W EIGH A HEAD ■ Sartorius offers a number of innovations for every area of moisture detection Page 6 ■ Slight modifications make all the difference Automatic process control of blister packs improved by using the Sartorius SYNUS™ checkweigher Page 11 ■ Growth, characteri- zation and processing of crystals Sartorius semi- microbalance impresses an entire institute Page 20 ■ Just a mouse click away from your purchase Sartorius sells spare parts through its ISSS e-Shop Page 35 19 19
Transcript
WEIGHAHEAD
� Sartorius offers anumber of innovationsfor every area of moisture detection Page 6
� Slight modificationsmake all the difference Automatic process control of blister packsimproved by using the Sartorius SYNUS™checkweigherPage 11
Front cover photo:Products and services shouldalways go hand in hand, with a close-knit team providing a high level of responsiveness andcustomer attention. Sartorius as a service partner does just that,offering you the widest range of services to match the productswe supply. Read more about ouroffer on page 34.
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Dear Readers,
You certainly are aware of how importantservice is for all of us. Not only do the func-tions of a product have to meet our require-ments, but also the services that are offeredin connection with the product. That is whySartorius would like to introduce you in this issue to the array of services it offers inits FACTS® service program and what you can expect of these (p. 34). Also on theimportant subject of service, you won’t wantto miss the article on our ISSS e-Shop thatenables you, the customer, to order spareparts from wherever you are located and nomatter what time of day or night! Find outmore about this in an interview that the German-language WeighAhead editing team conducted with Mr. Malte Pramann,Project Manager of the ISSS e-Shop (p. 35).
To decide in favor of a specific product, you need to consider various conditions,specification requirements and other criteria.General product information brochures pro-vide useful descriptions to help make aninformed purchasing decision, yet they mayall tout the same specifications and features.The real challenge lies in finding the oneproduct that is best for you, and that willmake a difference in your work and increaseproductivity at your company. You canreduce this hurdle by reading up on our peerapplication reports. They will give you first-hand accounts on how satisfied other cus-tomers are with Sartorius products and services that are used in your branch ofindustry and that meet requirements compa-rable to yours.
Therefore, it is a great pleasure for us to pres-ent you with a large number of reports fromvarious countries on a wide diversity of appli-cations in which products from the Sartoriusproduct portfolio are successfully used.
Editorial
For instance, find out how blister packsundergo automatic process control in Chinathanks to the SYNUS™ checkweigher (p. 11)or how a Sartorius analytical balance canoperate under weightless conditions (p. 16).In addition, this issue of WeighAhead informsyou about the use of a Sartorius semi-microbalance in the growth, characterizationand processing of crystals (p. 20).
We are positive that you will find many useful articles that are bound to apply to yourapplication and give you ideas to adopt inyour processes. Enjoy reading and discoveringthese benefits!
Cordially,
Jessica Fröhlich*Marketing, Mechatronics Division, and German-language WeighAhead Editor
* Jessica married shortly after her signature was scanned in and changed her las name to “Fröhlich.” Please note that her e-mail address has changed to [email protected].
Please use the fax form to obtain more information on theindividual articles or to receiveproduct information. You canalso use this form to specifywhether or not you would like tocontinue receiving new issues ofWeighAhead free of charge bypost – in case you have notalready done so.
On the Sartorius website,www.sartorius.com, you alsohave the option of registeringyour name for regular sub-scription to WeighAhead. In theleft column headed by “Mecha-tronics,” just click on either“Products – Laboratory” or “Products – Process,” and then on “Customer Journal ‘WeighAhead” in the right-handcolumn. Then click on either“Request WeighAhead” to writein your request on the form, or “Online Subscription WeighAhead” to become a regu-lar subscriber by completing the form. You can also click onDownloads to download issues inEnglish, French, German, Italianor Spanish.
We value your opinions. Do youhave any constructive criticism or ideas? If you do, please e-mail them to me [email protected]. You can also reach me, Mrs. Jessica Fröhlich, by telephone in Germany at +49.551.308.1695 or my assistant, Ms. Stefanie Sittig, at+49.551.308.3675.
Sartorius presents:Innovative solutions for your process
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Products
Here is a line-up of our product innovations – short, concise and informative.
July – September 2006The demands and expectations on productquality in the food and pharmaceutical indus-tries are continuously increasing. As a result of growing quality consciousness, every man-ufacturer is now confronted with a number of new laws and regulations in the productionarea. Under the aspect of product liability,metal contaminants in products particularlypose a high risk. Sartorius metal detectorshelp minimize this risk as they detect metalcontaminants before they can spoil end products for consumers or damage processmachinery. Therefore, they provide a highlevel of protection for both consumers andmachinery.
High detection accuracyThe technology used in the new Sartoriusdetectors ensures the highest sensitivity for all types of metal in diverse products. Whenmetal is detected, a relay is activated; itspotential-free switch-over contact can beused for any control processes, such as stop-ping the processing machine or conveyor belt,activating marking devices or ejectors, etc.
The search sensitivity of the detector meetsthe highest requirements of various industries.In addition to detecting magnetic metal parts, Sartorius metal detectors also reliablyidentify high-alloy steel particles and non-ferrous metals (copper, brass, aluminum, lead,etc.). Once they find any of these particles,they dependably eject contaminated products. Their automatic self-monitoring and qualityassurance routines ensure the highest possiblesafety. The stainless steel housing (AISI 304/BS 304) even meets the highest requirementson hygiene in accordance with HACCP. As aresult, Sartorius metal detectors give users thekey to ISO 9000/ISO22000 and HACCP and IFS compliance.
The Sartorius metal detector is available in achoice of two versions to accommodate theuser’s application: MDE with a fixed frequency– an affordably priced model with ruggedtechnology for quality control of most prod-ucts, and MDP – the premium multi-frequen-cy system that operates in three selectablefrequency ranges to 1 MHz along with specialfiltering technology. The MDP enables metalcontaminants to be reliably detected even incritical production processes and in productswith a high degree of electrical conductivity.
Following traces of metal contaminants Sartorius MDP and MDE Metal Detectors
User-friendly operationExceptional ease of operation is what bothversions have in common. Thus, the metaldetector is simple to set using just the func-tion keys and by following the displayprompts in a choice of languages. The user canassign a joker key to a relevant function forconvenient “touch-and-go” access. Context-sensitive, menu-driven dialogues ensure clear,easy-to-understand operator guidance. Theoperating terminal is integrated into the toppart of the housing, and features for the premium version include a 4-line, 20-charac-ter alphanumeric and backlit LCD, a keypadoverlay with 16 function keys and three LEDs.Configurable passwords protect the detectorfrom unauthorized changing of the settings.
Comprehensive documentation It goes without saying that all metal-detectedand error messages are logged immediatelyfollowing their occurrence. Various selectablereports document the system status and allevents that occur during production. For thepremium version, various optional interfacesare available, for example, for connection tothe Sartorius ProControl for Windows® soft-ware system. Therefore, this enables monitor-ing according to HACCP concepts.
Metal contaminants don’t stand a chance withSartorius metal detectors
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Products
The variety of weighing systems is as great as are the branches of industry in which theyare used. Thus, special customer requests andthe extension of existing weighing applica-tions are simply a matter of everyday life. The adaptation of a weighing system to localcircumstances usually requires a great deal of time and effort.
Sartorius, the Goettingen-based technologygroup, has now built a bridge between theindividual requirements of weighing systemsand easy-to-use, uncomplicated programming– even for beginners – with the PR 1750/60graphic development tool.
This programming system for X-family con-trollers and the Combics Pro terminal providesthe option to create customer-specific soft-ware or simply to extend the standard soft-ware of existing weighing applications. The X-family controllers and the Combics Pro terminal can thus unfold their full perform-ance capabilities. Programming of thePR 1750 can take place, on the one hand, inthe standard programming languages inaccordance with IEC 61131; on the otherhand, it is also possible to create and simulatethe programming procedures in a new, fullygraphic form. In addition, PR 1750/60 has special functions in order to meet the specialrequirements of weighing and batching technology.
The fully graphic operation of the develop-ment tool was specially developed for thePR 1750. In doing so, the graphic optionsextend beyond the usual measure of tradi-tional programming tools and make it easyeven for beginners to create programs quickly and easily. No knowledge of specialsyntax is required. The pictorial representationexpresses more than any programming text “formulated” in accordance with specific rules.
Faster project documentation Finally, the program code for a complete proj-ect can now be created automatically fromthe graphics environment in IEC 61131 for-mat. The consistent use of graphics createssignificant time savings due to shorter famil-iarization periods as well as improved projectplanning and thus reduces commissioningrisks. Software support and maintenance costsare also reduced due to the ease and flexibilityof modification and the customer-specificproject documentation. The greater trans-parency of the program makes the program-
ming procedure easier to understand. Errorscan be found more easily or directly avoided.The dependability and reliability of the entiresystem is increased as a result.
Comprehensive debugging and diagnosticfunctions facilitate convenient testing andshorten the time taken both in searching forerrors and commissioning. Variables can bemonitored in running, “online” operation. In doing so, the values of variables can berecorded via a logic analyzer and stored in afile – similar to a “data logger” function.
In addition, the programmed operatingsequences and control procedures can be tested directly on the PC using the built-ingraphic simulation. At the same time, theequipment (X-Controllers / Combics Pro) canbe fully modeled and simulated on the PCincluding the operation and control of inputsand outputs. This makes it possible to simulatedifferent conditions and the behavior of theassociated inputs and outputs. Thus, the morecomplex behavior of process equipment canbe adjusted and tested without the necessityto connect external I/O modules.
To receive further information on these products and solutions, use the Reader ServiceCodes below or visit our Internet website atwww.sartorius.com.
Reader Service Codes:241: Metal detector242: PR 1750
Easy, fast and practical programming of weighing systemsSartorius PR 1750
The Sartorius PR 1750/60 development tool for individualadaptation of weighing systems
Sartorius offers a number of innovationsfor every area of moisture detection
Sartorius presents its “Moisture Analysis”product line with extensive modifications and improvements. The range of thermo-gravimetric analyzers has been modified.Sartorius is using new measuring technologyto round out its equipment range and expand its area of activity from laboratoryanalysis technology to online process control.
Three become oneThe infrared drying balance program has beenstreamlined and is now much more clearlystructured. The MA45, MA50 und MA145moisture analyzer series have been combinedinto one model called the MA150. A newweighing system with a weighing capacity of150 g and 1-mg resolution shows increasedweighing power in the familiar space-savingdesign from the MA45. The MA150 addsnumerous additional functions that were pre-viously only available in the premium seg-ment. On the whole, the new MA150 offers agreat deal more performance and flexibility –and all this for the price of its forerunner, theMA45. In comparison to competitive models,the MA150 is at the high end of the standardsegment.
For simple routine analyses, the moisture analyzer series also offers the MA35 compactentry-level model. One step above theMA150, with an integrated analytical balancesystem and a type-approval certificate, theMA100 model series offers the top-perfor-mance weighing results and technology cus-tomers expect of Sartorius.
More than just hot airThe WDS 400 Water Detection System fea-tures a new look along with its redesignedtechnology. The WDS 400 has long sinceestablished itself as a high-resolution alter-native to Karl Fischer titration. In addition to not needing costly detection reagents, adistinct cost advantage, the analyzer alsooffers an additional benefit: An integrated airpump with a downstream drying cartridgeallows it to use air from the room as a carriergas. For many analyses, this solution furtherreduces the running costs considerably, sincethere is no need to introduce nitrogen intothe system as a carrier gas. Only inflammablesamples or substances that react with oxygenwhen heated still require the use of nitrogen.
