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Curriculum Vitae

Yosra S.R. Elnaggar, Ph.D. Personal Data Name: Yosra Shaaban Rabea Elnaggar Gender: Female Date of Birth: January 9, 1982 Citizenship: EGYPT Contact: Tel: 002 01277629944

002 01147591065 Email: yosra_pharm@yahoo.com Address: 18 Masged Elhedaya St., Alexandria, Egypt

Work Experience 1- 1 February 2016-Present: Associate Professor of Pharmaceutics; Faculty of

Pharmacy and drug manufacturing; Pharos University in Alexandria. 2- 29 December 2015- 30 January 2015: Associate Professor of Pharmaceutics,

Faculty of Pharmacy, Alexandria University, Egypt. 3- 25 September 2010 – 28 December 2015: Lecturer of Pharmaceutics,

Faculty of Pharmacy, Alexandria University, Egypt. 4- August 2012-January 2013: Director of Central Laboratory at Faculty of

Pharmacy, Alexandria University, Egypt. 5- 21 August 2007 – 24 September 2010: Assistant Lecturer of Pharmaceutics,

Faculty of Pharmacy, Alexandria University, Egypt. 6- 5 January 2005 – 20 August 2007: Demonstrator of Pharmaceutics, Faculty

of Pharmacy, Alexandria University, Egypt.

Education 1- Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Alexandria University, Egypt,

2010. Thesis Title: "Development and Evaluation of Some New Disperse Drug Delivery Systems Using Nanotechnology"

2- M.Sc. in Pharmaceutical Sciences, Pharmaceutics, Alexandria University, Egypt, 2007. Thesis Title: “Development and Evaluation o Selected Oral Dosage Forms”

3- Bachelor of Pharmaceutical sciences “Distinction, Honor”, Alexandria University, Egypt, 2004.

Teaching Experience Teaching Topic Course content University Academic

program/Level 1. Pharmacy orientation

-Information resources -Code of ethics /

Alexandria University

Clinical Pharmacy program, first year

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(Introduction to pharmacy)

heritage of pharmacy -Routes of administration -Pharmacy careers, organizations -

(Credit hour system).

2. Physical pharmacy -State of matter -Phases and Phase transitions; - Colloids - Aerosols

Alexandria University

Classical Pharmacy program, first year

3.Sterile dosage forms

-Parenteral products -Ophthalmic dosage forms

- Alexandria university - Damanhur university - Pharos University of Alexandria (PUA)

-Classical pharmacy program, second year (Credit hour system)

4.Semisolid dosage forms

-Cream, Ointment and gels

-Damanhur University

Classical Pharmacy program, second year

5.Pharmaceutical dosage forms -2

Parenteral products Alexandria University

Clinical pharmacy program third year (Credit hour system)

6. Hospital pharmacy -Parenteral infusions - IV admixtures - IV incompatibilities -Heamodialysis/peritoneal dialysis - Peritoneal irrigation - Radiopharmaceuticals - Medical gases -Blood substitutes and Plasma expanders

Pharos University in Alexandria (PUA)

Hospital pharmacy program, Fourth year students (Credit hour system)

7. Special course for postgraduate master and PhD students

-Seminar course on selected topics :Lipid based delivery systems, self-emulsifying formulations, liposomes and modified generations, delivery systems for phytopharmaceuticals, chronotherapy and

Alexandria University

-Postgraduate master students -PhD students

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validation in industry - Seminar course for PhD degree students

8. Clinical pharmacy Introduction and bases for clinical pharmacy; pharmaceutical care compartments; evidence based medicine; taking medication history; smoking-drug interaction; food-drug interaction; SOAP and FARM notes; interferences of laboratory data; medication errors; medical health problems.

Pharos University in Alexandria PUA

5th year students (Credit hour system)

9. History and Ethics in Pharmacy Practice

Ethics in pharmacy practice Ethics in research (plagiarism) Academic integrity for undergraduate students

Pharos University in Alexandria PUA

Freshmen students (Spring 2016)

10. Bachelor Graduation Project

Nanotechnology in cancer therapy)

Pharos University in Alexandria PUA

Senior 5th year students (spring 2016)_

Industrial Trainings Completed the Pharmaceutical Manufacturing Practicing Program (PMPP), 80 training hours, in Amria Pharmaceutical Industry, 2003.

