、門脇孝：血糖コントロールはどこまで厳格にすべきか？. 内分泌・糖尿病・代謝内科32: 331-336, 2011.04

46)原一雄、門脇孝：肥満・メタボリックシンドロームの遺伝因子. 月刊糖尿病3:65-72, 2011.04

47)山内敏正、門脇孝：アディポネクチンおよびアディポネクチン受容体の構造と機能. 実験医学29:40-46, 2011.03

48)門脇孝：【糖尿病の診断と管理のイノベーション　早期診断と適切な管理フローチャート】病型からみた糖尿病の病態と診断は今　わが国の2型糖尿病の病態とその特徴. 糖尿病UP-DATE 28:004-021, 2012.06

49)窪田直人, 植木浩二郎, 山内敏正, 門脇孝：【シグナル伝達研究最前線2012　翻訳後修飾、解析技術、疾患との連関から創薬応用まで】(第3章)シグナル伝達の破綻と疾患との連関　糖尿病とインスリンシグナル. 実験医学30: 802-807, 2012.03

50)窪田直人, 門脇孝：インスリン抵抗性の分子機構と認知症. Dementia Japan26:258-265, 2012.09

51)笹子 敬洋、植木 浩二郎、門脇 孝：大血管障害抑制の視点からみたチアゾリジン薬. Angiology Frontier 11:38-44, 2012.03

52)原一雄、門脇孝：ゲノムと2型糖尿病　GWASによる最新の知見. 最新医学67:17-26, 2012.01

53)山内敏正、門脇孝：最新臨床糖尿病学上－糖尿病学の最新動向－　Ⅱ．糖尿病研究の進歩　インスリン作用およびインスリン抵抗性発現機序　インスリン抵抗性発現の分子機構　　インスリン抵抗性発現にかかわるアディポサイトカインの役割. 日本臨牀70:166-174, 2012.05

④In vivoイメージング技術・質量分析技術による新規診断技術

54)西村 智:生体分子イメージング手法. International Review of Thrombosis 7:304-309, 2012

55)西村 智:生体イメージングによる血栓形成過程の可視化. 血栓と循環20:92-94, 2012

56)西村 智:オーバービュー. 血管医学　企画特集 血管系のin vivoイメージング13:105-106, 2012

57)西村 智:生活習慣病への生体イメージングアプローチ.　血管医学　企画特集 血管系のin vivoイメージング 13 :159-168, 2012

58)西村 智, 長崎実佳:生体二光子イメージングによる慢性炎症下の病態解析：生活習慣病の病態解明を目指して. Medical Science Digest 38: 141-142, 2012

59)西村　智:血管in vivoイメージングと生活習慣病への応用. 実験医学この一冊でデータがさえる！ in vivoイメージングの原理と実践　　182-196, 2012

60)西村 智:生体分子イメージングでみる生活習慣病：肥満脂肪組織炎症と血栓形成過程.　薬学雑誌 132: 425-431,2012

61)西村 智:生体イメージングにより明らかになる血栓形成過程.　Coagulation & Inflammation 6:13-15; 2012

62)相澤健一、鈴木亨：バイオマーカーの探索・発見・同定の試み. Heart View 16: 306-3108, 2012)

63)相澤健一、鈴木亨：新しい動脈硬化のバイオマーカー開発 － 新しいプロテオーム技術を用いて－. 循環器専門医 20: 237-244, 2012)