Time is no longer a factorFirst introduced as a prototype at theACHEMA trade show in 2006, a new moistureanalyzer based on microwave resonance technology is now in series production andavailable from Sartorius. The LMA300P iswell suited to the non-destructive analysis of pourable and granulated products. Thespecial allure of this technology is its excep-tionally fast measurement time of less thanone second! Since in most cases no samplepreparation is necessary, the LMA300P num-bers among the fastest moisture analyzers on the market. Designed as a modular labora-tory instrument, diverse sensors of differingdesigns are available for the analyzer and canbe attached to the evaluation unit, dependingon the task at hand.
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Products
The new MA150 with considerable more power and flexibility
Thanks to its short measurement time andvery low maintenance needs, microwave reso-nance technology is also exceptionally well-suited for use in online processes. In additionto a laboratory instrument for offline analy-sis, Sartorius also offers this equipment forcontinuous analysis during the productionprocess. Users can select individual solutionsfrom a wide range of sensors, and control and evaluation electronics.
An overview of the newly designed laboratoryline for water and moisture analysis is avail-able in the comprehensive brochure “Full-range moisture analysis from a single source”published recently. We would be happy toprovide you with individual additional infor-mation on process measurement technology.
Reader Service Code: 243
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Products
The LMA300P…
…and how it functions.
Accolades from Frost & Sullivan for theMoisture Analysis Technology segment.
ResonatorMicrowavegeneratorIntegrated
PC
Sample
Sensor
Sartorius water analysis productsThe completely revamped PP series
The renowned and proven combination pH,conductivity and ion meters of the PP serieshave been revamped completely to provideeven faster and more reliable results. Theiruser friendliness is setting benchmarks worldwide. These are the key features of thisworld-class family of meters that are avail-able in the following four models:• PP-15: pH, redox/ORP and temperature
measurements• PP-20: pH, redox/ORP, conductivity and
temperature measurements• PP-25: pH, ion-selective analysis, redox/ORP
and temperature measurements• PP-50: pH, redox/ORP, ion-selective
analysis, conductivity and temperaturemeasurements
Only one of the many new features will bedescribed in brief here: • No matter which temperature sensor is
used, the new meters of the PP series auto-matically recognize the PT-1000, NTC10 kohm and NTC 30 kohm temperatureprobes. This eliminates all measuring errorscaused by improper temperature compen-sation related to a non-conforming temperature probe.
• The Sartorius meter has the most automati-cally recognized buffers analysts need:Seven different sets and a total of 33 differ-ent buffer solutions are automatically rec-ognized. Moreover, any buffer set you haveindividually defined to suit your specificapplication can be added and saved in themeter.
• The addition of the latest Motorola Coldfireprocessors has really revved up the speed of the PP meters to new heights. This alsomeans that the measuring speed dependson the sensor alone. And fast data transferallows the sensor drift to be monitored better than ever before.
• There are still many conductivity cells onthe market that only allow one-point con-ductivity calibration and afterwards use thisvalue for the entire test range. Since thecell constant can change, one-point calibra-tions should only be used when your samplehas a relatively constant value. If the ana-lyst needs to measure different sampleswith markedly variable conductivities, it ismuch more preferable to calibrate severalpoints. The PP series can perform one-pointas well as multi-point conductivity calibra-tions, which greatly improves the accuracyof the readings.
• The Sartorius PP series offers unparalleleduser-friendliness and operator convenience.Instead of cryptic acronyms or special sym-bols that are not understandable unless yourefer to the operating manual, the PPmeters’ large, easy-to-read display can beviewed glare-free from virtually any angleand gives the user all the instructions writ-ten out in words. Online help prompts canbe accessed from every menu level, lettingthe analyst work fast and error-free.
Ask us for a presentation and test of our newSartorius PP series meters.
Reader Service Code: 244
On top of the basic functions, the Professional Meterseries features a range of options for setting up optimum measuring conditions for a wide variety ofapplications.
Determining the volume of E1 weightsAutomatic testing facility for determining the volume of solids
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Applications
IntroductionThe determination of mass using convention-al testing facilities is generally carried out inair under normal conditions. The mass of air(1 m3 weighs approximately 1.2 kg), however,causes a systematic error in the procedure.Every solid body is affected by buoyancy inrelation to the amount of air it displaces(Archimedes’ Law). Air buoyancy makes a 1-kgstainless steel weight appear to be approx.0.15 g lighter than it is. If the test weight hasthe same density as its mass reference, the airbuoyancy can be discounted, since weightsthat have the same mass will have the samebuoyancy. But if the test weight has a lower
density than its mass reference, then it takesup more space with 1 kg than the 1-kg massreference. Thus, the test weight is subjectedto more buoyancy and seems lighter than it actually is.
This is why determination of density is indis-pensable for precise determination of mass,which is essential for metrology institutes,accredited calibration services and similarlaboratories. This is reflected in internationalregulations, such as OIML R111 for a one-kilogram E1 weight, which allows a mass tol-erance of only 0.5 mg. Such precision cannotbe attained in the determination of masswithout determining the density of theweights and making the necessary correctionfor buoyancy.
High-precision measurement of the density of solids through comparative measurementswith density standards, such as those carriedout by national metrology institutes – including the BEV – are generally too time-consuming for large numbers of test weights,due to the complicated preparation andinstallation in measurement cells.
Requirements and objectivesBuilding on years of excellent cooperation,the BEV and the Institute of Production Engi-neering of the Vienna University of Technolo-gy, together with Sartorius AG in Goettingen,Germany, have developed and built a fullyautomatic testing facility for determining thevolume of weights. The goal was to enablehydrostatic density determination in accor-dance with OIML R111 (class E1 for multiplesolid bodies or weights). The procedure isbased on mass comparison, as opposed toweighing, with specific steps taken to ensurethat the temperature in the measurementchamber is as stable as possible. The result is atesting facility that analyzes the density of upto eight weights ranging from 1 g to 1 kg.With this approach, uncertainty of measure-ment is not related to mechanical factors, andthus depends on ambient conditions and thequality of the measuring instruments.
SummaryDetermination of the volume of weights is necessary for the correction of air buoyancy,and thus is an essential capability for today’s metrology institutes. The Austrian FederalOffice of Metrology and Surveying (BEV) and the Vienna University of Technology, at the request of and in cooperation with Sartorius AG in Goettingen, have developed a fully automatic load alternator for weighing below the mass comparator, for use in volume determination of E1 weights and plummets using 1-kg mass comparators. Thus,the hydrostatic weighing principle can be applied for serial volume on masses from 1 g to1 kg through direct comparison with a single volume reference (e.g., a silicon sphere).This is implemented with a newly developed, fully automatic insertion mechanism forboth completely submersed weights and substitution weights. This system is used at theBEV for volume measurements in connection with the determination of mass, as well asin other metrology institutes and accredited calibration laboratories.
Fig. 1: Volumetric mass comparator VD1005: prototype at the BEV
System designThe testing facility is constructed in the formof a tower (Fig. 2). A double-walled storagecontainer for liquids is installed on the lowestlevel. The outer layer contains normal waterand serves to regulate the temperature; it issupplied and regulated by an external ther-mostat. Baffle plates provide for a homoge-nous flow of water around the internal con-tainer at all times. A stable temperature isensured by means of a 40-mm layer of insula-tion around the entire system and the use ofinsulated metal inserters. Additionally, theinsulation of the individual levels of the test-ing facility prevents convection currentsaround the mass comparator. The inner vessel– the measurement cell – has been kept assmall as possible in order to use as little aspossible of the highly purified measuring liq-uid and, with the exception of a small entryportal, is completely surrounded by the liquidin the outer layer. Even regulation of thetemperature on all sides makes it possible toreduce the formation of temperature layersto a negligible level. The temperature of themeasuring liquid is monitored by two diago-nally mounted high-precision sensors (25-ohm standard platinum-resistant thermome-ters (SPRT) in compliance with ITS 90). Forboth the substitution weights and the testweights, a position below the mass compara-tor was chosen. (Figs. 3 and 4). This eliminates
off-center loading problems on the weighcell. The specially developed load alternatormakes it possible to insert the 1-g to 1-kgweights and density references spheres withno rearrangement required, and to positionthem precisely in the suspension device of themass comparator. The insertion mechanismpositions the weights on the magazine spacesin the measuring fluid vessel.
The entire control system as well as all elec-tronic components are housed in a controlcabinet (Fig. 1). The system is controlled by an industrial computer, which is also usedto evaluate the data. To determine environ-mental parameters, the unit has sensors for air pressure, humidity and air tempera-ture. A number of additional sensors are provided in order to exclude errors in themeasuring process.
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Applications
Fig. 2: CAD model of the unit
Mass comparator
Load alternator
Magazine for alternatingsubstitution weights
Weight insertionmechanism
Magazine for alternatingtest weights
Thermostated H2Ostorage container
Thermal insulation allaround the system
Fig. 3: Magazine for substitution weights, insertion mechanism, and view from aboveof the magazine in the weighing chamber
Measurement procedureUnlike other systems,this unit uses a masscomparator to compareeach test weight directlywith a volume refer-ence. This means, how-ever, that either the testweights must have areference of their ownwith a similar mass, orthe measured weight ofeach object must becorrected through ref-erence to a differentmass by using substitu-tion weights in air. Bothof these methods areenabled by this unit.
Thus it is possible to adapt test weights withdifferent masses directly to a volume refer-ence (e.g., a silicon sphere). Although thedensity of the measurement fluid as a trans-mitter is constantly monitored, it is of sec-ondary importance due to this mass dissemi-nation capability. It is important, however, tomake sure that the density remains constantduring the course of a measurement (approx-imately 2 minutes). The software’s user inter-face prompts the operator to prepare themeasurement inserting the reference weights,the test weights and the appropriate substi-tution weights. This entails use of the weightinsertion mechanism; it is important at thispoint to make sure there are no air bubbleson the weights once they are immersed in theliquid. A total of nine spaces are available forthe reference and test weights. Once thesequence and number of cycles have beenentered, the measurement can begin.
SoftwareThe software (Fig. 5) assists the operator inthe preparation and execution of the mea-surements. In addition to the fully automaticmeasurement program, operators have theoption of performing individuals steps sepa-rately (single-step mode). In addition, theprogram shows the operator all the measure-ment data from the sensors in real time aswell as the current progress of the measure-ment.
The result of each measurement is the vol-ume, the density and the mass of each testweight, with complete documentation of theconditions of measurement and default val-ues. Measurement values and all associateddata can be provided as raw value output oron printouts that contain a complete evalua-tion of the measurement data.
In validation and testing of the initial systemat the BEV, in-house comparative measure-ments of the density of solid bodies – in thiscase with a plummet (Pyrex sphere; massapprox. 119 g, volume approx. 97 m3) – withthe new testing facility showed a deviation involume of less than 0.9 mm3 and in mass ofless than 0.07 mg. Comparisons with refer-ence weights at the BEV also showed excel-lent results. One unit is already being used tomeasure the volume of weights with a massof 1 g to 1 kg in the scope of mass determina-tion at the BEV, and for ongoing in-house and external calibrations.
Christian Buchner, Dietmar Steindl, Federal Office ofMetrology and Surveying, ViennaJohannes Bernreiter, Christoph Einspieler, Institute for Production Engineering, University of Technology, Vienna
Reader Service Code: 245
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Applications
Fig. 4: Suspension and loadalternator system
Fig. 5: Software (German-language version shown)
Load alternatorSuspension
Mass comparator
Magazine for alternatingsubstitution weights
Magazine for alternatingtest weights
Weight insertionmechanism
Locking device
Slight modifications make all the differenceAutomatic process control of blister packs improved by using theSartorius SYNUS™ checkweigher
Customer requirementsDuring its factory construction period,Boehringer Ingelheim already established aclose relationship with Sartorius: it purchasedseveral sets of Sartorius FB & FD industrialplatforms and MA50 moisture analyzers afterhaving tried competitors’ products. In 2005,with a larger number of products and a largervolume of production, Boehringer Ingelheimadded an automatic plastic/aluminum capsulemachine for 7-capsule packaging. Althoughthe packaging machine had a built-in X-rayscanning feature for rejecting packs with nocapsules, it could not detect packs that weremissing only some capsules.
