What will the longevity company Calico research? A once annual pill that gives a third longer lifespan; Link deprenyl to aptamers that highly concentrate longevity pharmaceuticals at the particular neural tissues linked to the longevity effect. Longevity that causes beauty; Which among a plural combinatoric library of the beauty peptides also improve human tissue culture hayflick duration, along with longevity these coproduce surface tissue youthification. A single gene therapy dose that doubles mammal longevity; A spermidine probiotic LKM512 is published as near doubling lab mammal longevity. Gene therapy to produce spermidine endogenously is a one dose longevity drug. I urge people to put up public domain technologies like these or much better
Transcript
What will the longevity company Calico research?
A once annual pill that gives a third longer lifespan; Link deprenylto aptamers that highly concentrate longevity pharmaceuticals at
the particular neural tissues linked to the longevity effect.
Longevity that causes beauty; Which among a plural combinatoriclibrary of the beauty peptides also improve human tissue culture hayflick duration, along with longevity these coproduce surface
tissue youthification.
A single gene therapy dose that doubles mammal longevity; A spermidine probiotic LKM512 is published as near doubling lab
mammal longevity. Gene therapy to produce spermidineendogenously is a one dose longevity drug.
I urge people to put up public domain technologies like these or much better
Download these public domain longevity technologies now.
As the originator of all of these ideas I place them at the public domain. I may have asked another person or group to place this at their youtube site. I may be reached at
[email protected] or leave a youtube comment. Music is the creative commons version of Pachelbel's
canon D, from Lincoln Center. http://freemusicarchive.org/search/?sort=track_date_published&d=1&quicksearch=pachelbel Images from wikipedia.
A tremendously lucrative approach to computationally rich genetics is to look at the genetics of actual humans who have the highest measured wellness from successful repairs, then compare the genes of all those who have angioplasty recovery above the 99th pctile or those who have natural incision healing above the 999th pctile to modal responders. Then use computational genetics to find the constellation of genes that
cause (or strongly contribute) to superb outcomes. Then create siRNA drugs that temporarily move the functional phenotype of those having voluntary medical
procedures towards the superrecovery genetic activity form.
Those groups of siRNA that duplicate the phenotypic effect of super successful outcomers are quantitatively demonstrated to improve the outcomes of medical
procedures. Because this approach could work on the 100 most frequent medical procedures or more, Calico has an any procedure, we have a drug that makes it occur more successfully universal product. Possibly linking almost every procedure to a new kind of drug. A twentieth of trillion us$ is $10 billion. So if a successtropic procedure
drug doubles effectiveness or halves risk, yet is a 20th of the expense of the entire procedure then the company’s “drug suite” is a 10 or 20 billion annual revenue value.
Calico creating siRNA drugs that cause other people to function as if they had superhealer genes improves all medical outcomes at a variety of procedures. Create siRNA that modulate the genetic expression of other patients to function similarly to
the super repairable persons. The high fiscal value of making every medical procedure genetically upgradeable to greater success with a new group of drugs is notable.
Many of the public domain audiofiles at the download link contain content or approaches that may be slightly novel; the ethinyl group on
ethinyl estradiol causes a 10,000 times greater chemical potency. What then is the effect of ethinylizing mercaptoethanol, a simple drug that increases mammal lifespan 40 to 100 pct. Or, noting the
spermidine longevity effect, what is the effect of different length polyamines?
Similarly, castration is published as creating double digit longevity increases. Notably which is the testosterone removal that increases longevity? Testosterone has a variety of steroid preforms as well as metabolites. Immunizing against specific preforms or metabolites,
like dihydrotestosterone, could give castration like longevity increase without castration, absent any effect on sexual function or fertility.
Another approach would be to look at mRNA differences between castrated and noncastrated mammals, then create an siRNA drug that reproduces that effect then possibly linking that siRNA to aptamers to
concentrate the siRNA at particular tissues much like an ADC (antibody drug conjugate)
Again, continuing the theme that some of the longevity technology audio recordings may be slightly novel; reapplying known drugs with modified more effective forms is a rapid path to profitability. Along with completely new drugs there are also amplified higher effectiveness
versions of effective longevity drugs.
Metformin as well as deprnyl are published as creating greater longevity. Headless chickens are published as continuing to live. Some longevity drugs like deprenyl are linked to CNS effects. What
are the varied effects of different longevity drugs on headless chickens as compared with fully corticated chickens?
A milder approach to this research would be to create drug versions with a high AMU polyglycinelinked to the longevity chemical like metformin or spermidine to keep it on the body side of the blood brain barrier, which frequently excludes molecules over 400 AMU. This is way to find CNS
or body only chemical longevizing effects, which may represent new mechanisms of longevity. It is possible that strongly CNS or strongly body longevizing drug versions have different extraneous
effects, thus this could also be a way to minimize side effects at a new production pharmaceutical.
Calico is likely aware of its paths to highest profitability. It is certainly possible that combining known FDA approved longevizing drugs like deprenyl with metformin with mercaptoethanol, when tested as a combined group on lab mammals could create a very rapid basically preapproved drug,
that is a rapid new revenue source with peer reviewed high efficacy at several species simultaneously.
