Weill Co rnell Medical College...at NewYork-Presbyterian Hospital/Weill Cornell Medical Center...

The Newsletter of the Department of Pathology and Laboratory Medicine at NewYork-Presbyterian Hospital/Weill Cornell Medical Center

Volume 21 • January 2015

Research Highlightsby David P. Hajjar, PhD

The Department is delighted to welcome Dr. Jacob Rand,Professor of Pathology and Laboratory Medicine, as Vice

Chairman for Laboratory Medicine and Director of the Clinical

Laboratories.

Dr. Rand comes to us from Montefiore Medical Center and

the Albert Einstein College of Medicine where he served as

the Director of Hematology, Advanced Coagulation and Protein

Separation Laboratories and as Professor of Pathology,

Medicine, and Obstetrics and Gynecology, and Director of the

Hematology Laboratories. Dr. Rand’s record of achievement

spans across disciplines, with strong backgrounds as a

clinical physician, clinical laboratory director, teacher and

basic scientist.

Dr. Rand received his Medical Degree from Albert Einstein

College of Medicine and did residencies in Autopsy Pathology

at Montefiore Hospital/Albert Einstein College of Medicine

with Drs. Harry Zimmerman and Leopold Koss, and in Internal

Medicine with Dr. Richard Gorlin at Mount Sinai Hospital. Dr.

Rand then returned to Montefiore for Hematology fellowship

training in both clinical and laboratory hematology with the

legendary “clotter” Dr. Theodore Spaet. He then joined the

faculty of the Mount Sinai School of Medicine where he rose

to Professor of Medicine and Pathology, served as director of

the Medical School blood course, was Chief of the Clinical

Thrombosis & Hemostasis Service, directed the clinical

hematology laboratories, and did basic and translational

research. continued on page 3

Contents

Weill Cornell Medical College

Drs. Jacob Rand and Xiao-Xuan Wu.

1Research Highlights

2Focus

3Clinical Pathology Update

4-6Keynotes

7Pathology Faculty’s

Global Travels

8Resident’s Corner

9-11Faculty Publications

122015-2016 CME Conference Calendar

Newly Awarded Grants in Pathology

Figure 2: Atomic force microscopy images of the effectof hydroxychloroquine on a gallery of antiphospholipidimmune complexes that were formed on a planar bilayerover an ultrasmooth mica chip. (for complete description seeRand JH, Wu XX, Quinn AS, Chen PP, Hathcock JJ, TaatjesDJ. Hydroxychloroquine directly reduces the binding ofantiphospholipid antibody-beta2-glycoprotein I complexes tophospholipid bilayers. Blood. 2008 Sep 1;112(5):1687-95.)

Localization of Annexin A5 on the surfaceof placental trophoblasts

Figure 1: Expression of AnxA5 (green fluorescence) oncultured syncytialized human placental trophoblasts.Blue (DAPI) fluorescence marks the nuclei. [bars = 50 ��m.Confocal microscopy 3-dimensional projections of Z-axisimage stacks, voxel size (�m): width 0.73, height 0.73, anddepth 1.50] (for complete description, see Wu XX, Guller S,Rand JH. Hydroxychloroquine reduces binding of antiphos-pholipid antibodies to syncytiotrophoblasts and restoresannexin A5 expression. Am J Obstet Gynecol. 2011 Dec;205(6):576.e7-14.)

Atomic force Microscopy: Structure of aPL Ig-�2GPI Complexes

-HCQ

+HCQ

(green: AnxA5; blue: nucleus)

NewYork-Presbyterian Hospital/Weill Cornell Medical Center

2 www.cornellpathology.org

The Department is thrilled to announce theformation of the new Division of Molecular andGenomic Pathology and the opening of its new,state-of-the-art Molecular Pathology Laboratory.The Division of Molecular and Genomic Pathology

will be led by Dr. Mark A. Rubin, Vice Chairmanfor Molecular and Genomic Pathology and Professor

of Pathology and Laboratory Medicine.

The focus of the Molecular and GenomicPathology Division is to provide Weill Cornell

Medical College physicians with molecular informa-

tion that will facilitate the diagnosis of diseases,

monitor the prognosis of the patients and assist

in the selection of appropriate therapeutic options.

Our state-of-the-art facility uses innovative genomic

technologies to interrogate and identify disease

related entities in solid tumors, hematologic malig-

nancies, infectious diseases and inherited diseases.

Working closely with our clinicians, our mission is to

provide molecular testing of the highest quality with

a direct impact on patient care.

The Division of Molecular and GenomicPathology at NewYork-Presbyterian/Weill Cornell

Medical College is comprised of two main entities:

The Molecular Pathology and Molecular Hemato-

pathology Laboratories, both of which are CLIA-

certified and accredited by New York State

Department of Health (NYSDOH) and the College

of American Pathologists (CAP).

The Molecular Diagnostics Laboratory offers

molecular pathology services in infectious disease,

transplant, genetics and solid tumors, including a

NYSDOH-approved 50-gene panel next-generation

sequencing test for identification of mutations in

cancer. The laboratory is directed by Hanna Rennert,

PhD, FACMG, and Helen Fernandes, PhD.

The Molecular Hematopathology Laboratoryperforms molecular-based tests to aid in the diag-

nosis and management of hematologic cancers and

offers expert consultation in specialized molecular

testing for hematopathologists and clinical hema-

tologists. The primary goal of the laboratory is to

provide accurate molecular diagnostic information

using modern technology to facilitate the delivery

of excellent personalized health care to patients

inflicted with hematologic malignancies. The

laboratory is directed by Wayne Tam, MD, PhD.

The Institute for Precision Medicine (IPM) atWeill Cornell Medical College and NewYork-

Presbyterian Hospital is a translational research

hub, under the direction of Dr. Mark Rubin. The

IPM team of physician-scientists are directing their

collective expertise and wealth of knowledge to

pinpoint the molecular underpinnings of disease

and spur the discovery of novel therapies. The

Division of Molecular and Genomic Pathology works

in close collaboration with the IPM.

Division Faculty:

Focus by Daniel M. Knowles, MD

(left to right) Faculty: Drs. Liu, Fernandes, Tam, Cesarman and Rennert.

Dr. Hanna Rennert (right) working with molecularpathology technical staff.

Mark A. Rubin, MD Ethel Cesarman, MD, PhD Helen Fernandes, PhD

Yen-Chun Liu, MD,PhDHanna Rennert, PhDWayne Tam, MD, PhD

Next generation sequencing data in Integrative GenomicViewer (IGV) showing deletion of exon 19 sequence inEGFR (EGFR del19) and the corresponding Sangersequencing below. The solid line in IGV corresponds to thedeleted exon 19 sequence relative to the reference gene.The black arrow in the Sanger sequencing electrophero-gram represents the first nucleotide of the deletion.

u

3

Two new TransfusionMedicine faculty join the Department

Dr. Yen-Michael S. Hsureceived his PhD from the

University of Texas Graduate

School of Biomedical Sciences

MD Anderson Cancer Center

in Houston, Texas in 2008

and his MD from the

University of Texas Medical

School at Houston in 2010. He subsequently

completed residency training in Clinical Pathology

at Washington University School of Medicine

in 2013. He recently completed a Blood

Banking/Transfusion Medicine Fellowship at the

Blood Centers of the Pacific/UCSF Medical Center,

and is joining the department as an Assistant

Professor of Pathology and Laboratory Medicine

and Assistant Director of Transfusion Medicine

and Cellular Therapy.

Dr. Hsu can be reached at:

[email protected] or at: 212-746-2212.

Dr. Ljiljana Vasovic received

her medical degree, clinical

training and two years of

research training at the

University of Belgrade in

Serbia. This was followed

by a research fellowship at

Memorial Sloan Kettering

Cancer Center from 1992 to 1998. She com-

pleted her training in Anatomic and Clinical

Pathology at Lenox Hill Hospital in 2002, did a

fellowship in Hematopathology at Albert

Einstein College of Medicine in 2003, and a

fellowship in Transfusion Medicine at the

Brigham and Women’s Medical Hospital in Boston

in 2004. She was then recruited to the

Montefiore Medical Center where she served in

the Trans-fusion Medicine Division and as an

Assistant Professor of Pathology at the Albert

Einstein College of Medicine. Dr. Vasovic joins us

as an Assistant Professor of Pathology and

Laboratory Medicine, and will hold the titles

of Associate Director of Cellular Therapy and

Assistant Director of Transfusion Medicine. She is

board certified in Anatomic Pathology and

Clinical Pathology, Transfusion and Blood Banking,

and Hematology.

Dr. Vasovic can be reached at:


We are also delighted to welcome two clinical chemists:

Dr. John V. Mitsios receivedhis Masters of Science in

Biochemistry in 2002 and

his PhD in Chemistry in

2006 from the University of

Ioannina, Greece. In 2010, he

completed a post-doctoral

fellowship at the University

of California-San Diego, followed by a two-year

Clinical Chemistry fellowship at the Washington

University School of Medicine in St. Louis, Missouri.

He joins the department as an Assistant Professor

of Pathology and Laboratory Medicine and as

Assistant Director, Central Laboratory and Assistant

Director, Point of Care Services.

Dr. Mitsios can be reached at:


Dr. Joshua A. Haydenreceived his PhD from the

Carnegie Mellon University

in 2011. Subsequently, he

completed a post-doctoral

fellowship at MIT in 2012,

and recently completed a

two-year long fellowship in

Clinical Chemistry at the University of Washington,

Seattle. He is trained in all aspects of clinical

chemistry including test development, test

interpretation, test utilization, quality assurance

in the clinical laboratory, regulatory compliance

and risk management. Dr. Hayden joins the

Department of Pathology as an Assistant

Professor of Pathology and Laboratory Medicine,

the Assistant Director of the Central Laboratory

and Director, Toxicology and Therapeutic Drug

Monitoring.

Dr. Hayden can be reached at:


Yen-Michael S. Hsu,MD, PhD

Ljiljana Vasovic, MD, PhD

John V. Mitsios, PhD

Joshua A. Hayden, PhD

Dr. Rand has made significant contributions to

our understanding of the role of von Willebrand

factor in mediating platelet adhesion to sub-

endothelial components. He also co-founded the

first international web-based registry for the

acquired form of the bleeding disorder known as

von Willebrand disease.

In addition, Dr. Rand and his research group

have made major contributions to unraveling the

pathogenesis of an enigmatic autoimmune

thrombophilic condition, the antiphospholipid

syndrome (APS), that results in vascular throm-

bosis and pregnancy complications.

The antiphospholipid-annexin A5 research team

members include Dr. Rand’s longtime laboratory

manager and research partner, Dr. Xiao-XuanWu, who joined the Department of Pathology andLaboratory Medicine at Weill Cornell Medical

College, along with Dr. Rand.

Dr. Rand’s work has led to the discovery of the

“Disruption of the Annexin A5 Anticoagulant

Crystal Shield” concept as a thrombogenic

mechanism in this disorder (see Figure 1). The

finding, which has been validated in clinical trials,

was translated into a novel clinical assay for this

disease process. On the therapeutic end, Rand’s

team has discovered several drugs that in in

vitro studies, appear to target and reverse this

disease mechanism.