Language qualifications English Fluent (National TOEFL score 587 out of 680) Arabic: Mother tongue.

Awards 24 November 2015: Received Alexandria University Award for Scientific Motivation for the year 2015.

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Awards for international publications 1- Alexandria University Award for publication in top 20 % of pharmacy and

pharmacology journal rank (red jasper, 2009): International Journal of Pharmaceutics 380 (1-2): 133-141 (2009).

2- Alexandria University Award for publication in top 50 % of Nanotechnology journal rank (ISI, 2011): International Journal of Nanotechnology 8 (8-9): 749-763 (2011).

3- Alexandria University Award for publication in top 20 % of pharmacy and pharmacology and nanotechnology journal rank (ISI): International journal of nanomedicine 2011:6 3195–3205 (2011).

4- Alexandria University Award for publication in top 20 % of pharmacy and pharmacology and nanotechnology journal rank (ISI): International journal of nanomedicine 2012:7 3787–3802 (2012).

5- Alexandria University Award for publication in top 50 % of pharmacy and pharmacology and nanotechnology journal rank (ISI): International Journal of Nanomedicine 2013:8 2385–2397 (2013)

6- Alexandria University Award for publication in top 50 % of pharmacy and pharmacology and nanotechnology journal rank (ISI): International journal of Pharmaceutics. 454 : 462– 471 (2013)

7- Pharos University of Alexandria (PUA) award for publication in top 5 % of pharmacy and pharmacology ISI journal rank : Journal of Controlled Release 180 : 10–24 (2014).

8- Alexandria University award for publication in top 5 % of pharmacy and pharmacology ISI journal rank : Journal of Controlled Release 180 : 10–24 (2014)

9- Alexandria University Award for publication in top 5 % of pharmacy and pharmacology journal rank (ISI): Journal of Controlled Release 194: 92–102(2014)

10- Alexandria University Award for publication in top 20 % of pharmacy and pharmacology journal rank (ISI): International journal of pharmaceutics (486): 588-98 (2015).

11- Pharos University of Alexandria (PUA) Award for publication in top 20 % of pharmacy and pharmacology ISI journal rank International journal of pharmaceutics (486): 588-98 (2015)

12- Alexandria University Award for publication in top 20 % of pharmacy and pharmacology journal rank (ISI): Pharmaceutical Research 32:2901–2911 (2015)

13- Alexandria University Award for publication in top 50 % of pharmacy and pharmacology journal rank (ISI): Journal of Pharmaceutical Sciences. 104:3544–3556, (2015)

14- Alexandria University Award for publication in top 20 % of pharmacy and pharmacology and nanotechnology journal rank (ISI): International Journal of Nanomedicine 10 5459–5473 (2015)

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Author Nominations 1- Nominated as “Favorite Author” in the International Journal of

Nanomedicine favorite author reward program, January 2012 2- Nominated to be included in Marquiz Who's Who in the World list, 2012

(29th Edition). Special Carrier Development Training courses (workshops)

1. FLDC workshops (Faculty Leadership Development Center); Alexandria University)

Course Name

# of training days

Certified by

1. Effective Teaching (April 2007)

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2. Research Methodology (April 2007)

3. Effective Communication Skills (April 2007)

4. Thinking Skills (May 2007)

5. Code of Ethics (December 2007)

6. Teaching with Technology (January 2008)

7. Quality Standards in Teaching (January 2008)

8. International Publishing of Scientific Research (June 2010)

9. Legal and Financial Aspects in University Environment (June 2010).

10. Preparing Research Project (July 2010)

11. Reference Management Programs (Endnote) August 2014

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12. Decision Making and Problem Solving Workshop (August 2014)

13. Student Evaluation and Assessment Techniques (August 2014)

14. Effective Presentation Skills (March 2015)

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15. Management of Crisis and Disaster (April 2015)

16. Credit Hour System (May 2015)

2. EDC-CPD workshops at Pharos University in Alexandria (PUA)

Workshop Name Date

1. Academic integrity

1-10 February 2016

2. Student's assessment

3. Learning styles

4. Motivation strategies and feed back

5. Interactive learning

6. Syllabus design and construction

7. Managing lectures

Community and Students Services

December 2012- Present: Head of Alamal student’s social group, Faculty of Pharmacy, Alexandria University, Egypt.