64)藤生克仁、真鍋一郎：慢性炎症と心腎連関. 　呼吸と循環60: 699-706, 2012

65)藤生克仁：心腎連関の悪循環を断ち切る！分子機序の解明と新しい治療法への応用. News Flash 2:2, 2012

66)藤生克仁：トピックス（尿細管異常と心線維化）, CARDIAC PRACTIVE 23: 39-43, 2012

675)西村 智:巨核球形成・血小板産生のメカニズムとその異常. 血液フロンティア 23: 43-50, 2013

68)藤生克仁、真鍋一郎：心腎連関の機序の最新知見. 血管医学 14:37-44, 2013

69)西村　智：生体分子イメージングによる血栓の可視化、血栓止血学会誌　Vol 24, No.8, 396-401pp, 2013

70)西村　智：生体分子イメージングによる血栓形成・血管機能の可視化、日本血栓止血学会誌　2013, vol24, no.6, pp 588-592

国外誌

①抗体創薬・エピゲノム創薬・核内受容体創薬

１)Kenji Ishimoto, Keisuke Tachibana, Ikuko Hanano, Daisuke Yamasaki,　Hiroki Nakamura, Megumi Kawai, Yasuomi Urano, Toshiya Tanaka, Takao　Hamakubo, Juro Sakai, Tatsuhiko Kodama, and Takefumi Doi：Sterol regulatory element-binding protein 2 and nuclear factor Y controls human farnesyl diphosphate synthase expression and affects cell proliferation in hepatoblastoma cells. Biochem. J.,　429, 347-357, 2010

2)Jie Cheng, Yatrik M. Shah, Xiaochao Ma, Xiaoyan Pang, Toshiya Tanaka, Tatsuhiko Kodama, Kristopher W. Krausz and Frank J. Gonzalez：Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. J. Pharmacol. Exp. Ther., 355: 32-41, 2010

3)Kenji Daigo, Takeshi Kawamura, Yoshihiro Ohta, Riuko Ohashi, Satoshi Katayose, Toshiya Tanaka, Hiroyuki Aburatani, Makoto Naito, Tatsuhiko Kodama, Sigeo Ihara and Takao Hamakubo：Proteomic Analysis of Native Hepatocyte Nuclear Factor-4 (HNF4) Isoforms, , Phosphorylation Status, and Interactive Cofactors. J. Biol. Chem., 286: 674-686, 2011

4)Bin Yu, Hisashi Ueta, Yusuke Kitazawa, Toshiya Tanaka, Kensuke Adachi, Hiromitsu Kimura, Miwa Morita, Yasushi Sawanobori, Hai Xin Qian, Tatsuhiko Kodama, Kenjiro Matsuno：Two immunogenic passenger dendritic cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities. Hepatology 56:1532-1545, 2012

5)Midorikawa Y, Tsuji S, Takayama T, Aburatani H: Genomic approach towards personalized anticancer drug therapy. Pharmacogenomics. 13:191-9, 2012

6)Matsumura Y, Sakai J, Skach WR.:「Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.」, J Biol Chem, 8, 288, 31069-31079, (2013)

7)Ohguchi H, Hideshima T, Bhasin MK, Gorgun GT, Santo L, Cea M, Mimura N, Suzuki R, Tai Y-T, Carrasco RD, Raje N, Richardson PG, Harigae H, Sanda T, Sakai J, Anderson KC.:「The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.」, Nature Commun,1, Jan 5,7, 10258, (2016)

　②低侵襲・高精度診断・治療機器

8)Shimazoe K, Torit, T, Wang Y, Takahashi H :Application of dynamic time over Threshold method to germanium detector Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE Publication Year: 2011, Page(s): 714 – 716, 2011

9)Shimazoe K, Wang Y, Takahashi H, Kamada K, Yoshino M, Kataoka J, Yamaya Y, Yanagida T, Yoshikawa A, Kumagai K: Time over Threshold based digital animal PET (TODPET) Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEEPublication Year: 2011 , Page(s): 3267 – 3271,2011

10)Shimazoe K, Nguyen H, Orita T, Wang Y, Shi B, Suzuki T, Takahashi H: "Application of dynamic time-over-threshold method to pixellatedCdTe detector," Nuclear Science Symposium Conference Record (NSS/MIC), 2010 IEEE , vol., no., pp.3888-3890, Oct. 30 2010-Nov. 6, 2010