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Applications
Product and system parameters:
Average pack weight: 5.33 g; size: 106 mm + 66 mm + 6 mm
Average capsule weight: 0.467 g
Throughput: Over 180 packs/min
Arrangement: Packs are aligned vertically due to space limitation and are capsule-side down whengoing through checkweigher
Requirement: 100% rejection of packages missing one ormore capsules
Weighing resolution: ± 0.2 g
Ejector mechanism for rejection: Blower ejector nozzles
The blister packs runthrough an automaticprocess control
Company profileBoehringer Ingelheim was founded in Ingel-heim am Rhein (Germany) in 1885, where the corporate headquarters are still locatedtoday. At present, Boehringer Ingelheim is thebiggest pharmaceutical group in Germany,and it is the only privately-held family enter-prise in the world’s top 20 pharmaceuticalcorporations. In 2004, Boehringer Ingelheim’sannual profits reached 82 billion euros(106 billion U.S. dollars), making the company 15th in the world pharmaceutical listings.Even more remarkably, Boehringer Ingel-heim’s annual sales growth had alreadyreached second place in the industry’s top 20. In 2002, Boehringer Ingelheim invest-ed U.S. $2.9 million to establish a ChineseGMP-accredited factory in Zhangjiang HighTech Park in Shanghai. The products launched in China include Mucosolvan®, Glurenorm®,Actilyse®, Mobic®, Atrovent®, Ingelvac®,Aujeszky®, Ingelvac® and others, with anannual sales growth of up to 25–30%.
Customer:Boehringer Ingelheim Shanghai Pharmaceuticals Co., Ltd.Factory Location:Zhangjiang High Tech Park,ChinaApplication:Automatic Process CheckweighingIndustry:PharmaceuticalProject Time:December 2005Product:SYNUS™ Checkweigher
SolutionSartorius Aachen launched a new dynamiccheckweigher, SYNUS™, in 2005. The SYNUS™checkweigher’s wide range of weighingcapacities – 1 kg, 2 kg and 7 kg – can meetmost food and pharmaceutical manufac-turers’ weight checking needs. Thanks to theSYNUS™ checkweigher’s innovative modulardesign with its adjustable-height platformand patented electromagnetic force compen-sation (EMC) weigh cell, it displays impressivefeatures like the combination of exceptionalprecision with extremely short stabilizationtimes, maximum stability and rugged, indus-try-grade construction (IP protection rating:IP44; IP65 optional). Moreover, the creativeUSB data connection feature brings greaterconvenience for data transfer and storage. Its15” extra-large touchscreen with its user-friendly interface, which supports many dif-ferent languages (including Chinese), facili-tates the whole operation. Sartorius Beijingintroduced SYNUS™ to Boehringer Ingelheim
and SYNUS™ was selected due to its remark-able flexibility and reliability. Since their cap-sule pack weight is light, a 1-kg checkweigherwould have been the ideal choice, but thisversion was not officially launched at thattime and a 2-kg version was finally selected.
To optimize the planning and design of theproduct, capsule packs were sent toSartorius’s Beijing office for preliminary tests. Forty tests were carried out at a beltspeed of 1.2 m/s (240 units/min) and an aver-age pack weight of 5.33 g. The maximumweight recorded was 5.42 g, the minimumwas 5.28 g, with a standard deviation of 0.03.Normal distribution was applied with sixtimes the standard deviation to cover 100%of samples; products with a weight deviationof over 0.18 g were rejected. This approxima-tion was also valid under comparatively idealfactory conditions, although we did have todeal with several installation and operationproblems.
Problems with installation and operationSolution to problems caused by the gapbetween belts:Cause: The product, capsule side facing down,had only loose contact with the belt andwhen the packs moved forward to the weigh-ing belt from the infeed belt, the gapbetween belts induced slight vibrations,affecting the weighing accuracy. Solution: A stainless steel transit plate wasadded between belts to narrow the gap andthus eliminate the vibration.
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Applications
Improvement of the weighing process of the SYNUS™checkweigher
A stainless steel transit plate reduces the gap [1]between the two belts and eliminates vibration.
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4
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Problem with ambient conditions:SYNUS™ was placed in a small closed work-shop where there was a pressure differencebetween the room and corridor. Moreover,there was an air inlet right above the check-weigher; air flowed to the floor and thenupward to the air outlet in the ceiling, whichcaused a draft. Originally, the SYNUS™ draftshield was designed for protection fromdrafts coming from the front and from above,but now drafts were coming from below andthe side. The filter pressure regulator nozzlein the weighing module was too small to off-set sudden pressure changes, such as thosethat occurred when the workshop door wasopened and closed, so the weighing accuracywas negatively affected.
Solution: The checkweigher was fitted with alarger draft shield and the original bolt (forprotection during transport) underneath theweighing module and yellow cover wereremoved. Another filter pressure regulatornozzle was also added to ensure uniformpressure inside and outside the weighing unit.
Solution of vertically aligned product-in-feed problem
Customer requirement: Products infed tothe packaging machine and checkweigherwere vertically aligned. They needed to beturned 90 degrees without any decrease inthe infeed speed, and then traverse theweighing belt at a suitable belt rate of 0.8m/sto ensure there would be only one capsule on the weigher at a time. But the capsulepacks are very thin and their position couldeasily change before they passed to theweighing belt, resulting in different end-times determined by the photoelectric barrier.Furthermore, if a weighing accuracy of 0.02 gcould be achieved, 100% rejection of incom-plete products would be possible.
Solution: First, it was necessary to eliminatethe vibration effect caused by capsule packrotation, by fine-tuning the weighing con-veyor belt. Then the two feeder sideboardswere adjusted to ensure capsule packs are fedinto the checkweigher in a consistent posi-tion. The photoelectric barrier was moved to aposition underneath the belt so that the lightwould illuminate the capsule packs verticallyto increase the light block area and give amore accurate determination of end time.Finally, tests were performed to determinethe optimum parameters for the system. Anumber of holes were drilled in the collectionbox to fine-tune the rejection mechanics, toensure that all defective products would be blown into it.
ConclusionTwo hundred product tests were performedwith the above adjustments and the systemachieved 100% accuracy in detecting defec-tive products, which fully satisfied the cus-tomer’s requirements during the test run.
The 2-kg SYNUS™ checkweigher’s standarddeviation can be as low as 0.02 g; when multiplied by 6, the result is an accuracy of0.15 g. The latest 1-kg weigher can achieveeven greater accuracy, thus fulfilling evenstricter requirements.
Reader Service Code: 246
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Applications
The newly-designed draft shield [1]
Sideboards ensure correct performance at BoehringerIngelheim in Shanghai.
Certified competence and decades of experienceFounded by Erich Webers in 1958 as a familycompany providing general laboratory sup-plies and equipment, the Webers company isnow being run by the third generation in theform of Axel Webers in Bottrop-Kichhellen,Germany. It not only offers a pipette serviceand services piston-operated volumetricdevices in keeping with ISO 8655, but alsosells medical laboratory supplies. Pipette service is performed in labs throughout Germany and has even expanded to include15 other countries, with South Africa as the largest foreign market.
When the pipette service first began in 1992,the first workstation was also created. Today,employees at a total of eight workplaces testover 12,000 pipettes a year with completecalibration certification in accordance withISO 8655. And these numbers are on the rise.The recognized service team was trained andqualified by a wide variety of manufacturersat home and abroad. Additionally, the com-pany is both ISO 9001:2000 and ISO13485certified. Its pipette service is available allpipettes from well-know manufactures andincludes the following services:
• Maintenance with a complete calibrationcertificate (cleaning, pressure test, lubrica-tion, calibration)
• Repairs with original components• Special treatment with respect to
• Loan pipettes• A reusable transport system (padded hard-
top case to protect equipment)• Quality management• Service contracts
Large hospitals and universities in Germanyare among the company’s customers whohave their pipettes regularly tested. Providingthe best quality service is of the highestimportance to Webers.
Testing of the smallest volumesIn the company laboratory, there are twotried-and-true Sartorius R200D balancesalong with two ME5 ultramodern microbal-ances and the WZA225-CW weigh cell. Thesehighly accurate balances with a readability of0.001 mg and a weighing capacity of 5 g(ME5) or with a resolution of 0.01 mg and aweighing capacity of up to 220 g for theWZA225-CW are used to verify the smallestof volumes. Areas of application are the test-ing of piston pipettes and burettes, dilutors,and dispensers. External monitoring ofinspection, measurement and test equipmentis done by Sartorius and documented by aDKD (German Calibration Service) calibrationcertificate.
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Applications Precision measurements for liquid handling devices in the test laboratorySartorius impresses Webers GmbH Laborbedarf all across the board
Medical analyses require validated processes and precise results. For this, the mainte-nance and calibration of volumetric devices, such as pipettes, dispensers and burettes,must be exact and expert to ensure the necessary accuracy and precision. Webers primarily uses Sartorius balances and weigh cells for this purpose.
The Sartorius ME5 microbalances deliver fast weighing results in laboratories.
Calibration of pipettes is an important element of quality assurance.
The CE-compliant weigh cell WZA225-CWis used successfully in the laboratory.
To calibrate a piston pipette, the tip of thepipette is filled with distilled water and trans-ferred into a pipette channel where theweight of the liquid from the pipette is deter-mined. The volume is then calculated basedon temperature, air pressure and density. Theobjective here is to record the systematicmeasurement error (the difference betweenthe nominal and the actual value) along withrandom measurement errors (repeated stan-dard deviation). This process, called gravi-metric testing, is the reference method usedto test piston-operated volumetric devices.
Product qualities, service and qualificationabsolutely convincing in combinationThe ME5 balances impressed the laboratoryemployees by delivering incomparably fastresults (response time of only 10 seconds) andproviding exceptional repeatability, in partic-ular. As such, they fulfill the highest demandsfor precision. Furthermore, they also offer
complete functionality for use in testing witha completely automatic isoCAL calibrationfunction, a SQmin function to determineminimum sample quantity according to theUSP, and the S.U.R.E. measurement uncer-tainty display in keeping with the DKD. Customer-specific adaptability of Sartoriusproducts was also a clear advantage for the Webers company.
Mr. Axel Webers, the managing director,expressed it as follows: “Sartorius offersexcellent service that is fast and accommo-dating, offering immediate assistance, when necessary. Sartorius employees are highlyqualified, which was clearly reflected in thetraining seminars conducted for us at ouroffices. We are already looking forward toworking together in the coming years.”
Reader Service Code: 247
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Applications
A member of the qualified Webers service team shownperforming pipette calibration, a daily routine.
Spot-on fillingSartorius for the best of both worlds: high-resolution scales and bioreactors
With the aim of manufacturing biopharmaceutical agents at its own production plant in Ulm, Merckle Biotec went out looking for a provider that supplies both high-resolutionscales and bioreactors in its product portfolio.
Merckle Biotec GmbH was founded in 2004 in Ulm, Germany, as a wholly-owned sub-sidiary of Merckle GmbH. Within the Ratio-pharm Group, one of the world’s leadinggenerics manufacturer, Merckle Biotec isresponsible for producing active biopharma-ceutical ingredients and finished dosageforms with a primary focus on biosimilars.These are copies of bioengineered medicinalproducts and, in turn, some biosimilars imi-tate endogenous proteins. Their manufactur-ing requires much greater outlay than that of classical generic chemicals.
One step in the production process at Merckle Biotec is filling compounds for thefermentation stage. In 2005, the companywent out searching for high-resolution scalesand bioreactors that they could integrate into their processes. It needed products thatwere suited for setting up a proprietary pro-duction plant for active biopharmaceuticalsubstances that matched to a seamless fit.This is where Sartorius, as a supplier to bothsectors of the process business, came into
play by offering both high-resolution scalesand bioreactors. Because Merckle Biotecdecided on Sartorius as a full-range solutionprovider, the scales could be perfectly inte-grated into the automated fermentationprocess, and the was system up and runningin no time.
