ASTRI Proprietary
Healthcare Electronics
John Tsang, WM
Optoelectronics 08 July 2016
ASTRI Proprietary
Healthcare Electronics
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Source: http://www.gettyimages.com/
• Small Size – Portable – Wearable – implantable – injectable / swallowable
• Real time / Continual Measurement
– Physiology – Environment – Food
• Wireless connectivity / IoT
• Alerts / Tips
ASTRI Proprietary
Dream Devices
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Non-invasive Blood Glucose Meter
Source: https://www.youtube.com/watch?v=SxXnjY7jy9g
Food Sensor
Source: http://the-sun.on.cc/cnt/news/20140905/00407_003.html
ASTRI Proprietary
Non-invasive Blood Glucose Meter
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Products with CE Mark
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1998 1999 2003 2007 2011 2012 2013
Diasensor 2000 Pendra glucose Watch Glucotrack (糖无忌)
Combo-Glucometer CNOGA
GlucoWatch OrSense NBM 200G C8 MediSensors HypoMon
FDA cleared on Mar 2001
ASTRI Proprietary
Products with CE Mark
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1998 1999 2003 2007 2011 2012 2013
Diasensor 2000 Pendra glucose Watch Glucotrack (糖无忌)
Combo-Glucometer CNOGA
GlucoWatch OrSense NBM 200G C8 MediSensors HypoMon
FDA cleared on Mar 2001
ASTRI Proprietary
Skin Structure
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DOI: 10.1038/srep07013
Stratum corneum
Epidermis
Dermis
Interstitial fluid
Glucose Molecules
• Human skin is ~2–3 mm thick
• No blood vessels and very little glucose in epidermis
• Interstitial body fluid constitutes ~45% of the volume fraction of human skin (Dermis)
ASTRI Proprietary
Glucowatch
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Source: ISBN 0 642 82610 2
• GlucoWatch ( CE mark @ Dec 1999) • FDA cleared on Mar 2001 • Adjunctive medical device • Reverse iontophoresis • Out of business due to skin irritation and
unreliable hypoglycemia detection
ASTRI Proprietary
Pendra glucose Watch
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• Pendra glucose Watch (CE Mark @ May 2003) • Adjunctive Type IIb medical device • Impedance Spectroscopy • Withdrawn due to inaccurate and failed to warn of
dangerous blood sugar levels.
Source: www.pendra.narod.ru/downloads/Presentation_Warsaw_110904.pdf
ASTRI Proprietary
Non CE Mark Products
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Symphony™ Transdermal Continuous Glucose Monitor
(tCGM) System
Google smart contact lens
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HypoMon, AiMedics
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• 4 electrodes • Change of bodies physiological responses (e.g.
ECG and skin impedance) • Recalled at Aug 2013 and identified that it is not
performing as well as expected
Source: Nguyen HT, Ghevondian N, Jones T (2006): Neural-network Detection of Hypoglycemic Episodes in children with Type 1 Diabetes using Physiological Parameters, 28th Annual Int Conf of the IEEE Eng in Med and Biol Society, New York, 6053-6056.
ASTRI Proprietary
Glucotrack (糖无忌)
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Glucotrack (CE mark @ Jun 2013) • Multi-sensors technology: ultrasonic,
electromagnetic, and thermal • Calibration valid for 6 months • Zones A & B: 95.9% Zone A: 41.3%;
Source: http://www.integrity-app.com/the-glucotrack/
ASTRI Proprietary
Combo-Glucometer, CNOGA
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• Combo-Glucometer, CNOGA (CE Mark @ Mar 2011)
• Skin pigment tone • Optical: 300 nm to 1200 nm • Diabetics Type 2 only • Initial individual calibration (65 -100
invasive measurements in less than 2 weeks time)
Source: http://cnogacare.co/
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Optical Method
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DOI: 10.1038/srep07013
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OrSense NBM 200G
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• OrSense NBM 200G (Jun 2007)
• Tested on over 450 diabetic subjects
• Occlusion Spectroscopy
• Red/near-infrared (R/NIR)
• Unavailable for the market yet
https://www.youtube.com/watch?v=uGbhElP-UUc
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C8 MediSensors
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• Raman • Out of business
Source: J Diabetes Sci Technol Vol 3, Issue 2, March 2009
ASTRI Proprietary 17
Food Sensor
ASTRI Proprietary
Food Sensor (Optical Method)
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Ref: Chem. Soc. Rev., 2012, 41, 5706–5727
Sowoidnich New Food. 2013. p. 14.
