XDM Quad™ Single-Use Mixing System
DATA SHEET
The Xcellerex XDM Quad Mixing System is designed for convenient and
efficient mixing of buffer, media, product, and other process fluids. The single-use
system eliminates the hassle of time-consuming and costly clean-in-place (CIP),
steam-in-place (SIP), and cleaning validation. The result is more efficient processing
and rapid batch-to-batch turnover time.
The XDM Quad is comprised of a full-featured and integrated rigid containment
system complete with motor and controls, and an irradiated USP Class VI, single-
use LDPE fluid contact layer bag equipped with a disposable bottom-mounted
impeller. The engagement between motor and disposable impeller is via a robust
magnetic coupling, and agitation is driven through stainless steel bearings within
the impeller, imparting high torque and rapid mixing to the system.
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The XDM Quad Mixing System is available in 50L, 100L , 200L, 500L and 1000L sizes.
Key Features
l Powerful integrated magnetic agitator with compact VFD and AC motor
l Optimized, disposable impeller
l Square configuration offers enhanced mixing efficiency through natural baffling effect.
l Workable heights and low center of gravity increase level of safety
l Bottom is slanted on two planes for extremely low bag hold-up volume
l Compact unit with handles and casters for ease of mobility
l Fitted square bag minimizes bag wrinkles
l Real-time sensing and sampling capability via mixer window and bag probe ports, sampling port and thermowell for non-invasive temperature sensing
l Integrated holders for 50ml conical buffer tubes
l Bags have integrated 3” Tri-clamp port for powder addition
l Translucent lid is included for protection of bag and is equipped with securing feature for bag powder addition port and hopper
l 500L and 1,000L systems equipped with removable door for easy bag loading
l Two standard bag types: BASIC and PLUS (additional lines, probe ports, and con-nections)
l System also available in either polypropylene, single-wall stainless steel or jacketed stainless steel (for heating and cooling applications).
l Fully wash-down rated
The system delivers flexibility with the availability of two
standard bag types that include varying numbers of tubing lines
and connections, and sampling and sensing capabilities to ac-
commodate a wide array of applications. Key features of the bag
and rigid container also permit seamless transitioning between
powder-liquid and liquid-liquid mixing applications. The XDM
Quad Mixing System is available in either polypropylene, single-
wall stainless steel or or jacketed stainless steel (for heating and
cooling applications).
®
www.xcellerex.com • 1-866-Xcellerex
XDM
Qua
d™ Mixe
rs: S
YSTE
M SP
ECIF
ICAT
IONS
XDM
QUA
D (P
olyp
ropy
lene
) Sys
tem
sXD
M Q
UAD-
S (St
ainl
ess S
teel
) Sys
tem
sXD
M Q
UAD-
T (Ja
cket
ed St
ainl
ess S
teel
) Sys
tem
s
50 Li
ter10
0 Lite
r20
0 Lite
r50
0 Lite
r50
Liter
100 L
iter
200 L
iter
500 L
iter
1000
Liter
50 Li
ter10
0 Lite
r20
0 Lite
r50
0 Lite
r10
00 Li
ter
DIM
ENSI
ONS
Conta
iner In
terior
(In
ches
LxW
xH)
15.5
x 15.5
X 15
.520
x 20
x 20
25 x
25 x
2533
x 33
x 33
15.5
x 15.5
X 15
.520
x 20
x 20
25 x
25 x
2533
x 33
x 33
41 x
41 x
4115
.5 x 1
5.5 x
15.5
20 x
20 x
2025
x 25
x 25
33 x
33 x
3341
x 41
x 41
Exter
ior
(Inch
es Lx
WxH
)22
.5 X 2
7 X 45
27.5
x 33 x
4132
.5 x 3
8 x 40
40.5
x 46.5
x 48
21.37
5 X 33
.375
X 42
24 x
33.5
x42
26.5
x 37 x
4235
.25 x
48.25
x 56
.7543
.25 x
55.25
x 5
6.75
21.37
5 X 33
.375
X 42
26.75
X37x
4226
.75 x
38.5
x 42
38 .3
75 x
50.37
5 x 5
6.75
47.5
x 58.6
25 x
56.75
Slope
to Dr
ain~
0.5 pe
r foot
Cross-
Secti
on~
0.5 pe
r foot
Cross-
Secti
on~
0.5 pe
r foot
Cross-
Secti
on
Caste
r Dim
ensio
ns
(ø x W
)4 x
24 x
24 x
2
Jacke
t Volu
meNA
NA1.2
L2 L
2.65 L
5.8 L
9.1 L
WEI
GHT
Syste
m W
eight
(empt
y)11
5 lbs
.14
3 lbs
.18
3 lbs
.30
4 lbs
.15
0 lbs
.18
1 lbs
.30
9 lbs
.39
7 lbs
.60
6 lbs
.20
0 lbs
.23
6 lbs
.38
1 lbs
.50
3 lbs
.79
2 lbs
.
