WHY MLS Laser Therapy

PITCHING QUALITY

WHAT DO YOU OFFER WHEN

YOU SEE THESE CASES?

EFFECTIVE

FAST & LONG LASTING RESULTS

NO INVASIVE

WE HAVE THE ANSWER,

MLS® LASER THERAPY.

WHAT IS IT? WHY IS IT EFFECTIVE?

WHICH ARE THE RESULTS?

WHY INCORPORATING IT IN YOUR CLINIC?

What is MLS® Laser Therapy?

MLS® Laser Therapy is an innovative technique, revolutionizing the therapeutic approach

of musculo-skeletal and dermatology problems in Veterinary, and it’s the result of a long

path of scientific research and technological innovation.


2 SPECIFIC WAVELENGTHS:

808 & 905 nm

2 EMISSION MODALITIES:

CONTINUOS & PULSED

COMBINATION AND

SYNCHRONIZATION

SPATIAL OVERLAPPING

TARGET AREA

2 PRODUCT FAMILIES

2 ADDITIONAL

INTERCHANGEABLE HEADS

APPLICATIONS MODALITIES

SPECIFIC PROTOCOLS


2 SPECIFIC WAVELENGTHS

OPTIMAL PENETRATION

MLS® Laser Therapy is based on two laser sources with 2 different wavelengths:

Ab

sorp

tio

n

coef

fici

ent

808 and 905 nm

The chosen wavelengths

represent the most studied

ones and guarantee that

energy is taken to the

deepest possible level


2 EMISSION MODALITIES (CONTINUOS & PULSED)

ADVANTAGES OF BOTH HP & LLLT

The MLS® (Multiwave Locked System) impulse is based on 2 different emissions

granting different biological effects:

A pulsed emission (905 nm) with the same power as Low Level Laser Therapy

A continuous/chopped emission (808nm) with the typical characteristics of High Power.

808nm FW

905nm PW

f=1-2000Hz

808nm CW

905nm PW f=2000Hz


COMBINATION & SYNCRONIZATION

SINERGY OF THERAPEUTIC EFFECTS

The combination and synchronization in one single pulse of specific continuous and pulsed

emissions, produces the synergy and strengthening of the single effects:

analgesic, anti-inflammatory, anti-edema.

SPATIAL OVERLAPPING

HOMOGENEOUS ENERGY DISTRIBUTION

Two laser sources form a spatial overlap over most of the length, distributing the energy on

the treatment area in homogeneous way.


TARGET AREA

INTRO-ARTICULAR + MUSCLE STIMULATION

The emitted energy is directed through an optical group over a large Target Area, so a

large volume below the skin with two different applicators:

Handpiece (3cm2)

optical windows & trigger points

Multidiode applicator (20 cm2)

Big areas & muscular stimulations


2 DIFFERENT PRODUCT FAMILIES


2 INTERCHANGEABLE HEADS

INTRAORAL + LASER PUNCTURE (Vet Orange only)


APPLICATIONS MODALITIES

POINT BY POINT & SCANNING

POINT BY POINT

This technique allows to easily treat

small and irregular areas (ex. joints)

SCANNING

This technique may be used over smooth

areas (muscles, paraspinal areas) or on

extensive wounds


SPECIFIC PROTOCOLS

FOR CATS, DOGS, EQUINE & EXOTICS

Mphi Vet is equipped with software with special protocols for cats, dogs, equine and exotic

animals*. The desired species can be selected from the main menu and then the user is

guided to most suitable protocol.

*only Vet Orange


MLS® Laser Therapy born from ASAlaser experience:

historical scientific tradition, leader position in the market.

ASAlaser has more than 30 years history completely focus on laser therapy, driving this

market from the beginning.


After a long experience in manufacturing different type of lasers for Surgery and Physical Therapy, e.g..:

• Low Level Laser (LLLT, class 3B): Diode

• High Power Laser (HP, Class 4):

- CO2 25W,

- Semiconductor Diode 6W,

- Argon 10 W

ASA, looking to the future, has begun a new line of research, that has led to the identification of a new patented pulse, giving rise to the new therapy


MLS® Laser Therapy, the same technology used in human field, is the last result of our long

scientific tradition.