11)A H Malik, K Shimazoe, and H Takahashi: “EGS5 simulation for the development of non- contacting system to online measure the radio -tracer concentration in blood,” 12th International Conference on Radiation Shielding (ICRS-12) and 17th Topical Meeting of the Radiation Protection and Shielding Division of the American Nuclear Society (RPSD -2012) , Nar a , Japan, Sept2-7, 2012

12)Orita T, Takahashi H, Shimazoe K, Fujiwara T: “Ultra linear dynamic Time-over-Threshold with a simple CR-RC filtering” Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE Publication Year: 2011 , Page(s): 742 – 744,2011

13)K Shimazoe, H Takahashi, K Kamada, Y Usuki, M Yoshino, J Kataoka, T Yanagida, A Yoshikawa, K Kumagai:　Development of a Time Over Threshold Based PET Detector" Proceedings of the 26th Workshop on Radiation Detectors and Their uses, Feb 1-3, 2012

14)Kenji Shimazoe, Hiroyuki Takahashi, Hiroshi Mori, Toshimitsu Momose, Kaoru Fujita:"Development of Positron Detector for Multi-Modal Endoscope", Proceedings of the 25th Workshop on Radiation Detectors and Their uses, Feb 1-3, 2011

15)Shimazoe K, Takahashi H, Shi B, Furumiya T, Ooi J, Kumazawa Y, Murayama H:"Novel Front-End Pulse Processing Scheme for PET System Based on Pulse Width Modulation and Pulse Train Method," Nuclear Science, IEEE Transactions on , vol.57, no.2, pp.782-786, April 2010

16)Takayuki Akimoto, Kanako Okuhira, Katsuji Aizawa, Shogo Wada, Hiroaki Honda, Toru Fukubayashi, Takashi Ushida, Skeletal muscle adaptation in response to mechanical stress in p130Cas−/− mice. Am J Physiol Cell Physiol, Mar; 304(6):C541-547 (2013)

17)J. H. Park, T. Ushida, T. Akimoto. Control of cell differentiation by mechanical stress. , J Phys Fitness Sports Med, 2(1): 001-014 (2013)

18)K.Kumagai, T.Asaoka, K.Furukawa and T.Ushida, Fabrication of scaffold for bone regeneration by taylor made stereolithography, Advances in Science and Technology, 86, 70-74 (2013)

19)A.Tamura, T.Asaoka, K.Furukawa, T.Ushida and T.Tateishi,α-TCP/HAp functionally graded porous beads for bone regenerative scaffold, Advances in Science and Technology, Vol.86, 63-69 (2013)

20)Asaoka T, Ohtake S, Furukawa KS, Tamura A, Ushida T. Development of bioactive porous α-TCP/HAp beads for bone tissue engineering. J Biomed Mater Res A. Nov;101(11):3295-3300 (2013)

21)Chang Ho Seo, Heonuk Jeong, Katsuko S. Furukawa, Yuji Suzuki, Takashi Ushida,The switching of focal adhesion maturation sites and actin filament activation for MSCs by topography of well-defined micropatterned surfaces, Biomaterials 34(7): 1764-1771 (2013)

22)Shuji Sawada, Michihiro Kon, Shogo Wada, Takashi Ushida, Katsuhiko Suzuki, Takayuki Akimoto, Profiling of circulating microRNAs after a bout of acute resistance exercise in humans, PLosOne Volume 8 Issue 7, e70823 1-8 (2013)

23)Akira Tsukamoto, Kei Tanaka, Tatsuya Kumata, Kenji Yoshida, Yoshiaki Watanabe, Shogo Miyata, Katsuko S. Furukawa, Takashi Ushida, 1-MHz ultrasound enhances internal diffusivity in agarose gels, Applied Acoustics Volume 74, Issue 10, October 1117–1121 (2013)

24)Keiichi NAKAGAWA, Akira Tsukamoto, Tatsuhiko ARAFUNE, Hongen LIAO, Etsuko KOBAYASHI, Takashi USHIDA, Ichiro SAKUMA, A Miniaturized Shock-Wave Device for Mounting on Forceps , J Biomechanical Sci & Engineering, Vol.8, No.1, 1-10 (2013)

