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. USA Toll-free 1 877 GeneTex(1 877 436 3839) Il!e Fax 949 309 2888 Tene ex E-mail info@genetex com International Tel 886 3 6208988 Fax 886 3 6208989 www genetex com E-mail internationa/@genetex com Your Expertise, Our Antibodies, Accelerated Discovery. DNMT3a, DNMT3b - De novo methylation DNMTl - Maintenance of methylation TET family - Cytosine demethylation RINGlA/1B BMI NH 2 ri N 0 Cytosine (C) e n s Yto 2 NL < Acm N_Dthcs e m ' 5 \ 0 NH2 HO~J N 0 5'-carboxylcytosine (5-cac) y h \ ` GKAKHH N' S R K GGKA 1 5 C' TETs <. e n . , ` VA K A P A S K A P E P N' / TETl Antibody TET2 Antibody DNMTl Antibody TFIIIC90 GCNS PCAF TFIIIC90 CBP GCNS MOZ PCAF CBP N' RTK RKS G- K RK LA K RKS TGG K 2 3 4 8 9 10 14 17 18 23 26 27 28 30 36 Jm :? l 9 7 RL K NSDl Pr-Set7 SET9 SUV4-20H1~2 K 20 16 K8 L K12 ; K R S N' 5 3 1 PRMT4 PRMTS JMJD6 700 700 62 54 600 600 1 57.46 500 •C nntro I lgG 500 • • ,oo,,o , £ •5 · mC an~bod y (GTX6 29446) £ •5• hmC ;f!. 30 0 a, 300 200 200 10 0 100 0.49 1 09 DD OD 5-mC 5-hmC 5-h mC 5-mC SmC Antibody 5hmC Antibody (Kb) 1- 0 85- 0.65- 0. 5- 0.4 - 0.3 - Methylated cytosine DNA MLLl~S SETlA~B Ashl SET7/9 LSDl JARIDlA~D SUV39H1~2 ESET CLLS RIZ CLR4 LSDl JHDM2A~B JMJD2A~D 0 ls o merizat,on Isom erase SET2 NSDl SMYD2 JHDMlA~B JMJD2A~C $ Ubiquitinat,on Ubiquitin Ugases e Acetylation Acetyl transferases Deacetylt ransferases ~ Phosphorylation Kinases ill Methylat,on Methyltransferases Demethylases N' N terminus C' C terminus PP-E004-190124