September 2012-to present: Member in student affairs and learning committee. September 2012-to present: Member in testing committee for selection of eligible students to visit Koyoto Pharmaceutical University (Japan)

September 2012-to present: Member in faculty committee for students with

special academic support Seminars and presentations

1. Oral disintegrating tablets: Recent advances and premises; (7/7/2007); Faculty of Pharmacy, Alexandria University.

2. Lipid based delivery systems for oral delivery: biopharmaceutical challenges and regulatory status (25/5/2008) Faculty of Pharmacy, Alexandria University.

3. Self-nanoemulsifying drug delivery systems: Recent review (2/8/2010) Faculty of Pharmacy, Alexandria University.

4. Phytosomes as Nanomedicines for Enhanced Diosmin Delivery. An oral Presentation at the Annual conference of Alexandria University Held at Faculty of Medicine, Alexandria University Egypt (27-28 / 12/2012).

Research interest

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Nanomedicine and pharmaceutical nanotechnology as an imperative tool to improve therapeutic efficacy of drugs mainly in cancer therapy. I have a good experience in elaboration and appraisal procedures of Lipid nanocarriers, polymeric nanoparticles and drug nanosuspensions. Nanomedicines of interest encompass nano-sized delivery systems including Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), Nanoemulsion, Self-nanoemulsifying Drug Delivery Systems (SNEDDS), Liposomes, Self-emulsifying phospholipid dispersions, Phytosomes, Bilosomes, transfersomes, ethosomes, Hylauossomes, polymersomes. Nano-structured gels and chitosan nanoparticles. My experience in optimization and assessment of delivery systems covers different non-invasive routes of administration including oral, sublingual, intranasal, and dermal and transdermal routes of administration, with detailed hands on experience in in-vitro transdermal studies via human and animal skin modeling, Alzheimer,s animal model and cancer cell line techniques. Recent delivery approaches focused on cancer and disease targeting via both passive and active techniques, with higher emphasis on herbal drugs. Another important approach is employment of bioactive nanocarriers to improve bioavailability of drugs suffering pre-systemic clearance. Furthermore, research interest encompasses pharmaceutical technology with higher concern in Orally Disintegrating Tablets (ODT); manufacturing; evaluation and patents.

Projects

Title Development of potential vaccine candidates against Schistosoma mansoni using novel

delivery systems Date Role Funding Agency 2010-2011

Co Investigator

Enhancement Program (ALEX REP); Alexandria, Egypt.

International Peer review Peer reviewer in the following highly ranked international journals in pharmaceutics:

1. International Journal of Pharmaceutics (November 2009). 2. Drug Development and Industrial Pharmacy (February 2010). 3. Current Drug Delivery (March 2010). 4. Recent Patents in Drug Delivery and Formulation (May 2010) 5. European Journal of Pharmaceutical Sciences (January 2011). 6. Journal of Nanoparticle Research (May 2011) 7. International Journal of Nanomedicines (July 2011) 8. Pharmaceutical research (January 2012). 9. European Journal of Pharmaceutics and Biopharmaceutics (May 2012) 10. DARU Journal of Pharmaceutical Sciences (March 2013) 11. Drug Delivery letters ( April 2013) 12. Artificial cells, NANOMEDICINE and Biotechnology (May 2016)

Supervising thesis

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1. Nanocarriers as Promising Approach in Pharmaceutical Products Development

(Master thesis, registered October 2010, Defended August 2012). 2. A novel drug delivery approach for optimization of the pharmaceutical quality of

herbal drugs (Master thesis, registered October 2010, Defended May 2013) 3. Self-emulsifying lipid dispersion: an approach to improve delivery characteristics

of some poorly-soluble phytopharmaceuticals (Master thesis , registered September 2011)

4. Preparation and Evaluation of gel microemulsions and lipogels to enhance the efficacy of poorly permeable drugs (Master thesis, registered September 2011).