25)Dajiang Du, Teruo Asaoka, Takashi Ushida, Katsuko S Furukawa, Fabrication and perfusion culture of anatomically shaped artificial bone using stereolithography, Biofabrication, Sep 12;6(4):045002 (2014)

26)Keiichi Nakagawa, Atsushi Iwasaki, Yu Oishi, Ryoichi Horisaki, Akira Tsukamoto, Aoi Nakamura, Kenichi Hirosawa, Hongen Liao, Takashi Ushida, Keisuke Goda, Fumihiko Kannari, and Ichiro Sakuma,Sequentially timed all-optical mapping photography (STAMP)", Nature Photonics 8, 695–700 (2014)

27)Erna G Santoso; Keita Yoshida; Yasushi Hirota; Masanori Aizawa; Osamu Yoshino; Akio Kishida; Yutaka Osuga; Shigeru Saito; Takashi Ushida; Katsuko S Furukawa, Application of detergents or high hydrostatic pressure as decellularization processes in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models, PLosOne Jul 24;9(7):e103201 (2014)

28)Shuji Sawada, Takayuki Akimoto, Masaki Takahashi, Ryota Sakurai, Shoji Shinkai, Takashi Ushida, Yoshinori Fujiwara, Katsuhiko Suzuki, Effect of Aging and Sex on Circulating MicroRNAs in Humans, Advances in Aging Research, 3, 152-159 (2014)

29)Kenji Yoshida, Kazuya Obata, Akira Tsukamoto , Takashi Ushida , Yoshiaki Watanabe, Limited damage of tissue mimic caused by a collapsing bubble under low-frequency ultrasound exposure, Ultrasonics , 54 1603–1609 (2014)

30)Azhim A, Syazwani N, Morimoto Y, Furukawa K, Ushida T. , The use of sonication treatment to decellularize aortic tissues for preparation of bioscaffolds. J Biomater Appl. Vol. 29(1) 130–141 (2014)

31)Chang Ho Seo, Heonuk Jeong, Takashi Ushida, Kevin Montagne, Feng Yue, Yuji Suzuki and Katsuko S. Furukawa, Micropit surfaces designed for accelerating osteogenic differentiation of murine mesenchymal stem cells via enhancing focal adhesion and actin polymerization, Biomaterials Feb;35(7): 2245-52 (2014)

32)Shimazoe, K., et al. "Fabrication and Characterization of Cubic SrI 2 (Eu) Scintillators for use in Array Detectors." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment (2015).

33)Tian, Yang, Hiroyuki Takahashi, and Kenji Shimazoe. "Characteristics of an Energy-Resolving System Using Dynamic Time Over Threshold Method." IEEE TNS 2015 accepted

34)T. Orita, K. Shimazoe, H. Takahashi, The dynamic time-over-threshold method for multi-channel APD based gamma-ray detectors, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Volume 775, 1 March 2015, Pages 154-161

35)Florian R Schneider1,3, Kenji Shimazoe2, Ian Somlai-Schweiger1 and Sibylle I Ziegler1l. "A PET detector prototype based on digital SiPMs and GAGG scintillators." Physics in medicine and biology 60.4 (2015): 1667.