FROM HUMAN

MEDICINE..

…TO VETERINARY

MEDICINE


MLS® Laser Therapy is not just the result of a simple assembling of different laser

sources, but the real therapeutic solution coming from a long scientific pathway, moving

from POWER to DISCIPLINE.

WHAT IS IT?WHY IS IT

EFFECTIVE?



SCIENTIFIC EVIDENCES… BEYOND THE ATP

Why is it effective?

The MLS® impulse modulates cellular metabolism and improves the supply of energy

The increase of PP1 (Protein phosphatase 1) created by the therapeutic process,

regulates the muscle relaxation / contraction process

It stimulates also the accumulation of glycogen supplies (energy source needed for

muscular activity)


The thermal effects of MLS® Laser Therapy generate indirect photomechanical effects

They mechanically stress the cells. This kind of stress favors tropism, homeostasis and

cell differentiation

It favors the recovery of damaged tissue

The MLS® impulse produces measured thermal effects and always remains under the

danger threshold

It stimulates biochemical reactions and vasodilatation

It increases the ratio of oxygen and nutrients in the treated area

Moderate vasodilatation favors inflammatory process recovery and oedema reabsorption



Proteomic studies conducted on muscle cells (myoblasts) have shown that MLS®

treatment induces an increase of anti-inflammatory protein NLRP 10

NLPR 10 inhibits the production of pro-inflammatory interleukins IL-1β and IL-18,

reducing inflammation

The decrease of inflammation leads to a normalization of vascular function and thus a

decrease of edema

The reduction of inflammatory mediators and edema implies a reduction of pain

symptoms



The MLS® impulse grants proved analgesic effect

0

2

4

6

8

Rat 1 Rat 2 Rat 3 Rat 4PA

W P

RES

SUR

E (G

)

Effect of MLS treatment on hyperalgesia induced by CCI

CONTRA

IPSI

IPSI + I MLS appl




WHY INCORPORATING

IT IN YOUR CLINIC?

Why incorporating it in your clinic?

MLS® Laser Therapy is indicated for the treatment of several conditions in small animals

(pets and exotic), and equine related to locomotor apparatus and dermatology.

JOINTS:

trauma, DJD, osteoarthritis

MUSCLES:

sprain, strain, trigger points and stress

point therapy, injuries, muscle

contractures

TENDONS & LIGAMENTS: tendonitis,

desmitis, partial ruptures

all_videos/caso3_simba.mp4

all_videos/caso3_simba.mp4

all_videos/caso5_Jeff.mp4

all_videos/caso5_Jeff.mp4


IVDD and spinal pathologies

BONE HEALING

post surgery or post fracture

PAIN MANAGEMENT

post surgery

PAIN

acute or chronic


OEDEMA

SKIN WOUNDS


LICK GRANULOMAS

BURNS

HOT SPOTS

ANAL GLANDS IMPACTION


DERMATITIS,

PYODERMITIS

STOMATITIS


ADVANTAGES FOR VETERINARY

New therapeutic treatment for pain management, inflammation, pathologies of

osteo-muscular apparatus and skin diseases

No invasive, no side effects

Combination between therapy and diagnostic as alternative / combined solution

of pharmacology treatment

Scientific innovation that increases the value of the clinical center and the number

of patients, and therefore, the economic return



Loyalty of customers and greater prestige/professionalism for the hospital/clinic

Deliver best patient outcomes:

precision in diagnosis and treatment removes the guesswork

Economical Return:

considering that MLS® Laser Therapy will become a routine practice before or after

the received service, and the growing number of patients thanks to the new

offered treatments



Standard of care:

Incorporating MLS® Laser Therapy is a “must have” technology in a VET practice. It

will be the “standard of treatment”

Lead the way:

start to use state of the art technology that puts you at the forefront of your

profession

As number of users grows:

in all the markets, it becomes not an optional offer used only by elite practices, but an

indispensable treatment tool

Competitive landscape:

as soon as you will start offering the MLS®, your competitors will be under pressure to

keep pace and get the technology as well


ADVANTAGES FOR PATIENTS AND OWNERS

Faster return to normal conditions and therefore to life with the owner or agonistic

activity

Improved quality of life for animals and their owners

Reduction or exclusion drug use (vs pharmacologic treatments)

Not trying to doping

http://www.asaveterinary.com/en/roi-calculator





Elephant Sanctuary - Tennessee

Which are the results?