The organisms in the process tanks need justthe right amount of nutrients. Pumps areused to continuously feed in the liquid sub-strate. Now, high-resolution Sartorius stain-less steel gravimetric sensors with industrialplatforms constantly monitor the pumps’ per-formance and correct the system’s pumpingperformance in the event that any targets are out of tolerance. That means the companycan fill several 1,000 liters of liquid nutrientsubstrate – spot on – with high accuracy forweeks on end. It also means that they reliablymeet the strict requirements for GMP pro-duction.
Reader Service Code: 248
Sartorius stainless steel balances are used effectivelyfor manufacturing biopharmaceuticals.
Working in weightlessnessAnalytical balance LA310S for high precision and repeatability
Facts worth knowing about theDrop TowerSince 1990, the Drop Tower has beenoffering scientists from all over theworld the possibility of carrying outexperiments under conditions ofshort-term weightlessness, withoutthe need to climb aboard a spaceshuttle. The large laboratory is thusa cost-effective and permanentlyavailable alternative to research inouter space. A further advantage isthat the microgravity in the BremenDrop Tower is of the highest qualityand provides excellent preparationfor longer term experiments onboard the International Space Station (ISS). The tests carried outthere assist the automotive andaerospace industries to optimizefuel-saving engines and even toimprove aerosol can heads. Theproperties of magnetic fluids arealso investigated in the Drop Tower.
The principle of the Drop Tower isactually quite straightforward: All objects which fall freely or movepowerlessly within a space are auto-matically well-nigh weightless. Thus, the same also applies to the2.5-meter (8.2-foot) high, 80-cen-timeter (2.6-foot) thick drop cap-sule, which hurtles through the drop tube in the Bremen Drop Tower. The object under experimentation is located in the closed, pressure-tight research cylinder. The droptube is completely detached and hasno contact whatsoever with theexternal concrete tower, which is avisible landmark within the sur-rounding region. This protects thedrop tube from outside influences.
Requirements on the Sartorius analytical balanceAnalytical balances from Sartorius are used in a variety of applications at ZARM and arepart of the of the Institute’s basic laboratoryequipment. The LA310S was commissioned in 2005. The general objective of the Institutein this case was to record scientific data withhigh precision and excellent repeatabilitywith fast response times. Thus, the aim was toachieve high time efficiency, i.e. fully automated acquisition of measurement data.However, in doing so, the specific goal was to measure the volume of fluid that is suc-tioned into a porous medium in order toinvestigate the flow performance over timeof fluids in porous media.
Measuring fluid volume with the LA310SA porous test sample is immersed in a fluid.The surface tension of the fluid has an effecton the sample as soon as it comes into con-tact with the surface of the fluid. As a result,there then follows an abrupt increase in theweight force (within the range of a few mil-liseconds). At the same time, the porous sam-ple begins to absorb the fluid, leading to afurther increase in the weight force. Thistakes place relatively slowly within the rangeof a few seconds up to several minutesdepending on the conditions of the experi-ment. The aim of the research is to deliver aprecise measurement of the increase inweight over time. A weight resolution of atleast 0.5 mg (5 µN) is required. The samplingrate must be as high as possible and a mini-mum of 10 Hz. A metrological approach is the method of choice for the direct measure-ment of the forces.
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Applications
The Center of Applied Space Technology and Microgravity (ZARM) is a scientificinstitute in the specialized area of production technology at the University ofBremen. Its main clients are the German Aerospace Center (DLR) and the Euro-pean Space Agency (ESA). Within a just twelve years, ZARM has grown tobecome the largest and one of the most important university institutes for spaceaviation in Europe. Its large central laboratory is the 146-meter high DropTower, in which earthbound experiments can be carried out under high qualityconditions of short-term weightlessness. The LA310S is used here for the pur-pose of research into the flow performance of fluids in porous media.
The Bremen Drop Tower during the day…
An analytical balance with below-balanceweighing equipment was selected to measurethe very small forces that arise. A further reason for using this balance was the highlycompetent, professional, customer-orientedadvice and support provided by the employ-ees of Sartorius. For example, after discussingthe measurement problem in detail over thetelephone, a modified balance was offered in order to double the measurement rate.Sartorius employees also supported a testunder experimental conditions at ZARM last-ing several hours, so as to guarantee that the device would meet the requirements priorto buying.
The LA310S analytical balance greatly exceed-ed all requirements. The weight resolution is0.1 mg (1 µN) and the time resolution 50Hz. The weighing system’s outstanding stepresponse should also be specially highlighted.
In conjunction with SartoConnect communi-cation software and a standard PC, theLA310S analytical balance facilitated auto-mated, efficient acquisition of the requiredscientific data. With the help of the LabViewprogramming environment (National Instru-ments), it was possible to implement a fullyautomated system for the measurement offorces arising during the wetting and satura-tion of porous media. Measurements of thisprecision in terms of weight and time resolu-tion had not previously been possible.
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Reasons for using the Sartoriusanalytical balanceIn addition to the reasons alreadymentioned, on-site installation andcalibration of the balance wereamong other persuasive sellingpoints that Sartorius was able tooffer to ZARM. The detailed, profes-sional, friendly instruction in theoperation of the complex device wasalso very well received by employeesat the Drop Tower. The balance itself delivers excellent technicaldata such as the step responserecorded in the context of the testsat ZARM, i.e. the weighing system’soutstanding response time perfor-mance. Frank Ciecior, technicalemployee at ZARM, made the fol-lowing comments concerningSartorius: “We were of the opinionthat precise weighing requires along measurement time – the moreprecise the measurement, the longerthe time required. Since getting toknow precision weighing systemsfrom Sartorius, we have learned that speed and accuracy go hand inhand. We had a difficult measure-ment problem to solve. By using theLA310S, all our requirements weremet – indeed far exceeded. We nowhave high precision, repeatable sci-entific data. For me, Sartorius is syn-onymous with precision weighingtechnology.”
…and the Drop Tower at night.
The interior of the Drop Tower in which weightlessness experiments are carried out…
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Applications
Measuring micronewtons in milliseconds:Data relating to the outstanding time per-formance recorded with the LA310S:System excitation:0.1414 g (max. value), measurement rate50 Hz.System response:Achievement of the maximum value of0.1454 g after 120 ms (6 measurements) –the maximum value is only 4 mg higherthan the actual value (overshoot is lessthan 3%).After a further140 ms (7 measurements)the measurement values lie within thedefined tolerance band of +/-0.5 mg(+/–5 µN), i.e., after a total of 260 ms, anaccuracy of better than 0.5 mg is achievedat the given excitation.The maximum rise time (0.1 → 0.9 of themax. mass) is 0.040 s – this corresponds toa maximum cut-off frequency of 25 Hz.The actively controlled weighing systemused is therefore in a position to measureevents of an amplitude of 140 mg up to a frequency of 25 Hz at an accuracy ofbetter than +/– 0.5 mg (+/– 5 µN). Furthermore, at a sampling rate of 50 Hz,these events can also be correctly evalu-ated in accordance with the sampling theorem.
Reader Service Code: 249
The step response of the balance
The LA310S analytical balance in use at the Bremen Drop Tower
Moisture analysis of medical suture materialsApplications for the WDS 400 in the medical devices industry
Weigao was founded in 2000 as a state-owned industrialization base within the scopeof a high-tech research and developmentscheme of the Peoples’ Republic of China.Weigao manufactures more than 110 differ-ent product groups with over 2,000 specifica-tions. This high-tech enterprise not only gar-ners an 80% share of the domestic market,but Weigao also exports its wares to 30 othercountries, including the USA, Germany,Romania, Australia and the United Kingdom.
In October 2005, Weigao went looking forequipment that could analyze the moisturecontent of medical suture material fast andaccurately.
Water content must be subject to strict con-trols as otherwise a too high water contentwill affect the product quality and lead to its rejection because of non-conformity. Theaverage sample weight is around 300 mg; the proportion of water must be less than500 ppm.
After extensive interaction with Sartorius inBeijing and an authorized Sartorius dealer,Weigao confirmed that the WDS 400 waterdetection system from Sartorius in combina-tion with Sartorius analytical balances would satisfy the company’s requirements to the fullest.
Selective Water DetectionThe WDS 400 joins three of the classic, recognized standard measuring methods intoone high-resolution and easy-to-use combi-nation method:
• The principle of convection heating of thedrying oven is used for sample heating.
• The selective absorption of evaporatingwater using hygroscopic phosphorus pen-toxide derives from the moisture analysis of gases.
• Coulometric detection of bound wateraccording to Faraday’s law is used in Karl-Fischer titration, for example.
The mode of operationAfter weighing-in the sample on a semi-micro- or microbalance, the specimen to bemeasured is heated in the stainless steel ovenbuilt into the WDS 400. In accordance withthe analytical requirements, several tempera-tures can be combined into one heating pro-file. The maximum drying temperature is400°C. The water extracted from the samplematerial by thermal forces is absorbed by acarrier gas and conducted to the electro-chemical sensor of the WDS 400.
Once in the sensor, the gas charged watersteam flows across a phosphorus pentoxidelayer that selectively absorbs water.
Using the current applied to the sensor, thebound water is broken down electrolytically;in other words, into its elements hydrogenand oxygen. Faraday’s law is used to convertthe amount of electricity used for this processinto the mass of water molecules involved inelectrolysis.
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Applications
Shandon Weigao Group Medical Polymer Company Limited is located in the Chinese city of Weihai in Shandong Province. Its focus of activity is the research, development,production and sale of brand-name single-use analyzers for medical applications sold to hospitals, blood donor centers and other healthcare organizations. About a yearago, the company invested in a WDS 400 for determination of trace amounts of water in medical suture material.
The WDS 400 is used at Weigao to determine the moisturecontent of medical suture materials.
Curve showing measured data obtained during wateranalysis of the material
The performance features in brief
• Selective detection of– Surface water– Capillary water– Water of crystallization
• Detection limit of 1 µg of water
• Range of application for up to approx. 40%water content
• Measuring accuracy of ± 2% from theabsolute measurement
• Sample heating from room temperature up to 400°C
• Readings in ppm (parts per million), %, mgwater or mA test current
• 15–2,000 mg sample quantity
• Windows® user interface with graphicalevaluation of the analysis
Because the suture material absorbs moisturefrom the ambient environment very rapidly,we designed a glass cover for the WDS 400,which is flooded with dried nitrogen duringthe measurement.
The Weigao Group’s managing specialistresponsible for WDS 400 applications,Mr. Song Yimin, explained that the main reason they chose the WDS 400 was the ana-lyzer’s accuracy and speed of measurement:qualities that were as evident at installationas during routine use. The accuracy is higherthan with the classic detection methods likeKarl-Fischer titration, and the time it takes to weigh samples with an average weight of50–100 mg is only around 10 minutes.
As an end-user of Sartorius products, Weigao Group also gave exceptionally highrecognition to the professionalism of theSartorius staff.
Reader Service Code: 250
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Applications
Networked with a PC, the WDS 400 transmits evalua-tions generated by its software to the PC.
The speed and accuracy of the WDS 400 won overemployees at Weigao.
Growth, characterization and processing of crystals Sartorius semi-microbalance impresses an entire institute
Did you know that light-emitting diodes (LEDs) are special crystals and that they haveconsiderable advantages over traditional light bulbs? With a lifetime 30 times longerthan that of a conventional bulb while consuming only 22 of the electricity, they are significantly longer-lasting and more environmentally friendly. Among its other responsi-bilities, the Institute of Crystal Growth in Berlin-Adlershof works on growing such crystals, and successfully employs the ME235S semi-microbalance to accurately weighthe different materials involved.