The most exciting candidate is hydroxychloro-

quine (HCQ) (see Figure 2), a synthetic anti-

malarial drug that has been used for over 60 years

for treating that infection and for other auto-

immune conditions – particularly systemic lupus

erythematosus (SLE). A prospective clinical trial

of this medication, sponsored by investigators

at the Hospital for Special Surgery, is currently

underway. We welcome them both! ■

Research Highlightscontinued from page 1

Clinical Pathology Update

We have a new Websiteand Video Gallery!Visit us at: www.cornellpathology.org



◗ Dr. Ethel Cesarman has been continuing to focusher research on understanding the pathobiologyand improving the diagnosis and treatment ofcancers frequently associated with viral infection.She has been involved in supervising the pathologicdiagnosis of Kaposi’s sarcoma and lymphoma inAfrica, and improving the diagnostic methodologiesby developing new point-of-care assays. Towardsthese efforts, she traveled in February to Tanzania,Kenya and Uganda, where she worked with pathol-ogists at these sites towards initial testing of asolar-powered PCR device, coupled with cell phonedetection. Dr. Cesarman was invited to participate ina Provocative Questions Workshop on HIV and AIDSResearch on March 2014 at the NIH, and to serve asa reviewer for a Special Emphasis Panel/ScientificReview Group for Centers for AIDS Research inNovember. In 2014, she was invited to give a sem-inar at the Sibley School of Mechanical andAerospace Engineering in Cornell University inIthaca. Dr. Cesarman presented at a meetingorganized by the International Network for CancerTreatment and Research (INCTR) in Tanzania enti-tled: “4th Meeting and Tutorial on Infectious Agentsand Lymphoma: What can we learn from Africa?”She was also an invited speaker at the 55thNational Congress of the Mexican Association forthe Study of Hematology (AMEH) in Guadalajara,Mexico.

◗ In November, Dr. Scott Ely was granted a USpatent for the use of duplex immunostaining, alongwith his collaborators, Dr. Selina Chen-Kiangand Dr. Maurizio DiLiberto. It is a broad patentcovering the use of any membranous stain in con-junction with any nuclear stain. Along with otherfaculty, the trio published a high-impact paper thathas generated much discussion and commentary(Cancer Discovery 4(9):1022-1035, 2014). Dr. Elytraveled to Berlin, Germany to address the GlobalTechnology Community regarding the use of multi-plex IHC and image analysis for diagnosis, prognosisand prediction in lymphoma and myeloma. In April, Dr. Ely gave an address at the International

Myeloma Workshop, in Kyoto, Japan, regarding theuse of these platforms and presented clinicalvalidation in a talk entitled New Assay PredictsMyeloma Survival and Progression. In July, hewas invited to participate in the InternationalMyeloma Foundation's Black Swan initiative-sponsored round table discussion on the use of flowcytometry for minimal residual disease (MRD) test-ing. In October, Dr. Ely traveled to Dublin Ireland, todeliver a talk, “Cell-Specific Proliferation: A Valuableand Feasible Indicator in All Cancers,” at theDepartments of Pathology, in Trinity College Dublin,The University of Dublin, and St. James Hospital.During the same trip, Dr. Ely addressed the

Myeloma Ireland Consortium, National HematologyClinical Trials Program at the Mater UniversityHospital with a talk entitled, “Myeloma Proliferation,a Feasible Risk Stratification Tool.”

◗ In September 2014, Dr. Annarita Di Lorenzoattended the annual meeting of the American HeartAssociation on Hypertension in San Francisco, CAwhere she presented a poster: “Endothelial-derivedsphingolipids preserve systemic vascular functionand blood pressure” (Cantalupo A, Zhang Y, KothiyaM, Galvani S, Obinata H, Bucci M, Giordano FJ,Jiang XC, Hla T, Di Lorenzo A). In addition, Dr. DiLorenzo currently serves as a reviewer for theAmerican Heart Association’s vascular wall biologystudy section.

◗ In June 2014, Dr. Domenick J. Falcone receiveda dedicated service award for longstanding leader-ship in the Medical College curriculum, and anaward for teaching excellence in the Host Defensescourse. Dr. Falcone was appointed basic sciencetheme leader for the Essential Principles ofMedicine (EPOM) segment of the new curriculum.In addition, he was selected to serve as leader ofthe Injury, Infection, Immunity and Repair learningunit of EPOM.

◗ In 2014, Dr. David Hajjar was selected by theNational Academy of Sciences to be a JeffersonScience Fellow, working in the U.S. StateDepartment as a Foreign Affairs Officer, Bureau ofOceans, Environment and Science - Offices of Inter-national Health and Science and Technology toadvise the Secretary of State on issues related tohuman health and disease. He was also awarded anHonorary Doctorate of Humane Letters (D. Litt.)from the University of New Hampshire, and servedas Co-Chairman of the International Conference onScience and Technology, Education and Innovation,held at University of Cambridge, England, August2014. Dr. Hajjar received the Weill Cornell MedicalCollege Dedicated Service Award in June 2014.

◗ In 2014, Dr. TimothyHla was invited to attendthe following conferencesto lecture on the role ofsphingolipids in healthand disease: KnightCardiovascular Center,Oregon Health andScience University, Portland,OR, University of Pennsylvania School of VeterinaryMedicine, Philadelphia, PA, International VascularBiology Meeting, Kyoto, Japan, Gordon ResearchConference in Barcelona, Spain, ExperimentalBiology 2014, ASBMB Symposium on Sphingolipids,and Molecular Medicine of Sphingolipids, EMBOConferences, Kloster Banz, Franconia, Germany. Hewas also invited as a Visiting Professor to theDuke/National University of Singapore School ofMedicine, Singapore in April 2014. In addition, hewas invited to present at the Lipid Mediators in

Health and Disease, Karolinska Institutet,Stockholm, Sweden, which honored the 1982 NobelPrize Laureate Bengt Samuelsson. Dr. Hla traveled toGermany to attend the Kloster Seeon meeting onangiogenesis, to give a research presentation, andhe visited the Max Planck Institute for Heart andLung Research, Bad Nauheim, where he discussedvascular biology research with scientists and alsogave a research presentation.

◗ Dr. Rana Hoda held the 5th Annual Papanicolaoututorial on updated diagnostic cytopathology in July2014. She was involved in presenting educationalcourses at the Annual Meetings of the USCAP inSan Diego, CA and at the ASCP in Tampa, FL. Dr.Hoda also presented on cytopathology-relatedtopics at the Annual Meetings of the EuropeanCongress of Cytology in Geneva, Switzerland andat the American Society of Cytopathology inDallas, TX. Dr. Hoda spent time in Kigali where sheparticipated in the training of Pathology Residentsat the University of Rwanda.

◗ Dr. Syed A. Hoda was involved in presentingeducational courses at the Annual Meetings of theUSCAP in San Diego, CA and at the ASCP in Tampa,FL. He also presented on breast pathology-relatedtopics at the Annual Meetings of the EuropeanCongress of Cytology in Geneva, Switzerland and atthe American Society of Cytopathology in Dallas, TX.Dr. Hoda spent time in Kigali where he participatedin the training of Pathology Residents at theUniversity of Rwanda.

◗ Dr. Yen-Michael S. Hsu was invited to givea lecture at the California Blood Bank SocietyTransfusion Medicine Regional Seminar, March 7,2014 (Stanford Medical Center, Palo Alto, CA), onthe topic of “Platelet Additive Solutions (PAS) andthe Impact on TRALI mitigation.”

◗ Dr. Manu Jain presented two posters in thefield of in vivo microscopy/optical imaging atthe International Academy of Pathology Congress2014, Bangkok, Thailand: “Rapid evaluation offresh ex vivo kidney tissue with full field opticalcoherence tomography” and “Identifying signaturesof normal and disease in freshly excised non-neoplastic kidney tissue with multiphotonmicroscopy.” Earlier this year, in March, her abstract“Characterization of prostate cancer by highresolution 7 Tesla MRI: Towards in vivo histology”was invited for a podium presentation in theEuropean Urology Congress 2014, Stockholm,Sweden. Later that month, she presented 3 posterson optical imaging techniques at the USCAP 2014annual meeting in San Diego.

◗ Dr. Stephen Jenkins was awarded the WeillCornell College of Medicine, Division of InfectiousDiseases Faculty Excellence Award for 2013/2014.In addition, he was named Co-chair of the MethodsWorking Group for the Subcommittee on Anti-microbial Susceptibility Testing for the Clinical andLaboratory Standards Institute.

Keynotesby Domenick J. Falcone, PhD

5

◗ Dr. Stephen Jenkins continuedDr. Jenkins is also currently serving on the

Program Committee for the Interscience Conferenceon Antimicrobial Agents and Chemotherapy (ICAAC)in the areas of Diagnostics and Transplant InfectiousDiseases. Dr. Jenkins also currently serves on theNew York State Organ Transplant InfectiousDiseases Working Group. He was as an invitedspeaker and faculty member for the AmericanSociety for Microbiology at a workshop for physi-cians on antimicrobial resistance in Rabat, Moroccoin November 2013. He chaired and lectured atworkshops on antimicrobial resistance in May, 2014at the General Meeting of the American Societyfor Microbiology in Boston, MA and at ICAAC inWashington, DC in September, 2014. Dr. Jenkinswas also an invited speaker at the NIH Network onAntimicrobial Resistance in Staphylococcus aureussymposium held in Bethesda, MD in March, 2014.

◗ Dr. Daniel M. Knowles has been recognized asa lifetime member of the Worldwide Registry ofExecutives, Professionals and Entrepreneurs inSeptember 2014 and Dr. Knowles continues to belisted as one of the “BestDoctors in America.” Dr.Knowles organized theNortheast Association ofPathology Chairs annualmeeting in CambridgeBeaches, Bermuda fromSeptember 11th throughSeptember 14th 2014. Hechaired a session on genomics which featured MarkRubin representing the Weill Cornell program andgenomics experts representing the University ofPennsylvania, the Brigham and the Yale programs.Other agenda items included value-based initiativesin pathology and laboratory medicine. Dr. Knowlesdid a presentation on “Designing the IdealResidency Program.” Dr. Knowles was invited tolead a guided wine tasting for the Center AlumniCouncil (CAC)’s “Wine and Tapas” evening on May15, 2014 in the Griffis Faculty Club. Dr. Knowlesselected five wines and paired them with a tastingmenu created by Taasha Ramsay of the GriffisFaculty Club. More than 70 individuals participated.The tasting kicked off with a 2011 KistlerChardonnay, McCrae Vineyard, followed by aflight of three red wines, Orin Swift, The Prisoner2012, Brewer Clifton, Pinot Noir Zotovich 2009 andBeringer Vineyards Private Reserve CabernetSauvignon 2010. The night ended with a Sauterne,the Chateau Lafaurie Peyraguey 2007. Earlier thisyear, Dr. Knowles, Dr. Orazi and Dr. Chadburnattended the annual Tutorial on NeoplasticHematopathology, directed by Dr. Knowles, inMiami, Florida from January 27th to January 31st,

2014. The program consisted of lectures, casepresentations and discussions designed to providepathologists with an in-depth discussion of diag-nostic problems that arise in neoplastichematopathology. Dr. Amy Chadburn lectured on“Immune Deficiency-Associated Lymphoprolif-erative Disorders” and Dr. Attilio Orazi lecturedon “Myelodysplastic Syndromes” and “Myelo-dysplastic/Myeloproliferative Neoplasms.”