• Raman /NIR is an optical technique to probe
molecular vibration states thus it can show
the chemical fingerprints of the foodstuffs,
non-invasively
• Optical spectroscopic method can be used
for many food safety and quality (FSQ)
applications in food industry such as:
– pesticides residue on vegetables & fruits
– meat spoilage / freshness detection
– authentication for oil and may others
– Cheese protein quality
– adulterant in milk (Melamine)
– ... etc
Meat Spoilage Detection
0
1
ASTRI Proprietary 19
Industry Application
http://www.stemilt.com/our-stories/history-innovation/
• Non-destructive sweetness testing based on near-infrared technology (NIR) is put on Stemilt fruit packing lines.
• provide information about the sugar levels and overall quality of the fruit being packed
ASTRI Proprietary
SCiO (NIR)
SCiO (KickSTARTER) •Price: $299 / unit •Target: $200,000 ($2,241,170@ 3 June 2014) •Period: 29 Apr – 16 Jun 2014 •Sensitive: major components of foods (i.e. with typical concentration of 1% or more • Collaboration with ADI to develop a sensor-to-cloud personal and industrial IoT platform that analyzes liquids and solids
https://www.kickstarter.com/projects/903107259/scio-your-sixth-sense-a-pocket-molecular-sensor-fo https://www.youtube.com/watch?v=9Xa-uy9fLEE
ASTRI Proprietary
MS-technologies Israel
http://www.ms-technologies.com/products/foodscan/
Hand-held food contamination detector using HF-QCM sensor technology to detect the contamination caused by common pathogens such as Salmonella, E.coli O157:H7, Listeria and others.
• Contact or non-contact analysis • Real-time analysis in 6 seconds • Pre-emptive food poisoning • Wireless and/or GPS data transmission • 850 g with 8-hr battery
FOODSCAN (Electronic Noise)
− High-Frequency Quartz Crystal Microbalance (HF-QCM) Technologies
− A large bank of thin chemical coatings that can be applied on the active surface of HF-QCM sensors.
− Each of these coatings has a specific affinity to different target molecules.
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Market Analysis (Crowdfunding activities)
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200
400
600
800
1000
1200
1400
1600
Nov 13' Mar 14' May 14' Jun 14'
com
ple
tio
n r
ate
[%
]
Time
US$ 386K
US$ 40K US$ 78K
US$ 2.7M + 4M from VC
MyDx
Tellspec
PERES
SCiO
The funding raising completion rate for all these projects are > 100%
Optical Spectroscopy
Electronic Nose
$250 / unit
$89/ unit
$499 / unit
$299 / unit
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How do spectrometer work?
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Filtering Disperse Interference
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Conventional Technical Approaches
Linear Variable Filter (LVF) based Spectrometer Tunable filter spectrometer
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Interference pattern in the temporal domain by moving
mirror
Detector
FT spectrometer (Michelson Interferometer)
• Robustness is limited by moving mirror
𝐼 𝑡 = 1
2𝐿 𝑘 1 + cos 2𝜋 ∙ 𝑘 ∙ 𝛿𝑙 𝑑𝑘
∞
−∞
x
𝑘 =1
𝜆
L(k): Intensity at a particular k
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Conventional Dispersive Spectrometer
s d
• Resolution is limited by the grating ( 1/d)
and slit (1/s)
• Throughput is limited by the slit ( s)
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MEMS based Spectrometer
Classification: Disperse vs. Interference & Free-field vs. Waveguide
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Disperse
Interference
Free-field Waveguide
e.g. FT spectrometer e.g. AWG based SHS
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Free-field Spectrometer
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Complexity
No
velt
y
Macro-assembly
Micro-assembly
Wafer-scale Integration
Monolithic Integration
MEMS grating and movable slit
e.g. FP spectrometer components on AlN baseplate Pick & Place technology Axsun Technology
e.g. Disperse NIR spectrometer 950 – 1900 nm IMPS, Fraunhofer
e.g. Disperse IR spectrometer Wafer bonding DTU, Netherlands
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Foss 6500
PHAZIR
INSION MicroNIR, JDSU
Neospectra, Si-ware
Technology
Grating Disperse + Grating Light Valve
Waveguide Echelle Grating LIGA Molding / PMMA
Linear Variable Filter
Michelson Interferometer (moving mirror)
Max dimension
43 cm 30 cm
6.7 cm 4.5 cm 8.0 cm
Resolution
2 nm N.A. (10 -12 nm)
< 16 nm 6.5 nm 16 nm
Spectral Range
1000 -2500 nm
1000 -1600 nm
900 – 1700 nm 950 – 1650 nm
1250 – 1700 nm
Competitive Analysis
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ASTRI Proprietary
Elderly Demand on Portable Healthcare Electronics
• Potential Users: Elderly keen to technology, healthy
elderly living alone & active elderly;
• Chronic diseases elderly concerns most: blood
pressure, heart disease, cardiovascular disease
(stroke), diabetes, dementia.