5. Design and characterization of some modified vesicular systems as nano-metric drug carriers (Master thesis, registered November 2012)

6. Development of selected nano-structured systems for modulation of dermal and transdermal drug delivery. (PhD thesis, registered January 2013, defended February 2015)

7. Employment of Cell Culture technique in Development and Assessment of Selected Drug Delivery Systems (PhD thesis, registered July 2013)

8. Design and Characterization of Selected Nanomedicines for Improving Drug Efficacy in Alzheimer's disease Therapy (master thesis, registered July 2013; defended March 2015)

9. Development and evaluation of novel nano-systems for targeted cancer therapy, (PhD thesis, registered March 2014)

10. Preparation and Evaluation of Polymerosomes versus Lipid Vesicles for Improved Drug Delivery (Master thesis, registered September 2014).

11. Design and Characterization of Lipid-Polymer Hybrid Nanoparticles for Optimization of Drug Delivery. (Master thesis, registered October 2014).

12. Development and Appraisal of Gel-core Liposomes Improved Delivery of Selected Drugs (Master thesis, registered April 2015)

Workshops and conferences 1. Participant in "Nanotechnology Advances" conference (November 2008);

Science college, University of Alexandria, Egypt. 2. Participant in Workshop on characterization of nanoparticles using

dynamic light scattering; Malvern cooperation, material characterization (October 2010) faculty of pharmacy, Alexandria, Egypt

3. Participant in Workshop on different methods of students, evaluation and cognitive domains (October 2010), Faculty of Pharmacy; University of Alexandria, Egypt.

4. Participant in Workshop on construction of written, oral and practical examinations (December 2010); Faculty of Pharmacy; University of Alexandria, Egypt.

5. Participant in Workshop on e-learning: electronic and curricula of faculties of pharmacy in different universities (November 2010), Faculty of Pharmacy; University of Alexandria, Egypt.

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6. Participating by a poster and abstract in the FUE international conference on pharmaceutical technologies held in February 2012 at the Intercontinental city star, Future University, Cairo, Egypt.

7. Supervisor and organizer of the student scientific forum “Recent Advances in Pharmacy: Nanotechnology and Pharmacy Practice” held by pharmacy students on 31st March to 2 April 2012 at faculty of pharmacy, Alexandria University, Egypt.

8. Participant in BioVisionAlexandria2012 Conference: New life science: Linking Science to Society, held at Bibliotheca Alexandria 22nd -25th April 2012.

9. Participant in the Annual Conference of Pharmaceutics Department held in faculty of pharmacy, Alexandria University 4/9/2012.

10. Attendee in a lecture on "Interpretation of clinical laboratory data: part I" given on 4 November 2012 at Faculty of Pharmacy Alexandria University, Egypt.

11. Speaker and Participant by abstract in Annual Conference of Alexandria University held in Faculty of Medicine, Alexandria University 27th-28th December 2012.

12. Participated by published abstract in abstract in 5th international conference on drug discovery and therapy 5th ICDDT; February 18th-21st 2013, Dubai, UAE.

13. Participant in Research day for Pharmacy graduates, February, 22, 2014, faculty of pharmacy, Alexandria University, Egypt.

14. Poster presentation in 3rd FUE International Conference of Pharmaceutical Sciences (3rd FUE-ICPS) held in February 2012 at the Intercontinental city star, Future University, Cairo, Egypt February 9-11, 2015.

15. Poster presentation in 6th International Congress BioNanoMed 2015 - Nanotechnology enables Personalized Medicine held in Graz, Austria from 8 – 10 April (2015)

16. Poster presentation in First PUA International Conference on Advances in Pharmaceutical Sciences (ICAPS) held in Pharos University of Alexandria 27-28 October 2015).

17. Attendee in PUA field project discussion ceremony of bachelor students PUA (17 February 2016)

18. Reviewer to the poster session in BioVisionAlexandria 2016: New life sciences: The Road Ahead held in bibliotheca Alexandria 12-14 April 2016.

19. Workshop on Interactive learning and its technique. Faculty of pharmacy and drug manufacturing. Pharos University of Alexandria 1 March 2016

20. Attendee in Annual Scientific day of pharmaceutics Department. Faculty of pharmacy and drug manufacturing. Pharos University of Alexandria 15 March 2016

21. Attendee in Orientation workshop to Fulbright program. Faculty of Engineering. Pharos University of Alexandria. 22 March 2016

22. Attendee in Annual Scientific day of Faculty of pharmacy and drug manufacturing-PUA 26 April 2016

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23. Supervisor of Graduation project presentation on Implementations of nanomedicine in cancer therapy Faculty of pharmacy and drug manufacturing. Pharos University of Alexandria 4 May 2015

24. Supervisor on student posters in Pharmacist day of Faculty of pharmacy and drug manufacturing-Pharos University in Alexandria 5 May 2016.