MLS® EFFECTIVE IN DEPTH


MLS® EFFECTIVE IN DEPTH

Kansas City Zoo


MLS® EFFECTIVE IN DIFFICULT CONDITIONS

Gulf World Marina Park - Florida


CLINICAL CASES SELECTION

Jacinto, White Swiss Shepherd Dog with left elbow fractureCourtesy of Dr. Ángela Romano - "Laser Pets" - Bogotá, Colombia

Species: dog

Breed: White Swiss Shepherd Dog

Gender: male

Age: 1 YO

Name: Jacinto

Clinical case:

Jacinto had a Salter-Harris fracture to the left elbow. He had orthopaedic surgery and a screw was used to reduce the

fracture.

The fracture did not heal and Jacinto had lameness, edema and muscular hypotrophy.

X-ray shows arthrosis and sclerosis of the radius proximal line of growth.

A multivitamin, mineral and joint supplement has been recommended.

Therapy:

As two months later the fracture did not heal, Jacinto began MLS® Laser Therapy sessions.

The whole left forelimb was treated, especially the elbow joint.

For the first two sessions has been used the Edema program.

Later were used Pain (chronic) and Inflammation (chronic) programs twice a week.

Jacinto had 8 more applications two times a week, alternating Inflammation (acute), 18 Hz and, Sprain/Strain, 1168 Hz,

programs in each session.

https://youtu.be/SdgZxtw2TVA

https://youtu.be/SdgZxtw2TVA



Zeppelin, Jack Russell Terrier with bite injuries

Courtesy of Anita Jansen, Physiotherapist for dogs - “Hund i Form” - Sola (Rogaland), Norway

Species: Dog

Breed: Jack Russel Terrier

Gender: Male

Age: 7 YO

Name: Zeppelin

Clinical case:

During a walk, Zeppelin was attacked by a big size dog and was bitten in the neck, abdomen and left hind leg. He had

three injuries to the abdomen, one was very close to the urethra, and two in the neck and lumbar area. Zeppelin had

surgery in the night to suture abdominal wounds. He was sutured in the neck and lower back region, too.

Two days after the attack, began to appear the first bruises on Zeppelin’s abdomen. Because of the very strong

inflammation and infection, the value of the CRP exceeded 250 (normally is less than 35).

Therapy:

In addition to surgery, Zeppelin received immediately after the attack antibiotics and anti-inflammatory drugs.

Two days after surgery he had the first sessions MLS® Laser Therapy. The protocols adopted were “infected wound" and

then "wound."

Zeppelin had 4 sessions of MLS® Laser Therapy: the first two every three days, the others once a week until complete

healing, which occurred 3 weeks after surgery.

36 hours after the first treatment, bruises begin to decrease and the fever disappears

After the second session of MLS® Laser Therapy: the wounds are completely closed.

3 weeks after surgery, bruises have disappeared, and he is beginning again to extend the hind legs when resting.

Zeppelin participated in Rally-Obedience competition 6 weeks after the attack, and won Class 3!

https://youtu.be/xNIqPIJDukM

https://youtu.be/xNIqPIJDukM



Polyarthritis in a Highland fold

Courtesy of Dr. Roberta Burdisso, Physiotherapy Service Director at CHV Fregis - Paris, France

Species: Cat

Breed: Highland fold

Gender: Male

Age: 4 YO

Clinical case:

Highland fold is a feline breed with genetic predisposition to develop osteochondrodysplasia. Harold was visited for gait

problems. He was feeling severe pain in multiple joints (carpus, tarsus, knee) and in the cervicothoracic spine tract too.