MAT
ERIA
L OF
CONS
TRUC
TION
Conta
iner
Polyp
ropyle
ne30
4 Stai
nless
Steel
304 S
tainle
ss Ste
el
Insula
tion
NANA
Insula
tion i
s non
-asb
estos
, chlo
ride f
ree an
d coa
ted w
ith Th
urmalo
x mas
tic m
ateria
l
LidAc
rylic
Acryl
icAc
rylic
Caste
rsSS
/ Po
lyuret
hane
(Non
-Marr
ing)
SS /
Polyu
retha
ne (N
on-M
arring
)SS
/ Po
lyuret
hane
(Non
-Marr
ing)
MOT
OR/V
FDTyp
eAC
Moto
rAC
Moto
rAC
Moto
r
HP0.2
60.2
60.2
6
Watt
s19
719
719
7
RPM
0-20
00-
200
0-20
0
Electr
ical
115V
or 23
0V: (5
0/60
Hz)
115V
or 23
0V: (5
0/60
Hz)
115V
or 23
0V: (5
0/60
Hz)
Func
tiona
lityRu
n/Sto
p, Fo
rward
/Brea
k/Re
verse
Run/
Stop,
Forw
ard/B
reak/
Reve
rseRu
n/Sto
p, Fo
rward
/Brea
k/Re
verse
Powe
r Cord
10 ft.
10 ft.
10 ft.
Was
hdow
nMo
tor is
IP66,
CE Ce
rtifie
d/Dr
ive is
IP65 N
EMA 4
X, CE
Certi
fied
Motor
is IP6
6, CE
Certi
fied/
Drive
is IP6
5 NEM
A 4X,
CE Ce
rtifie
dMo
tor is
IP66,
CE Ce
rtifie
d/Dr
ive is
IP65 N
EMA 4
X, CE
Certi
fied
All
spec
ifica
tions
are
sub
ject
to c
hang
e w
ithou
t not
ice.
XDM QUAD OPTIONS & ACCESSORIESThe following options are available for all XDM Quad Mixing Systems:
u Dual pH/Conductivity Monitoring System
u pH probe
u Conductivity probe
u RTD probe
u Probe sheath assemblies
u Level indication (floor scale or load cells for stainless steel units)
u Temperature Control Unit for heating and cooling of jacketed stainless steel systems
NOTE: All probes and instrumentation are GMP compliant.
