OVERVIEW:

A 350+ page document, with 1,000+ insightful charts

Detailed profiles of the Top 100 CMOs with their market share in each segment

Understand the impact of Raw Materials, with precise needs for: Stainless Steel, Cobalt Chrome & Titanium

Our latest research on Additive Manufacturing for Orthopaedics is included: market analysis, main users & suppliers, top selling products and 2023 forecasts

This report also includes analysis of Orthobiologics, Peek and Polyethylene UHMW

THE WORLDWIDE ORTHOPAEDIC & SPINE CONTRACT MANUFACTURINGMARKET REPORT 2018-2023& TOP 100 SUPPLIER PROFILES

AVICENNE’S

UNIQUE WARRANTY

If you are not 100% satisfied with our

report, send it back to us with a letter indicating

the reasons and we will refund you in full!

PUBLISHED MAY 2019 • 8TH EDITION

N E WSpecial focus on Raw

Materials for orthopaedics:

Stainless Steel, Cr-Co

& Titanium needs for

OEMs and for Contract

Manufacturers

WHY BUY THIS REPORT?

Get accurate data and strategic insights on the worldwide US$ 5.7 Bn Orthopaedic & Contract Manufacturing market & players

For OEMs : obtain detailed information on top 100 contract manufacturers in the USA, Europe and rest of the world with their back-ground, owners, strengths and specialties. Apprehend the magnitude of latest manu-facturing trends (Additive Manufacturing, coating growth, navigation & robotics etc)

For investors & private equity firms: identify the best companies to invest in

www.avicenne.comDownload the detailed table of contents

1"WHERE IS GROWTH ?" IN-DEPTH ANALYSIS COVERING 14 SEGMENTS / 62 SUB SEGMENTS ON THE US$ 5.7 BN WORLDWIDE CONTRACT MANUFACTURING MARKET

2 ASSESS YOUR CUSTOMERS' NEEDS WITH OUR DETAILED ANALYSIS OF OEM CONTRACT MANUFACTURING DEMAND

Contract Manufacturing segmentation & Raw materials usage: 14 segments & 62 sub-segments

For each of the following OEMs, herebelow data is provided: Manufacturing strategy with underlying detailed volume and value data Facility locations for each product Outsourcing vs In house % for implants, instruments, cases & trays, coating, ceramics, packaging In-house vs Contract Manufacturing volumes per product for forging, casting, machining, coating, instruments, cases & trays, etc.

All other Challengers

Source : Avicenne 2018

FORG

ING &

CAST

ING

HIP STEM

HIP CUP

TIBIAL KNEE

LF PLATES

LC PLATES

FEMORAL KNEE (SPECIAL

FORGING)

FEMORAL KNEE

TIBIAL KNEE

HIP CUP

HIP STEM

FORG

ING

CAST

ING

MACH

ININ

G

STEM

FEMORAL

CUP

TIBIAL

INSERT

HEAD

LINER

HIP M

ACHI

NING

KNEE

MAC

HINI

NG

SPINE LUMBAR & CAGES

SPINE CERVICAL PLATES

TRAUMA INTERNAL PLATES

TRAUMA SCREWS & OTHERS

SPINE CERVICAL &

CAGES

HIP

KNEE

SPINE

TRAUMA

HIP

KNEE

SPINE

TRAUMA

SPIN

E, TR

AUMA

MA

CHIN

ING

INST

RUME

NTS

MACH

ININ

GCA

SES &

TRAY

S

OTHE

R PRO

CESS

ES

HEAD

LINER

HIP

STEM

KNEE

CUP

SPINE

FEMORAL

TRAUMA

TIBIAL

CERA

MICS

MISC

ELLA

NEOU

SCO

ATIN

GMA

RKIN

G, PA

CKAG

ING &

STER

ILIZA

TION

RAW

MAT

ERIA

LS

HIP STEM FORGED

IMPLANTS

HIP STEM

KNEE FEMORAL CASTED

TRAUMA INTERNAL PLATE

INSTRUMENTS

HIP CUP

KNEE TIBIAL FORGED

CASES & TRAYS

TRAUMA LF & LC PLATE

HIP HEAD

KNEE TIBIAL

HIP CUP CASTED

HIP HEAD CASTED

HIP STEM CASTED

TRAUMA PLATE MACHINED

SPINE LUMBAR MACHINED

HIP CUP FORGED

TRAUMA LF & LC PLATE

SPINE MACHINED

KNEE FEMORAL FORGED

TRAUMA SCREWS, HOOKS

MACHINED

TITAN

IUM

CR-C

OST

AINL

ESS S

TEEL

N E WOrthopaedics Additive

Manufacturing market

analysis: users, suppliers,

top selling products &

market forecasts

Ali MADANIPhone: + 33(0) 144 551 990a.madani@avicenne.com

1

Leveraging 25 years of high level contactsand market tracking & modelling

A 360° view ofOrthopaedics

OEM & Contract Manufacturer direct interviews with decision makers thanks to strong links with CEOs, R&D, Marketing, Sales...

Cross-checking of information thanks to our tried & tested operating models

25+ years of historical data on the Orthopaedics & Contract Manufacturing markets

Companies & markets; continuous tracking and detailed market and financial modelling

Highly detailed segmentation

Entire supply chain & all players: OEMs, Contract Manufacturers

All product types: implants, instruments, cases & trays, biologics, cements, ceramics

All manufacturing services: forging, casting, machining, coating, packaging, sterilization

Operating Models &Cross-checking of information

Implants

HipKnee Spine

ExtremitiesTrauma

Contract Manufacturing

Implants Cases trays

Worldwide coverage

Western Europe

Latin America, Middle East, Asia,..