Therapy:

The first three weeks Harold had 6 sessions of MLS® Laser Therapy: three sessions on the first week, two sessions on the

second and the last one on the third week. The maintenance program is going to be continued with two treatments per

month. The programs used were "back pain" for the column and "chronic arthritis" for the joints.

Today Harold walks normally and has 2 sessions per month as a maintenance program.



Skin lesion on a fancy hairless rat

Courtesy of Dr. Giordano Nardini, Clinica Veterinaria Modena Sud - Modena, Italy

Species: fancy hairless rat

Gender: Male

Age: 1 ½ YO

Name: Jerry

Clinical case:

This fancy hairless rat has been presented at first visit showing a crusty and ulcerated skin lesion on the neck. The lesion

was one week old, progressively worsening.

Therapy:

Antibiotic therapy has been administered (Baytril) and an MLS® Laser Therapy treatment cycle started. MLS® Laser

Therapy has been applied every other day using the pre-set program “Infected wound” for 4 sessions, then switching to

the pre-set program “Wound” starting from the 5th session, for a total number of 10 applications. Mphi Vet device has been

applied using the “point to point” modality and the lesion has been treated applying the handpiece on two points, for a total

treatment time of 12 seconds per session.

Along treatment the lesion quickly and progressively improved, and was looking almost completely healed at the end of the

cycle.

https://youtu.be/vtKSzASQgc4

https://youtu.be/vtKSzASQgc4



Tendon tear in a saddle horse

Courtesy of Dr. Tatjana Falconi, DVM hippiatrics - Brescia, Italy

Species: Horse

Breed: Sella italiano

Gender: Gelding

Name: Vaucluse

Clinical case:

A month and a half before the first visit, Vaucluse suffered a severe tear of carpal retinaculum of its left front limb. At the

first visit, 6 weeks after the injury happened, the horse showed lameness (4/5), with oedema and pain at the metacarpal

region.

Therapy:

MLS® Laser Therapy applied 3 times/week for 3 consecutive weeks.

The first application of MLS® Laser Therapy brought an obvious reduction of the oedema.

TESTIMONIALS

https://www.facebook.com/wyominganimalhospital

Which are the results?TESTIMONIALS

https://www.facebook.com/wyominganimalhospital


https://www.facebook.com/pages/Cranbrook-Veterinary-Centre/116156501924101

https://www.facebook.com/pages/Cranbrook-Veterinary-Centre/116156501924101


https://www.facebook.com/TVARF?fref=nf

https://www.facebook.com/TVARF?fref=nf


https://www.facebook.com/dittdyrshelseas

https://www.facebook.com/dittdyrshelseas


https://www.youtube.com/user/DrJyl/videos https://www.facebook.com/pages

/VARK/315934611068

https://www.youtube.com/user/DrJyl/videos

https://www.facebook.com/pages/VARK/315934611068


https://www.facebook.com/PolsloeVeterinaryClinic

https://www.facebook.com/PolsloeVeterinaryClinic


https://www.facebook.com/StonebridgeAnimalHospital

https://www.facebook.com/StonebridgeAnimalHospital


https://www.facebook.com/wyalusingpetclinic

https://www.facebook.com/wyalusingpetclinic


https://www.facebook.com/stbernards

https://www.facebook.com/stbernards


https://www.facebook.com/WOVH.NC

https://www.facebook.com/WOVH.NC


https://www.facebook.com/munfordanimal

https://www.facebook.com/munfordanimal

HOW WE CAN HELP YOU

ON LINE - Platform

ON SITE

Training

Internet Website www.asaveterinary.com

Newsletters

Marketing ToolsWEB

http://www.asaveterinary.com/

Interviews & Clinical cases

Marketing ToolsWEB

30 tutorials that show MLS® correct

functioning concerning single body

regions;

a selection of documented medical

cases;

special contents dedicated to single

illnesses pertaining to different animal

species.