What is the Institute of Crystal Growth(IKZ)?The IKZ is a research and service institutionthat focuses on the development and creationof mono- and multicrystalline materials withdimensions ranging from nanometers todecimeters. To this end, the Instituteresearches the scientific and technical basesfor the growth, processing and physico-chemical characterization of crystalline solidstate materials.
These are primarily used in micro- and opto-electronics in addition to power, sensor andacoustic electronics, photovoltaics, optics and
laser technology and for basic research. Many of the applications in modern equip-ment such as cell phones or lasers are madepossible by the use of specific physical qualities, which, in turn, require crystals withdefined characteristics.
The Institute provides partners in researchand industry with research and service, thusforging links between basic research, appliedresearch and industrial applications.
Oxide crystals for use as sensors and lasers
What conditions are necessary for crystal growth? Crystal growth requires the creation ofmolten matter and solutions containing different chemical elements and compoundsin highly exact mixing ratios. In addition to the basic elements of a crystal, doping elements in exceptionally small amounts mustbe admixed precisely. The IKZ was looking fora balance that could offer extremely accurateweighing in the µg range and deliver highlyrepeatable results to ensure optimal andextraordinarily precise mixtures. One key criterion was that the balance not drift.
Following a presentation of the SartoriusME325S-0CE semi-microbalance, the IKZdecided in favor of using it to assist them inreproducibly growing crystals with thedesired chemical and physical properties. Theexcellent repeatability of this balance is justone of its considerable advantages. Addition-ally, it exhibits astonishing imperviousness to external influences on location.
To be able to precisely mix a formula for crys-tal growing, an exact amount of each of therespective chemicals must be weighed inaccordance with the phase diagram. Onlythen can the desired element concentrationsin the crystal and, as such, the solid matterqualities be optimally adjusted or specificallychanged. Thanks to the reliability of theSartorius balance used, the employees at theInstitute can be sure that the weighed quan-tities are accurate. The Sartorius ME standsfor reliability and also offers unique prerequi-sites for unrestricted and consistent measur-ing accuracy.
What must be considered when weighingthe materials used for the growth processon the ME235S-0CE semi-microbalance?The preparation of in part very expensivechemicals for the growth process requiresspecial conditions: The balance is stored in aglove box that is rinsed with extremely dryand pure nitrogen. This is necessary forhygroscopic chemicals, for example, as theyattract water and their breakdown or chemi-cal instability must be prevented. Small sample containers are placed next to theME235S-0CE and used to weigh the differentchemicals exactly.
The nitrogen box has an integrated air lockused to transport the chemical cocktails inclosed containers out of the protective gasatmosphere – a process similar to the prin-ciples used on the shuttle in outer space. Thegas exchange required in the air lock to main-tain the extremely dry and clean conditions in the glove box is accomplished by a pumpand numerous gas exchanges. Working with gloves is essential in a protective gas glove box, resulting in unavoidable briefchanges in pressure inside the box. Sincehighly exact weighing with absolutely preciseresults is the highest imperative here, reliableoperation and error-free handling of the balance even when using the gloves must beassured.
In addition to its easy-to-read display andcontrol unit and mechanical stability, thespeed of the semi-microbalance is alsoadvantageous to the weighing process, allowing the balance to deliver consistentweighing results accurate to five decimalplaces in just eight seconds. Once the materi-als have been weighed, they can be dis-charged through the air lock and introducedinto the crystal growing equipment. After the growth experiment has run its course,employees at the Institute analyze the resultsto see if the desired correlation between thecomposition of the basic materials and thephysical and chemical properties of the crystal needed for its intended applicationhas been achieved.
Reader Service Code: 251
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Applications
The Sartorius ME235S-0CE semi-microbalance impressed IKZ by its stable and quick weighing results, along with its imperviousness to ambient conditions and influences.
Sample containers containing chemical compoundsthat have been weighed
Laboratory robot tests carotenoid productsusing Sartorius microbalances at BASF
Assured quality of ß-cartoene at the BASF GroupCarotenoids are natural pigments formed byplants and other organisms. Of the 800known carotenoids, around 200 can be pro-duced synthetically. One of these compounds,ß-carotene, is not only perfectly suited forcoloring foods and beverages, but also hap-pens to be very healthy as well. Most of usknow that ß-carotene is an important sourceof vitamin A when ingested with food. Itadditionally protects the body against UV-light induced stress.
BASF sells ß-carotene formulated as a water-soluble powder to food and beverage manu-facturers, among others. The laboratory robotthat works in the manufacturing process was developed at BASF’s Specialized Centerfor Automation Engineering to solve specialproblems.
The Specialized Center for Automation Engi-neering at BASF has the expertise to createrobotic systems for the sector of laboratoryautomation. This is done for the most part to meet BASF’s internal demands. However,the robot specialists also offer their servicesto external customers.
Advantages of using a laboratory robotBefore the company invested in robotic sys-tems, the samples were analyzed manually.That meant that the results were subject to inter-individual fluctuations. The measure-ments sometimes ranged so far out of theallowable tolerances that they often had tobe repeated. As a consequence, the decisionwas made to automate sample processing.
The robot’s task is to weigh, dilute and stir theß-carotenoid samples and to then dilute themagain until a measurement is possible. Thesample processing and measuring processesare always the same. First, a sample is placedon a belt before all further steps are run
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Applications
For two years now, Fine Chemicals Business Unit at BASF has been employing a laboratoryrobot to test and assure the quality of carotenoid products during the manufacturingprocess. This mechanical “employee” takes a load of work off the sample processing staffand carries out all the necessary analyses in automated fashion. Two microbalances fromSartorius are integrated into this process.
Sartorius microbalance in action at BASF. The QA laboratory closely monitors the robots.
Weighing in portablemixing vesselsEasy as 1-2-3
automatically. The analysis of a sampletakes around 15 minutes. During theprocess, the results are shown to the work-ers as a curve on the screen and are thenpassed on down the process control sys-tem of the production plant.
Use of Sartorius microbalances in thelaboratory robot processUsed for both sample processing and formeasuring the sample weight, the bal-ances are interfaced to process controlsoftware. On one of the balances, a sub-stance is weighed-in automatically, whichis made possible by the motorized draftshield system. This system is highly preciseand opens and closes again quickly. Thesecond balance is employed at the sitewhere water is added to the samplethrough a thin tube. This serves to dilutethe sample by ten-fold because samplesare not suited for analysis unless they arediluted. The measurement is performed byUV/VIS spectroscopy. The result includesinformation about the content as well asthe coloring strength and hue.
The use of two Sartorius balances wasimportant for BASF because these can beoperated automatically and generate thesame records. The integrated softwaresupports all applications in the laboratory.This means that laboratory work runssmoothly and efficiently. This not onlysaves BASF an enormous amount of time,but also gives them the security that theirresults are reliable. Yet, another com-pelling feature of the microbalances isthat they are impervious to external ambi-ent influences at the place of installation.
Reader Service Code: 252
The typical shear beam load cell offered bythe competition was failing regularly, soSartorius North America was called in tohelp. In close consultation with the cus-tomer, the “perfect” portable vessel weigh-ing solution was produced in a customizeddesign.
The customer required a fully wash-down,portable vessel weighing system that allows ingredients to be weighed during the mixing process. In cooperation withSartorius, a vessel weighing system wasdesigned to incorporate the PR6211 com-pression load cells with the PR6011/30SFlex-Lock kits. The use of the small PR6011load cells was favored due to the low vesselweight and the desired high resolution of10,000 digits.
Sartorius North America then suggested the PR6011/30S mounting kits to ensureadequate side protection when the vessel ismoved from one location to another. As thesmaller mounting kits do not offer adequate
protection against the lateral forces arisingin portable vessel weighing systems, adesign with a regular, impact-absorbentprotective wall was required.
An adapter kit was specially developed toenable the PR6211/22D1 load cells to fitexactly into the PR6011/30S mounting kit.In doing so, the thermal expansion of theconstruction had to be taken into consider-ation. An adapter kit made of hardenedsteel is required to allow proper force intro-duction over the entire lifetime of the vessel.
After a short planning phase, Sartoriusreceived an order for several vessel weigh-ing systems utilizing Combics 1 indicators.All vessels were calibrated without weights,verified with weights and now play a keyrole in formulating new consumer productssuch as shampoo, conditioner and bodylotions. For the manufacturer, the particu-larly noteworthy features are the display’shigh stability during the mixing process andthe system’s resistance to hot water wash-down. The clear backlit display, which is visi-ble from a wide angle, is also a highlight.
Reader Service Code: 323
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Applications
A major manufacturer of consumer products located in Cincinnati, Ohio, USA,approached Sartorius with the problem of inaccuracy and consistent load cell failurein its vessel weighing systems. Sartorius was in a position to offer a fast solution to this problem.
Ready-processed samples
Installation kit PR6011…
…with adapter U1-R6011ADAPT Complete tank system with Combics 1 indicator
Sartorius applies its know-how to culinary delicaciesBird’s nest market in Hong Kong uses Sartorius balances and moisture analyzers
For centuries, bird’s nests have been considered both a delicacy and a health-promoting dietary supplement in China.The nests in question are made by swallowsand said to increase strength. They are also rather rare, making them a valuablespecialty. The price is proof of their valueas a delicacy: in 1987, one pound cost as much as U.S. $375. People today stillgreatly value this gift of nature.
Recently, equipping delicatessens that offerthese and other products became part of the new market into which Sartorius has beenexpanding. A Sartorius Element ELT2001 balance was installed in all of the 32 retailchain outlets and warehouses throughoutHong Kong of Sartorius business partner Lo Hong Ka Birdnest Wholesale Ltd. Anothercompany in this market, the Hing Kee JavaEdible Bird’s Nest Co. Ltd., uses the SartoriusEB15DCE-I platform for stock distribution at its 13 stores. Both companies’ stores arelocated in the most popular and crowdedshopping areas in Hong Kong, and this fact,coupled with the large number of stores, hassignificantly increased Sartorius’s exposure at both companies together with brandawareness by the public.
Why did these specialty food sellers choose Sartorius?Throughout the entire product introductionphase, demonstration, delivery and employeetraining, both Lo Hong Ka and Hing Kee JavaEdible were very impressed by the experi-enced and professional service Sartoriusoffers. Service representatives made severalvisits to the customers to better understandtheir operations and needs, thus creating thebasis that enabled Sartorius to offer severalpossible solutions.
In addition to weighing options for the deli-cate bird’s nests, Sartorius also took a look atthe companies’ hygiene and quality demands.Sartorius helped Lo Hong Ka find a conven-ient way to determine moisture content for
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Applications
The bird’s nests are weighed on the Sartorius EB15DCE-I industrialscale that offers employees a wide array of functions.
This laboratory balance also delivers reliable and precise results whenweighing out a purchase for a customer.
hygiene and quality control. Bird’s nests mustbe kept in a very dry environment, for mois-ture affects the shelf life of the nests byallowing mold to grow faster. The nests arealso sold by weight. A high moisture contentleads to a significant drop in actual salesvalue. Sartorius was able to offer the cus-tomer a moisture analyzer as a quick and easyway of monitoring the moisture content oftheir products.
Lo Hong Ka is a GMP- and ISO- accreditedcompany that has its own laboratory forproduct quality control. Lo Hong Ka’s man-agement wanted to create a unified weighingstandard for the main offices and all salesoutlets, and chose the Sartorius ElementELT2001 balance to achieve this objective. Itseasy use and simple, yet stylish, design quicklywon the staff over. The balance’s design alsosuits the company image of Lo Hong Ka well.The clear allocation of individual keys to dif-ferent functions and the easy-to-understandsymbols enable intuitive operation. The large,white backlit and easy-to-read display alsooffers the sales staff exceptional convenience.
