WELCOME TO

PERIPHERALNERVOUS SYSTEM

FUNCTIONAL ORGANIZATION OF THE PNS

Nervous structures outside the brain and spinal cord- sensory and motor connections to the outside world - nerves thread throughout the body to allow the CNS to receive information and take action

Functional components of the PNS- sensory inputs and motor outputs- categorized as somatic or visceral- also classified as general or special

FUNCTIONAL COMPONENTS OF THE PNS Basic structural components:1. Sensory receptors – pick up stimuli from inside

and outside the body, then initiate impulses in sensory axons

2. Motor endings – the axon terminals of motor neurons that innervate the effectors

3. Nerves – bundles of peripheral axons and Ganglia - clusters of peripheral neuronal cell bodies- most are mixed nerves, contain both sensory and motor axons - some cranial nerves are purely sensory or purely motor in function

3 MAIN TYPES OF NERVE CELLS

sensory neurone

relay neurone/interneuron

motor neurone

SENSORY NEURONS

Carries impulses from receptors e.g pain receptors in skin to the CNS( brain or spinal cord)

RELAY NEURON/ INTERNEURONS

Carries impulses from sensory nerves to motor nerves.

MOTOR NEURON

Carries impulses from CNS to effector e.g. muscle to bring about movement or gland to bring about secretion of hormone e.g ADH

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SPINAL NERVESDorsal roots – sensory fibers arising from cell bodies in dorsal root gangliaVentral roots – motor fibers arising from anterior gray column of spinal cord

AUTONOMIC NERVOUS SYSTEM

AUTONOMIC NERVOUS SYSTEM

The autonomic nervous system is the subdivision of the peripheral nervous system that regulates body activities that are generally not under conscious control

General visceral motor part of the PNS Has 2 divisions (with opposite effects):

- Parasympathetic: ‘housekeeping’ activities (rest and digest)- Sympathetic: extreme situations (fight or flight)

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ANS is the subdivision of the peripheral nervous system that regulates body activities that are generally not under conscious control

Visceral motor innervates non-skeletal (non-somatic) muscles

Composed of a special group of neurons serving: Cardiac muscle (the heart)Smooth muscle (walls of viscera and blood vessels) Internal organsSkin

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Basic anatomical difference between the motor pathways of the voluntary somatic nervous system (to skeletal muscles) and those of the autonomic nervous system

Somatic division:Cell bodies of motor neurons reside in CNS (brain

or spinal cord)Their axons (sheathed in spinal nerves) extend all

the way to their skeletal muscles Autonomic system: chains of two motor

neurons1st = preganglionic neuron (in brain or cord)2nd = gangionic neuron (cell body in ganglion

outside CNS)Slower because lightly or unmyelinated

(see next diagram)

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Axon of 1st (preganglionic) neuron leaves CNS to synapse with the 2nd (ganglionic) neuron

Axon of 2nd (ganglionic) neuron extends to the organ it serves

Diagram contrasts somatic (lower) and autonomic:

autonomic

somatic

Note: the autonomic ganglion is motor

this dorsal root ganglion is sensory

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DIVISIONS OF THE AUTONOMIC NERVOUS SYSTEM (VISCERAL MOTOR PART OF IT)

Parasympathetic division Sympathetic division

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DIVISIONS OF THE AUTONOMIC NERVOUS SYSTEM

Parasympathetic division Sympathetic division

Serve most of the same organs but cause opposing or antagonistic effects

Parasysmpathetic: routine maintenance“rest &digest”

Sympathetic: mobilization & increased metabolism “fight, flight or fright” or “fight, flight

or freeze”

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WHERE THEY COME FROM

Parasympathetic/Craniosacral:Cervical (neck area)Caudal(tailbone)Brain(cranial nerves)

Sympathetic/thoracolumbar:Thoracicand LumbarVertebrae

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PARASYMPATHETIC NERVOUS SYSTEM“REST & DIGEST”

Also called the craniosacral system because all its preganglionic neurons are in the brain stem or sacral levels of the spinal cord Cranial nerves III,VII, IX and X In lateral horn of gray matter from S2-S4

Only innervate internal organs (not skin) Acetylcholine is neurotransmitter at end organ

as well as at preganglionic synapse: “cholinergic”

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PARASYMPATHETIC CONTINUED Cranial outflow

III - pupils constrictVII - tears, nasal mucus, saliva IX – parotid salivary glandX (Vagus n) – visceral organs of thorax & abdomen:

Stimulates digestive glands Increases motility of smooth muscle of digestive tract Decreases heart rate Causes bronchial constriction