Developed countries

BRICS countries

Other countries

Instruments Biologics

Secondary research

Primary research

Full value chain coverage

Instruments Cases & Trays Implants

AVICENNE provides four main data components : historical and forecasted market size and current market shares on each Product/Manufacturing method tandem, market breakdown by In house vs Contract Manufacturing and main OEM buyers, CMO’s main customers / OEM preferred suppliers.

• Implants: Tecomet, Orchid, Viant (Integer), Lisi, Avalign, Paragon (NN), Marle, Norman Noble, PCC, etc. (70+ companies mentioned)

• Instruments: Tecomet, Viant (Integer), In'tech, Paragon (NN), Avalign, Autocam Medical, Norwood, Orchid, Lisi, Tegra, KLS, Bradshaw (In'tech), CoorsTek, etc. (45+)

• Cases & trays: Tecomet, Paragon (NN), Viant (Integer), Avalign, Medin, Pyxidis (In'tech), Aesculap, RMS, Inomed, etc. (20+)

• Coating: Orchid, Eurocoating, Viant (Integer), DOT, APS Materials, Terolab, Medical Group, Medicoat, etc.

• Also main players data for forging, casting, etc.

3POSITION YOUR OFFER WITH OUR PRICE DASHBOARDS, AVAILABLE FOR EACH PRODUCT BY MANUFACTURING METHOD

5IDENTIFY CONTRACT MANUFACTURING MARKET TREND WITH FORECASTS UP TO 2023 IN VALUE

4UNDERSTAND COMPETITION DYNAMICS WITH MARKET SHARES & COMPANY DATA

6CONTRACT MANUFACTURING COMPANY RANKINGS & TOP 100 SUPPLIER PROFILES

For each product and its manufacturing method, the Average Selling Price (ASP) is provided, with the min/max spread.

Contract Manufacturing market is growing at 7% per year, a faster rate than the orthopaedic market.Main drivers for this faster growth are: Challengers who outsource more are taking away market share from Majors and gradual divestment from Majors.

Avicenne is also the creator of IMPLANTS, a worldwide conference focusing on Strategy, Innovation & Regulatory in the orthopaedic world.The 2018 and 14th edition of IMPLANTS attracted more than 150 international decision-makers for 2 days of presentations, tutorials and business networking. The speakers highlighted how manufacturing techniques and purchasing strategies are evolving, how Robotics and Additive Manufacturing will alter the future landscape and how to cope with Regulatory burdens.

SURVEY METHODOLOGY BASED ON DIRECT INTERVIEWS AND 25 YEARS OF EXTENSIVE MODELLING

Example of profile:

M U

S$

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

CAGR 2018-2023: 7%

CAGR 2012-2018: 6.8%CAGR

2018-2023

Implants:7.7%

Cases: 5.7%

Instrum: 6.1%

www.implants-event.com

PARIS / FRANCE

Created and chaired by

International conference on innovationfor orthopaedic implants and orthobiologics

2 0 19

S I N C E 2 0 0 515

Forging Hip stems

Hip cups

Femoral knee (oxinium)

Knee tibial

Trauma LC plates

US$

Casting Knee tibial

Knee femoral

Hip cup

Hip Stem

US$

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Ad hoc studies – please call or email us

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MAIN REPORTWorldwide Orthopaedic Contract Manufacturing Market Report 2018-2023 & Top 100 supplier profiles

NUMBER OF PAGESNUMBER OF EXHIBITS SINGLE-USER LICENSEPRODUCT OPTIONS

350+ pages

1,000+ exhibits€4,600

WORLDWIDE ORTHOPAEDIC CONTRACT MANUFACTURING MARKET REPORT 2018-2023& TOP 100 SUPPLIER PROFILES PUBLISHED MAY 2019 • 8TH EDITION

OTHER CONSULTING SERVICES: AD HOC STUDIES, VENDOR, COMMERCIAL & STRATEGIC DUE DILIGENCEAVICENNE was founded in 1992 by Ali Madani and has been operating on strategic and marketing studies in the medical sector since then. AVICENNE has advised major players in this industry (Medtronic, Stryker, Zimmer Biomet, Depuy Synthes, etc.) with their strategy development and implementation, technical and economic appraisals, mergers and acquisitions. AVICENNE has also advised many Private Equities firms on acquisitions and build-ups. AVICENNE has worked with mid-size companies on their entry strategy for new markets, adjacencies or new geographic territories as well as business model improvements and partnership strategies. Globally, AVICENNE has been involved in more than 320 projects for 100+ customers in the medical device industry. AVICENNE has published several annual surveys such as “European orthopaedic Market” and “Worldwide orthopaedic Contract Manufacturing market and top 100 supplier profiles”. AVICENNE’s Managing Partner, Ali Madani is a speaker and chairman of several medical device conferences worldwide. He founded “IMPLANTS” a medical device industry conference and exhibition, focusing on manufacturing, innovation and buying strategies, which he has chaired ever since.

Contact Ali Madani CEO of Avicenne

a.madani@avicenne.com Ph +33 1 44 55 19 90

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