The rugged Sartorius EB15DCE-I industrialscale is now in use at Hing Kee Java Edible.Without demanding a compromise betweenreliable weighing results and the highestaffordable quality, the EB scales offer addi-tional functions at the press of a button thatinclude totalizing, weighing in percent, tog-gling between gross and net values and massunit conversion, etc. Because of their backlitdisplays, these Economy series scales are easyto operate even under poor lighting condi-tions. Equipped with a shock-absorbing stain-less steel load plate, the scale featuringSPEED-UP technology delivers stable weightreadouts within a half a second. All theseattractive features add value by ensuringaccurate weighing results.
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Applications
The moisture content of dried foodstuffsreflects the ratio of actual value to price paidfor both incoming and resale products. To beable to reliably offer only the best products,Hing Kee Java Edible adheres to a high stan-dard of quality control. The company uses theMA45 moisture analyzer to monitor the mois-ture content of bird’s nests and other valu-able dried herbs and seafood products. Theanalyzer operates like a drying oven, usingthe gravimetric weigh and dry method, butdelivers results in just a few minutes. The staffparticularly appreciated how easy the MA45was to use. This makes working with it effi-cient, while providing precise informationabout the quality of the product purchased.
Lo Hong Ka – a pioneer in the ready-to-eat bird’s nest marketLo Hong Ka was established in 1988 and wasan instant success on the demanding HongKong market. Their ready-to-eat bird’s nestconcentrate was unique and set new stan-dards for the industry. Since being intro-duced, this product has won over many customers in Hong Kong for it offers conven-ience and efficiency at an affordable price. Lo Hong Ka’s founding concept was to open achain of specialty stores that would offer notonly its signature “bird’s nest concentrate,”but also an increasing range of natural healthproducts and beauty-enhancing foods to awide range of consumers. Soon after openingits stores in Hong Kong, Lo Hong Ka openedits doors for customers in Malaysia, Taiwanand Singapore.
At Lo Hong Ka, employees use a special combination of traditional and modern tech-nology for the gentle simmering process. This ensures that all the nutrients areretained. Additionally, the company strives toimplement Good Manufacturing Practice
(GMP) and Hazards Analysis Critical ControlPoints (HACCP) guidelines based on theMalaysia Standards (MS 1514:2001 and MS1480:1999) in its production.
Hing Kee Java Edible – “The bird’s nestsare upstairs”Hing Kee Java Edible has positioned all itssales areas like the nests themselves: these arenaturally found in the tops of trees, and thestores are located on the top floor of theirrespective buildings. This innovative salesmodel increased the recognition of the com-pany and saved a great amount of rent, forrental costs of the lower, more easily accessi-ble floors are considerably higher. These sav-ings in turn allowed for a drop in sales pricesfrom which the company’s customers profit.
Hing Kee Java Edible pursues a strategy ofefficient resource utilization. This strategy’ssuccess is based in part on increased invest-ment in quality control management toensure that all its products are top of the line.The company also takes care to maintain agood balance between price and quality toincrease customer loyalty. The number of customers has grown throughout the years,and by now the company is one of the topsellers of bird’s nests in Hong Kong. Thisproves that the choice to pursue consistentlyhigh product quality was correct and that itbenefits both the company and its customers.
Reader Service Code: 254
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Applications
One of the many stores that successfully use Sartorius know-how for daily processes.
The MA45 moisture analyzer allows staff to work efficiently, thanks in part to its ease of use.
Fahrenheit, Celsius, Kelvin & Co.On the history of temperature units
Daniel Gabriel Fahrenheit (born May 24, 1686, in Gdansk in today’sPoland; died September 16, 1736, in denHaag) was a German physicist and maker ofmusical instruments. The Fahrenheit tempera-ture scale (°F) was named after him.
His parents died at an early age, forcingFahrenheit to do an apprenticeship as a mer-chant in Amsterdam. He undertook extensivetravels and became a glass-blower in denHaag, specializing in the construction ofbarometers, altimeters and thermometers. In 1718, he gave lectures on chemistry andbecame a member of the Royal Society in 1724.
Fahrenheit developed precise thermometerswith three-point calibration (Fahrenheitscale) and thus founded the field of ther-mometry. At first, he used ethanol as the sub-stance for his thermometers, but beginning inabout 1718 he also used mercury, becomingthe inventor of the mercury thermometer. He used the lowest temperature he was ableto measure outdoors in winter, which was17.8°C (in Gdansk in the winter of 1708/09).Other sources cite the temperature attainedby mixing ice, water and ammonia. As a sec-ond reference temperature, he chose thetemperature of the human body (measuredon his own body, which was 37.8°C). AndersCelsius’s critique of Fahrenheit’s scalerevolved around the fact that these referencetemperatures could not be verified in practice.
For a time, the Fahrenheit scale was used inGermany. In the United States, temperature is still measured in Fahrenheit today. Becauseone degree Fahrenheit represents such a smallunit of measurement in weather forecasts, it is customary to give a temperature rangesuch as “in the 90’s” (meaning 90 to 100°F, or 32.2 to 37.8°C). Outside the U.S., theFahrenheit scale is no longer widely used.
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Spotlight
225.85°C = 500 K = 440.3°F
100°C = 373.15 K = 212°FBoiling point of water(1 bar pressure)
37.8°C = 301.93 K = 100°F
0°C = 273.15 K = 32°FMelting point of water(1 bar pressure)
- 17.8°C = 255.4 K = 0°F
- 273.15°C = 0 K = 459.7°FAbsolute zero
Structure of the temperature scale with three different units of temperature
Since 1970, only SI units have been used in scientific work – but a number of otherunits are still around. Some are customary and therefore authorized for official use,while others are part of everyday language. In natural sciences as in many other areas,a number of researchers attempted to quantify the measurement of temperature andmake it more precise, especially in the period from 1700 to 1850 when the naturalsciences were established. Of the scales developed at that time for measuring temper-ature, three are still in use today while a fourth is heard of only rarely. The researcherswho gave these scales their names are presented briefly in the following.
Anders Celsius(born Nov. 27, 1701, inOder, near Uppsala; died April 25, 1744, inUppsala) was a Swedishastronomer, mathemati-cian and physicist.
He studied at the Uni-versity of Uppsala andbecame a professor there in 1730. In 1736, hetook part in an expeditionto measure the shape ofthe Earth. In 1741, hecompleted constructionof the first Swedishobservatory in Uppsala.He was also a poet andauthor of popular sciencewritings. He died oftuberculosis in 1744, atthe age of 43.
Celsius invented the temperature scale namedafter him. In contrast to the Celsius scale inuse today, he fixed the freezing point ofwater at 100° and the boiling point of waterat 0°. It was not until shortly after his death – in 1745 – that his disciple, Karl von Linné,turned the scale around. Today, it is usedexclusively in the latter form. It is without adoubt the most widely used temperaturescale in the world, since it is firmly estab-lished both in the laboratory and in everydaylife. What was revolutionary about this scalewas that Celsius suggested its universal use in order to compare temperatures all over theworld. In contrast to other researchers, forthe determination of his reference points henoted the prevailing atmospheric pressure(760 mm on a column of mercury) as well asthe temperature, thus precisely defining theconditions of measurement.
At the Ninth General Conference on Weightsand Measures in 1948, the temperature scalewas renamed the Celsius scale in honor ofAnders Celsius. It is authorized in scientificuse and customary in everyday life, and is also known as the “empirical temperature.”Particularly in the definition of melting andboiling points and with regard to conditionsof measurements, the Celsius scale is usedalmost exclusively. In thermodynamic calcu-lations, in which the temperature goes intothe formula as a factor or multiplier, it is notpossible to use the Celsius scale. Here only theKelvin scale can be applied, as it is based onabsolute zero.
William Thomson,named First Baron Kelvin of Largs in 1892 and generally referred to as Lord Kelvin (born in Belfast, Ireland, on June 26, 1824,died in Netherhall near Largs, Scotland, onDecember 17, 1907), was a British physicist.
He was knighted in 1866 and granted a peer-age as the First Baron Kelvin of Largs in 1892.The name “Kelvin” derives from a river inGlasgow. From 1846 to 1899, he was profes-sor of theoretical physics in Glasgow and, inhis research, concentrated mainly on theareas of electricity and thermodynamics. Thisresearch resulted in the 1848 publication of apaper on thermodynamics based on Carnot’stheory of heat, in which, among other things,he introduced the absolute Kelvin scalenamed after himself. The unit of this scale,the “Kelvin,” is in its modern form the legallyprescribed SI unit of temperature. Since it isbased on absolute zero, temperatures in Kevinare absolute temperatures and can be used in calculations. However, the Kelvin scale hasnever caught on in everyday usage. Part ofthe reason undoubtedly lies in that “every-day” temperatures, even those of icy winters,begin at levels over 250°K, which makes thisscale less tangible than the Celsius scale.
Since absolute zero cannot be reached, ther-mometers can only be calibrated by means ofvarious reference points. There is only one“triple point” temperature, at which all threeaggregate states of water (solid, liquid andvapor) are present at the same time: 273.16°K(0.01°C). Using this triple point, thermometersare calibrated for use as reference instru-ments, to calibrate other thermometers andthus disseminate the unit of temperature.However, since no thermometer can cover theentire spectrum of temperature, additionalreference points are necessary. Each of thesereference points reflects a point of balance ofcertain molecules or atoms, e.g., the tempera-ture at which liquid helium becomes gaseous(3°K to 5°K) or the melting point of copper(1357.77°K).
Since all three temperature scales are used in laboratories around the world, the Docu-pHMeter and the Professional Meter offer the choice of using different tempera-ture scales in the display and on printouts.
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Spotlight
Docu-pHMeter with display set to ° Celsius
René Antoine Ferchault de Réaumur(born Feb. 28, 1683, in La Rochelle; died Oct. 17, 1757, in Bermondiere) was a Frenchscientist with a very broad range of interestsand working areas.
He made especially important contributionsin the field of entomology. He also made several discoveries with regard to steel pro-duction, discovered a type of frosted glass,which was named Réaumur porcelain afterhim, and an alcohol thermometer, for whichhe developed a completely new temperaturescale named after him: the Réaumur scale. It continued to be used in Europe even aftermercury replaced alcohol in thermometers. It was not until 1901 that the official mea-surement of temperature was changed fromRéaumur to Celsius. That was officially theend of the Réaumur scale. It is, however, stillused today in one particular instance: whenboiling a sugar solution, cooks and patissierscheck the temperature in degrees Réaumur.
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Spotlight
A comparison of temperature scales
Fahrenheit Celsius Kelvin Réaumur
Year of introduction 1714 1742 1848 1730
Lower reference Mix of ice, water Melting point Absolute zero Melting point point and ammonia of water (0°C) (–273.15°C = 0 K) of water
(0°F = –17.8°C (0°R = 0°C)0°C = 32°F)
Upper reference Body temperature, Boiling point Triple point of Boiling point of point high 100°F –~ 37.8°C of water water at atmos- water at atmos-
(Normal body at atmospheric pheric pressure pheric pressuretemp. 98.6°F –~ 37°C) pressure (100°C) (273.16 K = 0.01°C) (80°R = 100°C)
Conversion in °C C = (F-32) (5/9) C = K + 273.15 C = (5/4) R
Professional Meter, shown with the menu for selecting the temperature scales
Sartorius Limited in the UK offers a seminar to its customersRevised average weight legislation in the UK and how it affects packers
Thirty-eight representatives from some of theUK’s leading food manufacturers, such as Guiness, Cadbury, Coke-a-Cola and Unilever,attended a one-day seminar at the City ofManchester Stadium, the home of Manches-ter City Football Club, to learn about the lat-est changes to average weight legislation andreducing give-away or overfill.
There is nothing better than hearing this from the “horse’s mouth” and so Sartoriusenlisted the services of Howard Burnett fromNational Weights and Measures Laboratory.Mr. Burnett was responsible for training someof the UK’s Trading Standards Officers on thenew legislation, among other things.