◗ Dr. Juan Miguel Mosquera was a Visiting Lecturerat Emory University School of Medicine and theWinship Cancer Institute (Atlanta, GA January 2014),where he presented recent data on prostate cancerbiomarkers as part of the Early Detection ResearchNetwork (EDRN) multi-institutional studies. Dr.Mosquera was also a Visiting Lecturer at the 2014Cancer Biomarker Conference of The MethodistHospital Research Institute (Houston, TX, March2014), where he presented “Biomarker Testing inProstate Cancer.” At the 103rd Annual Meeting ofthe United States and Canadian Academy ofPathology (USCAP), held in March of this year inSan Diego, CA, Dr. Mosquera presented “NAB2-STAT6 Fusion and STAT6 ImmunohistochemistryHelp Differentiating Sino-nasal Hemangiopericytoma-Like Tumor from Solitary Fibrous Tumor.”

◗ Dr. Hanna Rennert wasinvited to give a plenarylecture at the KoreanSociety of LaboratoryMedicine Annual Meetingin Daegu, Korea inOctober 2013. The titleof her talk was “PracticalApproaches in MolecularOncology Testing.” She also presented a talk aboutthis subject at the Department of PathologyGrand Rounds, Hadassah-Hebrew UniversityMedical Center, Jerusalem, Israel in December of2013. In June 2013 she co-chaired a three dayMolecular Center of Excellence (MCOE) meeting inNew York, NY. The MCOE Annual Scientific Meetingis a collaborative effort between the MCOE (analliance of molecular centers across the USdesigned to be a “best practices” collaborative enti-ty, to advance scientific discussion with membershaving access to the experiences and technicalexpertise of other colleagues in the field) andRoche Diagnostics. As part of a Multi-InstituteCollaboration group with Roche Molecular Systems,Inc. focused on CMV clinical testing, Dr. Rennertpresented a poster entitled “CMV DNA viral loadtest: A comparison between methods at low CMVDNA levels (ENGAGE Study)” at the Clinical VirologySymposium in April of 2014. In addition, with coauthorsDrs. Tan and Dr. Blumenfeld, Dr. Hanna Rennert hasdeveloped a long-range PCR (LR-PCR) and nextgeneration sequencing (NGS) method, an amplicon-based genetic approach for identifying mutations inthe polycystic kidney disease (PKD) genes. This testis currently used for patients participating in theAutosomal Dominant Polycystic Kidney Disease(ADPKD) Data Repository Research Program of theRogosin Institute; it has been recently published inthe Journal of Molecular Diagnosis. In collaborationwith BioMérieux, Dr. Rennert has also presented aposter describing the development of a BK virusquantitative real-time PCR assay for monitoring viralload levels in transplant patients at the ClinicalVirology Symposium in April of 2014.

◗ The GME council approved Dr. Audrey N.Schuetz’s proposal for a Pathology elective inTanzania for interested pathology residents. She willmentor residents who wish to work on Pathologyand Lab Management projects while in WeillBugando Center in Mwanza, Tanzania. Dr. Schuetzrecently traveled to Port-au-Prince, Haiti on a traininggrant to provide guidance for the GHESKIO microbi-ology laboratory. As part of the Infectious Diseasescourse in Salzburg, Austria, she mentored interestedinternational students and lectured on severaltopics, including the diagnosis of tuberculosis. Dr.Schuetz was an invited speaker at the E.G. ScottMicrobiology Symposium in Delaware, which honorsthe grandfather of clinical microbiology and co-author of the classic text: Bailey and Scott’sDiagnostic Microbiology.

continued on page 6

BMA Medical Book Awards 2014First PrizePathologyPresented to

Attilio Orazi, Kathryn Foucar, Daniel M. Knowles

and Lawrence M. Weiss and Wolters Kluwer

Health | Lippincott Williams & WilkinsforKnowles’ Neoplastic Hematopathology

3rd edition

“This is a superb and comprehensive book withwell-thought out illustrations which is useful forboth established consultant haematopathologistsas well as trainees. It is also very useful for thosewho treat such patients clinically. This book pro-vides the intended target readership with in-depthknowledge that can be accessed easily either viathe book directly or via the weblink. There are anumber of haematopathology books out there butnone that cover the spectrum as well as this bookdoes, they tend to either concentrate on haemato-logical aspects or on pathological aspects, but notboth. The references are as up-to-date as a bookcan be, there is always additional material butthis is because knowledge is ever changing, thisbook would be highly recommended by me, infact in whilst reviewing it I have had a number ofcolleagues queuing up to borrow it. It has been apleasure to review and I have learnt much whilstdoing this. The only thing (and this is tiny nitpick-ing) it would have been good to have a seperatepaediatric chapter but I am biased being paedi-atrically based. Highly recommended.”

-The British Medical Association (BMA)

Knowles’ Neoplastic Hematopathology, ThirdEdition, won First Prize in the Pathology categoryat the 2014 British Medical Association (BMA)Medical Book Awards in October 2014. This is agreat achievement and a testament to the qualityof the text.

Keynotescontinued


◗ Dr. Audrey N. Schuetz continuedShe also spoke on Emerging Technologies at the

annual 2014 American Society for Clinical Path-ology meeting. She was an invited Grand Roundsspeaker at Case Western Reserve University in Feb-ruary 2014, where she spoke about toxoplasmosis.

◗ Dr. Surya Seshan receiv-ed the Jacob Churg Awardthis year from the RenalPathology Society (RPS)for outstanding contribu-tions to the field of RenalPathology at the USCAPmeeting in San Diego inMarch. She was an invited speaker at the 12th Banff

Conference on Allograft Pathology in Brazil, and spokeabout: “Antibody mediated rejection in pancreastransplants” and “Classification of lupus nephritis”in the RPS Consensus Meeting Updates on investi-gator initiated histological classification schemes,

at the American Society of Nephrology, Atlanta,Georgia, 2013 and the International Renal PathologyCourse in Ljubjlana, Slovenia in June 2014. Surya Seshan was a member of the Program

Committee and a lecturer for the renal pathologysessions of the International Academy of Pathologyheld in Bangkok, Thailand in October 2014. Sheis serving as the Chair of the ad hoc Committeefor the Renal Pathology Society InternationalConferences, and is a member of the PathologyCommittee of the International Society ofNephrology. In addition, Dr. Seshan has been theAbstract Reviewer for “Kidney and GenitourinaryPathology” for the College of American Pathologistsfor the last 6 years. Dr. Seshan also contributedseveral chapters to 3 books on subjects suchas para-neoplastic glomerulonephritides, de novoand recurrent glomerular diseases post trans-plantation and various aspects of pancreastransplantation.

◗ Dr. Jae-Hyuck Shim is the recipient of the 2014Cell Signaling Technology (CST) Academic ProjectGrant for PTMScan Discovery. Dr. Shim’s lab will beprovided with PTMScan Discovery services thatemploy CST proprietary motif antibodies for peptideenrichment in conjunction with tandem mass spec-

trometry for quantitative profiling of post-transla-tional modifications (PTMs) to cellular proteins.

◗ Dr. Rhonda K. Yantiss served as Chair of theNominations Committee and member of theExecutive Committee of the Rodger C. HaggittGastrointestinal Pathology Society. She was invitedto speak at the 2014 United States and CanadianAcademy of Pathology Long Course in San Diego,California and delivered Grand Rounds in theDepartment of Pathology at Yale University Schoolof Medicine. She also spoke at the 2014 Updatein Gastroenterology, Hepatology, & NutritionPost-Graduate Course sponsored by ColumbiaUniversity College of Physicians & Surgeons andWeill Cornell Medical College. Dr. Yantiss wasawarded the Arthur Purdy Stout Society Prize.She was invited to participate in the 9thInternational Congress on Peritoneal SurfaceMalignancies in Amsterdam, Netherlands todiscuss classification and diagnosis ofpseudomyxoma and appendiceal neoplasia. InNovember, Dr. Yantiss served as Course Directorand lectured at the Tutorial on Pathology of theGI Tract, Pancreas, and Liver held in the WaltDisney World Swan and Dolphin Resort in Orlando,Florida. ■

(left to right) S. Seshan, MD; S. Mathew, PhD; S. Subramaniyam, PhD; V. Pulijaal, PhD; S. Hoda, MD;G. Imperato; M. Jain, MD; R. Rao, MD; R. Hoda, MD; N. Narula, MD; H. Fernandes, PhD.

Celebrating Diwali!Diwali is an ancient Hindu festival celebrated in autumn every year. The festival signifies the victoryof light over darkness, knowledge over ignorance, good over evil, and hope over despair. It was apleasure to celebrate together!

Congratulations and best wishes to:

Congratulations to our Docs!

Listed in the May 30, 2014 issue of The New York Times Magazine in New YorkSuper Doctors:® Daniel M. Knowles, MD;Cynthia M. Magro, MD; Attilio Orazi, MD;Lora H. Ellenson, MD

Listed in the June 9-15, 2014 issue of New York Magazine in theBest Doctors 2014: Attilio Orazi, MD

Jennie and VictorBrodsky, on the birth of their little girlAllison Niaborn August 29, 2014,

6 pounds, 10 ounces, 20” long

Jessica and Scott Misner, on the birth of their baby boyJonathan Danielborn on May 2, 2014,


Hanna and JuanMosquera, on the birth of their little boySebastianborn October 15, 2014,


Nicole and JosephPanarelli, on the birth of their little boyJoseph Francisborn August 15, 2014,

5 pounds, 5 ounces, 18 1/2” long

Rhonda Yantiss and bigbrother Zachary, on thebirth of a new little girl Madeleine Claireborn May 8, 2014,

8 pounds, 6 ounces, 20 1/2” long


Keynotescontinued from page 5

Dr. Manu Jain visited the What Pho Temple

with reclining Buddha in

Bangkok, while attending

the International

Academy of Pathology

in Bangkok,Thailand,

to present two posters

Dr. Surya Seshan visited Bangkok, Thailand in October

2014. She served as a

member of the Program

Committee and as a lecturer

for the Renal Pathology

sessions of the International

Academy of Pathology.

Global travel itineraries from our renowned pathology faculty

Dr. Timothy Hla presented at the Lipid Mediators conference

at the Karolinska Institutet,

Stockholm, Sweden

to honor the

Nobel Prize Laureate,

Bengt Samuelsson.

7

Dr. Timothy Hla visited the Max Planck

Institute for Heart

and Lung Research

in Bad Nauheim,

Germany, where he

gave a presentation.

Welcome to ourNew Residents

Erika M. Hissong, MDPGY-1 Dr. Hissong graduated in May2014 from Indiana UniversitySchool of Medicine, where she was AOA. She received her BA in Biochemistry in 2010 from

Anderson University, Indiana.

Seung Ha (Anna) Nam, MDPGY-1 Dr. Nam graduated in May2014 from the University ofMissouri-Columbia School ofMedicine, where she wasAOA. She received her BS in

Chemistry in 2008 from Davidson College inNorth Carolina.

Luke C. Olson, MDPGY-1 Dr. Olson graduated in May2014 from the Geisel Schoolof Medicine at Dartmouth.He received his BA in Biologyin 2008 from Wesleyan

University. Luke completed a Post-SophomoreFellowship at the Dartmouth Medical Center.

Welcome to ourNew Fellows

Paula Ginter, MDBreast Pathology Dr. Ginter graduated in 2010from the Chicago MedicalSchool. She joined our AP/CPresidency-training program inJuly 2010 and served as the

Chief Resident for the year 2013-2014.