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Source: ITRI-IEK and OC&C joint study (2010-2011)
ASTRI Proprietary
Healthcare Electronics at ASTRI
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ASTRI Proprietary
Pulse Oximetry Module (15x15x1.7mm)
IP-protected Sensor Module (9x11x1.1mm)
Reflective Pulse Oximeter
Reflective pulse oximetry module Continual measurement of blood oxygen saturation, pulse
rate, breathing rate and heart rate variability Key features:
• Unaffected by nail polish or onychomycosis • Fulfilled FDA standard(Arms <3.5%) • Wireless connectivity • Easy integration with consumer electronics
Pulse Oximetry Dongle (57x27x14.5mm, 15g)
Patent No.: US 2012/0176599
CN 102727220A
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ASTRI Proprietary
Cardiovascular Monitoring Device
Parameters: • Heart Rate • Arterial Stiffness Index (ASI) • Continual Blood Pressure Measurement
(40 – 180mmHg 8mmHg) Features:
• Compact pressure senor • Cuffless • Continual Measurement • Wireless connectivity
ASTRI Proprietary
Cognitive Health Monitoring Device
• Measure pulse oximetry, breathing rate and balance in Autonomous Nervous System (ANS)
• Relieve your stress, and improve your sleeping quality & balance in ANS by controlling your breathing
Physiological &
Cognitive
Measurement Balance in
Autonomous
Nervous System
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ASTRI Proprietary
Non-Invasive Blood Glucose
• Working Principles: Measurement of
scattered light at different
wavelength in the spectrum
• Applications: pre-screening of pre-
diabetes and diabetes
• Usage: Put your finger on the sensor
Blood glucose level at
different time of a day
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ASTRI Proprietary
Compact Optical System for Food Safety/Quality
Current Future
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• Portable
• Control environment
• Rapid Detection (~1-2 min)
• Sample Preparation
• Accessory
• Ambient environment
• Real-time detection (< 1 min)
• Direct Measurement
ASTRI
Miniaturized
High-throughput
Broad range
High resolution
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Disclaimer
The information contained in this presentation is intended solely for your reference
and may be subject to change without further notice.
Such information's truthfulness, accuracy or completeness is not guaranteed and it
may not contain all the material information concerning Hong Kong Applied Science
and Technology Research Institute Company Limited and/or its affiliates
(collectively, "ASTRI"). ASTRI makes no representation or warranty regarding, and
assumes no responsibility or liability for, the truthfulness, accuracy or completeness
of any information contained herein.
In addition, the information may contain projections and forward-looking statements
that may reflect ASTRI’s current views with respect to future events and financial
performance. These views are based on current assumptions which may change
over time. ASTRI makes no assurance that such future events will occur, that such
projections will be achieved, or that ASTRI’s assumptions are correct.
Lastly, this presentation does not constitute an offer made by ASTRI whatsoever
(including an offer relating to ASTRI's technologies and/or services).
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ASTRI Proprietary
End of Presentation Thank you. Questions are welcome.
Corporate website: www.astri.org
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