Besides giving some background to the legislation that has been on the statute bookssince 1985, Mr. Burnett went on to outlinethe changes in the 2006 regulations.
It was clear from a question and answer session that there was still confusion over theregulations, and the combined benefit of having an expert on hand and being able tocompare notes with other people in the sameindustry clarified a number of points for thedelegates.
Although compliance with industry legis-lation is important, there is nothing betterthan the concept of saving money to makefinance directors and company boardsapprove capital for investment. This was rein-forced by a presentation by Colin Maher,Technical Specialist for QA systems at
Sartorius Limited. Mr. Maher gave a cleardemonstration that use of data generated byaverage weight control system SPCfWin cancreate savings that easily cover any initialinvestment and go on to generate additionalbottom line profit to businesses.
Such savings occur from the reduction inproduct giveaway, wastage, product isolationand reference testing. So, what starts life as a cost to comply with legislation ends upbeing a real cost-saving investment.
A presentation of the latest Process Weighing& Control products, including the SYNUS™checkweigher, IPCs and Combics terminals,gave delegates a chance to stretch their legsbefore the final presentation of the day. This closed the loop, by demonstrating aver-age weight control data capture withSPCfWin as well as automatic and manualtrend control adjustments to filling machinesresult in a seamless process control system for filling and packing.
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Training
Howard Burnett from the British NationalWeights and Measures Laboratory gavehelpful infomation to participants of thetraining seminar.
The advantages of the SYNUS™ checkweigher were presented.
Many representatives of leading food manufacturers in the UK attended theseminar that Sartorius Limited organized.
Indicator meets platform under a special obligation“Guide to Verification” for indicators now available online
To be able to construct a verifiable weighinginstrument from a control and display unit(indicator) and platform/weight sensor, the compatibility of the components has tobe checked and confirmed. The “Guide to Verification” contains all the specifications,conditions, information and documentsrequired for this purpose, including an easy-to-use Excel program for the manufacturer of weighing instruments or dealer.
Control and display unit: A control and display unit consists of an analogue/digitalconverter, digital electronics, display, controlunit and software applications, where appro-priate. It is sometimes also referred to as aterminal or indicator. Sartorius indicatorsinclude the following: Combics, CISPRO, isi + A/D converter, PR17.. weighing controllersand X-Series process controllers.
Platform/indicator: A strain-gauge weightsensor (analogue) comprises strain-gaugeload cell(s), load receptors and connectionelements. For Sartorius, these include, forexample, CAP...-.CE platforms and IF...-.CEflat-bed scales.
I. EC type-approval and test certificatesThe SARTICS EC type-approval certificatetogether with the general load cell accept-ance clause form the basis for verifiableweighing instruments using Sartorius indica-tors in combination with weight sensors orstrain-gauge load sensors / load cells (see Figure 1). The indicator test certificates areauthoritative as far as technical data is concerned. The load cells used must have atest certificate in accordance with OIML R60issued by one of the Notified Bodies of theEC. This contains the required load cell data.The load receptor and load cell must complywith the general principles and examplesspecified in the WELMEC 2.4 Guide(http://www.welmec.org/publications/2-4ge.pdf).
II. Indicators in combination with non-Sartorius platforms/weight sensorsThe compatibility of the modules must bechecked and confirmed in this case. The“Guide to Verification” is provided for thispurpose. Until now, this Guide was enclosedwith Sartorius indicators in the form of abooklet or CD. The current version wasrecently made available online in English and German at:http://www.sartorius.com/leitfaden_eichen/.French, Italian and Spanish versions are currently under preparation (see Figure 2).
The Guide contains– EC type-approval and test certificate,
complete with attachment– Illustration showing connections
and labeling– Declaration of Conformity with Directive
90/384/EC– Technical data of the indicators (in the
same form and sequence as in the compati-bility program)
– “Compatibility of the Modules” Excel program officially approved by WELMEC
– Explanations for the Excel program– Sample file as an example of a completed
compatibility declaration
The desired indicator is selected in the topsection of the Guide. The desired document orcompatibility program can be chosen fromthe menu on the left hand side (see Figure 3).The “Compatibility of the Modules” programprovides an easy and convenient way todetermine whether the desired configurationof a weighing instrument comprising indica-tor and platform is verifiable. To check this,the technical data is entered for the indicator,load cell, load receptor and desired weighinginstrument configuration (such as, for exam-ple, ranges, maximum capacity and verifi-cation scale interval). The program indicatesall compatible settings by “yes” in shadedgreen (see Figure 4). The manufacturer orassembler of the weighing instrument mustprint and sign the data sheets before present-ing them for verification. The Declaration of Conformity is valid only in conjunctionwith a completed and signed certificate of compatibility.
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Metrology
Figure 1: EC type-approval certificate for SARTICS
Weighing Instrument(EC type-approved certificate + test certificate for indicator + test certificate for load cell)
+
IndicatorA/D converter, digital electronics,display, control unit, applications(with own test certificate and type/model)
Weighing platformLoad receptor + load cell(s)(Load cells with test certificate)
III. Indicators in combination with Sartorius platformsSartorius has already provided certificates ofcompatibility for a large number of indica-tor/platform-weight sensor combinations.These combination options are listed in the“Compatibility Lists of the Modules” asapproved by the PTB* and printed in theinstallation and operating instructions (seeFigure 5). If the desired combination isincluded in the lists, the compatibility test isno longer necessary for verification purposes.It is sufficient to present the declaration ofconformity with the compatibility list fromthe installation and operating instructions forthe platform. Initial verification must be car-ried out by Sartorius or the weights andmeasures authority. Taking due account ofcertain conditions, special variants of the list-ed load sensors may also be built and verifiedwithout further testing, e.g. load sensors oflesser size.
The following applies in the case ofunmodified “standard load sensors”:– When configuring the weighing instrument,
only the ranges as defined in the lists for aplatform may be implemented. The maxi-mum capacity, Max, may be selected up tothe specified maximum; however, this mustamount to at least 500 verification scaleintervals. The minimum capacity, Min, andverification scale intervals may not bechanged. The two-range weighing instru-ments [.-NCE] are shown in the lists. How-ever, only a one-range weighing instrument[.-LCE] with fine or coarse range is allowed.
– When configuring the weighing instrument,the value specified in the lists for the initialzero setting range and the additional deadload must not be exceeded.
The following is applicable in addition to special variants (modified standard loadsensors):– Only the load cells defined for a platform
may be used.– Special platforms may only be built up to
the specified maximum size. Smaller plat-forms are allowable; however, the load cells may not be changed. In this case, thetechnical data of the larger platform mustalways be taken as the basis.
– The maximum cable length must beobserved.
* PTB - Physikalisch-Technische Bundesanstalt = German National Institute of Physics and Legal Metrology
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Metrology
Figure 2: The Guide to Verification is available online.
Figure 3: You select the desired indicator, document or compatibility program.
– The model name on the type plate must be retained. An additional plate with detailsof the special version is required.
– A higher dead load for the load sensordesign (weight of the load sensor receptoron the load cells) reduces the initial zero setting range as well as the additional dead load and/or maximum load.
The suitability of weighing instruments builtfrom combinations that are not contained in the lists, for example, different weighingranges or load cells, must be checked and the “Compatibility of the Modules” must bedefined for such special weighing instru-ments.
IV. Combics complete scalesCombics complete scales consist of fixedcombinations of indicators and platforms. All variants ending in -LCE and -NCE are verifiable. These are based on the SARTICSapproval and the compatibility lists of themodules approved by the PTB.
V. Connection of weighing modules, e.g.: IS...-0CEA weighing module (e.g. IS...-.0CE) with separate approval number can be connected,for example, to Combics 2, Combics 3 andCombics Pro (CISPRO) instruments and canalso be used for applications where mandato-ry verification is required (stand-alone or as areference weighing instrument). In doing so,the conditions stated on the weighing moduletest certificate and the iso-TEST D97-09-018approval must be observed.
If a platform and weighing module are con-nected at the same time, the indicator servesas both an indicator for the platform and a display and operating terminal for theweighing module, thus forming two weighinginstruments that share a single display andcontrol unit. Each weighing instrument has itsown identification plate, construction typeand approval. The descriptive (identification)plate of a weighing instrument comprisingplatform and indicator (showing approvalnumber, weighing instrument type, accuracyclass, CE marking, Notified Body number, dateof initial verification, type of measurementtechnology, metrology mark “M” and serialnumber) is attached to the indicator. In thecase of a weighing instrument comprisingterminal and weighing module, the identifi-cation plate is attached to a plate tag holderon the cable or to the weighing module itself.
Reader Service Code: 255
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Metrology
Figure 4: Technical data
Figure 5: The installationand operating instructionsprovide further informa-tion.
The facts speak for Sartorius ServiceAbout the FACTS® service program
New structure in the Sartorius service programTo make it easier to present all the services we offer, you will now find our entire rangeof services under the brand-name serviceprogram called FACTS®. This service programcovers five product names that are assignedto different customer processes for whichSartorius Service provides knowledgeable andfriendly support.
DISCOVER® - process analysisTo increase performance and to thus ensureefficient operations in the future, it is impor-tant to be thoroughly familiar with the actual situation. This is why highly experi-enced Sartorius Service employees with pro-found knowledge perform process and statusquo analyses. The first step for optimizing any process is to thoroughly analyze theactual situation. DISCOVER® focuses on plantand process surveys, GMP-compliance auditsand reviewing the particular quality systemand validation status.
INCREASE® - process optimizationThere’s always room for improvement in anyprocess. An INCREASE® study systematicallyimplements the potential identified by a DISCOVER® analysis to achieve an all-in-onesolution for your work processes. Whetheryou need to modernize or optimize yourproducts and processes, or outsource tasks orservices, use the expertise provided by ourspecialists.
CONFIDENCE® - qualification, validationIn the pharmaceutical, chemical and foodindustries, comprehensive qualification andvalidation of measuring systems and produc-tion plants is mandatory. The Sartorius Ser-vice team is committed to being your trustedpartner, from providing consultation all theway to complete documentation.
EXPAND® - trainingThe level of knowledge and training ofemployees is a critical success factor for anycompany. Sartorius will support you in thisarea by offering specialized training in thefields of laboratory and production. Let experienced instructors give you the latestknowledge and essentials in an easy-to-learnway. Whether you need training in the basicsor advanced training, you’ll find thatEXPAND® training courses are ideally designedfor the real world.
COMPLETE™ - installation, commissioning,maintenance, repairsProfessional installation and preventive andcorrective maintenance of your equipmentand systems ensure that they will runsmoothly, delivering optimal performance atall times. These services extend the lifetime of your equipment, preventing unnecessarydowntimes. Entrust your equipment, whetherSartorius brand or any other manufacturer’sbrand, to our professional network of experi-enced specialists spanning the globe.
Under the COMPLETE™ program, you will findall services to ensure that your equipment will operate perfectly. From installation toservice contracts all the way to full service,our array of services offers everything to keepyour equipment up and running. To guaran-tee that your equipment delivers accurateand traceable results, we offer services fortesting and issuing DKD calibration certifi-cates and for determining the minimum sample weight in compliance with USP.
You’ll also find our FACTS® service program onour website at www.sartorius.com.
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Service
We think in processes. It is possible to addvalue only if products and services areeffectively intermeshed. As a capable service partner, Sartorius offers you a trulycomprehensive spectrum of services. Theseare not only offered in conjunction withSartorius projects, but also are available for other manufacturers’ equipment andindependently of products.
Fig. left: When it comes to installation, preven-tive and corrective maintenance, withSartorius, the customer is always onthe safe side.
Fig. right:In performing our qualification andvalidation services, we documenteverything exactly for the customer.