25. Attendee in Ceremony of faculty of Pharmacy and drug manufacturing, Pharos University in Alexandria for Accreditation. 10 May 2016.

26. Attendee in Graduation project presentation on recent brain tumor therapy Faculty of pharmacy and drug manufacturing-Pharos University in Alexandria 17 May 2016.

Membership in Faculty committees 1. 2012-to present: Member in student affairs and learning committee 2. 2012-2013/ 2013-2014: Member of testing committee for selection of eligible

students to visit Koyoto Pharmaceutical University (Japan) 3. 2013-2014: Department representative member in Library committee 4. 2013-2014: Member in Faculty committee of students with special needs 5. 2013-present: Member in quality assurance committee of pharmaceutics

department International publications: (h-index: http://scholar.google.com/citations?hl=en&user=chHQ6I0AAAAJ) 1. Yosra. S.R. Elnaggar*, Magda. A. El-Massik, Ossama. Y. Abdallah. Self-

nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization. International Journal of Pharmaceutics 380 (1-2): 133-141 (2009).

2. Yosra S.R. Elnaggar*, Magda A. El-Massik, Ossama Y. Abdallah,and Abd Elazim R. Ebian. Maltodextrin: A Novel Excipient Used in Sugar-Based Orally Disintegrating Tablets and Phase Transition Process. AAPS PharmSciTech. 11(2): 645-651 (2010).

3. Yosra. S.R. Elnaggar*, Magda. A. El-Massik, Ossama. Y. Abdallah. Sildenafil Citrate Nanoemulsion versus Self-nanoemulsifying Delivery Systems: Rationale Development and Transdermal Permeation. International Journal of Nanotechnology 8 (8-9): 749-763 (2011) {Selected for the release media of that special issue dedicated to nanomedicine].

4. Yosra. S.R. Elnaggar*, Magda. A. El-Massik, Ossama. Y. Abdallah. Fabrication,

Appraisal, and Transdermal Permeation of Sildenafil Citrate Loaded Nano-structured Lipid Carriers versus Solid Lipid Nanoparticles. International Journal of Nanomedicine 6: 3195–3205 (2011).

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5. Manal A. Elsheikh*, Yosra S.R. Elnaggar, Eman Y. Gohar , Ossama Y.Abdallah . Impact of Nanomedicine on the In-vitro and In-vivo Characteristics of Raloxifene Hydrochloride. An abstract and poster presentation in the FUA International Conference on Pharmaceutical Technologies, Future University, Cairo, Egypt (9-11 February 2012).

6. Manal A. Elsheikh , Yosra S.R. Elnaggar*, Eman Y. Gohar, Ossama Y.Abdallah.

Nanoemulsion Liquid-preconcentartes for Raloxifene Hydrochloride: Optimization and In-vivo Appraisal. International Journal of Nanomedicine, 7: 3787–3802 (2012).

7. Yosra S.R.Elnaggar1*, May S. Freag1, Ossama Y. Abdallah1. Optimization and Ex-vivo Permeation of Phytosomes as Platforms for Improved Diosmin Delivery. Published abstract in 5th international conference on drug discovery and therapy (5th ICDDT); Dubai, UAE 18-21 February (2013).

8. May S. Freag1, Yosra S.R.Elnaggar1*, Ossama Y. Abdallah. Lyophilized Phytosomal Nanocarriers (LPNs) as Platforms for Enhanced Diosmin Delivery: Optimization and Ex-vivo Permeation. International Journal of Nanomedicine 8: 2385–2397 (2013).

9. May S. Freag1, Yosra S.R.Elnaggar1*, Ossama Y. Abdallah. Development of Novel Polymer-stabilized Diosmin Nanosuspensions: In-vitro Appraisal and Ex-vivo permeation International journal of Pharmaceutics. 454: 462– 471 (2013).