Marketing ToolsASAVETERINARY APP (TABLET)

Poster Roll up

Marketing Tools

Flyer Pets

Marketing Tools

The results of the work of medics and specialists who collaborate with ASA, that illustrate

the actions principles of MLS® Laser Therapy and the scientific evidence that brought to

their clinical validation.

Scientific publicationENERGY FOR HEALTH

IACOPETTI I, PERAZZI A, MANIERO V, MARTINELLO T, PATRUNO M, GLAZAR M, BUSETTO R. (2015)

Effect of MLS® Laser Therapy with Different Dose Regimes for the Treatment of Experimentally Induced Tendinopathy in

Sheep: Pilot Study

Photomedicine and Laser Surgery; 33(3): 154-163. doi:10.1089/pho.2014.3775.

BENNETT C A, OLMOS S R (2014)

Treatment of Chronic Craniofacial Pain with Mphi Laser and Orthotic

ENERGY FOR HEALTH; 13:4-8

VILIANI T (2014)

Laserpuncture with MLS® (Multiwave Locked System) system Mphi: safety and clinical efficacy in joint disease, preliminary

data.


ROSSI F, PINI R, ROMANO G, CIALDAI F, FUSI F, MONICI M (2014)

A predictive analysis of thermal effects in pigmented skin and underlying tissues during IR laser therapy


PASTERNAK K, NOWACKA O, WRÓBEL D, PIESZYŃSKI I, BRYSZEWSKA M, KUJAWA J (2014)

Influence of MLS laser radiation on erythrocyte membrane fluidity and secondary structure of human serum albumin

Mol Cell Biochem; 388:261–267

KURYLISZYN-MOSKAL A, KITA J, DAKOWICZ A, CHWIEŚKO-MINAROWSKA S, MOSKAL D, KOSZTYŁA-HOJNA B,

JABŁOŃSKA E, KLIMIUK PA (2014)

The influence of Multiwave Locked System (MLS) laser therapy on clinical features, microcirculatory abnormalities and

selected modulators of angiogenesis in patients with Raynaud’s phenomenon.

Clin Rheumatol; DOI 10.1007/s10067-014-2637-8

MLS® Laser Therapy - Bibliography

MOMANU A (2013)

Comparison of analgesic and anti-inflammatory effects of the classical low level laser therapy and multiwave locked

system in inflammations of serous bursae.

Sports Medicine Journal / Medicina Sportiva; 9 (4):2234-2240

MONICI M, CIALDAI F, RANALDI F, PAOLI P, BOSCARO F, MONETI G. CASELLI A (2013)

Effect of IR laser on myoblasts: a proteomic study.

Molecular Biosystems; 9 (6):1147-61

GALANTI G, STEFANI L, IACCHI A, LONERO L, MORETTI A (2013)

The effect of MLS laser therapy in élite football players affected by muscles injuries: a controlled clinical trial.


PASTERNAK K, WRÓBEL D, GWORYS K, KUJAWA J (2012)

Wpływ promieniowania laserowego mls na aktywności atpazowe błon erytrocytów ludzkich (Effect of MLS laser radiation

on the atpase activity of human erythrocyte membranes)

Kwart. Ortop. 1, str. 74, ISSN 2083- 8697

KĘDZIERSKI T, STAŃCZAK K, GWORYS K, GASZTYCH J, SIBIŃSKI M, KUJAWA J (2012)

Comparative Evaluation of the Direct Analgesic Efficacy of Selected Physiotherapeutic Methods in Subjects with Knee

Osteoarthritis. Preliminary Report

Ortop Traumatol Rehabil.;14 (6):537-44

GWORYS K, GASZTYCH J, PUZDER A, GWORYS P, KUJAWA J (2012)

Influence of Various Laser Therapy Methods on Knee Joint Pain and Function in Patients with Knee Osteoarthritis

Ortop Traumatol Rehabil.;14 (3): 269-77.