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BAg ASSEMBlY DETAIlSXDM Quad Mixing Systems are available with two standard bag assembly types: BASIC and PLUS
SINglE-USE BAg SPECIFICATIONSBASIC BAg ASSEMBlY PlUS BAg ASSEMBlY
Port Description 50L 100L 200L 500L 1000L 50L 100L 200L 500L 1000L
A Fill Port: 3 inch tri-clamp powder addition port, capped • • • • • • • • • •
B C-flex® tubing, 4’ with clamp, plugged (ID indicated) ½ inch ½ inch ½ inch ½ inch ¾ inch ¾ inch ¾ inch ¾ inch ¾ inch ¾ inch
C ½ “ ID C-flex® tubing, 4’ with clamp, female MPX connector, plugged NA NA NA NA NA • • • • •
D Sample Line: 1/8” ID sample line with clamp, and luer lock connection NA NA NA NA NA • • • • •
E, F Probe Port: Female Kleenpack® Connector port for probe connection NA NA NA NA NA • • • • •
F Female Kleenpack® Connector port for probe connection NA NA NA NA NA • • • • •
G Thermowell: for non-invasive temperature sensing NA NA NA NA NA • • • • •
H Sample Line: 1/8” ID sample line with clamp, and luer lock connection • • • • • • • • • •
I Harvest/Drain: C-flex® tubing, 6’ with clamp, plugged (ID indicated) ½ inch ½ inch ½ inch ½ inch ¾ inch ½ inch ½ inch ½ inch ½ inch ¾ inch
SINglE-USE BAg SPECIFICATIONS50 liter 100 liter 200 liter 500 liter 1000 liter
DIMENSIONS Dimensions (inches LxWxH) 15.5 x 15.5 x 14.5 20 x 20 x 19 25 x 25 x 24 33 x 33 x 32 41 x 41 x 37
VOlUME Maximum 55L 125 L 246 L 571 L 1019 L
Nominal 50L 100 L 200 L 500 L 1000 L
Minimum (Mix) 17 L 28 L 44 L 76 L 117 L
Hold Up <20ml < 20 mL < 20 mL < 20 mL < 20 mL
FIlM Fluid Contact Layer LDPE (USP Class VI)
PRESSURE RATINg Maximum, operating 2 psi, 1 psi
IMPEllER # of Blades 3
Diameter 7.5”
Blade Height x Width 4.2” x 2.5”
Blade Pitch 57º
Material of Construction Molded HDPE impeller with 316 SS bearing
TEMPERATURE RANgE 2º – 60ºC
POWDER PORT Dimensions 3” TC
STERIlIZATION Gamma Irradiated
The XDM QUAD disposable impeller assembly is welded to the bottom of the bag.
All specifications are subject to change without notice.
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XDM QUAD MIXER SYSTEM DETAIlS
uv
w
y
uMotor controller (fully wash down rated)
vConvenient buffer tube holders (4)
wAC motor and magnetic drive (fully wash down rated)
xHandles for ease of mobility
yNotches for supporting bag tubing (polypro. units)
zProbe port window and support bar for (A) pH/Conductivity, (B) inline sampling, and (C) temperature.
Detail of probe port window and support bar for inline sampling and sensing, such as pH, conductivity and temperature.
{
|
~
{ Removable lid with integrated support for powder addition port and hopper
| Hopper and 3-inch triclamp for easy powder addition
} Removable door for easy bag installation and removal (500L and 1000L only)
~ Mixer bottom is slanted on two planes toward drain for minimal holdup volume; Magnetic impeller drive is easily accessible
}
zA
B
x
C
0%
20%
40%
60%
80%
100%
0 20 40 60 80 100
Minutes
% D
iss
olv
ed
75% Corn Syrup, 274 cp
85% Corn Syrup, 561 cp
90% Corn Syrup, 1000 cp
1% NaCL in Corn Syrup, XDM200
The XDM Quad demonstrates effective mixing even at high viscosities
6g/L NaCL, XDM500
The XDM Quad demonstrates rapid mixing of common salt solutions.
9.0
9.5
10.0
10.5
11.0
11.5
0 60 120 180 240 300
Time (seconds)
Co
nd
ucti
vit
y (
mS
/cm
)
APPlICATIONS AND PERFORMANCE DATA
DMEM/F-12 Medium, XDM500
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The XDM Quad demonstrates effective mixing of common cell culture media.