36)K. Shimazoe, K. Horiki, H. Takahashi, Development of a prototype scintillator-based portable γ-ray imager with coded aperture for intraoperative applications, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Volume 784, 1 June 2015, Pages 394-397

37)Nakamura, Y., K. Shimazoe, and H. Takahashi. "A new digital-analog multiplex method using an adder circuit." Journal of Instrumentation 10.03 (2015): C03048

38)Shimazoe, K., et al. "Development and characterization of 16-channel silicon photomultiplier prototype with sub-mm pixels for high-resolution PET system."Journal of Instrumentation 9.11 (2014): C11018

39)K. Shimazoe, H. Takahashi, K. Kamada, A. Yoshikawa, K. Kumagai, J. Kataoka, S. Itoh, H. Sato, Y. Usuki, Development of a prototype of time-over-threshold based small animal PET scanner, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Volume 753, 21 July 2014, Pages 84-90

40)Kamada, K.; Shimazoe, K.; Ito, S.; Yoshino, M.; Endo, T.; Tsutsumi, K.; Kataoka, J.; Kurosawa, S.; Yokota, Y.; Takahashi, H.; Yoshikawa, A., "Development of a Prototype Detector Using APD-Arrays Coupled With Pixelized Ce:GAGG Scintillator for High Resolution Radiation Imaging," Nuclear Science, IEEE Transactions on , vol.61, no.1, pp.348,352, Feb. 2014

41) K. Horiki, K. Shimazoe et. Al: Study on 3D gamma-ray imaging for medical diagnosis with coded aperture,　Ionizing radiation 40(1), 59-62, 2014-03

42)Hideyuki Suenaga, Katsuko S. Furukawa, Yukako Suzuki, suyoshi Takato, Takashi Ushida, Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids, J Mater Sci: Mater Med 26:254- (2015)

43)Ting SY, Montagne K, Nishimura Y, Ushida T, Furukawa KS., Modulation of the Effect of Transforming Growth Factor-β3 by Low-Intensity Pulsed Ultrasound on Scaffold-Free Dedifferentiated Articular Bovine Chondrocyte Tissues., Tissue Eng Part C Methods. Oct;21(10):1005-14. (2015)

44)Du D, Asaoka T, Shinohara M, Kageyama T, Ushida T, Furukawa KS., Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering., Biomed Res Int.;2015:859456 (2015)

45)Andy Tsung Hsun Wu, Teruo Aoki, Megumi Sakoda, Seiichi Ohta, Shigetoshi Ichimura, Taichi Ito, Takashi Ushida, Katsuko S Furukawa, Enhancing osteogenic differentiation of MC3T3-E1 cells by immobilizing inorganic polyphosphate onto hyaluronic acid hydrogel, Biomacromolecules, 12;16(1):166-73, Jan 2015

46)Stephanie Yin Wai Ting, Kevin Montagne, Yoshihiro Nishimura, Takashi Ushida1, Katsuko S Furukawa,Modulation of the effect of transforming growth factor-β3 by low-intensity pulsed ultrasound on scaffold-free dedifferentiated articular bovine chondrocyte tissues, Tissue Engineering Part C Methods,21(10):1005-14,Oct 2015

47)N. Syazwani, M. Shafig, T. Ushida, A. Azhim, Simulation and Experimental Measurement of Acoustic Intensity on Sonication and Decellularization using Sonication Treatment, Journal of Signal Processing 19 (4) 179-182 (2015)

48)A. Azhim, M. Shafig, A. Rahman Rasyada, K. Furukawa and T. Ushida, The impact of Acoustic Intensity on Solution Parameters and Decellularization using Sonication Treatment, Journal of Biomaterials and Tissue Engineering 5 , 1-9 (2015)

49)Dajiang Du, Teruo Asaoka, Makoto Shinohara, Tomonori Kageyama, Takashi Ushida, and Katsuko Sakai Furukawa，Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering, BioMed Research International, Volume 2015 (2015), Article ID 859456, 9 pages

50)S. Wada, Y. Kato, S. Sawada, K. Aizawa, J. H. Park, A. P. Russell, T. Ushida, T. Akimoto. MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle. Pflügers Archiv, 467(2), 389-398, 2015

51)Jeonghyun Kim , Kevin Montagne , Takashi Ushida , Katsuko Furukawa, Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor, Biosci Biotechnol Biochem., 79(2):239-41 (2015)