RIOJA TORO J, ESTÉVEZ POY PJ, MARTÍNEZ PARDO F (2012)

Estudio prospectivo, aleatorizado y controlado con placebo, para valorar la eficacia del tratamiento con láser, asociado o

no aortesis de muneca en el síndrome del túnel del carpo idiopático. (A prospective, randomized and placebo controlled

study of the efficacy of treatment with laser, with or without splinting of wrist in idiopathic carpal tunnel syndrome)

Rehabilitación (Madr); 46(2):92--102

MONICI M, CIALDAI F, ROMANO G, CORSETTO PA, RIZZO AM, CASELLI A, RANALDI F (2012)

Effect of IR Laser on Myoblasts: Prospects of Application for Counteracting Microgravity-Induced Muscle Atrophy.

MICROGRAVITY SCIENCE AND TECHNOLOGY; 25(1):35-42

RADER A (2012)

The affect of MLS therapy on nerve conduction parameters in developing diabetic sensory peripheral neuropathy.


NUNEZ G, BERTOLINI D, PISCOPO C (2012)

The MLS® therapy in postural myofascial pain and postraumatical of the neck.


GALANTI G, MORETTI A, LO NERO L (2012)

Application of MLS® laser on muscular contracture caused by functional overload in a young athlete - case report.


CARUSO G, GERVASI S, SALVADORI D (2012)

Physical treatment of post traumatic gonalgia by NIR laser therapy: a case report.



RAYEGANI SM, BAHRAMI MH, SAMADI B, SEDIGHPOUR L, MOKHTARIRAD MR, ELIASPOOR D (2011)

Comparison of the effects of low energy laser and ultrasound in treatment of shoulder myofascial pain syndrome: a

randomized single blinded clinical trial.

EUR J PHYS REHABIL MED; 47:391-90

CSAPO A (2011)

Efficiency of MLS® therapy in abarticular rheumatism revealed by digital thermography and visual analog scale.


KHAMSEH M E, KAZEMIKHO N, AGHILI R, FOROUGH B, LAJEVARDI M, DABAGHIAN F H, GOUSHEGIR A, MALEK M (2011)

Diabetic distal symmetric polyneuropathy: Effect of low-intensity laser therapy .

LASERS IN MEDICAL SCIENCE; 26 (6): 831-835

DRAGONE L, PALLADINI S, GLAZAR M (2011)

MLS® laser Therapy in dogs with pressure ulcers and open wound: case reports.


VIGNALI L, CIALDAI F, MONICI M (2011)

Effects of MLS® laser on myoblast cell line C2C12.


SMIDERLE C, SCAPIN M (2007)

MLS® therapy treatment of acute shoulder pain in inflammatory processes of the rotator cuff.


CORTI L, ROSA E, NORBIATO V, PEDRINI L (2007)

Clinical results in the treatment of ankle and knee distortion pathologies with MLS® therapy.



MOGNATO M, SQUIZZATO F, FACCHIN F, ZAGHETTO L, CORTI L (2004)

Cell growth modulation of human cells irradiated in vitro with low-level laser therapy.

PHOTOMEDICINE AND LASER SURGERY; 4(6): 523-526

CORTI L (2004)

MLS® laser therapy treatment of shoulder pain: a controlled comparative study.

SCIENTIFIC REPORT MLS

TASCA A (2004)

MLS® therapy treatment of various osteo/muscolar/tendinous pathologies.


VENTURIN A, ORTOLANI M (2004)

Treating chronic lumbago with MLS therapy. A controlled trial.


CORTI L, MACCARI M, ROSA E (2004)

Laser Treatment of Cervical Distortion.


GIGO BENATO D, GEUNA S, DE CASTRO RODRIGUES A, TOS P, FORNARO M, BOUX E, BATTISTON B, GIACOBINI-

ROBECCHI MG (2004)

Low-power laser biostimulation enhances nerve repair after end-to-side neurorrhaphy: a double-blind randomized

study in the rat median nerve model.

LASERS IN MEDICAL SCIENCE; 19: 57-65.


Many thanks for your time and interest…

…your considerations and comments will be very welcome: [email protected]

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WHY MLS Laser Therapy

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