Working across sectorsBuilding collaborative eco-systems

Lars SundstromSARTRE

Must be needs driven

Clinical Pull (Solves a problem or bottleneck) Commercial Pull (Overcomes a barrier to commercialisation) Basic Science Push (Application of new scientific knowledge)

Thus translation is all about collaborating and sharing knowledge across sectors.

Translation to benefit

ForwardBasic science(Bench)Research

Patients(Bedside)Products/PractiseReverse

Idea

Medical Need and Demand

Adoption

Prototype

Product

UniversityNHS

Community

Clinical practise

Translational Research

Translational Medicine

Industry

The Ecosystem

Many groups need to interact to make it happen- Different cultures- Different drivers

- Different incentives- Different languages

SARTRE - Building regional capacityBuilding critical mass

•2000 registered research active basic and clinical scientists •An active network and forum for discussions•Developing major new strategic regional initiatives•Supporting joint infrastructures•Influencing policy at a local and national level

Funding for translational projects

•MRC devolved funding scheme•~30 projects with ~200 scientists•POC fund (10X gearing)•Infrastructure funding

OI Case study (1) Starting with a solution

• Biosensor to detect Urinary Catheter blockage.

• Develop by biofilm experts in the dental school in Cardiff.

• Developed with a device company MBI Wales.

• Now in Clinical trials at the Bristol Urological Institute and in Cardiff and Vale Hospital.

INCENTIVE = £50K per project Must have a translational end-point

OI Case Study (2) Starting with a Problem

– Aimed at engaging physical sciences.

– To Solve biomedical problems.

– Expanded to include Bath and Exeter Universities.

– Funded by EPSRC devolved portfolio.

• Challenge led & crowd sourced– I got a problem looking for a

solution.– I got a solution looking for a

problem.

50K per institution (can be combined)Must be more than 1 institutionMust be multidisciplinary

Pathways to innovation

Push: I have an idea does anyone want to help me develop it ?

Pull: I have a problem does anyone have a solution ?

Crowd sourcing maximises potential across any network but Works best in an ‘open Innovation’ context.

The Plan

• Develop a set of projects around clinical pull.

• Develop proof of concept • Source follow on funding

• Site Miners• Finding unmet

needs• Scoping projects

NeedsSourcing

• Selecting the best• Refining the ideas• Building teams

Project evaluation • Developing proof of concept

• Follow on funding

Proving the concept

Collaboration in TR

Focused

Multidisciplinary

CompetitiveCollaborative

University research

Open Innovation and collaborative models

Research Institutes

SARTRE Type competence networks

Yesterday Today

Tomorrow

Global cooperation

Concentrated expertise

Distributed expertise

Individual expertise

Global expertise

Closed consortia

Future

Open Innovation paradigmsand Crowd Science

Generate ideas from all partnersCollaborate to find solutionsBuild teamsInnovateGenerate value

Needs some resourceSome managementAbility to develop joint projectsAbility to work across sectorsCollaboration

Challenges for OI in health• Collaboration vs Competition

– Individual vs Collective rewards– Cross institution working, open

innovation platforms

• Working globally– Team based working, crowd

sourcing, communication, project and alliance management

• Value systems– Protecting upside (IP) and

minimising downside (FTO)

• Culture change– Finding the right incentives– Leadership and change advocacy

Increasing R&D costs is leading to more open and collaborative models with industry.

Melese et al. Nature medicine 2009 15;5 502-507Munos et al. Nature Reviews Drug Discovery 2010 9; 203-214

Cooperative modelsOpen innovation models

Major problem- Development Gap is actually increasing

Basic ResearchDiscovery Research

“Valley of Death” -Development Gap ©Obama Administration

Commercial Development

Shift of companyResources

Shift of companyNeeds

‘Translational academic funding’ has increased by 30 % in the past 5 years in the UK. Also major EU Initiatives e.g. IMI

Shift of academicInterest ?

Universities

NHS R&DPartners Private sector partners:

Local(SMEs)International (Pharma/Biotech/Medtech)

Public sector Partners:NISCHR/NIHRRCs /TSB/EU

Value CreationLicense ProductNew Co

PartnershipPool of Ideas Projects

Assessment Application

Consolidation

Proof of Principle

Validation EnergyMomentum

Value

Portfoilo approaches to Joint value creation

Synergy, Critical mass, Scale and Collaboration are byproductsActive project management is essential with multiple actorsFlexible funding mechanisms are essential to catalyse collaborations

Building a new value chain through translational networks

Big Industry• Needs to provide pull• Participate in a shared risk

model• Provide resources and

expertise

SME• Anchor for local

investment• Pool of local

entrepreneurial talent• Shared risk with investors

Govt• Needs to provide

incentives for collaboration

• Funding• Commons and framework

agreements

Academia• Collaborative research• Milestone driven projects• Knowledge• Training• IP must not be a barrier• Sensible cost models

SEWAHSP/TIME/SARTREMediwales AHSCABPI