It is possible that particular atom configurations of deuterated metformin, derenyl, mercaptoethanol are actually patent unique, yet have mild dose duration increase benefits; while
retaining FDA recognition. Creating an instant patent on a new old effective drug.
You may also like visiting the public domain technology directory at mega.co.nz which also describes pharmacologically novel
nootropics as well as longevity pharmaceuticals. Many hundreds of new technologies are described.
if a file at the directory says Noot, it’s a nootropic
Beavers live 10 times longer than mice, yet the genetics are super similar >99/100. What are these longevity genes, will siRNA to particular mRNA have ultralongevizingeffects on mice; are there homologous differences at primates, creating a human
longevity protein drug. There could be conceptual similarities here to the published Human Accelerated Region HAR longevity genes.
There are peer reviewed publications suggesting multicentury lifespan of cetaceans, noting there are also some cetaceans with a tenth that lifespan, these multicenturylifespans could be genetically compared with the 1/10 lifespan of other cetaceans to find further areas of genetic longevity, notably at organisms that have multicentury
longevity. From a human perspective, that multicentury mammals are guiding longevity research may be particularly pleasant.
There are numerous approaches to longevity pharmaceutical profitability. Continually renewed voluntary activities are profitable. Numerous studies (PMID:2479433)
describe enterosorbants as longevizing at double digits. Creating a newer version of activated charcoal that is coated with titanium dioxide as well as delicious flavorings
gives a snack food that causes greater longevity with aesthetically neutral feces. Possibly as a horizontal integration approach Ralston Purina would value this as a large volume nonhuman product with tens of millions of repeat clients, generating billions
of revenue. Although there are numerous studies, the published 43% longevity increase at lab mammals has to be replicated to assure effect.
Other technologies are just different. The beneficial effects of the omega 3 lipid DHA are sometimes described as linked to greater membrane fluidity. A new drug then would be a drug that reduces cytoplasm viscosity, possibly an eentsier than usual length phospholipid or even mRNA drug that
affects the water to goop ratio. The physical chemistry of highly fluid cytoplasm may be a longevity drug, or possibly a cytofunction amplifier from the improved physical chemistry reaction rate
dynamics.
Slightly aware of the entrepreneurial ecosystem of preferences, as well as the meaningful comparison between engineering with research, there are numerous near effortless longevity drugs
producible. Probiotics bred, or engineered to produce the glycemic response reducing carbohydrate ribose would cause a reduction of glycemic response to food, strongly reducing
cardiovascular illness, cancer, as well as diabetes.
Notably though this is different than researching basic causes. It is however a commercially rapid drink or pill that prevents much disease. Perhaps simply linking the actual DHA molecule to ribose at
that part of the ribose molecule which preserves the glycemic reduction response from ribose is a new longevity drug that also supports cognition as a nootropic.
Also there is the obvious. ILGF1 genes, when nonfuctional are published as precluding all cancer as well as all heart disease. Creating an siRNA drug that causes the same effect as a nasal spray or
probiotic administered to those that have passed puberty represents a comprehensive lifesaving longevity drug.
Visit to download these public domain longevity technologies, as well as fresher better ideas now.
Epitalon, the tetrapeptide AEDG, is published as giving longevity (PMID: 11227856), thus having probiotics that produce this peptide is a longevity drug. From another
perspective however, customized enzymes that cause the AEDG peptide fragment to be produced from existing foods could be a new approach to this longevity drug. As
an enzyme, applied to food then removed, this approach could rapidify product profitability as it is absent most regulation. Numerous products permit brewing with
engineered organisms if the product is naturally sourced.
While cytology has progressed far beyond the hayflick effect, it seems possible that the earliest differentiations of zygotes like ectoderm or mesoderm could have
different hayflick effects. Thus finding the genes that effect hayflick durability at the same organism applied to mature tissues could permit more cytoreproductions, giving
greater longevity.
tRNA transport amino acids from which entire proteins are assembled. CR causes greater longevity, while also causing greater protein remodeling. Does a new
pharmaceutical that modifies the transport of amino acids, notably sulfur amino acids affect longevity? That would be new. Thus transfer RNA modulators that upmodulate
or otherwise modulate tRNA could be a new kind of longevity drug.
A little like telomeres, do actin or tubulin change their activity with sequential mitosis? Perhaps like telomeres, the daughter cytes have
identical, or shifting length or concentration of actin or tubulin after mitosis.Actin as well as tubulin partially direct transport channels, as well as the cytolocation of numerous cytostructures as well as morphology, thus any accumulated actin tubulin effect from cytodivision, could like telomere variations, be linked to longevity. Thus the genetics or pharmacology of
preferred tubulin actin may be linked to wellness, tissue youthfulness, as well as longevity.
Melatonin has published beneficial longevity effects. High AMU polyglycinelinked to melatonin would keep the melatonin activity bodyside thus causing
longevity without circadian effects. Melatonin has published molecular variations which cause mice to be many times less likely to die from radiation exposure (pubmed.org PMID: 8169792 PMID: 7773622). Would a polyglycine
heptane melatonin reduce cancer from environmental causes while also longevizing. Noting melatonin has microgram activity topical polyglycine
heptane melatonin could be a nice sunscreen beauty ingredient, the first to prevent cancer at topical areas while also conferring longevity.