Michael Chaump, MDCytopathologyDr. Chaump graduated in 2007from Drexel University College of Medicine. He did a generalsurgery residency from 2007to 2009 at Monmouth Medical

Center, New Jersey and switched in 2010 to doAP/CP residency training at The Warren AlpertSchool of Medicine/Rhode Island Hospital, wherehe completed his training in June 2014.

Erica Syklawer, MDDermatopathologyDr. Syklawer graduated in2010 from the University ofSouth Alabama, and thenjoined the AP/CP residency-training program at The Univ-

ersity of Texas Health Science Center at Houston,where she completed her training in June 2014.

Lowell Evan Michael, MD,PhD/ Dermatopathology Dr. Michael graduated in 2010from the MD/PhD program atThe University of MichiganMedical School. He then did atransitional internship year at

Memorial Sloan Kettering Cancer Center, followed bya Dermatology residency at The University of Alabama,where he completed his training in June 2014.

Nariman Gobara, MDGastrointestinal PathologyDr. Gobara graduated in 2005 from the Ain Shams University,Egypt. She then immigrated tothe United States and from2006 to 2008, was a Research

Assistant at the College of Biomedical Sciences atFlorida Atlantic University. In 2010, she joined theAP residency-training program at the North Shore-LIJ School of Medicine and completed her trainingin 2013. She completed a Surgical PathologyFellowship at NYPH-Columbia in June 2014.

Kenneth Hennrick, MDGenitourinary PathologyDr. Hennrick graduated in2010 from the Sackler School of Medicine, and then joinedthe AP/CP residency-trainingprogram at the University of

Wisconsin, which he completed in June 2014.

Adela Cimic, MDGynecologic PathologyDr. Cimic graduated in 2004from the University of Sarajevo,Bosnia and Herzegovina. From2004 to 2005, she did aninternship at the General

Hospital, Sarajevo and then completed post-graduate work from 2005 to 2007 at the ClinicalCenter of the University of Sarajevo, Heart Center,where she also did her AP residency training,completing her training in 2010. She then joined theWake Forest Baptist Medical Center as a ResearchFellow from 2010 to 2011. In 2011, she became anAP resident at Wake Forest Baptist Health Center,and completed her training in June 2014.

Shannon Covey, MDHematopathologyDr. Covey graduated in 2010from the Texas A&M HealthScience Center, and thenjoined the AP/CP residency-training program at The

University of North Carolina, where she completedher training in June 2014.

William Wu, MD, PhDHematopathologyDr. Wu graduated in 2008from the MD/PhD program atSUNY, Syracuse and stayed onat SUNY as a PostdoctoralAssociate in the Department

of Microbiology and Immunology. In 2009, hejoined the AP/CP residency-training program atthe University of California, Irvine completing theprogram in 2013. He completed his training asa Surgical Pathology Fellow at Memorial SloanKettering Cancer Center in June 2014.

Yi Ding, MD, PhDMolecular GeneticsDr. Ding graduated with herMD degree in 1997 fromBeijing Medical University,China. From 1999 to 2001,she was a Clinical Research

Associate at the National Center for AIDS Prevention& Control in Beijing. She also held the title ofResearch Scholar at the Aaron Diamond AIDSResearch Center at Rockefeller University duringthat time. From 2002 to 2008, she was a GraduateAssistant at the Skirball Institute of BiomolecularMedicine at the NYU School of Medicine, where shereceived her PhD and was subsequently promotedto Research Scientist. She left to join the AP/CPresidency-training program at NYU LangoneMedical Center, and completed her training inJune 2014.

Lohith ShakaladevenapuraBachegowda, MBBSTransfusion MedicineDr. Bachegowda graduatedin 2004 from Rajiv GandhiUniversity of Health Sciences,India. Subsequently, he prac-

ticed general medicine in India and the UnitedKingdom. In 2005, he was a resident in the internalmedicine program at the National Health Servicein the United Kingdom, but transferred in 2008to Drexel University College of Medicine andcompleted his training in 2011. In July 2011, hebecame a Hematology & Oncology Fellow at theAlbert Einstein College of Medicine and completedhis training in June 2014. ■

Resident's Corner Visit our Residency Program on Facebook: www.facebook.com/cornellpatholresidencypgm



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Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A,Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R,Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E:Targeting the Hsp90-associated viral oncoproteome ingammaherpesvirus-associated malignancies. Blood 122:2837-47, 2013.

Jiang L, Mancuso M, Lu Z, Akar G, Cesarman E, Erickson D:Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics. Scientific Reports 4:4137,2014.

Mancuso M, Cesarman E, Erickson D: Detection of Kaposi'ssarcoma associated herpesvirus nucleic acids using asmartphone accessory. Lab Chip 4:3809-16, 2014.

Vogel MJ, Xie L, Guan H, Tooze RM, Maier T, Kostezka U,Maier HJ, Holzmann K, Chun Chan F, Steidl C, Reichel JB,Weitzer CD, Gehringer F, Kick AB, Cesarman E, Roshal M,Gascoyne RD, Möller P, Wirth T, Ushmorov A: OXO1 repres-sion contributes to block of plasma cell differentiation inclassical Hodgkin Lymphoma. Blood [Epub ahead of print]Sep 17, 2014.

Cesarman E: Pathology of lymphoma in HIV. Curr Opin Oncol25:487-494, 2013.

Cesarman E: Gammaherpesvirus and lymphoproliferativedisorders. Annu Rev Pathol 9:349-72, 2014.

Cesarman E: How do viruses trick B-cells into becominglymphomas? Curr Opin Hemaol 21:358-68, 2014.

Zhao X, Lwin T, Zhang X, Huang A, Wang J, Marquez VE, Chen-Kiang S, Dalton WS, Sotomayor E, Tao J: Disruption of MYC-MiRNA-EZH2 loop to suppress aggressive B-cell lymphomasurvival and clonogenicity. Leukemia 27:2341-2350, 2013.

Saletore Y, Chen-Kiang S, Mason CE: Novel RNA regulatorymechanisms revealed in the epitranscriptome. RNA biology.10: 342-346, 2013.

Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ,Leonard JP, Mason CE, Chen-Kiang S: Induction of pro-longed early G1 arrest by CDK4/CDK6 inhibition reprogramslymphoma cells for durable PI3K� inhibition throughPIK3IP1. Cell Cycle 12:1892-1900, 2013.

Niesvizky R, Mark T, Ward M, Jayabalan DS, Pearse RN,Manco M, Stern J, Christos PJ, Mathews L, Shore TB, PekleK, Zafa, F, Xiang J, Ely S, Skerrit D, Chen-Kiang S, ColemanM, Lane ME: Overcoming the response plateau in multiplemyeloma: A novel bortezomib-based strategy for secondaryinduction and high-yield CD34+ stem cell mobilization. ClinCan Res 19:1534-46, 2013.

Rossi A, Mark T, Jayabalan D, Christos P, Zafar F, Peckle K,Pearse R, Chen-Kiang S, Coleman M, Niesvizky R: BiRd(clarithromycin, lenalidomide, dexamethasone): An updateon long term lenalidomide therapy in previously untreatedpatients with multiple myeloma. Blood 121:1982-5, 2013.

Senses KM, Gonen M, Barutcu AR, Kalaylioglu Z, Isbilen M,Konu O, Chen YT, Altorki NK, Gure AO: Cancer-testis geneexpression is associated with the methyenetetrahydrofolatereductase 677 C>T polymorphism in non-small cell lungcarcinoma. BMC Med Genetic 14:97, 2013.

DeSimone RA, Ginter PS, Chen YT: Granular cell tumor ofthe breast eliciting exuberant pseudoepitheliomatoushyperplasia. Int J Surg Pathol 22:156-157, 2014.

Chen YT, Panarelli NC, Piotti KC, Yantiss RK: Cancer-Testisantigen expression in digestive tract carcinomas: Frequentexpression in esophageal squamous cell carcinoma and itsprecursor lesions. Cancer Immunol Res 2:480-486, 2014.

Chen YT: Detection of cancer/testis (CT) antigen expressionas a diagnostic aid in pathology practice. Onco Immunol3:e28132, 2014.

Simon MS, Leff JA, Pandya A, Cushing M, Shaz BH, CalfeeDP, Schackman BR, Mushlin AI: Cost-effectiveness of blooddonor screening for Babesia microti in endemic regions ofthe United States. Transfusion 54:889-99. 2014.

Baumann C, Lamesic G, Weiss M, Cushing MM, Haas T:Evaluation of the minimum volume of salvage bloodrequired for the successful use of two different autotrans-fusion devices. Paediatr Anaesth Sep 30, 2014.

D’Alfonso TM, Liu YF, Chen YB, Cimino-Mathews A, ShinSJ: SP3, a reliable alternative to HercepTest in determining

HER-2/neu (H2N) status in breast cancer patients. J ClinPathol 66:409-14, 2013.

D'Alfonso TM, van Laar R, Flinchum R, Brown N, Saint JohnL, Vahdat L, Shin SJ: BreastPRS effectively separatesOncotypeDX intermediate risk group to low and high riskgroups. Breast Cancer Res Treat 139:705-15, 2013.

D’Alfonso TM, Wang K, Chiu YL, Shin SJ: Pathologic upgraderates on subsequent excision (EXBX) when lobular carcinomain-situ (LCIS) is found in a needle core biopsy (NCB) with radi-ologic correlation. Arch Pathol Lab Med 137:927-935, 2013.

Nguyen MT, Stessin A, Nagar H, D'Alfonso T, Chen Z, Cigler T,Hayes MK, Shin SJ: Impact of oncotype DX recurrence scorein the management of breast cancer patients. Clin BreastCancer 14:182-90, 2014.

D'Alfonso TM, Ginter PS, Liu YF, Shin SJ: Cystic hyper-secretory (in situ) carcinoma of the breast: a clinicopathologicand immunohistochemical characterization of 10 cases withclinical follow-up. Am J Surg Pathol 38:45-53, 2014.

D’Alfonso TM, Hannah J, Liu YF, Chen Z, Zhou P, Shin SJ:Axl expression in molecular subtypes of breast cancer. J ClinPathol 67:690-696, 2014.

D’Alfonso TM, Padilla J, MacDonald TY, Mosquera JM, RubinMA, Shin SJ: MYB-NFIB gene fusion is present in mammaryadenoid cystic carcinoma (ACC) and cylindroma, two morpho-logically similar entities. Hum Pathol 45:2270-2280, 2014.

Chiron D, Diliberto M, Martin P, Huan X, Sharman J, Blecua JP,Mathew S, Vijay P, Eng K, Ali S, Johnson A, Chang B, Ely S,Elemento O, Mason CE, Leonard JP, Chen-Kiang S: Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal func-tional genomics in mantle cell lymphoma. Cancer Discov4:1022-1035, 2014.

Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, GiriD, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ:Caloric restriction reverses obesity induced mammary glandinflammation in mice. Cancer Prev Res 6:282-289, 2013.

Kothari P, Pestana R, Mesraroua R, Elchaki R, Khan KMF,Dannenberg AJ, Falcone DJ: IL-6-mediated induction ofMMP-9 is modulated by Janus kinase-dependent IL-10expression in macrophages. J Immunol 192:349-357, 2014.