10. Yosra S.R. Elnaggara*, Wessam M. El-Refaieb, Magda A. El-Massikb, Ossama Y. Abdallaha. Lecithin-based nanostructured gels for skin delivery: An update on state of art and recent applications. Journal of Controlled Release 180: 10–24 (2014).

11. Manal A. Elsheikh , Yosra S.R. Elnaggar ,*, Ossama Y. Abdallah . Rationale employment of cell culture versus conventional techniques in pharmaceutical appraisal of nanocarriers. Journal of Controlled Release 194: 92–102 (2014).

12. Eman MM Shehata, Yosra SR Elnaggar, Saly Galal, Ossama Y Abdallah. Enhanced dissolution and intestinal permeation of genistein from bioactive self-emulsifying phospholipid dispersion (SEPD). An abstract and poster presentation in the 3rd FUE International Conference of Pharmaceutical Sciences (3rd FUE-ICPS). Future University, Cairo, Egypt: 9-11 February (2015).

13. Samar M. Etman (1a), Yosra S.R. Elnaggar (1b), Doaa A. Abdelmonsif (2)*, Ossama Y. Abdallah (1c). Brain-Targeted Piperine-loaded Chitosan Nanoparticles: A novel era in Alzheimer's Therapy. 6th International Congress BioNanoMed 2015 - Nanotechnology enables Personalized Medicine, held in Graz, Austria from 8 – 10 April (2015).

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14. Wessam M. El-Refaieb, Yosra S.R. Elnaggara*, Magda A. El-Massikb, Ossama Y. Abdallaha. Novel Self-assembled, Gel-core Hyaluosomes for Non-invasive Management of Osteoarthritis: In-vitro Optimization, Ex-vivo and In-vivo Permeation. Pharmaceutical Research 32:2901–2911 (2015).

15. Yosra S.R. Elnaggara*. Multifaceted implementations of bile salts in pharmacy: An emphasis on nanomedicine. International Journal of Nanomedicine 10:3955-3971 (2015).

16. Wessam M. El-Refaiea, Yosra S.R. Elnaggarb*, Magda A. El-Massika, Ossama Y. Abdallahb. Novel Curcumin-loaded Gel-Core Hyaluosomes with Promising Burn-Wound Healing Potential: Development, In-vitro Appraisal and In-vivo Studies. International journal of pharmaceutics 486: 588-98 (2015).

17. Yosra S.R. Elnaggara*, Samar M. Etmana ,Doaa A. Abdelmonsif b, Ossama Y. Abdallaha. Optimization and In-vivo Appraisal of Piperine-loaded Intranasal Chitosan Nanoparticles as Brain-Targeted Dual Acting Therapy in Alzheimer's disease. Journal of Pharmaceutical Sciences. 104:3544–3556, 2015).

18. Yosra S.R. Elnaggara*, Samar M. Etmana ,Doaa A. Abdelmonsif b, Ossama Y. Abdallaha.Novel Piperine-loaded Tween-integrated Monooleain Cubosomes as Brain-targeted Oral Nanomedicine in Alzheimer's disease: Pharmaceutical, Biological and Toxicological Studies. International Journal of Nanomedicine: 10 5459–5473 (2015).

19. Sara M. Talaat, YosraS.R. Elnaggar, OssamaY. Abdallah. Novel Lecithin-

Microemulsion Based Gels (LMBGs) for Targeted Dermal Delivery of Terconazole: Optimization, Microbiological and Permeation Studies. Poster presentation in First PUA International Conference on Advances in Pharmaceutical Sciences (ICAPS) held in Pharos University of Alexandria 27-28 October 2015).

20. May S. Freag1, Yosra S.R.Elnaggar1*, Ossama Y. Abdallah. In-vitro Cytotoxicity and Pharmacokinetics of PEGylated Monoolein-based Liquid Crystalline Nanoparticles of Aloe-emodin for Cancer Therapy” International journal of Nanomedicine. Accepted for publication (June 2016).

21. Yosra S.R.Elnaggar1*, May S. Freag1, Ossama Y. Abdallah. Layer-by-Layer Polyelectrolytes Coated Liquid Crystalline Nanoparticles of Rapamycin for Active Cancer Targeting: In-vitro Characterization and In-vivo Studies. Nanomedicine UK. Submitted manuscript (JUNE 2016).