World-renowned Authors

RelevantContent

UpToDate’s Value Proposition

Easy to Use

UpToDate synthesizes the most recent medical information into evidence-based, practical recommendations clinicians trust to make the right point-of-care decisions.

• 9,000+ topics in 18 specialties

• Additional 5,000+ unique drug entries

• 700+ patient information topics

• 4,800+ physician authors, editors and peer reviewers

• 7,700+ graded recommendations

• 450,000+ users in 149 countries

UpToDate Facts-at-a-Glance

Adult and Pediatric Emergency Medicine

Adult Primary Care and Internal Medicine

Allergy and Immunology

Cardiovascular Medicine

Dermatology*

Endocrinology and Diabetes

Family Medicine

Gastroenterology and Hepatology

Geriatrics

Hematology

Hospital Medicine

Specialties Covered in UpToDateInfectious Diseases

Nephrology and Hypertension

Neurology

Obstetrics, Gynecology and Women’s Health

Oncology

Pediatrics

Psychiatry*

Pulmonary, Critical Care and Sleep Medicine

Rheumatology

Surgery* *In development

UpToDate has users in149 countries

UpToDate Is Trusted Worldwide

UpToDate’s Editorial Process

• Authored and edited by leading physicians

• World-renowned expertise

• Hand-searching of 460+ journals

• Three-tiered peer review process

UpToDate’s Editorial Process

UpToDate

EditorialProcess

Our authors collaborate withmultiple specialty editors tocreate or update the topic.

Final topic contentconsensus is reached.

New clinical studiesare released thatimpact care.

Topic isavailable tocliniciansworldwide viaUpToDate.

The topic ispeer-reviewed.

A gradingeditor reviews

the gradedrecommendations.

Graded Recommendations

Grades denote strength of recommendation and quality of evidence

• Strong recommendation = Grade 1 [ “We recommend” ]

• Weak recommendation = Grade 2 [ “We suggest” ]

• Evidence = Grade A, B or C [ High, moderate or low quality ]

Hierarchy of Evidence

High - Quality

Low - Quality

Meta-analyses of randomized trialsof high methodological quality

Randomized trials with methodological limitations

Observational studiesUnsystematic clinical observations

Graded Recommendations

Users Say

UpToDate Improves Care

89% changed management

94% improves quality of care

81% changed diagnostic testing

0% 20% 40% 60% 80% 100%

Source: UpToDate Subscriber Survey, 2010

UpToDate “changes the wayyou practice medicine — really.”

Medical Professionals

Endorse UpToDate

Pam Wetzel, MDChief Medical Information OfficerSwedish American Hospital, Rockford, IL

Marc Greenwald, MDChief of MedicineSignature Healthcare-Brockton Hospital, Brockton, MA

Medical Professionals

Endorse UpToDate

UpToDate “applicability to patients is in evidence every day.”

R.M. Valentijn, MDMDHAGA Hospital, the Hague, the Netherlands

“UpToDate is …a new way of practicing medicine …for day-to-day practice there is no other product.”

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