Kraft CS, Binongo JN, Burd EM, Eaton ME, McCloskeyCB, Fernandes H, Hill CE, Caliendo AM: Successful use ofPlasma Preparation Tubes™ (PPTs) in the COBAS(®)AmpliPrep/ COBAS(®) TaqMan(®) HIV-1 Test. J Clin Virol57:77-9, 2013.

P Zhang, A Baisre, N Mirani, Fernandes H: Molecular hetero-geneity of head and neck squamous cell carcinoma defined bynext generation sequencing. Am J Pathol 184:1323-30, 2014.

Geyer JT, Subramaniyam S: Micronuclei and nuclear bud-ding in chronic lymphocytic leukemia. Br J Hematol [Epubahead of print] Aug 22, 2014.

Nguyen MT, Giorgadze T: Campanula cervica exfolia. Int JSurg Pathol 22:527, 2014.

David D, Masineni SN, Giorgadze T: Fine-needle aspirationdiagnosis of high grade adenoid cystic carcinoma metasta-tic to the pancreas. Diagn Cytopathol [Epub ahead of print]Feb 19, 2014.

Sheyn A, Mayerhoff R, Svider PF, Giorgadze T, MontgomeryPC, Mutchnik S, Coticchia J: Demonstration of the role ofan im-plantable bioscaffold in airway reconstruction: apilot study utilizing an animal model. Int J PediatrOtorhinolaryngol 78:82-87, 2014.

Zulfiqar M, Liu S, Shi D, Madan S, Jacques S, King L, ShidhamV, Giorgadze T: Metastatic colorectal adenocarcinoma incervicovaginal cytology specimens confirmed by immuno-cytochemical stains on liquid base specimens: Two studycases with review of the literature. Cytojournal 10:9, 2013.

Giorgadze TA: The vigilant eye. Int J Surg Pathol 21:46, 2013.

Giorgadze T, Qureshi F, Jacques SM, Aulicino M: Retroperi-toneal recurrence of a stage 1 renal cell carcinoma 4 yearsfollowing core biopsy and fine needle aspiration: possibleneedle tract seeding. Diagn Cytopathol 41:470-472, 2013.

Goss C, Giardina P, Degtyaryova D, Kleinert D, Sheth S,Cushing M: Red blood cell transfusions for thalassemia:results of a survey assessing current practice and proposalof evidence-based guidelines. Transfusion 54:1773-81, 2014.

Cohn CS, Stubbs J, Schwartz J, Francis R, Goss C, CushingM, Shaz B, Mair D, Brantigan B, Heaton WA: A comparison ofadverse reaction rates for PAS C versus plasma plateletunits. Red blood cell transfusions for thalassemia: results of asurvey assessing current practice and proposal of evidence-based guidelines. Transfusion 54:1927-34, 2014.

Wang Q, Ma X, Chen Y, Zhang L, Li X, MiaoR, Duan Y, Hajjar DP, Han J: Activation of liver X receptor induces interferon production and inhibits tumor growth. Biocheml J 459:345-354, 2014.

Hajjar DP, Moran GW, Siddiqi A, RichardsonJE, Anadon LD, Narayanmurti V: Prospects forpolicy advances in science and technology in the gulf arabstates: The role for international partnerships. Int J Higher Ed3:45-57, 2014.

Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T,Hwa J, Hla T: Individual variation of human sphingosine 1-phosphate receptor 1 coding sequence leads to heterogene-ity in receptor function and drug interactions. J Lipid Respii: jlr.P054163. [Epub ahead of print] PubMed PMID:25293589, Oct 7, 2014.

Xiong Y, Yang P, Proia RL, Hla T: Erythrocyte-derived sphin-gosine 1-phosphate is essential for vascular development. JClin Invest pii: 77685. doi: 10.1172/JCI77685. [Epub ahead ofprint] PubMed PMID: 25250575, Sep 24, 2014.

Murakami K, Kohno M, Kadoya M, Nagahara H, Fujii W, SenoT, Yamamoto A, Oda R, Fujiwara H, Kubo T, Morita S, NakadaH, Hla T, Kawahito Y: Knock out of S1P3 receptor signalingattenuates inflammation and fibrosis in bleomycin-inducedlung injury mice model. PLOS One 9:e106792, 2014.

Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M,Dai K, Hla T, Haberman AM, Melnick A: The BCL6 RD2domain governs commitment of activated B Cells to formgerminal centers. Cell Rep 8:1497-508, 2014.

Li MH, Harel M, Hla T, Ferrer F: Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling inneuroblastoma. J Pediatr Surg 49:1286-91, 2014.

Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, KennedyS, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S,Davidson NO: Intestinal epithelial HuR modulates distinctpathways of proliferation and apoptosis and attenuatessmall intestinal and colonic tumor development. Cancer Res74:5322-5335, 2014.

Xiong Y, Hla T: S1P control of endothelial integrity. Curr TopMicrobiol Immunol 378:85-105, 2014.

Chang SH, Hla T: Post-transcriptional gene regulation byHuR and microRNAs in angiogenesis. Curr Opin Hematol21:235-40, 2014.

Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA:Treatment with the immunomodulator FTY720 (fingolimod)significantly reduces renal inflammation in murine unilateralureteral obstruction. J Urol 191:1508-16, 2014.

Garris CS, Blaho VA, Hla T, Han MH: Sphingosine-1-phos-phate receptor 1signalling in T cells: trafficking andbeyond. Immunol 142:347-53, 2014.

Blaho VA, Hla T: An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res 55:1596-1608, 2014.

Li X, Lu YC, Dai K, Torregroza I, Hla T, Evans T: Elavl1aregulates zebrafish erythropoiesis via posttranscriptionalcontrol of gata1. Blood 123:1384-92, 2014.

Mendelson K, Evans T, Hla T: Sphingosine 1-phosphatesignalling. Development 141:5-9, 2014.

Ozerdem U, Hoda SA: Intracytoplasmic inclusion bodiesand myoid-type of differentiation in the stroma of a benignphyllodes tumor. Breast J 20:544-6, 2014.

Hoda SA, Swistel A: Editorial: Data! data! data! Charting thecourse for mammary magnetic resonance imaging. Breast J20:451-2, 2014.

Heymann JJ, Halligan AM, Hoda SA, Facey KE, Hoda RS:Fine needle aspiration of breast masses in pregnant and lac-tating women: experience with 28 cases emphasizingThinprep findings. Diagn Cytopathol doi:10.1002/dc.23197.Jun 27, 2014.

Ozerdem U, Hoda SA: Basal cell carcinoma of the nipple.Breast J 20:427-9, 2014.

Eisenberg RE, Hoda SA: Lobular carcinoma in situ with col-lagenous spherulosis: clinicopathologic characteristics of 38cases. Breast J 20:440-1, 2014.

Ozerdem U, Hoda SA: Correlation of maximum breast carcin-omadimension on needle core biopsy and subsequent excisionalbiopsy: a retrospective study of 50 non-palpable imaging-detected cases. Pathol Res Pract 210:603-5, 2014.

Ozerdem U, Swistel A, Antonio LB, Hoda SA: Invasive Pagetdisease of the nipple: a brief review of the literature andreport of the first case with axillary nodal metastases. Int JSurg Pathol 22:566-9, 2014. continued on page 10

Faculty Publications in 2014



Faculty Publications continued

Eisenberg RE, Chan JS, Swistel AJ, Hoda SA:Pathological evaluation of nipple-sparingmastectomies with emphasis on occult nip-ple involvement: the Weill-Cornell experience

with 325 cases. Breast J 20:15-21, 2014.

Ozerdem U, Hoda SA: Swiss cheese disease of the breast:macroscopic appearance of microscopic slides offers adiagnostic clue. Int J Surg Pathol 22:66-7, 2014.

Ginter PS, Winant AJ, Hoda SA: Cystic apocrine hyperplasiais the most common finding in MRI detected breast lesions.J Clin Pathol 67:182-6, 2014.

Hsu YM, Despotis GJ: Coronary artery bypass grafting intwo thrombophilic patients with protein S deficiency: AnesthAnalg Case Rep 2:92-94, 2014.

Hsu YM, Burnham CA: MALDI-TOF MS identification ofanaerobic bacteria: assessment of pre-analytical variablesand specimen preparation techniques. Diagn MicrobiolInfect Dis 79:144-8, 2014.

Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, HsuYM, Yang L, Guan JH, Xu GT, Lin X: CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras foranti-fungal immunity. J Exp Med 211:2307-2321, 2014.

Piva R, Deaglio S, Famà R, Buonincontri R, Scarfò I,Bruscaggin A, Mereu E, Serra S, Spina V, Brusa D, Garaffo G,Monti S, Dal Bo M, Marasca R, Arcaini L, Neri A, Gattei V,Paulli M, Tiacci E, Bertoni F, Pileri SA, Foà R, Inghirami G,Gaidano G, Rossi D: The Krüppel-like factor 2 transcriptionfactor gene is recurrently mutated in splenic marginal zonelymphoma. Leukemia [Epub ahead of print] PubMed PMID:25283840, Oct 6, 2014.

Abate F, Zairis S, Ficarra E, Acquaviva A, Wiggins CH, FrattiniV, LasorellaA, Iavarone A, Inghirami G, Rabadan R: Pegasus:a comprehensive annotation and prediction tool for detectionof driver gene fusions in cancer. BMC Syst Biol 8:97, 2014.

Boi M, Zucca E, Inghirami G, Bertoni F: PRDM1/BLIMP1: atumor suppressor gene in B and T cell lymphomas. LeukLymphoma 7:1-6, 2014.

Boi M, Rinaldi A, Kwee I, Bonetti P, Todaro M, Tabbò F, PivaR, Rancoita PM, Matolcsy A, Timar B, Tousseyn T,Rodríguez-Pinilla SM, Piris MA, Beà S, Campo E, Bhagat G,Swerdlow SH, Rosenwald A, Ponzoni M, Young KH, PiccalugaPP, Dummer R, Pileri S, Zucca E, Inghirami G, Bertoni F:PRDM1/BLIMP1 is commonly inactivated in anaplasticlarge T-cell lymphoma. Blood 122:2683-93, 2013.

Spaccarotella E, Pellegrino E, Ferracin M, Ferreri C, CuccuruG, Liu C, Iqbal J, Cantarella D, Taulli R, Provero P, Di Cunto F,Medico E, Negrini M, Chan WC, Inghirami G, Piva R: STAT3-mediated activation of microRNA cluster 17~92 promotesproliferation and survival of ALK-positive ana-plasticlarge cell lymphoma. Haematologica 99:116-24, 2014.

Jain M, Narula N, Salamoon B, Aggarwal, A, Altorki NK,Stiles B, Mukherjee S: Full-field optical coherence tomogra-phy (FFOCT): a potential alternative to frozen section analy-sis. J Pathol Inform 4:26, 2013.

Jain M, Narula N, Salamoon B, Aggarwal, A, Altorki NK,Stiles B, Mukherjee S: Multiphoton microscopy: a potential“optical biopsy” tool for real-time evaluation of lung tumorswithout the need for exogenous contrast agents. Arch PatholLab Med 138:1037-1047, 2014.

Durand M, Jain M, Aggarwal A, Robinson BD: Real-time invivo periprostatic nerve tracking using multiphotonmicroscopy in a rat survival surgery model: a promising pre-clinical study for enhanced nerve-sparing surgery. BJU Int[Epub ahead of print] Aug 14, 2014.