Sacral outflow (S2-4): form pelvic splanchnic nervesSupply 2nd half of large intestineSupply all the pelvic (genitourinary) organs

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PARASYMPATHETIC

(only look at this if it helps you)

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SYMPATHETIC NERVOUS SYSTEM“FIGHT, FLIGHT OR FRIGHT”

Also called thoracolumbar system: all its neurons are in lateral horn of gray matter from T1-L2

Lead to every part of the body (unlike parasymp.) Easy to remember that when nervous, you sweat;

when afraid, hair stands on end; when excited blood pressure rises (vasoconstriction): these sympathetic only

Also causes: dry mouth, pupils to dilate, increased heart & respiratory rates to increase O2 to skeletal muscles, and liver to release glucose

Norepinephrine (aka noradrenaline) is neurotransmitter released by most postganglionic fibers (acetylcholine in preganglionic): “adrenergic”

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SYMPATHETIC NERVOUS SYSTEM CONTINUED Regardless of target, all

begin same Preganglionic axons exit

spinal cord through ventral root and enter spinal nerve

Exit spinal nerve via communicating ramus

Enter sympathetic trunk/chain where postganglionic neurons are

Has three options…

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OPTIONS OF PREGANGLIONIC AXONS IN SYMPATHETIC TRUNK

1. Synapse on postganglionic neuron in chain ganglion then return to spinal nerve and follow its branch to the skin

2. Ascend or descend within sympathetic trunk, synapse with a posganglionic neuron within a chain ganglion, and return to spinal nerve at that level and follow branches to skin

3. Enter sympathetic chain, pass through without synapsing, form a splanchnic nerve that passes toward thoracic or abdominal organs

These synapse in prevertebral ganglion in front of aorta

Postganglionic axons follow arteries to organs

(see next slides for drawing examples)

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SYNAPSE IN CHAIN GANGLIA AT SAME LEVEL OR DIFFERENT LEVEL

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PASS THROUGH GANGLIA AND SYNAPSE IN PREVERTEBRAL GANGLION

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SYMPATHETIC

SENSORY RECEPTORS OF THE PNS

SENSORY RECEPTORS OF THE PNS Also classified according to:

a) Location – based on body location or location of stimuli to which they respondb) Type of stimulus detected – kinds of stimuli that most readily activate themc) Structure – divided into 2 broad categories free or encapsulated nerve endings

CLASSIFICATION BY LOCATION

Exteroceptors – sensitive to stimuli arising from outside the body- located at or near body surfaces- include receptors for touch, pressure, pain, temperature, and most receptors of the special sense organs

Interoceptors (visceroceptors) – receive stimuli from internal viscera (digestive tube, bladder, lungs)- monitor a variety of stimuli such as changes in chemical concentration, taste stimuli, stretching of tissues, and temperature- activation causes visceral pain, nausea, hunger, or satiety

CLASSIFICATION BY LOCATION Proprioceptors – monitors degree of stretch

and sends input on body movements to the CNS- located in musculoskeletal organs such as skeletal muscles, tendons, joints, and ligaments

CLASSIFICATION BY STIMULUS DETECTED Mechanoreceptors – respond to mechanical forces

- such as touch, pressure, stretch, vibrations, and itch Thermoreceptors – respond to temperature

changes Chemoreceptors – respond to chemicals in

solution (molecules tasted or smelled) and to change in blood chemistry

Photoreceptors in the eye – respond to light Nociceptors – respond to harmful stimuli that

result in pain (noci = harm)

CLASSIFICATION BY STRUCTURE General sensory receptors – widely

distributed Nerve endings of sensory neurons moniter:

- Touch- Pressure- Vibration- Stretch- Pain- Temperture- Proprioception

CLASSIFICATION BY STRUCTURE

General sensory receptors are divided into 2 groups- Free nerve endings- Encapsulated nerve endings

Note: there is no perfect ‘one receptor – one function’- one receptor can respond to several kinds of stimuli and different receptor types can respond to similar stimuli

FREE NERVE ENDINGS Abundant in epithelia and underlying CT Respond to pain and temperature Monitor affective senses – those to which

people have an emotional response (pain) 2 specialized types of free nerve endings:

- Merkel discs: lie in the epidermis- Hair follicle receptors: wrap around hair follicles

FREE NERVE ENDINGS Merkel discs – a disc-shaped epithelial cell

innervated by a sensory nerve ending - slowly adapting receptors for light touch (respond and send out action potentials even after continual stimulation)

Hair follicle receptors – receptors for light touch- monitor the bending of hairs- rapidly adapting (sensation disappears quickly even if the stimulus is maintained)

Itch receptor – in the dermis (newly discovered)