52)N. Syazwani, A. Azhim, Y. Morimoto, K. S. Furukawa, T. Ushida, Decellularization of Aorta Tissue Using Sonication Treatment as Potential Scaffold for Vascular Tissue Engineering, Journal of Medical and Biological Engineering, 35(2), 258-269 (2015)

53)Du D, Ushida T, Furukawa KS., Influence of cassette design on three-dimensional perfusion culture of artificial bone., J Biomed Mater Res B Appl Biomater. Jan;103(1):84-91 (2015)

54)Nakamura, Y., et al. "Development of a novel handheld intra-operative laparoscopic Compton camera for 18F-Fluoro-2-deoxy-2-D-glucose-guided surgery." Physics in Medicine and Biology 61.15 (2016): 5837.

55)Koyama, Y.Nakamura, K.Shimazoe, H.Takahashi, I.Sakuma, Prototype of a Single Probe Compton Camera for Laparoscopic Surgery, Nuclear Inst. and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, PII: S0168-9002(16)30615-5 DOI: 10.1016/j.nima.2016.06.071

56)K. Shimazoe, A. Koyama, H. Takahashi, S. Sakuragi, Y. Yamasaki, Fabrication and characterization of rectangular strontium iodide scintillator coupled to TSV-MPPC array, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Available online 16 June 2016, ISSN 0168-9002

57)K. Shimazoe, A. Choghadi, H. Takahashi and K. Watanabe, "Single Side Readout Depth of Interaction Method With Wavelength Discrimination," in IEEE Transactions on Nuclear Science, vol. 63, no. 2, pp. 679-684, April 2016.

58)Shimazoe, K., et al. "Electron Pattern Recognition using trigger mode SOI pixel sensor for Advanced Compton Imaging." Journal of Instrumentation 11.02 (2016): C02030.

59)Nakamura, Y., K. Shimazoe, and H. Takahashi. "Silicon Photomultiplier-Based Multi-Channel Gamma Ray Detector Using the Dynamic Time-Over-Threshold Method." Journal of Instrumentation 11.02 (2016): C02016.

60)Lipovec, A., K. Shimazoe, and H. Takahashi. "Development of high-resolution gamma detector using sub-mm GAGG crystals coupled to TSV-MPPC array."Journal of Instrumentation 11.03 (2016): C03026.

書籍出版

1)酒井寿郎： 核内受容体標的薬（LXR,FXR,PPAR）. Mebio 27 :114-127, 2010, 株式会社メジカルビ

ュー社

2) Mamoru Mitsuishi and Paolo Bártolo：Procedia CIRP ―First CIRP Conference on BioManufacturing－. Vol.5,

Elsevier, 2013.

3)佐久間一郎：石田隆行，桂川茂彦，藤田広志　監修：医用画像ハンドブック，第９編　第６章外科手術支援，オーム

社，分担執筆，pp.1355-1376，２００９.11.25

4)藤生克仁、永井良三：「血管平滑筋細胞、血管生物医学事典」, 2011

5)藤生克仁、真鍋一郎：「モデル動物（マウス）、血管生物医学事典」, 2011

6)西村智：生体分子イメージングで見る血管機能とその破綻、Surgery Frontier Vol 21 No.1, pp76-80, 2013

7)西村 智：生体分子イメージングによる微小循環の可視化と病態解析、臨床高血圧Vol19, No.4 pp.12-18, 2013

8)西村 智：生体二光子イメージングによる生活習慣病の分子機構と慢性炎症の寄与、日本レーザー医学会誌Vol 34 No.2 ､77-81pp, 2013

9)西村 智：特集：慢性炎症から血管をみる生体二光子イメージングによる生活習慣病の解析、Vacular Medicine Vol 9 No. 1, 46pp-53pp, 2013