Palmer SG, DeVito I, Jenkins SG, Niewiesk S, Porotto M,Moscona A: Circulating clinical strains of human parain-fluenza virus reveal the viral entry requirements for in vivoinfection. J Virol 88:13495-502, 2014.

Locke JB, Zuill DE, Scharn CR, Deane J, Sahm DF, GoeringRV, Jenkins SG, Shaw KJ: Identification andCharacterization of Linezolid-resistant USA300 Staphylo-coccus aureus Isolates from a New York City medical centerpossessing the cfr multidrug resistance gene. AntimicrobAgents Chemother 58:6949-52, 2014.

Satlin MJ, Soave R, Racanelli AC, Shore TB, Van Besien K,Jenkins SG, Walsh TJ: The emergence of vancomycin-resistant enterococcal bacteremia in hematopoietic stemcell transplant recipients. Leuk Lymphoma [Epub ahead ofprint] Feb 24,2014.

Satlin MJ, Jenkins SG, Chen L, Helfgott DC, Feldman EJ,Kreiswirth BN, Schuetz AN: Septic shock caused by KPC-producing 1 in a neutropenic patient with leukemia. J Clin

Microbiol 51:2794-2796, 2013.

Patel SJ, Oliveira AP, Zhou JJ, Alba L, Furuya EY, WeisenbergSA, Jia H, Clock SA, Kubin CJ, Jenkins SG, Schuetz AN,Behta M, Della-Latta P, Whittier S, Rhee K, Saiman L: Riskfactors and outcomes of infections caused by extremelydrug-resistant gram-negative bacilli in patients hospitalizedin intensive care units. Am J Infect Control 42:626-631,2014.

Satlin MJ, Jenkins, SG, Walsh TJ: The global challenge ofcarbapenem-resistant enterobacteriaceae in transplantrecipients and patients with hematologic malignancies. ClinInfect Dis 58:1274-1278, 2014.

Banach DB, Francois J, Blash S, Patel G, Jenkins SG,LaBombardi V, Kreiswirth BN, Srinivasan A, Calfee DP: Activesurveillance for carbapenem-resistant enterobacteriaceaeusing stool specimens submitted for testing for clostridiumdifficile. Infect Control Hosp Epidemiol 35:82-84, 2014.

Folcik VA, Garofalo M, Coleman J, Donegan JJ, Rabbani E, SusterS, Nuovo A, Magro CM, Di Leva G, Nuovo GJ: Idiopathic pul-monary fibrosis is strongly associated with productive infec-tion by herpesvirus saimiri. Mod Pathol 27: 851-62, 2014.

Magro CM, Yang SE, Zippin JH, Zembowicz A: Expression ofsoluble adenylyl cyclase in lentigo maligna: use of immuno-histochemistry with anti-soluble adenylyl cyclase antibody(R21) in diagnosis of lentigo maligna and assessment ofmargins. Arch Pathol Lab Med 136:1558-64, 2013.

Hagen JW, Schaefer JT, Magro CM: CD20+ mycosis fun-goides: a report of three cases and review of the literature.Am J Dermatopathol 35:833-41, 2013.

Hagen JW, Magro CM: Indolent CD8+ lymphoid proliferationof the face with eyelid involvement. Am J Dermatopathol36:137-41, 2014.

Lonze BE, Zachary AA, Magro CM, Desai NM, Orandi BJ, DagherNN, Singer AL,Carter-Monroe N, Nazarian SM, Segev DL,Streiff MB, Montgomery RA: Eculizumabprevents recurrentantiphospholipid antibody syndrome and enables successfulrenal transplantation. Am J Transplant 14: 459-65, 2014.

Allmendinger AM, Mallery RM, Magro CM, Wang N, EganRA, Samuels MA, Callahan A, Viswanadhan N, Klufas RA, HsuL, Prasad S: Cauda equina involvement in Susac's syn-drome. J Neurol Sci 337:91-6, 2014.

Liu Y, Magro C, Loewenstein JI, Makar RS, Stowell CP,Dzik WH, Hochberg EP, Oaklander AL, Sobrin L: A man withparaneoplastic retinopathy plus small fiber polyneuropathyassociated with Waldenström Macroglobulinemia (Lympho-plasmacytic Lymphoma): Insights into mechanisms. OculImmunol Inflamm [Epub ahead of print] Mar 21, 2014.

Magro CM, Wang X, Subramaniyam S, Darras N, MathewS: Cutaneous double-hit B-cell lymphoma: an aggressiveform of B-cell lymphoma with a propensity for cutaneousdissemination. Am J Dermatopathol 36:303-10, 2014.

Magro CM, Hagen JW, Crowson AN, Liu YC, Mihm M,Drucker NM, Yassin AH: Hypopigmented interface T-cell dyscra-sia: A form of cutaneous T-cell dyscrasia distinct from hypo-pigmented mycosis fungoides. J Dermatol 41: 609-17, 2014.

Kiuru M, Schwartz M, Magro C: Cutaneous thrombogenicvasculopathy associated with bevacizumab therapy.Dermatol Online J 20(6), 2014.

Magro CM, Abraham RM, Guo R, Li S, Wang X, Proper S,Crowson AN, Mihm M: Deep penetrating nevus-like border-line tumors: A unique subset of ambiguous melanocytictumors with malignant potential and normal cytogenetics.Eur J Dermatol 2014 Aug 14. [Epub ahead of print]

Gordon J, Udeh U, Doobay K, Magro C, Wildman H, DavidsM, Mersten JN, Huang WT, Lyman S, Crow MK, Spiera RF:Imatinib mesylate (Gleevec™) in the treatment of diffusecutaneous systemic sclerosis: results of a 24-month openlabel, extension phase, single-centre trial. Clin ExpRheumatol 2014 Aug 15. [Epub ahead of print]

Karadeniz A, Lally L, Magro C, Levy R, Erkan D, LockshinMD: Lepromatous leprosy mimicking systemic lupus erythe-matosus: a clinical pathology conference held by the divi-sion of rheumatology at Hospital for Special Surgery. HSS J10:286-91, 2014.

Shapiro L, Whelan P, Magro C: Case 18-2014: A man with arash, myalgia, and weakness. N Engl J Med 371:1361, 2014.

Wu R, Zippin JH, Magro C: Double-positive CD4(+)CD8(+)Sézary syndrome: an unusual phenotype with an aggressiveclinical course. Cutis 93:E18-25, 2014.

Haddad H, Sundaram S, Magro C, Gergis U: Eosinophilicfasciitis as a paraneoplastic syndrome, a case report and reviewof the literature. Hematol Oncol Stem Cell Ther 7:90-2, 2014.Yan J, Nie K, Mathew S, Tam Y, Cheng S, Knowles DM, Orazi

A, Tam W: Inactivation of BANK1 in a novel IGH-associatedtranslocation t(4;14)(q24;q32) suggests a tumor suppressorrole in B-cell lymphoma. Blood Cancer J 4:e215, 2014.

Prandi D, Baca SC, Romanel A, Barbieri CE, Mosquera J,Fontugne J, Beltran H, Sboner A, Garraway LA, Rubin MA,Demichelis F: Unraveling the clonal hierarchy of somaticgenomic aberrations. Genome Biol 15:439, 2014.

Ginter PS, Mosquera JM, MacDonald TY, D'Alfonso TM, RubinMA, Shin SJ: FISH MYC amplification and MYC proteinexpression in atypical vascular lesions, mammary angiosar-comas and angiosarcomas of other sites. Hum Pathol45:709-16, 2014.

Galletti G, Matov A, Beltran H, Fontugne J, Mosquera JM,Cheung C, MacDonald TY, Sung M, O’Toole S, Kench JG,Chae SS, Kimovski D, Tagawa ST, Nanus DM, Rubin MA,Horvath LG, Giannakakou P, Rickman, D: ERG inducestaxane resistance in castration-resistant prostate cancer.Nature Comm 5:5548, 2014.

Andrews W, Paul S, Narula N, Altorki NK: Localized meso-thelioma tumour arising synchronously with a primary contralat-eral lung cancer. Interact Cardiovasc Thorac Surg 17:1061-2, 2013.

Arbustini E, Narula N, Dec GW, Reddy KS, Greenberg B,Kushwaha S, Marwick T, Pinney S, Bellazzi R, Favalli V,Kramer C, Roberts R, Zoghbi WA, Bonow R, Tavazzi L, FusterV, Narula J: The MOGE(S) Classification for a Phenotype-Genotype Nomenclature of Cardiomyopathy: Endorsed by theWorld Heart Federation. J Am Coll Cardiol 62:2046-72, 2013.

Trujillo O, Narula N, Ginter P, Kacker A: Bilateral thyroid nod-ules. LAMA Otolaryngol Head Neck Surg 140:381-2, 2014.

Arbustini E, Narula N, Dec GW, Reddy KS, Greenberg B,Kushwaha S, Marwick T, Pinney S, Bellazzi R, Favalli V,Kramer C, Roberts R, Zoghbi WA, Bonow R, Tavazzi L,Fuster V, Narula J: MOGE(S) nosology in low-to-middle-income countries. Nat Rev Cardiol 64:304-18, 2014.

Brenner M, Benavides S, Mahon SB, Lee J, Yoon D, Mukai D,Viseroi M, Chan A, Jiang J, Narula N, Azer SM, Alexander C,Boss GR: The vitamin B12 analog cobinamide is an effectivehydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol52:490-7, 2014.

Lally L, Pernis A, Narula N, Huang WT, Spiera R: Increasedrho kinase activity in temporal artery biopsies from patientswith giant cell arteritis. Rheumatol [Epub ahead of print],Sept 10, 2014.

Arbustini E, Narula N, Tavazzi L, Serio A, Grasso M, Favalli V,Bellazzi R, Tajik JA, Bonow RD, Fuster V, Narula J: TheMOGE(S) classification of cardiomyopathies for clinicians. JAm Coll Cardiol 64:304-18, 2014.

Renjen P, Kovanlikaya A, Narula N, Brill PW: Importance ofMRI in the diagnosis of vertebral involvement in generalizedcystic lymphangiomatosis. Skeletal Radiol 43:1633-8, 2014.

Tam W, Murray A, Orazi A, Knowles DM: Organization andoperation of a hematopathology laboratory. In: Knowles’Neoplastic Hematopathology (3rd), A. Orazi, LM Weiss, KFoucar, DM Knowles (eds), Lippincott Williams & Wilkins(publ) 265-285, 2014.

O'Malley DP, Zuckerberg L, Smith LB, Barry TS, Gunn S, TamW, Orazi A, Kim YS, Weiss LM: The genetics of interdigitatingdendritic cell sarcoma share some changes withLangerhans cell histiocytosis in select cases. Ann DiagnPathol 18:18-20, 2014.

Kim DY, Rhee I, Paik J: Metabolic circuits in neural stemcells. Cell Mol Life Sci 71:4221-41, 2014.

Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A,Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D,Guan KL, Shrager JB: mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving theactivation of FoxO and E3 ubiquitin ligases. Sci Signal7:ral8, 2014.

Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C,Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X,Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y,Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q:Prolyl hydroxylation by EglN2 destabilizes FOXO3a by block-ing its interaction with the USP9x deubiquitinase. Genes Dev28:1429-44, 2014.