Just a mouse click away from your purchase Sartorius sells spare parts through its ISSS e-Shop
In its spare parts sales unit, Sartorius AG hasbeen relying on lean, e-commerce enabledprocesses since 2005. At the same time, thisgives both its domestic and foreign customerssignificant added value. Spare parts can beordered from anywhere any time at the ISSSe-Shop*.
The editorial staff of WeighAhead spoke withMalte Pramann, ISSS e-Shop Project Managerin the Service business area of Sartorius AG.
WeighAhead: What is the paramountobjective connected with the ISSS e-Shop?M. Pramann: We would like to offer our cus-tomers an ordering platform for spare partsthat is easy to use and rich in content at thesame time. By coupling it directly to our SAPR/3 business resource planning system, ordersare booked immediately and electronically,and goods ordered can be shipped promptly,enabling us to dramatically reduce our stocks.
WeighAhead: Why an e-Shop for spareparts and why in the ISSS?M. Pramann: When we launched the ISSSInternet portal in 2001, we had already set up an extensive electronic spare parts catalogwith product numbers, prices, descriptions,drawings and even photos. The electronic cat-alog covers the entire breadth of Sartorius AGspare parts for both the laboratory and theprocess technology sectors. This is based on astructured and consistent data administrationsystem maintained by our spare parts man-agement. The system is continually updatedand is matched up exactly to the data of ourSAP R/3 planning systems. This stable foun-dation was used to set up the connection toour resource planning system, while an intu-itive user interface was developed for theISSS e-Shop. The shop is accessed with anystandard Internet browser.
WeighAhead: What are the advantages for customers who purchase through theISSS e-Shop?M. Pramann: Availability, delivery date andcustomer’s personalized net prices are gener-ated and displayed “live” on the ISSS e-Shopwebsite. Through feedback from our dealers,we know that this function is very well liked.Moreover, the next step to completing thepurchase is then just a mouse click away. Theuser doesn’t even need to enter a deliveryaddress either because the system identifiesthe customer when he logs in. Furthermore,customers appreciate the fact that spare parts are documented fully; the photos andexploded-view diagrams make it really easy for them to find the products they arelooking for.
WeighAhead: Who uses the ISSS e-Shop?M. Pramann: First of all, our service techni-cians and franchised distributors worldwideuse the e-Shop for their spare parts supply.Second, the platform bonds more and moreexternal customers to us. Beyond this, the e-Shop is even capable of posting the inven-tory for each technician. It also utilizes whatis called cross-company selling, which enablesus to connect customers with our interna-tional sales organizations. Over 50% of ourtotal pan-European spare parts orders aremeanwhile transacted through the ISSS e-Shop. Increasing numbers of our service tech-nicians are equipped with UMTS cards anduse them to order spare parts on their laptopswhile they are on the road. That makes it pos-sible for our technicians to order just aboutevery spare part through ISSS.
WeighAhead: What was the biggest challenge of this project?M. Pramann: The truly biggest challenge indeveloping the user interface was to make it guide the user through the ordering trans-action with the fewest number of entries andmouse clicks possible. What we achieved isthat the user can order spare parts withouttouching the PC keyboard one single time.Intelligent logic must support the user fromthe beginning to the end of the transactionand account for all eventualities. Anotherchallenge is to ensure 100% back-end inte-gration with our SAP R/3 resource planningsystem and the entire order processing chain.
WeighAhead: What do the next steps look like?M. Pramann: Right now, we are getting moreand more customers connected worldwide. By the end of 2006, we will further havemade cross-company selling available in theISSS e-Shop all over Western Europe. USA andAsia will follow. Going forward, we are addi-tionally planning to extend the spare partsoffering to other Sartorius brands.
Do you order spare parts from Sartorius morethan once a year and still haven’t registeredfor the ISSS e-Shop? Don’t miss out on themany advantages! Sign up with us by [email protected] or phone+49.551.308.4440.
Reader Service Code: 257
* ISSS stands for Internet Service Support System and is an Internet portal of the Sartorius Service businessarea. The ISSS e-Shop is an integrated module of the ISSS Internet portal.
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Service
ISSS logo
Malte Pramann, ISSS e-Shop Project Manager ofthe Sartorius AG Servicebusiness area
Excerpt from the ISSS e-Shop menu including a drawing of a spare part
Success is rewardedSartorius quality, commitment and support have won over Texas Scales
Upon his return, Chris Chinni sent us a letter,stating:“…Texas Scales has been selling the Sartoriusproduct line for 20 years now. In that time we have seen the many changes from a labbalance company to one of the largest scalecompanies on Earth. We have been sellingSartorius for counting scales since the verybeginning when the “I” series was $3000 andour competitors were half that. We have soldmicrobalances to hygienic load cell systems to 10,000 lb capacity floor scales. I thoughtthat we knew the power of the Sartoriusproduct family. That is until we toured theirfactories…”
“…We saw the entire process of building balances, weigh cells, load cells, scales, andevery aspect of the Sartorius Group processfrom different angles and through it all thewords that came to mind were quality, crafts-manship, and commitment. Those havebecome tired old clichés in many industries,but in the Sartorius world it is a mindset. We loved our trip and tours; the commitmentthat Sartorius has shown us has been incred-ible.”
Sartorius dealers Texas Scales, located inCibolo, Texas, won the U.S. Sales Competition2005. Their prize: a one-week round trip toSartorius German manufacturing sites for twosales representatives and their wives. The tripproved to be a great success.
A group of seven people arrived in Germanyfrom Texas, USA, on July 15, 2006, anticipat-ing an exciting visit. Texas Scales’ delegateswere Chris Chinni (owner) and Amada Vento(top sales representative), as well as theirwives. During their stay, the group wasaccompanied by our local Regional SalesManager, John Zorn, his wife and daughter.
Ingolf Popel, Senior Sales Manager, PW&C –Industrial Scales, coordinated their stay. Apart from touring Sartorius’s productionplants in Hamburg, Goettingen and Aachen,their trip also included numerous outings sothat the tourist aspect did not fall short.
It was not the outstanding quality of ourproducts alone that impressed Texas Scales.Our organization and workflow processes andthe customer-oriented policies at all sites are decisive factors for Texas Scales, placingeven more weight on Sartorius products inthe future. During the discussions followingthe tour of our plants, Texas Scales had theopportunity of identifying new applicationsand business sectors.
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OurPartners
The enthusiastic Sartorius partners at the new factory in Goettingen… …and during one of their outings
The Bristol-Myers Squibb Companyselects Sartorius as a preferred supplierCost savings are now easier to implement
Who is Bristol-Myers Squibb?As one of the world’s leading healthcare corporations, Bristol-Myers Squibb belongs to the elite among the pharmaceutical makers, offering a broad range of front-runner products on the market. The groupemploys a workforce of 42,000 in over 100countries and achieves sales of aroundU.S. $19.2 billion. In Germany, the core busi-ness sectors include prescription medicines,medical devices for wound and stoma care,baby food and nuclear medicine diagnostics.Bristol-Myers Squibb markets prescriptionmedicines for the following indications:• Cardiovascular diseases/lipid metabolism• Oncology/cancer• Infectious diseases (immunology/HIV)• Neuroscience (neurology/psychiatry)
The Bristol-Myers Squibb success story beganat various locations: in 1858, Dr. EdwardRobinson Squibb founded the original com-pany in Brooklyn, New York, dedicated to theproduction of “consistently pure medicines.”Bristol-Myers Company was founded in 1887by two young men, William McClaren Bristoland John Ripley Myers, who both attended a local college in upstate New York. With$5,000, they first created the ClintonPharmaceutical Company, which evolved over time into Bristol-Myers. In 1989, Bristol-Myers and Squibb merged to becomethe Bristol-Myers Squibb Company, nowheadquartered in New York.
What are the advantages of the PreferredSupplier Agreement with Sartorius?Mid-2006, the two companies signed anagreement covering all mechatronics prod-ucts, which has a pan-European scope. In the USA, a parallel agreement was already inplace for the laboratory sector.
Bristol-Myers Squibb Company and Sartoriuscame together as part of cost savings cam-paigns. The decision to select Sartorius as an innovative, global and flexible provider of a diversity of products for laboratory andprocess technologies not only enabled thecompany to reduce its original number ofsuppliers, but also to standardize the use ofproducts at its plants. Both firms are thrilledabout their new collaboration.
For more information about global agree-ments, please contact Jean-Luc Degen (e-mail: [email protected] ormobile: +33 607 42 37 36).
Reader Service Code: 258
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OurPartners
Bristol-Myers Squibb’s European and French headquarters in Rueil-Malmaison, France
You are invited!Sartorius Aachen has opened a showroom for its customers
Sartorius Aachen opened its first showroomon October 1, 2006, in which they have beenpresenting their full range of products, fromtheir checkweighers (models: SYNUS™,EWK3000 and EWK1000) to metal detectors(models: MDP, MDE and MDB), and on to aselection of beltweighers. These products canbe viewed both in operation and integratedall along the entire walkway circuit. Theatmosphere, mix and diversity displayedimpart the feeling of a tailor-made, individualexperience.
Would you be interested in seeing these prod-ucts "live and in action?" That would certainlybe the best method of personally learningabout their functionality and many advan-tages. While touring the showroom, you canfamiliarize yourself with the various products,and thus select those optimally suited to yourprocesses. In a face-to-face meeting,Sartorius experts can then specifically elabo-rate the individual details.
Furthermore, we offer you the opportunity oftesting your products in our showroom. Forexample, we can determine the sensitivity indetecting metals in your products, or testtheir accuracy on a checkweigher. Is thissomething you had always hoped to do? Then,do not hesitate any longer!
Should you wish to arrange an appointment,please contact Peter Taggenbrock, who wouldbe glad to hear from you. (E-mail: [email protected] in Germany: +49 (0) 2411827-0).
Reader Service Code: 259
Sartorius enjoyed great successat the PROPAK Asia 2006
From June 14 to 17, the PROPAK Asia 2006,the 14th the International Processing andPackaging Technology Event took place inBangkok, Thailand. This fair was the leadingprofessional exhibition for packaging andprocessing machinery, materials and relatedtechnologies. Through its strategic location inthe center of southeast Asia’s food, beverage,cosmetics, pharmaceutical, general consumergoods and industrial manufacturing indus-tries, PROPAK Asia was renowned for attract-ing key buyers from the entire Asian region.
Sartorius, an internationally leading mecha-tronics and biotechnology provider, had itsnewly opened Thailand subsidiary participatein this fair as a qualified partner for check-weighers, metal detectors and industrialscales. The highlight of the show was theintroduction of the SYNUS™, a height-adjustable bidirectional SPC-enabled check-weigher, and OBSERVER™, an economicalmetal detector for aluminum-foil packages,to the Thai market. Moreover, the enthusiastic
Sartorius Thailand team was able to presentCombics Lite industrial scales to its targetgroups.
For relaxation and a chitchat, Sartorius Thailand staff invited their customers to ahappy hour during which a famous Germanbeer brand was served. With the support from customers, dealers, partners and staff,Sartorius enjoyed great success during thefour-day show. In 2007, Sartorius will be continuing to explore new technologies tobring you the most advanced solutions.
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Trade Shows
You can experience “live” product demos at SartoriusAachen’s showroom.
Checkweighers, metal detectors and beltweighers areamong the equipment on display.
Visitors flocked to the Sartorius booth at the PROPAK.
Members of the Sartorius Thailand team who supported customers and partners day in and day outduring the trade show
The new SYNUS™ checkweigher
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Lab weighing equipment for my laboratory:
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Differential weighing
Animal weighing
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America
ArgentinaSartorius Argentina S.A.Int. A. Ávalos 4251B1605ECS MunroBuenos Aires
ChinaBeijing Sartorius Instrument & System Engineering Co., Ltd.Dong Hu Qu, Wang JingIndustrial ZoneChao Yang District100102 Beijing, P.R.C.P.O. Box 8516