10)西村 智：巨核球形成・血小板産生のメカニズムとその異常、血液フロンティア　2013 Vol 23 No.3 43-50pp

11)西村 智：特集：光バイオプシー　生体二光子忌め－ジングによる生活習慣病病態の可視化、光アライアンスVol24 No.9 7-11pp. , 2013

12)西村 智：血栓と循環、日本循環器学会学術集会　学会トピックス No.4 Vo. 21 No1 82pp, 2013

13)西村 智：特集血栓の画像化・イメージング　監修 西村 智　生体分子イメージングによる血栓の可視化、Thrombosis Medcine Vol3 No.2, 2013　19-27pp

14)藤生克仁、真鍋一郎、特集「臓器連関による代謝調節Up-to-Date」 心腎連関の機序の最新知見、血管医14(1),

37-44, (2013)

15)藤生克仁、真鍋一郎、連載「バイオマーカーと心血管疾患の評価」　GM-CSF、血管医学、14(2), (2013)

16)藤生克仁、生活習慣病におけるマクロファージ　マクロファージ極性変化による腎組織リモデリング機構、医学の

あゆみ、vol 246, No.11, 2013

17)藤生克仁、真鍋一郎、老化寿命研究の最前線、臓器間連携・細胞間相互作用による循環器・代謝疾患発症メカニズム、実験医学、Vol. 31, No. 20 (増刊), 2013　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

18)西村智：トピックス　生体分子イメージングによる血栓形成・血管機能異常の可視化　一般内科外来でみる出血傾向、内科 Vol 114 No.2279-283p, 2014

19)西村智：メタボリックシンドロームにおける免疫・炎症性細胞のクロストーク、糖尿病学２０１４　診断と治療社　　44-49pp, 2014

20)西村智：肥満に伴う脂肪組織リモデリング　日本臨床　増刊号　最新肥満症学　基礎・臨床研究の最前線Vol72, 324-330p, 2014

21)西村智：生体分子イメージングによる微小循環の可視化と病態解析、臨床高血圧 State of the ART Vo.19 No.4 12-16p, 2014

22)西村智：冠動脈硬化・急性冠症候群　急性血栓イベントを最新分子イメージングで解く、Medicina　Vo.51,No.4 590-593p, 2014

23)西村智：脂肪組織中の制御性B細胞は肥満によって起こる脂肪組織炎症を負に制御する、細胞工学 vol33 no4 Hot press pp434-45, 2014

24)西村智：二光子バイオイメージングと生活習慣病 1065-1068pp. , 2014

25)藤生克仁、真鍋一郎、心腎連関と交感神経、腎・高血圧の最新治療、Vol. 3, No.1, 12-18, 2014

26)西村智：骨の生体イメージング最前線　血管イメージングによる血栓形成・血小板造血の定量的解析、linical Calcium Vol 25 No.6 2015 61-68p, 2015

27)西村智：血管と血小板　めでみる血栓形成過程：二光子顕微鏡の生体への応用、新・血栓止血血管学163-168pp, 2015

28)西村智：血小板造血・血栓形成過程の可視化解析　二光子顕微鏡の生体への応用、Thrombosis Medicine Vol5 No.2 2015 page 11-15

29)西村智：からだのなかをみる喜び、近畿化学工業界きんかVol 67 No.9 10-11p, 2015

30)西村智：血管バリアと炎症―肥満脂肪組織と血栓から、臨床免疫・アレルギー科　64(1) 97-102p, 2015

31)西村智：南山堂医学大事典　第２０版, 2015

32)西村智：肥満に伴う脂肪組織炎症と免疫細胞、内分泌・糖尿病・代謝内科2015, 39(6), 496-500

33)西村智：代謝・内分泌系の慢性炎症　肥満に伴う脂肪組織炎症の免疫制御メカニズム、別冊BioClinica慢性炎症と疾患Vol4 No.1 54-58pp, , 2015

34)西村智：二光子・非線形顕微鏡によるバイオイメージング監修 西村智はじめに 1035-1040pp、医学のあゆみ Vol 251 No.11, , 2015

35)西村智：特集 一般内科外来でみる出血傾向「ぶつけてないのにアザ！」にあわてな