Kleiman DA, Beninato T, Sultan S, Crowley MJ, Finnerty B,Kumar R, Panarelli NC, Liu YF, Lieberman MD, Seandel M,Evans T, Elemento O, Zarnegar R, Fahey TJ: Silencing ofUCHL1 by CpG promoter hyper-methylation is associatedwith metastatic gastroenteropancreatic well-differentiatedneuroendocrine (carcinoid) tumors. An Surg Oncol [Epubahead of print] May 23, 2014. continued on page 11

11

Faculty Publications continued

Panarelli NC: Drug-induced Injury in the gastrointestinaltract. Review Sem Diag Pathol 2:165-175, 2014.

Tan YC, Michaeel A, Liu G, Blumenfeld J, Donahue S, ParkerT, Levine D, Rennert H: Molecular diagnosis of autosomaldominant polycystic kidney disease using next generationsequencing. J Mol Diagn 16:216-28, 2014.

Ben-Dov IZ, Tan YC, Morozov P, Wilson PD, Rennert H,Blumenfeld J, Tuschl T: MicroRNA as potential biomarkers inautosomal dominant polycystic kidney disease. PLOS ONE9:1-8 (e86856), 2014.

Tan AYC, Blumenfeld J, Donahue S, Parker T, Levine D,Rennert H: Autosomal dominant polycystic kidney diseasedue to somatic and germline mosaicism. Clin Genet DOI:10.1111/cge.12383. [Epub ahead of print] April 26, 2014.

Liu G, Michaeel A, Tan AYC, Blumenfeld J, Donahue S, ParkerT, Levine D, Rennert H: Mutation analysis of PKD1 and PKD2using whole genome amplified DNA and long-range PCRsequencing. Gene pii: S0378-1119(14)00771-9. doi: 10.1016/j.gene.2014.07.008. [Epub ahead of print] Jul 8, 2014.

Pflueger D, Sboner A, Storz M, Roth J, Compérat E, BruderE, Rubin MA, Schraml P, Moch H: Identification of moleculartumor markers in renal cell carcinomas with TFE3 proteinexpression by RNA sequencing. Neoplasia 15:1231-1240,2013.

Gao* D, Vela* I, Sboner* A, Iaquinta PJ, Karthaus WR,Gopalan A, Dowling C, Wajala JN, Undvall EA, Arora VK,Wongvipat J, Kossai M, Ramazanoglu S, Barboza LP, Di W,Cao Z, Zhang Q, Sirota I, Ran L, et al: Organoid culturesderived from patients with advanced prostate cancer. Cell7741:159 *equal contribution, 2014.

William Lee W, Teckie S, Wiesner T, Ran L, Prieto GranadaCN, Lin M, Zhu S, Cao Z, Liang Y, Sboner A, Tap WD, FletcherJA, Huberman KH, Qin LX, Viale A, Singer S, Zheng D, BergerMF, Chen Y, Antonescu CR, Chi P: PRC2 is recurrently inacti-vated through EED or SUZ12 loss in malignant peripheralnerve sheath tumors. Nature Gen [Epub ahead of print],2014.

Mertz K, Pathria G, Wagner C, Saarikangas J, Sboner A, Romanov J, Gschaider M, Lenz F, Neumann F, Schreiner W,Nemethova M, Glassmann A, Lappalainen P, Stingl G, SmallV, Fink D, Chin L, Wagner S: MTSS1 is a metastasis driver ina subset of human melanomas. Nat Comm 5:3465, 2014.

Blattner M, Lee DJ, O'Reilly C, Park K, MacDonald TY, Khani F,Turner KR, Chiu Y, Wild PJ, Dolgalev I, Heguy A, Sboner A,Ramazangolu S, Hieronymus H, Sawyers CL, Tewari AK, MochH, Yoon G, Known Y, et al: SPOP mutations in prostate canceracross demographically diverse patient cohorts. Neoplasia16:14-20, 2014.

Antonescu CR, Sung Y, Chen C, Zhang L, Chen H, Singer S,Agaram NP, Sboner A, Fletcher CM: Novel ZC3H7B-BCOR,MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyx-oid tumors-molecular characterization shows genetic over-lap with endometrial stromal sarcoma. Genes Chrom Cancer53:183-93, 2014.

Harrington SM, Bell M, Bernard K, Lagacé-Wiens P, SchuetzAN, Hartman B, McQuiston JR, Wilson D, LaSalvia M, Ng B,Richter S, Taege A: Case report: A novel fastidious, partiallyacid-fast, anaerobic Gram-positive bacillus associated withabscess formation at diverse medical centers. J ClinMicrobiol 51:3909-3907, 2013.

Schuetz AN: Invasive fungal infections: Biomarkers andmolecular approaches to diagnosis. Clin Lab Med 33:505-525, 2013.

Gomes RM, Cerio DR, Loghmanee C, McKinney J, Patel M,Miraglia J, Yousef-Bessler M, Zippin JH, Schuetz AN, PinhoPB: Cutaneous cryptococcoma in a patient on TNF-� inhibi-tion. J Clin Med 2:260-263, 2013.

Simon MS, Somersan S, Singh HK, Hartman B, Wickes BL,Jenkins SG, Walsh TJ, Schuetz AN: Endocarditis caused byRhodotorula infection. J Clin Microbiol 52:374-378, 2014.

Merkler A, Parlitsis G, Patel S, Oliveira C, Lavi E, Schuetz A,May A, Bier D, Simpson SA, Kiss S, Dinkin M: Infection of theoptic apparatus and hypothalamus by Mycobacteriumhaemophilum. Neurol 83:659-660, 2014.

Narayanan S, Schuetz AN: Current Trends inInstrumentation and Technology: Outlook for the Future, InClinical Laboratory Management. Second edition. LS Garcia,ed. Washington, D.C.: ASM Press, pp. 933-965, 2014.

Schuetz AN: Antimicrobial resistance in anaerobic bacteria

and susceptibility testing. Clin Infect Dis 59:698-705, 2014.

McCarthy M, Rosengart A, Schuetz AN, Kontoyiannis DP,Walsh TJ: Mold infections of the central nervous system. NEngl J Med 371:150-160, 2014.

Piotti KC, Scognamiglio T, Chiu R, Chen YT: Expression ofcancer/testis (CT) antigens in squamous cell carcinomaof the head and neck: Evaluation as markers of squamousdysplasia. Pathol Res Pract 209:721-726, 2013.

Birk A, Liu S, Soong Y, Mills W, Singh P, Warren JD, SeshanSV, Pardee J, Szeto H: Cardiolipin-as a novel target to re-energize ischemic mitochondria. J Am Soc Nephrol24:1250-1261, 2013.

Chatterjee R, Hoffman M, Cliften P, Seshan S, Liapis H, JainS: Targeted exome sequencing integrated with clinicopatho-logical information reveals novel and rare mutations in atyp-ical, suspected and unknown cases of Alport syndrome orproteinuria. PLOS ONE Oct 10;8, 2013.

Salvatore S, Reddi AS, Chandra CB, Okechukwu CN,Chevalier JM, Seshan SV: Collapsing glomerulopathy super-imposed on diabetic nephropathy: insights into etiology ofan under-recognized, severe pattern of glomerular injury.Nephrol Dial Transplant 29:392-9, 2014.

Matignon M, Ding R, Dadhania D, Mueller F, Hartono C,Snopkowski C, Li C, Lee J, Sjoher D, Seshan S, Sharma V, YangH, Nour B, Vickers A, Suthanthiran M, Muthukumar T: Urinarycell mRNA profiles and differential diagnosis of acute kidneygraft dysfunction. J Am Soc Nephrol 25:1586-97, 2014.

Usui J, Glezerman I, Salvatore S, Chandra B, Flombaum C,Seshan SV: Clinicopathological spectrum of kidney diseasesin patients treated with vascular endothelial growth factorinhibitors: a report of 5 cases and review of literature. HumPathol 45:1918-27, 2014.

Liu S, Soong Y, Seshan SV, Szeto HH. Novel cardiolipintherapeutic protects endotheilial mitochondria during renalischemia and mitigates microvascular rarefaction, inflammationand fibrosis. Am J Physiol Renal Physiol 306:F970-80, 2014.

Reddi AS, Kothari N, Kuppasani K, Seshan SV: Albuminuria-Proteinuria in diabetic nephropathy: an update. J Clin LabInvest Updates 2:22-31, 2014.

Ross D, Liu YF, Pipa J, Shin SJ: The diagnostic utility of theMinimal Carcinoma (MC) Triple Stain in breast carcinomas.Am J Clin Pathol 139:62-70, 2013.

Varma S, Shin SJ: Spindle cell lesions of the breast. AdvAnat Pathol 20:95-109, 2013.

Shinohara MM, Tozbikian G, Wolfe JT, Shin SJ, Mies C,Elenitsas R: Cutaneous metastatic breast carcinoma withclear cell features. J Cutan Pathol 40:753-7, 2013.

Zhang Y, Shin SJ, Liu D, Ivanova E, Foerster F, Ying H, ZhengH, Xiao Y, Chen Z, Protopopov A, DePinho RA, Paik JH: ZNF365promotes stability of fragile sites and telomeres. CancerDiscov 3:798-811, 2013.

Shin SJ, Lal A, DeVries S, Suzuki J, Roy R, Hwang E, SchnittSJ, Waldman F, Chen YY: Florid lobular carcinoma in-situ:molecular profiling and comparison to classic lobular carci-noma in-situ and pleomorphic lobular carcinoma in-situ.Hum Pathol 44:1998-2009, 2013.

Kawaguchi K, Lu F-I, Kaplan R, Liu YF, Chadwick P, Chen Z,Brogi E, Shin SJ: The utilities of immunohistochemicalstains GATA-3 and Napsin to distinguish metastatic mam-mary carcinoma from primary lung adenocarcinoma: a tis-sue microarray study of 211 cases. Appl ImmunohistochemMol Morph 22:266-74, 2014.

Wernicke AG, Varma S, Greenwood EA, Christos PJ, ChaoKSC, Liu H, Bander NH, Shin SJ: Prostate-specific mem-brane antigen expression in tumor-associated vasculatureof breast cancers. APMIS 122:482-9, 2014.

Wells JM, Pipa J, Shin SJ: Lobular neoplasia of the breastrevisited with emphasis on the role of E-cadherin immuno-histochemistry. Am J Surg Pathol 38:434-5, 2014.

Kaplan R, Koslow S, Qiu Q, Chen Z, Swistel A, Shin SJ:Sentinel lymph node biopsy is a reliable method for lymphnode evaluation in neoadjuvant chemotherapy treatedbreast cancer patients. Am Surg 80:171-1, 2014.

Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB,Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, ShenH, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, FerrariM, Shin SJ, Brown M, Chang JC, Liu XS, 6, Glimcher LH:XBP1 promotes triple negative breast cancer and does soby controlling the hypoxia response. Nature 508:103-7,2014.

Desman G, Ozerdem U, Shin SJ:Neighboring look alikes: distinguishingbetween breast and dermatologic lesions.Adv Anat Pathol 21:228-47, 2014.

Wells JM, Liu YF, Ginter PS, Nguyen MT,Shin SJ: Elucidating encounters of atypicalduct hyperplasia arising in gynecomastia.Histopathol [Epub ahead of print], Sep 12, 2014.

Shin SJ, DeLellis RA, Treaba D: Immunohistochemistry ofEndocrine Tumors. In Dabbs DJ (4th ed): DiagnosticImmunohistochemistry with Genomic and TheranosticApplications, Saunders Elsevier Inc., Philadelphia, 2014.

