workshop cnr isof_r2b

GRAPHENE RESEARCH@ ISOF

Graphene = a single layer of carbon atoms, arranged in honeycomb lattice, forming a perfect, completely aromatic network.

• Highly stable • Very good mechanical properties • High thermal and electrical conductivity • Excellent stability in air.

The nanochemistry group at ISOF works on the production of graphene by chemical exfoliation, its chemical functionalization through covalent or supramolecular interactions, and its characterization at nanometric scale.

R2B, BOLOGNA, 8-9 GIUGNO 2011

GRAPHENE OXIDE

• Can be produced in large scale.

• Highly soluble in water and in some organic solvents.

• Present in solution as monoatomic single sheets.

• Sheet size can be tuned from 1 um to 100 um.

• Can be chemically functionalized.


Size control on 2 orders of magnitude (1-100 um)

Height Histogram Height Profile

4.8 um 60 um


Uniform, deposition on large areas (> 100 um) on any given substrate


Silicon

Quartz

Glass

Deposition on any given substrate (by finding the right conditions)


All monolayers up to 45% surface coverage

Coverage evolution Thickness evolution


Treossi, E., et al., JACS 2009, 131, 15576.

Visualizing graphene sheets by fluorescence quenching OM image

100 µ m 100 µ m 100 µ m Fluorescence image

100 µ m 100 µ m 100 µ m R2B, BOLOGNA, 8-9 GIUGNO 2011

Covalent functionalization of graphene sheets with optically active oligothiophenes.

500 nm

Melucci, M., et al., Journal of Materials Chemistry 2010, 20, 9052. R2B, BOLOGNA, 8-9 GIUGNO 2011

p-type µ = 1 cm2/Vs n-type µ = 0.2 cm2/Vs


2 µm 2 µm

e-

VD = 1 V

C-AFM

KPFM

AFM

∇-AFM

Nanoscopic monitoring of GO reduction Current mapping

Potential decay mapping

High

High

Low

Low


KPFM

Kelvin Probe Force Microscopy

AFM

• Maps the electric potential with resolution of few nm and few mV. • Contactless, minimal perturbation of sample potential. • Can be performed on working devices (transistors, photovoltaic blends)

Review paper: Palermo, V., et al., Advanced Materials, (2006) 18, 145. Liscio, A., et al., Accounts of Chemical Research, 2010


Self-assembly from nano- to macro-scale

150 x 125 µm

soluble fullerenes (PCBM )

50 µm

SVA= 18 hours 1 µ m SVA= 18 hours 1 µ m ORIGINAL 1 µ m ORIGINAL 1 µ m

Perylenes

Coronenes


Depositing organic semiconductors on graphene

topography Potential, KPFM

Z range = 5 nm Z range = 150 mV

RGO Single sheet

Pyrene nanocrystals

pyrene


Charge mobility/graphene coverage

SOU

RC

E

DR

AIN

P3HT

Selective improvement of hole mobility

Improved charge mobility in Polythiophene-RGO FET

ION/IOFF ratio ∼ 105


Design and synthesis of mul2func2onal

π-‐conjugated organic and hybrid materials

Manuela Melucci, Laura Favare/o, Massimo Zambianchi


π-‐Conjugated Materials

Proper8es: Fluorescence, Charge transport, Self-‐assembly…..

Applica8ons: organic electronics (FET, LED, PVD, oLET), nano(bio)technology (sensing,

imaging)


From molecular to complex hybrid materials

Property-‐specific design and synthesis of……

Sustainable chemistry

Molecular materials

Hybrid 1D, 2D, 3D (nano)materials

graphene NPs Nanowires

20 µm 50 µm

SiC SiO2

(Bio) Polymers


Thin film transistor

Liquid crystals

Crystals,fibers, helics and more…………..


MOLECULAR MATERIALS FOR ORGANIC DEVICES

Engineered biopolymers for photovoltaics: renewable materials for a renewable energy technology


30 nm

Mul2color dye-‐doped silica nanopar2cles for bioimaging


Chemosensors

Mul2color emission by N-‐complexa2on

pH 5 pH 4 pH 1 pH 7 Op2cal devices for pH/ ca2on sensing

MW

surface anchoring

20 µm

pH 1

pH 7


MDSD LAB

Molecular design synthesis and delivery Laboratory

http://mdsdlab.bo.cnr.it

Via Gobetti 101 40129 Bologna Tel. 051 639 8283 Fax. 051 639 8349



NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE

O

ON + Br

Hydroquinone,

50°C; 24h

O

ON

Br

H2O, N2, 300 rpm, 80°C

methylmethacrylate, 15 min; AIBA, 4h

NBr

(1)

7 5



NN

O

O

OO

ON

NN

13

+Na-O3S

AcO O OH

OOAc

HO

PhO

OHOPh

NH

Ph

O

O

O

O

NaO3S

Na+

11



NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE

CORE di PMMA co-polimerizzato con

Fluorofori


NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE

APPARATI EXTRA-CORPOREI PER LA RIMOZIONE DELLA EPARINA E

DELLE CITOCHINE INFIAMMATORIE


NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE SCAFFOLDS MOLECOLARI CON ATTIVITA’ BIOLOGICA


NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE SCAFFOLDS MOLECOLARI CON ATTIVITA’ BIOLOGICA

PROGETTAZIONE - SINTESI - ANALISI PRECLINICA

TUMORE ALLA PROSTATA IN FASE AVANZATA/RESISTENTE

TERAPIA ORMONALE SOSTITUTIVA (andropausa, calo della libido, depressione, osteoporosi da glucocorticoidi e da postmenopausa)

ANABOLIZZANTI NELLA CACHESSIA NEOPLASTICA

SINDROME DI KENNEDY



  Asia 3-4/100.000

  Europa 40/100.000

  Stati Uniti 70/100.000

  Età

  Origine etnica

  Storia familiare

  Dieta

Nat Rev Cancer, (2001)

TUMORE ALLA PROSTATA


NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE ANDROPAUSA

LA PERCENTUALE DI SOGGETTI CON BASSI LIVELLI DI TESTOSTERONE AUMENTA CON L’ETA’

Effetti negativi dell’abuso di androgeni

-  blocco transitorio della spermatogenesi ed infertilità -  ipertro"a prostatica > carcinoma prostata

-  sleep-apnea -  obesità viscerale

-  dislipidemia ed aterosclerosi -  poliglobulia

-  epatotossicità > epatomi


NANOPARTICELLE POLIMERICHE PER APPLICAZIONI BIOLOGICHE MODULATORI SELETTIVI DI AR: NUOVA GENERAZIONE

WO/2010/092546: Androgen Receptor Modulating Coumponds, Preparation and uses Thereof

WO/2010/116342: Non-Steroidal Compounds for Androgen Receptor Modulation, Processes for the Preparation and Uses Thereof

Applicants: CONSIGLIO NAZIONALE DELLE RICERCHE, Dipartimento di Progettazione Molecolare ISTITUTO SCIENTIFICO ROMAGNOLO PER LO STUDIO E LA CURA DEI TUMORI (I.R.S.T.) S.R.L.

Inventors: Greta Varchi, Andrea Guerrini, Anna Tesei, Giovanni Brigliadori.

MDSD LAB

Molecular design synthesis and delivery Laboratory

http://mdsdlab.bo.cnr.it

Via Gobetti 101 40129 Bologna Tel. 051 639 8283 Fax. 051 639 8349


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