XDM500
DMEM/F-12 Medium Mixing Study
Glucose & L-Gln Trends
0
1
2
3
4
5
6
7
8
9
10
0 60 120 180 240 300
Mix Time (Seconds)
Co
mp
on
en
t C
on
cen
trati
on
L-Gln (mmol/L)
Glucose (g/L)
XDM500
DMEM/F-12 Medium Mixing Study
Sodium Trend
0
10
20
30
40
50
60
70
80
90
100
0 60 120 180 240 300
Mix Time (Seconds)
Co
mp
on
en
t C
on
ce
ntr
ati
on
[m
mo
l/L
]
Na+ (mmol/L)
XDM500
DMEM/F-12 Medium Mixing Study
Potassium Trend
0
1
2
3
4
5
6
7
8
9
10
0 60 120 180 240 300
Mix Time (Seconds)
Co
mp
on
en
t C
on
ce
ntr
ati
on
[m
mo
l/L
]
K+ (mmol/L)
XDM500
DMEM/F-12 Medium Mixing Study
Osmo Trend
0
50
100
150
200
250
300
350
400
0 60 120 180 240 300
Mix Time (Seconds)
[mO
sm
/kg
]
Osmo (mOsm/kg)
VIDEO DEMONSTRATION Base & Acid Addition / Phenolphthalein Dye Test, XDM500
A video demonstration of this mixing test is available at www.xcellerex.com/mixerdemo
SODIUM TREND
OSMOlaRITy TRENDPOTaSSIUM TREND
GlUcOSE & l-GlN TRENDS
u Buffer and Media Prepu pH adjustmentsu Resuspensionu Chromatography poolingu Viral inactivationu UF/DFu Formulationu Product Mixing
XDM QUAD APPlICATIONSu
Product Code Size Type
888-0141 50L Basic
888-0351 50L Plus
888-0164 100L Basic
888-0154 100L Plus
888-0165 200L Basic
888-0155 200L Plus
888-0166 500L Basic
888-0156 500L Plus
888-0167 1,000L Basic
888-0157 1,000L Plus
Ask about our made-to-order bags for UF/DF.
XDM Quad Bag Assembly Ordering Codes
Xcellerex, Inc. Toll Free: 1-866-Xcellerex170 Locke Drive Tel: 508-480-9235 Marlborough, MA 01752 [email protected] www.xcellerex.com rev. xdmQ-010711
TM
Product Code Size Type
XDM-50 50L Standard Polypropylene
XDM-100 100L Standard Polypropylene
XDM-200 200L Standard Polypropylene
XDM-500 500L Standard Polypropylene
XDM-50-S 50L Stainless Steel
XDM-100-S 100L Stainless Steel
XDM-200-S 200L Stainless Steel
XDM-500-S 500L Stainless Steel
XDM-1000-S 1,000L Stainless Steel
XDM-50-S-LC 50L Stainless Steel with Load Cells
XDM-100-S-LC 100L Stainless Steel with Load Cells
XDM-200-S-LC 200L Stainless Steel with Load Cells
XDM-500-S-LC 500L Stainless Steel with Load Cells
XDM-1000-S-LC 1,000L Stainless Steel with Load Cells
XDM-50-T 50L Jacketed Stainless Steel
XDM-100-T 100L Jacketed Stainless Steel
XDM-200-T 200L Jacketed Stainless Steel
XDM-500-T 500L Jacketed Stainless Steel
XDM-1000-T 1,000L Jacketed Stainless Steel
XDM-50-T-LC 50L Jacketed Stainless Steel with Load Cells
XDM-100-T-LC 100L Jacketed Stainless Steel with Load Cells
XDM-200-T-LC 200L Jacketed Stainless Steel with Load Cells
XDM-500-T-LC 500L Jacketed Stainless Steel with Load Cells
XDM-1000-T-LC 1,000L Jacketed Stainless Steel with Load Cells
* Various electrical requirements can be accommodated. Please specify at time of order.
XDM Quad System Ordering Codes*
ORDERINg INFORMATION
Product Code Description
888-0138 Probe Sheath Assemblies
XDM-Q-HH Hopper (includes fitting for fastening to 3” tri-clamp port)
XDM-Q-PB pH Probe
XDM-Q-CB Conductivity Probe
XDM-MTR-P-C pH/Conductivity Monitoring System
XDM-Q-RTD RTD for Temperature Measurement
Accessory Ordering Codes
For information on Xcellerex’s other innovative single-use technology, including XDR single-use bioreactors and the FlexFactory biomanufacturing platform, please visit www.Xcellerex.com
To order XDM Quad systems, bag assemblies or components,
please call 1.866.XCEllEREX
(1.866.923.5537) 1.508.480.9235