Rutherford S, Tam W, Martin P: Marginal zone lymphoma. InCancer Consult: Expertise for clinical practice. Abutalib, S.A.& Markman, Maurie (eds), Wiley-Blackwell (publ) 275-281,2014.

Cao Z, Ding B.S, Guo P, Lee SB, Butler JM, Casey SC, SimonsM, Tam W, Felsher DW, Shido K, Rafii A, Scandura JM, RafiiS: Angiocrine factors deployed by tumor vascular nicheinduce B cell lymphoma invasiveness and chemoresistance.Cancer Cell 25:350-65, 2014.

Oricchio E, Ciriello G, Jiang M, Boice MH, Schatz JH, HeguyA, Viale A, de Stanchina E, Teruya-Feldstein J, Bouska A,McKeithan T, Sander C, Tam W, Seshan VE, Chan WC,Chaganti RS, Wendel HG: Frequent disruption of the RBpathway in indolent follicular lymphoma suggests a newcombination therapy. J Exp Med 211:1379-91, 2014.

Jiang Y, Redmond D, Nie K, Eng KW, Clozel T, Martin P, Tan L,Melnick AM, Tam W, Elemento O: Deep-sequencing revealsclonal evolution patterns and mutation events associatedwith relapse in B-cell lymphomas. Genome Biol 15:432, 2014.

Tam W, Pasqualucci L: Protooncogenes and tumor sup-pressor genes in hematopoietic malignancies. In: Knowles’Neoplastic Hematopathology (3rd), A Orazi, LM Weiss, KFoucar, DM Knowles (eds), Lippincott Williams & Wilkins(publ) 168-193, 2014.

Rock JB, Washington MK, Adsay NV, Greenson JK, Mont-gomery EA, Robert M, Yantiss RK, Lehman AM, Frankel WL:Debating deposits: An interobserver variability study oflymph nodes and pericolonic tumor deposits in colonic ade-nocarcinoma. Arch Pathol Lab Med 138:636-642, 2014.

Ocean AJ, Christos P, Sparano JA, Shah MA, Yantiss RK,Cheng J, Lin J, Papetti M, Matulich D, Schnoll-Sussman F,Besanceney-Webler C, Xiang J, Ward M, Dilts KT, KeresztesR, Holloway S, Chen EZ, Wright JJ, Lane ME: Phas II trial ofbortezomib alone or in combination with irinotecan inpatients with adenocarcinoma of the gastroesophagealjunction or stomach. Invest New Drugs 32:542-548, 2014.

Zeremski M, Dimova RB, Benjamin S, Makeyeva J, YantissRK, Gambarin-Gelwan M, Talal AH: FibroSURE as a noninva-sive marker of liver fibrosis and inflammation in chronichepatitis B. BMC Gastroenterol 14:118, 2014.

Malatesta M, Peschiaroli A, Memmi EM, ZhangJ, Antonov A,Green DR, Barlev NA, Garabadgiu AV, Zhou P, Melino G,Bernassola F: The Cul4A-DDB1 E3 ubiquitin ligase complexrepresses p73 transcriptional activity. Oncogene 32:4721-4726, 2013.

Kong F, Zhang J, Li Y, Hao X, Ren X, Li H, Zhou P: Engineeringa single ubiquitin ligase for the selective degradation of allactivated ErbB receptor tyrosine kinases. Oncogene 33:986-95, 2014.

Lee J, Shieh JH, Zhang J, Liu L, Zhang Y, Eom JY, Morrone G,Moore MAS, Zhou P: Improved ex vivo expansion of adulthematopoietic stem cells by overcoming CUL4-mediateddegradation of HOXB4. Blood 121:4082-4089, 2013.

Hannah J, Zhou P: The CUL4A ubiquitin ligase is a potentialtherapeutic target in skin cancer and other malignancies.Chin J Cancer 32:478-82, 2013.

Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang, Z, Lee EY,Lee MY: A novel function of CRL4(Cdt2): regulation of thesubunit structure of DNA polymerase � in response to DNAdamage and during the S phase. J Biol Chem 288:29550-61, 2013.

Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H,Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P,Karajannis M, Giancotti FG: CRL4DCAF1-Mediated inhibitionof Lats1/2 Promotes YAP-dependent oncogenesis in NF2mutant tumor cells. Cancer Cell 26:48-60, 2014.

Fattah F, Hara K, Fattah KR, Yang C, Wu N, Warrington R,Chen DJ, Zhou P, Boothman DA, Yu H: The transcription fac-tor TFII-I promotes DNA translesion synthesis and repair.PLOS Genet 10:e1004419, 2014. ■



Newly Awarded Grantsin Pathology;National Cancer Institute (NIH) Research GrantTitle: Cell Cycle Reprogramming for TherapeuticTargeting of BTK in LymphomaPrincipal Investigator: Selina Chen-Kiang, PhDPeriod of Support: 08/05/14-07/31/19 Total Direct Costs: $1,037,500

;National Cancer Institute (NIH) Research GrantTitle: Cell cycle sensitization to PI3K therapy in lymphomaPrincipal Investigator: Selina Chen-Kiang, PhDPeriod of Support: 11/01/2014-10/31/2017Total Direct Costs: $540,054

;Goldhirsh-Yellin Foundation Research GrantTitle: Molecular Characterization of MetastaticNeuroendocrine Tumors of the Gastrointestinal TractPrincipal Investigator: Thomas J. Fahey IIICo-Investigator: Yi-Chieh Nancy Du, PhDPeriod of Support: 02/01/14-01/31/17Total Direct Costs: $197,088

;Fondation Leducq Research GrantTitle: Sphingosine 1-phosphate in neurovascular biology and disease (SphingoNet)Principal Investigator: Timothy Hla, PhDPeriod of Support: 10/01/14-09/30/19Total Direct Costs: $1,658,100

;Seed Grants for Collaborations Between Cornell University-Ithaca and Weill CornellMedical College Research Grant

Title: Redox-linked mechanisms of HuR protein regulation in angiogenesis

Principal Investigator: Timothy Hla, PhDPeriod of Support: 07/01/2014-06/30/2015Total Direct Costs: $23,746

;National Institute on Aging (NIH) Research GrantTitle: The Mechanisms Underlying How OxidativeStress Influences Neural Stem Cell FatePrincipal Investigator: Jihye Paik, PhDPeriod of Support: 09/15/14-05/31/19Total Direct Costs: $1,025,000

;Prostate Cancer FoundationJanssen Special Challenge Award

Title: Targeting and mechanistic insights underlyingN-Myc driven Neuroendocrine Prostate CancerPrincipal Investigator: David Rickman, PhD (Co-PI Mark A. Rubin, MD)Period of Support: 04/04/14-04/04/16Total Direct Costs: $500,000

;National Cancer Institute (NIH) Research GrantTitle: Mechanistic Insights Underlying ERG-inducedTaxane Resistance in Castration-Resistance inCastration-Resistant Prostate CancerPrincipal Investigator: David Rickman, PhDPeriod of Support: 04/11/14-02/28/19Total Direct Costs: $1,265,135

;National Cancer Institute (NIH) Research GrantTitle: Precision Medicine Approach to Prostate CancerActive SurveillancePrincipal Investigator: Mark A. Rubin, MDPeriod of Support: 08/01/2014-07/31/2019Total Direct Costs: $2,754,075

;NYSTAR Designated Center for Advanced Technology CAT Grant

Title: Topical Therapeutics for Skin Diseases associated with DNA DamagePrincipal Investigator: Pengbo Zhou, PhDPeriod of Support: 07/01/2014-06/30/2015Total Direct Costs: $49,500

;National Center for Advancing TranslationalSciences Seed Grant

Title: Attenuation of the Oncogenic CUL4A UbiquitinLigase by Small-Molecule InhibitorsPrincipal Investigator: Pengbo Zhou, PhDPeriod of Support: 09/01/2014-05/31/2015Total Direct Costs: $10,000 ■

Volume 21 • January 2015

Editor Daniel M. Knowles, MDCo-Editor David P. Hajjar, PhD

Managing Editor Gina L. Imperato, MPADesign JBRH Advertising & Design, Inc.

The Pathologist is an annual publication of the Department of Pathology and Laboratory Medicine

at NewYork-Presbyterian Hospital /Weill Cornell Medical Center.

If you have any comments or questions, please contact:Managing Editor, Gina L. Imperato • tel: (212) 746-6464

e-mail: [email protected]

6th Annual Papanicolaou Tutorial onUpdated Diagnostic CytopathologyuJuly 23-24, 2015Weill Auditorium and Archbold CommonsNew York, New YorkCourse Director: Rana S. Hoda, MDTargeted AudienceCytopathologists, pathologists, residents and cytotechnologistsCourse Goals and Objectives This 2-day program will consist of lectures, case presentations and discussions designed to providepathologists with a special interest in cytopathology,pathologists-in-training and cytotechnologistswith an in-depth discussion of current criteria andchanging concepts in Diagnostic Cytopathology.Diagnostic cytopathology performs a vital role inthe evaluation and treatment of patients with non-neoplastic and neoplastic disease. This course isneeded to advance the specialized knowledge ofpracticing cytologists and further, to encourage theexploration of current approaches and concepts inclassification, differential diagnosis and manage-ment. It is designed to provide updated practical,problem-solving knowledge and information forcytopathologists, pathologists, residents andcytotechnologists.

7th Annual SymposiumTutorial on Pathology of theGI Tract, Pancreas and Liver

uNovember 9-13, 2015Walt Disney World Swan and Dolphin ResortOrlando, FloridaCourse Director: Rhonda K. Yantiss, MD

Targeted AudienceGeneral surgical pathologists and pathologists-in-training

Course Goals and Objectives This course is designed to update physicians onadvances in our understanding of gastrointestinaldiseases, address problems faced during thepathologic evaluation of tissue samples, and providepathologists with a framework for interpretation ofboth histologic patterns of disease and results ofmolecular analyses. The program will consist oflectures, case presentations and discussionsdesigned to provide attendees with an in-depthdiscussion of diagnostic problems that arise whenevaluating materials obtained from the gastro-intestinal tract, pancreas, and liver, and informthem regarding the application and interpretationof immunohistochemical and molecular studies inthe diagnosis and classification of these diseases.

Tutorial on NeoplasticHematopathologyuJanuary 25-29, 2016The WestinNew Orleans, LouisianaCourse Director: Daniel M. Knowles, MDAssociate Course Director: Attilio Orazi, MDTargeted AudiencePathologists, pathologists-in-training and medical oncologists/hematologistsCourse Goals and Objectives This 5-day course is designed to update physicians on the latest advances in Neoplastic Hemato-pathology. The program will consist of lectures,case presentations and discussions designed toprovide pathologists, pathologists-in-training andmedical oncologists/hematologists with an in-depth discussion of diagnostic problems that arisein neoplastic hematopathology. In addition todiscussions of recent advances in the morphologicclassification of hematopoietic tumors, the applica-tion and interpretation of immunological and cyto-chemical studies and molecular techniques in thediagnosis and classification of these diseases willbe presented.

Orlando, FL New Orleans, LA

Reserve early. Space is limited! CME Information/Registration: Ms. Jessica Misner (212)746-6464 • [email protected]

cme2015-2016

New York, NY

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